11,936 Matching Annotations
  1. Last 7 days
    1. However, the entire repair process for DSBs is notably more efficient in DR than in other organisms; DR is able to restore hundreds of copies of damaged double strands in an hour

      I guess that answers my last question, but raises another question: what allows the repair process to only be most efficient in DR than other organisms, could there be some other important aspect involved in the mechanism?

    2. The first binding between drRecO and ssDNA occurs in the drSSB-free space of ssDNA and generates a heterotrimer of the drSSB-ssDNA-drRecO complex as an intermediate state. The second binding between drRecO and ssDNA induces the dissociation of drSSB from ssDNA by facilitating a conformational change in ssDNA.

      So ultimately from these findings there are two steps involved in a conformational change in the ssDNA and can avoid using ATP?

    3. molecular mechanism of D. radiodurans (DR) RecO (drRecO) in SSB displacement from ssDNA at the single-molecule level. DR is the toughest bacterium known, with outstanding resistance to ionizing radiation and DNA damage-inducing reagents (Blasius et al., 2008; Cox and Battista, 2005; Slade and Radman, 2011), which are the main causes of DSBs, a form of fatal biological damage at the genomic level

      I wonder if a section of the genome that helps encode for this mechanism and trait for resistance to ionizing radiation can be inserted in other organisms or be used to prevent DNA damage from radiation

    4. In summary, our results demonstrate that drRecO binds to ssDNA sequentially using its two binding sites, which gives drRecO the ability to displace drSSB from ssDNA even though the binding affinity of drRecO for ssDNA is two orders of magnitude smaller than that of drSSB.

      It is amazing that cells are capable of performing actions like this and the researchers were able to show this through their results. I would usually assume that a molecule would need a stronger binding affinity to displace another bound protein, so it was interesting to learn how DrRecO can accomplish this with a much lower binding affinity.

    5. RecO is believed to play a key role in this step because RecO is able to interact with SSB, ssDNA, and dsDNA simultaneously

      So (if I'm interpreting this correctly) RecO is thought to be involved in helping to recruit the rest of the RecFOR machinery to the site of the break because it can interact with SSB, ssDNA, and dsDNA even though SSB binds strongly to ssDNA, right?

  2. Aug 2021
    1. RRID:AB_10861977

      DOI: 10.7554/eLife.70564

      Resource: (Abcam Cat# ab113687, RRID:AB_10861977)

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      SciCrunch record: RRID:AB_10861977


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    2. RRID:AB_303395

      DOI: 10.7554/eLife.70564

      Resource: (Abcam Cat# ab290, RRID:AB_303395)

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      SciCrunch record: RRID:AB_303395


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    1. RRID:Addgene_113005

      DOI: 10.7554/eLife.67294

      Resource: RRID:Addgene_113005

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      SciCrunch record: RRID:Addgene_113005


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    2. RRID:AB_10015282

      DOI: 10.7554/eLife.67294

      Resource: (Jackson ImmunoResearch Labs Cat# 711-035-152, RRID:AB_10015282)

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      SciCrunch record: RRID:AB_10015282


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    3. RRID:AB_2338133

      DOI: 10.7554/eLife.67294

      Resource: (Jackson ImmunoResearch Labs Cat# 112-035-062, RRID:AB_2338133)

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      SciCrunch record: RRID:AB_2338133


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    4. RRID:AB_2338510

      DOI: 10.7554/eLife.67294

      Resource: (Jackson ImmunoResearch Labs Cat# 115-035-164, RRID:AB_2338510)

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      SciCrunch record: RRID:AB_2338510


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    5. RRID:AB_2340447

      DOI: 10.7554/eLife.67294

      Resource: (Jackson ImmunoResearch Labs Cat# 706-035-148, RRID:AB_2340447)

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      SciCrunch record: RRID:AB_2340447


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    6. RRID:AB_2568986

      DOI: 10.7554/eLife.67294

      Resource: (Nakamura A; Development. 2001 Cat# me31B, RRID:AB_2568986)

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      SciCrunch record: RRID:AB_2568986


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    7. RRID:AB_10598029

      DOI: 10.7554/eLife.67294

      Resource: (MBL International Cat# PM013-7, RRID:AB_10598029)

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    8. RRID:AB_528189

      DOI: 10.7554/eLife.67294

      Resource: (DSHB Cat# F2F4, RRID:AB_528189)

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      SciCrunch record: RRID:AB_528189


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    9. RRID:BDSC_4274

      DOI: 10.7554/eLife.67294

      Resource: (BDSC Cat# 4274,RRID:BDSC_4274)

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      SciCrunch record: RRID:BDSC_4274


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    10. RRID:BDSC_6839

      DOI: 10.7554/eLife.67294

      Resource: (BDSC Cat# 6839,RRID:BDSC_6839)

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      SciCrunch record: RRID:BDSC_6839


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    11. RRID:BDSC_24163

      DOI: 10.7554/eLife.67294

      Resource: (BDSC Cat# 24163,RRID:BDSC_24163)

      Curator: @scibot

      SciCrunch record: RRID:BDSC_24163


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    12. RRID:BDSC_38437

      DOI: 10.7554/eLife.67294

      Resource: (BDSC Cat# 38437,RRID:BDSC_38437)

      Curator: @scibot

      SciCrunch record: RRID:BDSC_38437


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    13. RRID:BDSC_3248

      DOI: 10.7554/eLife.67294

      Resource: (BDSC Cat# 3248,RRID:BDSC_3248)

      Curator: @scibot

      SciCrunch record: RRID:BDSC_3248


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    14. RRID:DGGR_110658

      DOI: 10.7554/eLife.67294

      Resource: (DGGR Cat# 110658,RRID:DGGR_110658)

      Curator: @scibot

      SciCrunch record: RRID:DGGR_110658


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    1. RRID:SCR_002798

      DOI: 10.7554/eLife.68268

      Resource: GraphPad Prism (RRID:SCR_002798)

      Curator: @scibot

      SciCrunch record: RRID:SCR_002798


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    2. RRID:BDSC_18896

      DOI: 10.7554/eLife.68268

      Resource: (BDSC Cat# 18896,RRID:BDSC_18896)

      Curator: @scibot

      SciCrunch record: RRID:BDSC_18896


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    3. RRID:BDSC_24819

      DOI: 10.7554/eLife.68268

      Resource: (BDSC Cat# 24819,RRID:BDSC_24819)

      Curator: @scibot

      SciCrunch record: RRID:BDSC_24819


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    4. RRID:BDSC_56254

      DOI: 10.7554/eLife.68268

      Resource: (BDSC Cat# 56254,RRID:BDSC_56254)

      Curator: @scibot

      SciCrunch record: RRID:BDSC_56254


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    5. RRID:BDSC_8765

      DOI: 10.7554/eLife.68268

      Resource: (BDSC Cat# 8765,RRID:BDSC_8765)

      Curator: @scibot

      SciCrunch record: RRID:BDSC_8765


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    6. RRID:BDSC_5905

      DOI: 10.7554/eLife.68268

      Resource: (BDSC Cat# 5905,RRID:BDSC_5905)

      Curator: @scibot

      SciCrunch record: RRID:BDSC_5905


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    1. RRID:Addgene_12253

      DOI: 10.7554/eLife.64148

      Resource: RRID:Addgene_12253

      Curator: @scibot

      SciCrunch record: RRID:Addgene_12253


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    2. RRID:AB_2875675

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 751690, RRID:AB_2875675)

      Curator: @scibot

      SciCrunch record: RRID:AB_2875675


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    3. RRID:AB_2875614

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 751621, RRID:AB_2875614)

      Curator: @scibot

      SciCrunch record: RRID:AB_2875614


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    4. RRID:AB_394629

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 553108, RRID:AB_394629)

      Curator: @scibot

      SciCrunch record: RRID:AB_394629


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    5. RRID:AB_394806

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 553355, RRID:AB_394806)

      Curator: @scibot

      SciCrunch record: RRID:AB_394806


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    6. RRID:AB_394774

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 553310, RRID:AB_394774)

      Curator: @scibot

      SciCrunch record: RRID:AB_394774


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    7. RRID:AB_394595

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 553062, RRID:AB_394595)

      Curator: @scibot

      SciCrunch record: RRID:AB_394595


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    8. RRID:AB_396936

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 557915, RRID:AB_396936)

      Curator: @scibot

      SciCrunch record: RRID:AB_396936


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    9. RRID:AB_394618

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 553088, RRID:AB_394618)

      Curator: @scibot

      SciCrunch record: RRID:AB_394618


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    10. RRID:AB_394643

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 553127, RRID:AB_394643)

      Curator: @scibot

      SciCrunch record: RRID:AB_394643


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    11. RRID:AB_10694494

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 5453, RRID:AB_10694494)

      Curator: @scibot

      SciCrunch record: RRID:AB_10694494


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    12. RRID:AB_2228008

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 2764, RRID:AB_2228008)

      Curator: @scibot

      SciCrunch record: RRID:AB_2228008


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    13. RRID:AB_2062127

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 9239, RRID:AB_2062127)

      Curator: @scibot

      SciCrunch record: RRID:AB_2062127


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    14. RRID:AB_2716685

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)

      Curator: @scibot

      SciCrunch record: RRID:AB_2716685


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    15. RRID:AB_10167668

      DOI: 10.7554/eLife.64148

      Resource: (Santa Cruz Biotechnology Cat# sc-25778, RRID:AB_10167668)

      Curator: @scibot

      SciCrunch record: RRID:AB_10167668


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    16. RRID:AB_11210179

      DOI: 10.7554/eLife.64148

      Resource: (Millipore Cat# 07-178, RRID:AB_11210179)

      Curator: @scibot

      SciCrunch record: RRID:AB_11210179


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    17. RRID:AB_626736

      DOI: 10.7554/eLife.64148

      Resource: (Santa Cruz Biotechnology Cat# sc-7382, RRID:AB_626736)

      Curator: @scibot

      SciCrunch record: RRID:AB_626736


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    18. RRID:AB_203288

      DOI: 10.7554/eLife.64148

      Resource: (Bethyl Cat# A300-081A, RRID:AB_203288)

      Curator: @scibot

      SciCrunch record: RRID:AB_203288


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    19. RRID:AB_2160739

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)

      Curator: @scibot

      SciCrunch record: RRID:AB_2160739


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    20. RRID:AB_2070042

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 9664, RRID:AB_2070042)

      Curator: @scibot

      SciCrunch record: RRID:AB_2070042


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    21. RRID:AB_2798429

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 14220, RRID:AB_2798429)

      Curator: @scibot

      SciCrunch record: RRID:AB_2798429


      What is this?

    22. RRID:AB_2631168

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 13987, RRID:AB_2631168)

      Curator: @scibot

      SciCrunch record: RRID:AB_2631168


      What is this?

    23. RRID:AB_2143306

      DOI: 10.7554/eLife.64148

      Resource: (Bethyl Cat# A300-105A, RRID:AB_2143306)

      Curator: @scibot

      SciCrunch record: RRID:AB_2143306


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    24. RRID:AB_2688010

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 14197, RRID:AB_2688010)

      Curator: @scibot

      SciCrunch record: RRID:AB_2688010


      What is this?

    25. RRID:AB_2688009

      DOI: 10.7554/eLife.64148

      Resource: (Cell Signaling Technology Cat# 14689, RRID:AB_2688009)

      Curator: @scibot

      SciCrunch record: RRID:AB_2688009


      What is this?

    26. RRID:CVCL_0258

      DOI: 10.7554/eLife.64148

      Resource: (ECACC Cat# 94042252, RRID:CVCL_0258)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0258


      What is this?

    27. RRID:CVCL_0093

      DOI: 10.7554/eLife.64148

      Resource: (ATCC Cat# CRL-1873, RRID:CVCL_0093)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0093


      What is this?

    28. RRID:CVCL_0004

      DOI: 10.7554/eLife.64148

      Resource: (KCB Cat# KCB 90029YJ, RRID:CVCL_0004)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0004


      What is this?

    29. RRID:SCR_002798

      DOI: 10.7554/eLife.64148

      Resource: GraphPad Prism (RRID:SCR_002798)

      Curator: @scibot

      SciCrunch record: RRID:SCR_002798


      What is this?

    30. RRID:AB_2868885

      DOI: 10.7554/eLife.64148

      Resource: (BD Biosciences Cat# 550475, RRID:AB_2868885)

      Curator: @scibot

      SciCrunch record: RRID:AB_2868885


      What is this?

    31. RRID:Addgene_68343

      DOI: 10.7554/eLife.64148

      Resource: RRID:Addgene_68343

      Curator: @scibot

      SciCrunch record: RRID:Addgene_68343


      What is this?

    32. RRID:SCR_001881

      DOI: 10.7554/eLife.64148

      Resource: DAVID (RRID:SCR_001881)

      Curator: @scibot

      SciCrunch record: RRID:SCR_001881


      What is this?

    33. RRID:SCR_017270

      DOI: 10.7554/eLife.64148

      Resource: ComplexHeatmap (RRID:SCR_017270)

      Curator: @scibot

      SciCrunch record: RRID:SCR_017270


      What is this?

    34. RRID:SCR_001802

      DOI: 10.7554/eLife.64148

      Resource: CASAVA (RRID:SCR_001802)

      Curator: @scibot

      SciCrunch record: RRID:SCR_001802


      What is this?

    35. RRID:AB_2753213

      DOI: 10.7554/eLife.64148

      Resource: (Miltenyi Biotec Cat# 130-091-224, RRID:AB_2753213)

      Curator: @scibot

      SciCrunch record: RRID:AB_2753213


      What is this?

    36. RRID:Addgene_12259

      DOI: 10.7554/eLife.64148

      Resource: RRID:Addgene_12259

      Curator: @scibot

      SciCrunch record: RRID:Addgene_12259


      What is this?

    37. RRID:Addgene_12251

      DOI: 10.7554/eLife.64148

      Resource: RRID:Addgene_12251

      Curator: @scibot

      SciCrunch record: RRID:Addgene_12251


      What is this?

    38. RRID:CVCL_1418

      DOI: 10.7554/eLife.64148

      Resource: (DSMZ Cat# ACC-15, RRID:CVCL_1418)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_1418


      What is this?

    39. RRID:CVCL_0064

      DOI: 10.7554/eLife.64148

      Resource: (DSMZ Cat# ACC-102, RRID:CVCL_0064)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0064


      What is this?

    40. RRID:CVCL_0006

      DOI: 10.7554/eLife.64148

      Resource: (RCB Cat# RCB1189, RRID:CVCL_0006)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0006


      What is this?

    41. RRID:CVCL_8227

      DOI: 10.7554/eLife.64148

      Resource: (RRID:CVCL_8227)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_8227


      What is this?

    42. RRID:CVCL_B488

      DOI: 10.7554/eLife.64148

      Resource: (RRID:CVCL_B488)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_B488


      What is this?

    43. RRID:CVCL_UL49

      DOI: 10.7554/eLife.64148

      Resource: (RRID:CVCL_UL49)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_UL49


      What is this?

    44. RRID:Addgene_57822

      DOI: 10.7554/eLife.64148

      Resource: RRID:Addgene_57822

      Curator: @scibot

      SciCrunch record: RRID:Addgene_57822


      What is this?

    1. RRID:SCR_020309

      DOI: 10.7554/eLife.66768

      Resource: Nanodrop 2000c Spectrophotometer (RRID:SCR_020309)

      Curator: @scibot

      SciCrunch record: RRID:SCR_020309


      What is this?

    2. RRID:AB_2536530

      DOI: 10.7554/eLife.66768

      Resource: (Thermo Fisher Scientific Cat# G-21234, RRID:AB_2536530)

      Curator: @scibot

      SciCrunch record: RRID:AB_2536530


      What is this?

    3. RRID:AB_2536527

      DOI: 10.7554/eLife.66768

      Resource: (Thermo Fisher Scientific Cat# G-21040, RRID:AB_2536527)

      Curator: @scibot

      SciCrunch record: RRID:AB_2536527


      What is this?

    4. RRID:AB_262044

      DOI: 10.7554/eLife.66768

      Resource: (Sigma-Aldrich Cat# F1804, RRID:AB_262044)

      Curator: @scibot

      SciCrunch record: RRID:AB_262044


      What is this?

    5. RRID:AB_477583

      DOI: 10.7554/eLife.66768

      Resource: (Sigma-Aldrich Cat# T6199, RRID:AB_477583)

      Curator: @scibot

      SciCrunch record: RRID:AB_477583


      What is this?

    6. RRID:AB_302613

      DOI: 10.7554/eLife.66768

      Resource: (Abcam Cat# ab1791, RRID:AB_302613)

      Curator: @scibot

      SciCrunch record: RRID:AB_302613


      What is this?

    7. RRID:AB_10013427

      DOI: 10.7554/eLife.66768

      Resource: (Takara Bio Cat# 632380, RRID:AB_10013427)

      Curator: @scibot

      SciCrunch record: RRID:AB_10013427


      What is this?

    1. RRID:AB_355445

      DOI: 10.7554/eLife.49818

      Resource: (R and D Systems Cat# AF566, RRID:AB_355445)

      Curator: @scibot

      SciCrunch record: RRID:AB_355445


      What is this?

    2. RRID:AB_2133200

      DOI: 10.7554/eLife.49818

      Resource: (Millipore Cat# MAB5272, RRID:AB_2133200)

      Curator: @scibot

      SciCrunch record: RRID:AB_2133200


      What is this?

    3. RRID:AB_2298772

      DOI: 10.7554/eLife.49818

      Resource: (Millipore Cat# MAB377, RRID:AB_2298772)

      Curator: @scibot

      SciCrunch record: RRID:AB_2298772


      What is this?

    4. RRID:AB_10013382

      DOI: 10.7554/eLife.49818

      Resource: (Agilent Cat# Z0334, RRID:AB_10013382)

      Curator: @scibot

      SciCrunch record: RRID:AB_10013382


      What is this?

    5. RRID:AB_10000240

      DOI: 10.7554/eLife.49818

      Resource: (Aves Labs Cat# GFP-1020, RRID:AB_10000240)

      Curator: @scibot

      SciCrunch record: RRID:AB_10000240


      What is this?

    6. RRID:AB_221569

      DOI: 10.7554/eLife.49818

      Resource: (Molecular Probes Cat# A-11122, RRID:AB_221569)

      Curator: @scibot

      SciCrunch record: RRID:AB_221569


      What is this?

    1. RRID:AB_2314986

      DOI: 10.7554/eLife.49226

      Resource: (J. Sevigny, Laval University; Quebec; Canada Cat# NTPDase2, RRID:AB_2314986)

      Curator: @scibot

      SciCrunch record: RRID:AB_2314986


      What is this?

    1. RRID:SCR_015406

      DOI: 10.7554/eLife.49995

      Resource: University of Pennsylvania Center for Molecular Therapy for Cystic Fibrosis (RRID:SCR_015406)

      Curator: @scibot

      SciCrunch record: RRID:SCR_015406


      What is this?

    2. RRID:SCR_014847

      DOI: 10.7554/eLife.49995

      Resource: Salk Institute Gene Transfer Targeting and Therapeutics Core (GT3) (RRID:SCR_014847)

      Curator: @scibot

      SciCrunch record: RRID:SCR_014847


      What is this?

    3. RRID:SCR_002448

      DOI: 10.7554/eLife.49995

      Resource: UNC Joint Vector Laboratories (RRID:SCR_002448)

      Curator: @scibot

      SciCrunch record: RRID:SCR_002448


      What is this?

    1. RRID:AB_659848

      DOI: 10.7554/eLife.47891

      Resource: (Cell Signaling Technology Cat# 9753, RRID:AB_659848)

      Curator: @scibot

      SciCrunch record: RRID:AB_659848


      What is this?

    1. RRID:AB_2535789

      DOI: 10.7554/eLife.18825

      Resource: (Molecular Probes Cat# A-21203, RRID:AB_141633)

      Curator: @scibot

      SciCrunch record: RRID:AB_2535789


      What is this?

    2. RRID:AB_2535792

      DOI: 10.7554/eLife.18825

      Resource: (Thermo Fisher Scientific Cat# A-21206, RRID:AB_2535792)

      Curator: @scibot

      SciCrunch record: RRID:AB_2535792


      What is this?

    3. RRID:AB_11125547

      DOI: 10.7554/eLife.18825

      Resource: (Bio-Rad Cat# 170-6516, RRID:AB_11125547)

      Curator: @scibot

      SciCrunch record: RRID:AB_11125547


      What is this?

    4. RRID:AB_771432

      DOI: 10.7554/eLife.18825

      Resource: (GE Healthcare Cat# 27-4577-01, RRID:AB_771432)

      Curator: @scibot

      SciCrunch record: RRID:AB_771432


      What is this?

    1. RRID:SCR_002798

      DOI: 10.7554/eLife.22911

      Resource: GraphPad Prism (RRID:SCR_002798)

      Curator: @scibot

      SciCrunch record: RRID:SCR_002798


      What is this?

    2. RRID:SCR_014199

      DOI: 10.7554/eLife.22911

      Resource: Adobe Photoshop (RRID:SCR_014199)

      Curator: @scibot

      SciCrunch record: RRID:SCR_014199


      What is this?

    3. RRID:SCR_000011

      DOI: 10.7554/eLife.22911

      Resource: Leica DMRE Fluorescence Microscope (RRID:SCR_000011)

      Curator: @scibot

      SciCrunch record: RRID:SCR_000011


      What is this?

    4. RRID:SCR_003070

      DOI: 10.7554/eLife.22911

      Resource: ImageJ (RRID:SCR_003070)

      Curator: @scibot

      SciCrunch record: RRID:SCR_003070


      What is this?

    5. RRID:SCR_013311

      DOI: 10.7554/eLife.22911

      Resource: BD Biosciences (RRID:SCR_013311)

      Curator: @scibot

      SciCrunch record: RRID:SCR_013311


      What is this?

    6. RRID:CVCL_4388

      DOI: 10.7554/eLife.22911

      Resource: (ATCC Cat# CRL-4000, RRID:CVCL_4388)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_4388


      What is this?

    7. RRID:CVCL_6890

      DOI: 10.7554/eLife.22911

      Resource: (RRID:CVCL_6890)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_6890


      What is this?

    8. RRID:SCR_008410

      DOI: 10.7554/eLife.22911

      Resource: Invitrogen Antibodies (RRID:SCR_008410)

      Curator: @scibot

      SciCrunch record: RRID:SCR_008410


      What is this?

    1. RRID:SCR_001905

      DOI: 10.7554/eLife.16695

      Resource: R Project for Statistical Computing (RRID:SCR_001905)

      Curator: @scibot

      SciCrunch record: RRID:SCR_001905


      What is this?

    2. RRID:SCR_004097

      DOI: 10.7554/eLife.16695

      Resource: UCSF Chimera (RRID:SCR_004097)

      Curator: @scibot

      SciCrunch record: RRID:SCR_004097


      What is this?

    3. RRID:CVCL_0594

      DOI: 10.7554/eLife.16695

      Resource: (RCB Cat# RCB2767, RRID:CVCL_0594)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0594


      What is this?

    4. RRID:CVCL_0045

      DOI: 10.7554/eLife.16695

      Resource: (IZSLER Cat# BS CL 129, RRID:CVCL_0045)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0045


      What is this?

    5. RRID:SCR_014289

      DOI: 10.7554/eLife.16695

      Resource: ANY-maze (RRID:SCR_014289)

      Curator: @scibot

      SciCrunch record: RRID:SCR_014289


      What is this?

    6. RRID:SCR_014309

      DOI: 10.7554/eLife.16695

      Resource: Clocklab (RRID:SCR_014309)

      Curator: @scibot

      SciCrunch record: RRID:SCR_014309


      What is this?

    7. RRID:IMSR_JAX006852

      DOI: 10.7554/eLife.16695

      Resource: (IMSR Cat# JAX_006852,RRID:IMSR_JAX:006852)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_JAX:006852


      What is this?

    1. RRID:AB_10063035

      DOI: 10.7554/eLife.38181

      Resource: (Sigma-Aldrich Cat# A2220, RRID:AB_10063035)

      Curator: @scibot

      SciCrunch record: RRID:AB_10063035


      What is this?

    2. RRID:AB_10062721

      DOI: 10.7554/eLife.38181

      Resource: (Sigma-Aldrich Cat# A7345, RRID:AB_10062721)

      Curator: @scibot

      SciCrunch record: RRID:AB_10062721


      What is this?

    1. plasmid_44758

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_44758

      Curator: @scibot

      SciCrunch record: RRID:Addgene_44758


      What is this?

    2. plasmid_83480

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_83480

      Curator: @scibot

      SciCrunch record: RRID:Addgene_83480


      What is this?

    3. plasmid_1685

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_1685

      Curator: @scibot

      SciCrunch record: RRID:Addgene_1685


      What is this?

    4. plasmid_1414

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_1414

      Curator: @scibot

      SciCrunch record: RRID:Addgene_1414


      What is this?

    5. plasmid_1774

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_1774

      Curator: @scibot

      SciCrunch record: RRID:Addgene_1774


      What is this?

    6. plasmid_1847

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_1847

      Curator: @scibot

      SciCrunch record: RRID:Addgene_1847


      What is this?

    7. plasmid_1846

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_1846

      Curator: @scibot

      SciCrunch record: RRID:Addgene_1846


      What is this?

    8. plasmid_1860

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_1860

      Curator: @scibot

      SciCrunch record: RRID:Addgene_1860


      What is this?

    9. plasmid_1859

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_1859

      Curator: @scibot

      SciCrunch record: RRID:Addgene_1859


      What is this?

    10. plasmid_1208

      DOI: 10.7554/eLife.30454

      Resource: RRID:Addgene_1208

      Curator: @scibot

      SciCrunch record: RRID:Addgene_1208


      What is this?

    11. RRID:AB_2687461

      DOI: 10.7554/eLife.30454

      Resource: (Cell Signaling Technology Cat# 13202, RRID:AB_2687461)

      Curator: @scibot

      SciCrunch record: RRID:AB_2687461


      What is this?

    12. RRID:AB_259529

      DOI: 10.7554/eLife.30454

      Resource: (Sigma-Aldrich Cat# F3165, RRID:AB_259529)

      Curator: @scibot

      SciCrunch record: RRID:AB_259529


      What is this?

    13. RRID:AB_10622025

      DOI: 10.7554/eLife.30454

      Resource: (Cell Signaling Technology Cat# 5174, RRID:AB_10622025)

      Curator: @scibot

      SciCrunch record: RRID:AB_10622025


      What is this?

    14. RRID:AB_2315112

      DOI: 10.7554/eLife.30454

      Resource: (Cell Signaling Technology Cat# 4370, RRID:AB_2315112)

      Curator: @scibot

      SciCrunch record: RRID:AB_2315112


      What is this?

    15. RRID:AB_2263269

      DOI: 10.7554/eLife.30454

      Resource: (Proteintech Cat# 14822-1-AP, RRID:AB_2263269)

      Curator: @scibot

      SciCrunch record: RRID:AB_2263269


      What is this?

    16. RRID:CVCL_9Q53

      DOI: 10.7554/eLife.30454

      Resource: (ATCC Cat# CRL-4053, RRID:CVCL_9Q53)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_9Q53


      What is this?

    17. RRID:CVCL_0224

      DOI: 10.7554/eLife.30454

      Resource: (BCRC Cat# 60094, RRID:CVCL_0224)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0224


      What is this?

    1. RRID:AB_777102

      DOI: 10.7554/eLife.30224

      Resource: (Abcam Cat# ab32064, RRID:AB_777102)

      Curator: @scibot

      SciCrunch record: RRID:AB_777102


      What is this?

    2. RRID:AB_2556544

      DOI: 10.7554/eLife.30224

      Resource: (Thermo Fisher Scientific Cat# R37116, RRID:AB_2556544)

      Curator: @scibot

      SciCrunch record: RRID:AB_2556544


      What is this?

    3. RRID:AB_314677

      DOI: 10.7554/eLife.30224

      Resource: (BioLegend Cat# 307405, RRID:AB_314677)

      Curator: @scibot

      SciCrunch record: RRID:AB_314677


      What is this?

    4. RRID:AB_314669

      DOI: 10.7554/eLife.30224

      Resource: (BioLegend Cat# 307205, RRID:AB_314669)

      Curator: @scibot

      SciCrunch record: RRID:AB_314669


      What is this?

    5. RRID:AB_2341149

      DOI: 10.7554/eLife.30224

      Resource: (Innovative Research Cat# A23204, RRID:AB_2341149)

      Curator: @scibot

      SciCrunch record: RRID:AB_2341149


      What is this?

    6. RRID:AB_141607

      DOI: 10.7554/eLife.30224

      Resource: (Molecular Probes Cat# A-21202, RRID:AB_141607)

      Curator: @scibot

      SciCrunch record: RRID:AB_141607


      What is this?

    7. RRID:AB_2099233

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 7074, RRID:AB_2099233)

      Curator: @scibot

      SciCrunch record: RRID:AB_2099233


      What is this?

    8. RRID:AB_330924

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 7076, RRID:AB_330924)

      Curator: @scibot

      SciCrunch record: RRID:AB_330924


      What is this?

    9. RRID:AB_2687875

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 12349, RRID:AB_2687875)

      Curator: @scibot

      SciCrunch record: RRID:AB_2687875


      What is this?

    10. RRID:AB_10891618

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 8240, RRID:AB_10891618)

      Curator: @scibot

      SciCrunch record: RRID:AB_10891618


      What is this?

    11. RRID:AB_490807

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 2803, RRID:AB_490807)

      Curator: @scibot

      SciCrunch record: RRID:AB_490807


      What is this?

    12. RRID:AB_2214866

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 2045, RRID:AB_2214866)

      Curator: @scibot

      SciCrunch record: RRID:AB_2214866


      What is this?

    13. RRID:AB_2100484

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 2782, RRID:AB_2100484)

      Curator: @scibot

      SciCrunch record: RRID:AB_2100484


      What is this?

    14. RRID:AB_10693298

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 3130, RRID:AB_10693298)

      Curator: @scibot

      SciCrunch record: RRID:AB_10693298


      What is this?

    15. RRID:AB_10890862

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 7065, RRID:AB_10890862)

      Curator: @scibot

      SciCrunch record: RRID:AB_10890862


      What is this?

    16. RRID:AB_2713915

      DOI: 10.7554/eLife.30224

      Resource: (Enzo Life Sciences Cat# ALX-804-961-0100, RRID:AB_2713915)

      Curator: @scibot

      SciCrunch record: RRID:AB_2713915


      What is this?

    17. RRID:AB_2275120

      DOI: 10.7554/eLife.30224

      Resource: (Cell Signaling Technology Cat# 9746, RRID:AB_2275120)

      Curator: @scibot

      SciCrunch record: RRID:AB_2275120


      What is this?

    18. RRID:AB_626723

      DOI: 10.7554/eLife.30224

      Resource: (Santa Cruz Biotechnology Cat# sc-28383, RRID:AB_626723)

      Curator: @scibot

      SciCrunch record: RRID:AB_626723


      What is this?

    19. RRID:CVCL_1078

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_1078)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_1078


      What is this?

    20. RRID:CVCL_0234

      DOI: 10.7554/eLife.30224

      Resource: (CLS Cat# 300149/p748_Caki-1, RRID:CVCL_0234)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0234


      What is this?

    21. RRID:CVCL_0062

      DOI: 10.7554/eLife.30224

      Resource: (ATCC Cat# CRM-HTB-26, RRID:CVCL_0062)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0062


      What is this?

    22. RRID:CVCL_1544

      DOI: 10.7554/eLife.30224

      Resource: (KCLB Cat# 90226, RRID:CVCL_1544)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_1544


      What is this?

    23. RRID:CVCL_1555

      DOI: 10.7554/eLife.30224

      Resource: (KCLB Cat# 90028, RRID:CVCL_1555)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_1555


      What is this?

    24. RRID:CVCL_U998

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_U998)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_U998


      What is this?

    25. RRID:CVCL_U995

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_U995)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_U995


      What is this?

    26. RRID:CVCL_A536

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_A536)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_A536


      What is this?

    27. RRID:CVCL_A545

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_A545)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_A545


      What is this?

    28. RRID:CVCL_A570

      DOI: 10.7554/eLife.30224

      Resource: (KCLB Cat# 90513, RRID:CVCL_A570)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_A570


      What is this?

    29. RRID:CVCL_V000

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_V000)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_V000


      What is this?

    30. RRID:CVCL_U999

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_U999)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_U999


      What is this?

    31. RRID:CVCL_1427

      DOI: 10.7554/eLife.30224

      Resource: (ICLC Cat# HTL00012, RRID:CVCL_1427)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_1427


      What is this?

    32. RRID:CVCL_A543

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_A543)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_A543


      What is this?

    33. RRID:CVCL_V001

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_V001)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_V001


      What is this?

    34. RRID:CVCL_U996

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_U996)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_U996


      What is this?

    35. RRID:CVCL_A532

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_A532)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_A532


      What is this?

    36. RRID:CVCL_U994

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_U994)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_U994


      What is this?

    37. RRID:CVCL_U997

      DOI: 10.7554/eLife.30224

      Resource: (RRID:CVCL_U997)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_U997


      What is this?

    38. RRID:IMSR_CRL:394

      DOI: 10.7554/eLife.30224

      Resource: (IMSR Cat# CRL_394,RRID:IMSR_CRL:394)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_CRL:394


      What is this?

    1. RRID:SCR_006786

      DOI: 10.7554/eLife.30657

      Resource: WebGestalt: WEB-based GEne SeT AnaLysis Toolkit (RRID:SCR_006786)

      Curator: @scibot

      SciCrunch record: RRID:SCR_006786


      What is this?

    1. RRID:AB_10000340

      DOI: 10.7554/eLife.20898

      Resource: (Swant Cat# CB 38, RRID:AB_10000340)

      Curator: @scibot

      SciCrunch record: RRID:AB_10000340


      What is this?

    2. RRID:IMSR_JAX:007914

      DOI: 10.7554/eLife.20898

      Resource: (IMSR Cat# JAX_007914,RRID:IMSR_JAX:007914)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_JAX:007914


      What is this?

    1. RRID:SCR_001905

      DOI: 10.7554/eLife.17584

      Resource: R Project for Statistical Computing (RRID:SCR_001905)

      Curator: @scibot

      SciCrunch record: RRID:SCR_001905


      What is this?

    2. RRID:IMSR_JAX:000664

      DOI: 10.7554/eLife.17584

      Resource: (IMSR Cat# JAX_000664,RRID:IMSR_JAX:000664)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_JAX:000664


      What is this?

    3. RRID:SCR_003238

      DOI: 10.7554/eLife.17584

      Resource: Open Science Framework (RRID:SCR_003238)

      Curator: @scibot

      SciCrunch record: RRID:SCR_003238


      What is this?

    1. Addgene_42230

      DOI: 10.7554/eLife.19594

      Resource: RRID:Addgene_42230

      Curator: @scibot

      SciCrunch record: RRID:Addgene_42230


      What is this?

    2. RRID:AB_10596509

      DOI: 10.7554/eLife.19594

      Resource: (Agilent Cat# 200471, RRID:AB_10596509)

      Curator: @scibot

      SciCrunch record: RRID:AB_10596509


      What is this?

    1. RRID:CVCL_U427

      DOI: 10.7554/eLife.21470

      Resource: (RRID:CVCL_U427)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_U427


      What is this?

    2. RRID:CVCL_0224

      DOI: 10.7554/eLife.21470

      Resource: (BCRC Cat# 60094, RRID:CVCL_0224)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0224


      What is this?

    3. RRID:AB_10817224

      DOI: 10.7554/eLife.21470

      Resource: (Abgent Cat# AP10226b, RRID:AB_10817224)

      Curator: @scibot

      SciCrunch record: RRID:AB_10817224


      What is this?

    4. RRID:AB_439687

      DOI: 10.7554/eLife.21470

      Resource: (Sigma-Aldrich Cat# F7425, RRID:AB_439687)

      Curator: @scibot

      SciCrunch record: RRID:AB_439687


      What is this?

    5. RRID:AB_2537133

      DOI: 10.7554/eLife.21470

      Resource: (Thermo Fisher Scientific Cat# MA1-34492, RRID:AB_2537133)

      Curator: @scibot

      SciCrunch record: RRID:AB_2537133


      What is this?

    6. RRID:AB_2188830

      DOI: 10.7554/eLife.21470

      Resource: (Proteintech Cat# 11019-2-AP, RRID:AB_2188830)

      Curator: @scibot

      SciCrunch record: RRID:AB_2188830


      What is this?

    7. RRID:AB_2094414

      DOI: 10.7554/eLife.21470

      Resource: (Proteintech Cat# 16501-1-AP, RRID:AB_2094414)

      Curator: @scibot

      SciCrunch record: RRID:AB_2094414


      What is this?

    8. RRID:AB_444553

      DOI: 10.7554/eLife.21470

      Resource: (Abcam Cat# ab18588, RRID:AB_444553)

      Curator: @scibot

      SciCrunch record: RRID:AB_444553


      What is this?

    9. RRID:AB_10842176

      DOI: 10.7554/eLife.21470

      Resource: (Santa Cruz Biotechnology Cat# sc-365903, RRID:AB_10842176)

      Curator: @scibot

      SciCrunch record: RRID:AB_10842176


      What is this?

    10. RRID:AB_628305

      DOI: 10.7554/eLife.21470

      Resource: (Santa Cruz Biotechnology Cat# sc-147, RRID:AB_628305)

      Curator: @scibot

      SciCrunch record: RRID:AB_628305


      What is this?

    1. RRID:SCR_003070

      DOI: 10.7554/eLife.20059

      Resource: ImageJ (RRID:SCR_003070)

      Curator: @scibot

      SciCrunch record: RRID:SCR_003070


      What is this?

    2. RRID:SCR_002798

      DOI: 10.7554/eLife.20059

      Resource: GraphPad Prism (RRID:SCR_002798)

      Curator: @scibot

      SciCrunch record: RRID:SCR_002798


      What is this?

    3. RRID:AB_177523

      DOI: 10.7554/eLife.20059

      Resource: (Millipore Cat# AB5559, RRID:AB_177523)

      Curator: @scibot

      SciCrunch record: RRID:AB_177523


      What is this?

    4. RRID:AB_11214081

      DOI: 10.7554/eLife.20059

      Resource: (Millipore Cat# MAB351, RRID:AB_11214081)

      Curator: @scibot

      SciCrunch record: RRID:AB_11214081


      What is this?

    5. RRID:AB_2313773

      DOI: 10.7554/eLife.20059

      Resource: (BioLegend Cat# 801201, RRID:AB_2313773)

      Curator: @scibot

      SciCrunch record: RRID:AB_2313773


      What is this?

    6. RRID:AB_2629454

      DOI: 10.7554/eLife.20059

      Resource: (Abcam Cat# ab197070, RRID:AB_2629454)

      Curator: @scibot

      SciCrunch record: RRID:AB_2629454


      What is this?

    7. RRID:AB_177621

      DOI: 10.7554/eLife.20059

      Resource: (Millipore Cat# MAB377B, RRID:AB_177621)

      Curator: @scibot

      SciCrunch record: RRID:AB_177621


      What is this?

    1. AB_531826

      DOI: 10.7554/eLife.42434

      Resource: (DSHB Cat# TROMA-I, RRID:AB_531826)

      Curator: @scibot

      SciCrunch record: RRID:AB_531826


      What is this?