34 Matching Annotations
  1. Oct 2020
    1. "Taking LSD was a profound experience, one of the most important things in my life," Jobs said. "LSD shows you that there's another side to the coin, and you can't remember it when it wears off, but you know it. It reinforced my sense of what was important — creating great things instead of making money, putting things back into the stream of history and of human consciousness as much as I could." 


    1. Nobel-prize-winning chemist Kary Mullis, for example, explicitly stated that LSD helped him to develop the polymerase chain reaction (PCR) that allows you to replicate DNA sequences in a lab. How the drug gave him such an insight is uncertain – perhaps it was through a visual aspect of the trip or even a sudden flash of realisation. But whatever the cause, Mullis claimed it was undeniable that LSD was an aid in his Nobel-prize-winning discovery.

      problem solving

    1. A leading theory in the world of psychedelic neuroscience is called “Entropic Theory” (Carhart-Harris et al, 2014). It suggests that what happens to the brain when we take psychedelics mirrors our experience of increased creativity and expanded thinking. Basically, the brain becomes less organized, and more likely to make unusual connections between areas of the brain that don’t typically talk to each other.  Entropic theory tells us that a more “entropic” or disordered brain is likely to correlate with a more creative and expansive psychedelic experience.  Similarly, one brain mechanism that has been particularly interesting to researchers of depression may also be linked to creativity: the Default Mode Network (DMN). This is a system in the brain that is associated with rumination and self-centered thought. In people with depression and anxiety, the DMN is found to be overactive (Hamilton et al, 2011; Coutinho et al, 2016). Psychedelics have been shown to help “reset” the DMN, and this is associated with people being able to break out of toxic habits of thinking and reframe their view of the world into something healthier (Carhart-Harris et al, 2017). It is likely that this resetting of the DMN is also linked to creative thought, as dissolving the DMN can be correlated with less constrained, less obsessive thinking


    1. Divergent thinking, or non-linear creativity, is by nature difficult to define and measure.7 A recent 2018 study published in Proceedings of the National Academy of Sciences used functional magnetic resonance imaging (fMRI) to model the brain for creative ability.9 Across four independent datasets, researchers were able to predict creative ability in a robust manner. They found an association between high creative ability and dense connections primarily in the brain’s frontal and parietal cortices. These cortices contain high amounts of 5HT2 receptors, a specific subtype of serotonin receptor many psychedelics act upon.10


    1. In 1960, Allen Ginsberg wrote a letter to Timothy Leary, then a professor at Harvard. Leary had invited the poet to Cambridge to participate in his studies of the newly synthesized chemical psilocybin. Ginsberg responded with enthusiasm, then listed his qualifications: LSD in 1959, as a subject in a research study at Stanford University; ayahuasca on a trip to South America the following year; nitrous oxide; ether; mescaline; marijuana; datura; opiates. Part II of “Howl,” he added, was “Peyote writing.” His motivation in all this, he explained, was to recover a lost feeling, a “series of mystical experiences—connected with reading Blake” that he had gone through when he was younger.

      ginsberg and howl

    1. In Pollan’s new book, How to Change Your Mind: What the New Science of Psychedelics Teaches Us about Consciousness, Dying, Addiction, Depression, and Transcendence, he writes about how researcher James Fadiman even developed an optimal “creativity dose”: 100 micrograms of acid. (Caution to the inexperienced: A typical acid dose is between 50 and 150 micrograms, according to the major psychoactives website Erowid.org, while another outlet suggests 300 micrograms for confident users.)

      creativity dose

    1. According to the notorious biographer Albert Goldman, Lennon recorded himself reading the book’s paraphrase of the Tibetan Book of the Dead into a tape recorder. He played back the passage as the drug took hold, and was so enthralled by the result that he resolved to capture the LSD experience in song.

      lennon on lsd

    1. LSD (Lysergic acid diethylamide) is made from a substance found in ergot, which is a fungus that infects rye.Psilocybin is a naturally occurring substance found in mushrooms and is found in many parts of the world.Mescaline is derived from the Mexican peyote and San Pedro cactus and produces similar effects to LSD.DMT (Diemethyltryptamine) is structurally similar to psilocin, an alkaloid found in psilocybin mushrooms. It can be synthesised in the laboratory but is also a naturally occurring component of several plants.DOM is a member of the DOx family of compounds which are known for their high potency, long duration, and mixture of psychedelic and stimulant effects.22C-B (4-Bromo-2,5-dimethoxyphenethylamine) is a psychedelic drug first synthesised in 1974. 2C-B is considered both a psychedelic and a mild entactogenic. ‘Entactogen’ means ‘touching within’ and is a term used by psychiatrists to classify MDMA and related drugs.3Peyote Peyote (Lophophora williamsii) is the most well-known and potent psychedelic cactus, although the smallest and slowest growing. Instead of growing upward to form a column, it grows as ‘buttons’ low to the ground. It has been used by Native Americans for over 5000 years.425[-x]-NBOMe NBOMe (N-methoxybenzyl) is the name for a series of drugs that have psychedelics effects. Reports indicate that there are a number of different versions of NBOMe available – all with differing effects.

      Types of psychedelics

    1. Libraries have a responsibility to reflect the diversity of human thought. We cannot ignore the fact that there are thoughts contrary to our personal beliefs. We cannot ignore our history, which contains some very horrible, uncomfortable, and inconvenient facts. Just because a book is in a library, it doesn’t mean that library endorses those concepts or wants to prepetuate that history. Our primal tendency might be, “The First Amendment is great for everything that I believe in, but not so great for what anybody else believes.” Banning and prohibiting access to books will not deny that those thoughts exist. And it is worthwhile knowing what people have been or are thinking, knowing their strategies, in order to have those difficult conversations, or present those counterarguments.

      Argument against book banning

    1. In some cases, our use of cellphone cameras has the potential to liberate us when directed at the state, subjecting the powerful and privileged to forms of accountability that they’re not used to. That’s been made plain by the significant role of cellphone video in the movement against police brutality. The brutality isn’t new, but the widespread availability of high-definition pocket video cameras is. It’s also led to significant pushback against ordinary people who try to marshal the power of the state against ethnic minorities. Think of the sagas of Barbecue Becky and Permit Patty, who tried to call the police on innocent black citizens (including an eight-year-old girl) and were publicly shamed for their cruelty.

      With new and growing technology, laws need to be made to protect citizens. There are two sides to the coin, those who are innocent in their behaviors and those who are not, but it should not be left up to doxxers to determine which behaviors are right or wrong.

    1. Tony McAleer, a former white supremacist leader who now runs Life After Hate, a rehabilitation program for neo-Nazis, called doxxing a “ passive aggressive violence.” He said publicizing the names and workplaces of neo-Nazis may offer some level of solace to people outraged by them, but it makes his job more difficult.“For us, it slows things down. We try to integrate people back to humanity,” Mr. McAleer said. “If isolation and shame is the driver for people joining these types of groups, doxxing certainly isn’t the answer.”In short, once someone is labeled a Nazi on the internet, that person stays a Nazi on the internet.

      I almost feel like internet vigilantes are perpetuating violence and self harm. Interesting to think about doxxing as passive aggressive violence.

    1. In both peyote traditions, women are nurturers, providing food and drink, prayer and song to their families and community members. They are highly regarded for their creativity, which is shared publically in the peyote-inspired imagery with which Wixárika women adorn the textiles they create and the songs they sing. The Water Woman in the NAC ceremony shares wisdom and moral teachings in her inspiring oratory on how to live an honorable life following the Peyote Road.4

      Native women using peyote in ancient ceremonies, carrying on the traditions of their ancestors. Beatuiful textiles created with the inspiration of peyote visuals in mind.

    1. "We just need the green light to bring these healing tools above ground and carry on what has been done for centuries," Nicole Stewart from the group Decriminalize Nature Oakland told Hutson. "Healing ourselves through our relationship with nature. Let's start here in Oakland and be a beacon of hope and healing." Those possible therapeutic effects were highlighted in an agenda report filed to City Council by the resolution's sponsor, Council member Noel Gallo. Article continues after sponsor message "For millennia, cultures have respected entheogenic plants and fungi for providing healing, knowledge, creativity, and spiritual connection," the report states, saying that these plants may be beneficial for conditions such as substance abuse, anxiety and PTSD. "This initiative aims to empower the Oakland community by restoring their relationship to nature."

      Interesting comment from Noel Gallo - Oakland, CA city council memeber

    1. There have been few clinical trials on the effects of microdosing, so much of the body of evidence is anecdotal. However, pre-eminent researchers in the field of psychedelics aren't surprised by the glowing reports. David Nutt, director of the Centre for Neuropsychopharmacology at Imperial College London, has carried out groundbreaking imaging studies of the brain on LSD and magic mushrooms."These drugs change cortical functions, making them more fluid and less rigid. At least big doses do - that's what our imaging studies tell us - and maybe low doses to a lesser extent," he says. "This may help certain brain areas work in more flexible and expansive ways that might give better outcomes." Read next My weird, nostalgic quest to hunt down a lost online fruit game <img src="https://wi-images.condecdn.net/image/2bBwa2BRwbL/crop/200/square/f/2.jpg" class="" alt="" /> My weird, nostalgic quest to hunt down a lost online fruit game By Alex Lee It's a view echoed by David Nichols, professor of pharmacology at Purdue University, Indiana, and an expert in psychedelics. He says it's "quite possible" that low doses of LSD could have a stimulant effect by activating dopamine pathways in the brain. Like Adderall and Ritalin, it may excite the cerebral cortex, which controls high-order cognitive functions such as perception and sensation.  

      Despite the lack of clinical trails, doctors and scientist agree there are perceived benefits to microdosing and users continue to self-medicate in order to stay competitive in the workplace and to improve mental health

    1. Psychedelic microdosing benefits and challenges

      Harm Reduction Journal: Psychedelic microdosing benefits and challenges

    1. Creativity (12.9%) – Aside from a general sense of improved creativity, this also includes behaviors such as being more open, enhanced curiosity, ability to shift perspectives, and divergent thinking.

      Study results from Harm Reduction Journal

  2. Sep 2020
    1. State and federal governments argued that the psychedelic drug, also known as acid, threatened the fabric of US life, and they were right – LSD made neither good consumers nor loyal citizens in a time of war.

    1. It’s not enough to check the stuff that is suspicious: if you apply your investigations selectively, you’ve already lost the battle.

      Important point - even if information comes from a source you consider to be reliable, it's important to validate.