335 Matching Annotations
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    Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407559/
  3. Aug 2025
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    5-HT6 Receptor Inverse Agonists Modulate Diabetic Neuropathic Pain in Female Rats: Evidence for 5-HT6 Receptor Constitutive Activity
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70179
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    Microglia mediated by LAG3 regulate astrocyte morphogenesis in the brain white matter
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  6. Jul 2025
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    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    science.org/doi/10.1126/science.adm9805
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    A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients
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    FMRP drives mRNP targets into translationally silenced complexes
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    Spironolactone Partially Reverses Autism-Like Behaviors Linked to ErbB4 and mTOR Phosphorylation in the Mouse Prefrontal Cortex and Striatum
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    Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis
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    Component Analysis of Saxifraga stolonifera Extract and Its Mechanism of Melanin Inhibition
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  13. Jun 2025
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    Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
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    PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling
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    The Effect of FPR2 on the Regulation of Trophoblast Autophagy via the PI3K/AKT/mTOR Signaling Pathway in Preeclampsia
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    The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress
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    Potential Probiotic Lacticaseibacillus rhamnosus NKU FL1-11 Prevents Aging-Related Oxidative Stress and Inflammation via mTOR and FoxO Signaling Pathways in Zebrafish
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    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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  22. May 2025
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    YTHDF1 differentiates the contributing roles of mTORC1 in aging
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    mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
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    Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages
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  29. Apr 2025
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    Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy
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  32. Mar 2025
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    Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine
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    Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
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    Cytotoxic Autophagy: A Novel Treatment Paradigm against Breast Cancer Using Oleanolic Acid and Ursolic Acid
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  40. Feb 2025
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    The coagulation and tumor system are directly linked through the proteolysis and activation of epidermal growth factor receptor by thrombin
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  45. Jan 2025
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  48. Dec 2024
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    TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression
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    Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells
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    The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
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  54. Nov 2024
  55. www.biorxiv.org www.biorxiv.org
    Structure of the TXNL1-bound proteasome
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  58. Oct 2024
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  61. Sep 2024
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    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
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    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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  73. Jul 2024
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    Retinoic acid enhances HIV-1 reverse transcription and transcription in macrophages via mTOR-modulated mechanisms
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  80. Jun 2024
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    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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  83. May 2024
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    Adiponectin inhibits the progression of obesity-associated papillary thyroid carcinoma through autophagy
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    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
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  89. www.cell.com www.cell.com
    Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
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    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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  91. Apr 2024
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    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
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    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
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    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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  97. Mar 2024
  98. www.biorxiv.org www.biorxiv.org
    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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  99. Feb 2024
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    Trichinella spiralis inhibits myoblast differentiation by targeting SQSTM1/p62 with a secreted E3 ubiquitin ligase
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    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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  212. Jan 2022
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    Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes
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  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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  216. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
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    Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
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  218. Dec 2021
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    Translational and post-translational control of human naïve versus primed pluripotency
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    Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses
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  223. www.sciencedirect.com www.sciencedirect.com
    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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    Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment
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  226. Nov 2021
  227. 52.53.155.43 52.53.155.43
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  228. Oct 2021
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    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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  231. Sep 2021
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