532 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma
    1
    1. scibot 11 Nov 2024
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      DOI: 10.1016/j.devcel.2024.10.009

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    sciencedirect.com/science/article/pii/S1534580724006282
  3. Oct 2024
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    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
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    1. scibot 09 Oct 2024
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      DOI: 10.1016/j.chembiol.2024.09.004

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    sciencedirect.com/science/article/pii/S2451945624003969
  5. Sep 2024
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    Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.ccell.2024.08.019

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    sciencedirect.com/science/article/pii/S1535610824003180
  7. Aug 2024
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    Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures
    1
    1. scibot 30 Aug 2024
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      DOI: 10.1158/2767-9764.CRC-24-0214

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    ncbi.nlm.nih.gov/pmc/articles/PMC11350481/
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    Genome access is transcription factor-specific and defined by nucleosome position
    1
    1. scibot 29 Aug 2024
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      DOI: 10.1016/j.molcel.2024.08.009

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    sciencedirect.com/science/article/pii/S1097276524006634
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    Artificially inserted strong promoter containing multiple G-quadruplexes induces long-range chromatin modification
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    1. scibot 23 Aug 2024
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      DOI: 10.7554/eLife.96216

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    ncbi.nlm.nih.gov/pmc/articles/PMC11333042/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p300 KAT Regulates SOX10 Stability and Function in Human Melanoma
    1
    1. scibot 18 Aug 2024
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      DOI: 10.1158/2767-9764.CRC-24-0124

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    ncbi.nlm.nih.gov/pmc/articles/PMC11293458/
  12. Jul 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
    2
    1. scibot 31 Jul 2024
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      DOI: 10.1158/2159-8290.CD-23-0539

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    2. scibot 31 Jul 2024
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      DOI: 10.1158/2159-8290.CD-23-0539

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    ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
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    STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia
    1
    1. scibot 31 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114498

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    sciencedirect.com/science/article/pii/S2211124724008271
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    Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114496

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    sciencedirect.com/science/article/pii/S2211124724008258
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    Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.immuni.2024.06.015

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    sciencedirect.com/science/article/pii/S1074761324003212
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    TERT activation targets DNA methylation and multiple aging hallmarks
    1
    1. scibot 24 Jul 2024
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      DOI: 10.1016/j.cell.2024.05.048

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    sciencedirect.com/science/article/pii/S0092867424005920
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    An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II
    1
    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.molcel.2024.06.006

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    sciencedirect.com/science/article/pii/S1097276524004842
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    Implications of noncoding regulatory functions in the development of insulinomas
    1
    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.xgen.2024.100604

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    sciencedirect.com/science/article/pii/S2666979X24001988
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    BPS Publications
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    1. scibot 19 Jul 2024
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      DOI: 10.1111/bph.16431

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16431
  21. www.cell.com www.cell.com
    Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114350

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    cell.com/cell-reports/fulltext/S2211-1247(24)00678-8
  22. www.cell.com www.cell.com
    YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment
    1
    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114456

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    cell.com/cell-reports/abstract/S2211-1247(24)00785-X
  23. Jun 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-induced CTCF promotes EMT in breast cancer
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114367

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    sciencedirect.com/science/article/pii/S2211124724006958
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    An enhancer RNA recruits KMT2A to regulate transcription of Myb
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114378

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    sciencedirect.com/science/article/pii/S221112472400706X
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    LEUTX regulates porcine embryonic genome activation in somatic cell nuclear transfer embryos
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114372

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    sciencedirect.com/science/article/pii/S2211124724007009
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma
    1
    1. scibot 20 Jun 2024
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      DOI: 10.7554/eLife.83527

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    ncbi.nlm.nih.gov/pmc/articles/PMC11178360/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex
    1
    1. scibot 13 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114227

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    ncbi.nlm.nih.gov/pmc/articles/PMC11163479/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An integrative epigenome-based strategy for unbiased functional profiling of clinical kinase inhibitors
    1
    1. scibot 09 Jun 2024
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      DOI: 10.1038/s44320-024-00040-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11148061/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1371/journal.ppat.1012271

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    ncbi.nlm.nih.gov/pmc/articles/PMC11175508/
  31. www.sciencedirect.com www.sciencedirect.com
    Collaboration between distinct SWI/SNF chromatin remodeling complexes directs enhancer selection and activation of macrophage inflammatory genes
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      DOI: 10.1016/j.immuni.2024.05.008

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    sciencedirect.com/science/article/pii/S1074761324002620
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114291

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    pmc.ncbi.nlm.nih.gov/articles/PMC11238474/
  33. May 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression
    1
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      DOI: 10.1038/s41419-024-06684-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC11091074/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mecp2 fine-tunes quiescence exit by targeting nuclear receptors
    1
    1. scibot 17 May 2024
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      DOI: 10.7554/eLife.89912

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    ncbi.nlm.nih.gov/pmc/articles/PMC11095939/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Widespread impact of nucleosome remodelers on transcription at cis-regulatory elements
    1
    1. scibot 03 May 2024
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      DOI: 10.1101/2024.04.12.589208

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    ncbi.nlm.nih.gov/pmc/articles/PMC11042195/
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    A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification
    1
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      DOI: 10.1016/j.immuni.2024.04.007

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    sciencedirect.com/science/article/pii/S1074761324002127
  38. Apr 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein degradation of Lysine-specific demethylase 1 is mediated by Bre1 yet opposed by Lsd1-interacting lncRNAs during fly follicle development
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      DOI: 10.1016/j.isci.2024.109683

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    ncbi.nlm.nih.gov/pmc/articles/PMC11035368/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cis-regulatory control of transcriptional timing and noise in response to estrogen
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      DOI: 10.1016/j.xgen.2024.100542

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    ncbi.nlm.nih.gov/pmc/articles/PMC11099348/
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    Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction
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      DOI: 10.1016/j.immuni.2024.03.018

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    sciencedirect.com/science/article/pii/S1074761324001390
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    Human gene regulatory evolution is driven by the divergence of regulatory element function in both cis and trans
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    sciencedirect.com/science/article/pii/S2666979X24000922
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    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610824000904
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
  45. Mar 2024
  46. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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      DOI: 10.1016/j.xcrm.2024.101468

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    sciencedirect.com/science/article/pii/S2666379124001149
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    Epigenomic tomography for probing spatially defined chromatin state in the brain
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      DOI: 10.1016/j.crmeth.2024.100738

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    sciencedirect.com/science/article/pii/S2667237524000638
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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      DOI: 10.1016/j.devcel.2024.02.008

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    Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
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    End binding-3 inhibitor activates regenerative program in age-related macular degeneration
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    A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
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    Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming
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  95. Sep 2023
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    Palbociclib releases the latent differentiation capacity of neuroblastoma cells
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    Integrative analysis of single-cell RNA-seq and ATAC-seq reveals heterogeneity of induced pluripotent stem cell derived hepatic organoids
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    A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer
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  99. Aug 2023
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    Sepsis induces non-classic innate immune memory in granulocytes
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    XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
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  102. www.science.org www.science.org
    XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
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    Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO
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    Histone variants shape chromatin states in Arabidopsis
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    BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation
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    The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms
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    Alcohol-sourced acetate impairs T cell function by promoting cortactin acetylation
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    FOXA2 controls the anti-oxidant response in FH-deficient cells
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    Removal of epigenetic repressive mark on inflammatory genes in fat liver
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    Single genomic enhancers drive experience-dependent GABAergic plasticity to maintain sensory processing in the adult cortex
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    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin
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    Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification
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    The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming
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  119. May 2023
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    MYCOBACTERIUM MANRESENSIS INDUCES TRAINED IMMUNITY IN VITRO
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    Chemical-induced epigenome resetting for regeneration program activation in human cells
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    Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity
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    Histone deacetylase-mediated silencing of PSTPIP2 expression contributes to AAI-induced PANoptosis
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    Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma
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  125. Apr 2023
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    Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers
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    NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons
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    Novel enhancers conferring compensatory transcriptional regulation of Nkx2-5 in heart development
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    Systematic fine-mapping and functional studies of prostate cancer risk variants
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    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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    MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes
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    Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis
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    NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons
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    PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1
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    Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
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    ERCC6L2 mitigates replication stress and promotes centromere stability
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    Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas
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  138. Mar 2023
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    Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
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    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming
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    Aryl hydrocarbon receptor activity downstream of IL-10 signaling is required to promote regulatory functions in human dendritic cells
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  142. Feb 2023
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    Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Chromatin immunoprecipitation with mouse adipocytes using hypotonic buffer to enrich nuclear fraction before fixation
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  147. Jan 2023
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    EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release
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    Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
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  150. Dec 2022
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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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    Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma
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    Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
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  155. Nov 2022
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    Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
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    PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation
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    The target antigen determines the mechanism of acquired resistance to T cell-based therapies
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    Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes promotes chromatin compaction at promoters
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    Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription
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    Acute depletion of human core nucleoporin reveals direct roles in transcription control but dispensability for 3D genome organization
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  162. Oct 2022
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    Adiponectin ameliorates hypertrophic scar by inhibiting YAP transcription through SIRT1-mediated deacetylation of C/EBPβ and histone H3
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    Spatially resolved epigenomic profiling of single cells in complex tissues
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    Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer
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    p300/CBP sustains Polycomb silencing by non-enzymatic functions
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    Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes
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    Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia
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    A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation
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  170. Sep 2022
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    Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor
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    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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    The Il6 -39kb enhancer containing clustered GATA2- and PU.1- binding sites is essential for Il6 expression in murine mast cells
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    Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster
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  178. Jul 2022
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    Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases
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    Transcription factors TCF-1 and GATA3 are key factors for the epigenetic priming of early innate lymphoid progenitors toward distinct cell fates
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    Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
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    Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors
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    Dynamic Chromatin States Coupling with Key Transcription Factors in Colitis-Associated Colorectal Cancer
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    Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression
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    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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    NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
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    Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy
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    Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma
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    MUC1-C Dictates JUN and BAF-mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells
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    The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes
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    EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
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    STAT3-mediated allelic imbalance of novel genetic variant rs1047643 and B cell specific super-enhancer in association with systemic lupus erythematosus
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    Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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    An oncogenic enhancer encodes selective selenium dependency in AML
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    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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    Multimodal regulatory elements within a hormone-specific super enhancer control a heterogeneous transcriptional response
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    SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers
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    Multi-CUT&Tag to simultaneously profile multiple chromatin factors
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    Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos
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    Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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