1,104 Matching Annotations
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    Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
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    sciencedirect.com/science/article/pii/S0896627325007111
  3. Oct 2025
  4. 54.241.53.176 54.241.53.176
    2025.09.24.678297v1.full-html.html
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    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways
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  8. Sep 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    Crhr1 and epinephrine utilize the central Ras-MAPK pathway in mediating the acute stress-related locomotor activity in zebrafish larvae
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    FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia
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    Butyrolactone I from Aspergillus fungi blocks neutrophil FPR1 to alleviate acute respiratory distress syndrome
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    mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport
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    LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer
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    Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroinflammation via the NF-κB Signaling Pathway and HIF1α-Mediated Metabolic Reprogramming
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    Development of a cyst-targeted therapy for polycystic kidney disease using an antagonistic dimeric IgA monoclonal antibody against cMET
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  17. Aug 2025
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    Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy
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    Harmine suppresses pancreatic cancer through DYRK1A-mediated hyper-activated RAS/MAPK inhibition
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    Phosphorylation of Pyruvate Dehydrogenase as a Marker of Neuronal Inactivity in the Enteric Nervous System
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    The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells
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    ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis
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    Pharmacologic inhibition of CSF-1R suppresses intrinsic tumor cell growth in osteosarcoma with CSF-1R overexpression
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    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X Syndrome mice.
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    Early Life Social Isolation Dysregulates Social Reward Processing, BDNF Signaling, and Intracellular Vesicular Sorting in the Nucleus Accumbens of Male and Female Rats
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    The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma
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    Keratinocyte-derived VEGF-A is an essential pro-migratory autocrine mediator, acting through the KDR/GEF-H1/RhoA pathway
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  38. Jul 2025
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    RIT1 Drives Oncogenic Transformation and is an Actionable Target in Lung Adenocarcinoma
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    Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.
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    RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations
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    Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model
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    TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy
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    TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC
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    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    NOD1 promotes leukocyte clearance and limits inflammation in female mice during obesity‐associated acute lung injury
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    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps
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    The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function
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  63. Jun 2025
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    Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila
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    VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2
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    A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient
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    Distinct cAMP Regulation in Scleroderma Lung and Skin Myofibroblasts Governs Their Dedifferentiation via p38α Inhibition
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    EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC
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    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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    Deficiency of Fibroblast Growth Factor 2 Promotes Contractile Phenotype of Pericytes in Ascending Thoracic Aortic Aneurysm
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    FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
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    Tumor-derived ligands trigger tumor growth and host wasting via differential MEK activation
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    The RXR Agonist MSU-42011 Reduces Tumor Burden in a Murine Preclinical NF1-Deficient Model
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    PTEN protein phosphatase activity regulates metastasis by targeting PKCδ
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    Nerve growth factor signaling tunes axon maintenance protein abundance and kinetics of Wallerian degeneration
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    PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma
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    A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling
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    Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy
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  84. May 2025
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    Bromodomain-containing protein 4 knockdown promotes... : Neural Regeneration Research
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    Surrogate GPR139 Agonists Reverse Short‐Term Startle Habituation Impairment in Larval Zebrafish
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    Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes
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    Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
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    Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development
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  180. Sep 2024
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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  195. Aug 2024
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  209. Jul 2024
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