1,316 Matching Annotations
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    STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
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    sciencedirect.com/science/article/pii/S0092867424012005
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    The Arabidopsis blue-light photoreceptor CRY2 is active in darkness to inhibit root growth
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    Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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  5. Nov 2024
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    Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection
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    Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies
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    SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release
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    pmc.ncbi.nlm.nih.gov/articles/PMC11549447/
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    Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins
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  10. Oct 2024
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    Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis
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    Mass spectrometry identifies tau C-terminal phosphorylation cluster during neuronal hyperexcitation
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    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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  14. Sep 2024
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    Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor
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    Highlights from MBoC Selection: Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage
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    Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation
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    Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin
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    Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins
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    Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions
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    PCNA Deubiquitylases Control DNA Damage Bypass at Replication Forks
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    The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment
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    Determination of the Gene Regulatory Network of a Genome-Reduced Bacterium Highlights Alternative Regulation Independent of Transcription Factors
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    Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway
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    Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106
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    RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells
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    Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
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    TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis
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    Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
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    E3 ubiquitin ligase ANKIB1 attenuates antiviral immune responses by promoting K48-linked polyubiquitination of MAVS
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    Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration
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    Rho-dependent transcriptional switches regulate the bacterial response to cold shock
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    Defective CFTR modulates mechanosensitive channels TRPV4 and PIEZO1 and drives endothelial barrier failure
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    RNA interacts with topoisomerase I to adjust DNA topology
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    The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins
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    The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex
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    The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking
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    Ubiquitination and degradation of plant helper NLR by the Ralstonia solanacearum effector RipV2 overcome tomato bacterial wilt resistance
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    Oxidative stress reprograms the transcriptional coactivator Yki to suppress cell proliferation
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    The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy
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    The cullin Rtt101 promotes ubiquitin-dependent DNA−protein crosslink repair across the cell cycle
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    Mrc1 regulates parental histone segregation and heterochromatin inheritance
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    Lysosomal dysfunction by inactivation of V-ATPase drives innate immune response in C. elegans
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    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
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    WW domains form a folded type of nuclear localization signal to guide YAP1 nuclear import
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    Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
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    Protocol to detect OLA1 polyubiquitination by Aurora A in vivo and in vitro
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    Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence
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    The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
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    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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    Human V-ATPase function is positively and negatively regulated by TLDc proteins
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    Brucella-driven host N-glycome remodeling controls infection
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    The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin
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    Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring
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    RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation
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    Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and thetranslation of nuclear-encoded proteins
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    Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes
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    The Cby3/ciBAR1 complex positions the annulus along the sperm flagellum during spermiogenesis
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    Rab32 family proteins regulate autophagosomal components recycling
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    Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
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    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
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    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
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    UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
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    Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling
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  124. www.jneurosci.org www.jneurosci.org
    EHBP1 is critically involved in dendritic arbor formation and is coupled to factors promoting actin filament formation
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA
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  127. www.biorxiv.org www.biorxiv.org
    A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression
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    Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
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    A metabolically controlled contact site between vacuoles and lipid droplets in yeast
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    Machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing
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    Specialized replication mechanisms maintain genome stability at human centromeres
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    C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
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    Role of paraoxonase 3 in regulating ENaC-mediated Na+ transport in the distal nephron
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    ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
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    Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    p53 promotes antiviral innate immunity by driving hexosamine metabolism
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    PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
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    DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling
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    H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Growth-suppressor microRNAs mediate synaptic overgrowth and behavioral deficits in Fragile X mental retardation protein deficiency
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    Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies
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    Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis
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    In vivo characterization of a podocyte-expressed short podocin isoform
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    Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration
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    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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    SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer
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    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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    Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling
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    IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors
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    p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP
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    PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5
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