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Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.molcel.2025.08.014
  
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sciencedirect.com/science/article/pii/S1097276525006641
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PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis

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  DOI: 10.1016/j.isci.2025.113408
  
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sciencedirect.com/science/article/pii/S2589004225016694
Jul 2025
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G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.neuron.2025.06.020
  
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cell.com/neuron/fulltext/S0896-6273(25)00478-7
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Environmental stress promotes the persistence of juvenile traits in olfactory neurons as a protective mechanism

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113078
  
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sciencedirect.com/science/article/pii/S2589004225013392
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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

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1. scibot 22 Jul 2025
  
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  DOI: 10.1126/sciadv.adu6354
  
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science.org/doi/10.1126/sciadv.adu6354
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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

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  DOI: 10.1126/sciadv.adu6354
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12273755/
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Dynamic stimulation promotes functional tissue-like organization of a 3D human lymphoid microenvironment model in vitro

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  DOI: 10.1016/j.crmeth.2025.101105
  
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sciencedirect.com/science/article/pii/S2667237525001419
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TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak

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  DOI: 10.1016/j.ccell.2025.06.015
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00265-X
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RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation

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1. scibot 12 Jul 2025
  
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  DOI: 10.1101/2025.06.20.660705
  
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biorxiv.org/content/10.1101/2025.06.20.660705v1
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Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells

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  DOI: 10.1016/j.celrep.2025.115929
  
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sciencedirect.com/science/article/pii/S2211124725007004
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Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis

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  DOI: 10.1016/j.celrep.2025.115936
  
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sciencedirect.com/science/article/pii/S2211124725007077
Jun 2025
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PDF-html.html

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1. scibot 18 Jun 2025
  
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  DOI: 10.1242/dev.204810
  
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52.53.155.43/cd367a45a0df501674653a82f87cfd30eccc636f/PDF-html.html
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Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease

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1. scibot 15 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115355
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12124131/
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The effect of G-quadruplexes on TDP43 condensation, distribution, and toxicity

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.str.2025.05.006
  
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cell.com/structure/fulltext/S0969-2126(25)00184-4
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Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics

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  DOI: 10.1016/j.neuron.2025.05.014
  
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sciencedirect.com/science/article/pii/S0896627325003617
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Balanced synapse-to-synapse short-term plasticity ensures constant transmitter release

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1. scibot 04 Jun 2025
  
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  DOI: 10.1016/j.cub.2025.05.024
  
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sciencedirect.com/science/article/pii/S0960982225005998
May 2025
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Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits

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  DOI: 10.1016/j.neuron.2025.04.035
  
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sciencedirect.com/science/article/pii/S0896627325003472
Apr 2025
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Hijacking and integration of algal plastids and mitochondria in a polar planktonic host

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.cub.2025.03.076
  
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sciencedirect.com/science/article/pii/S0960982225003926
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Differential uptake of arginine derivatives by the human heteromeric amino acid transporter b0,+AT-rBAT (SLC7A9-SLC3A1)

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1. scibot 18 Apr 2025
  
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  DOI: 10.1007/s00210-024-03510-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11978698/
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Derivation of human trophoblast stem cells from placentas at birth

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  DOI: 10.1016/j.jbc.2025.108505
  
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sciencedirect.com/science/article/pii/S0021925825003540
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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  DOI: 10.1016/j.immuni.2025.03.005
  
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sciencedirect.com/science/article/pii/S1074761325001244
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Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

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  DOI: 10.1016/j.celrep.2025.115502
  
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Epithelial cell-fate switch triggering ectopic ligand-receptor-mediated JAK-STAT signaling promotes tumorigenesis in Drosophila

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  DOI: 10.1016/j.isci.2025.112191
  
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sciencedirect.com/science/article/pii/S2589004225004523
Mar 2025
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Derivation of human trophoblast stem cells from placentas at birth

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1. scibot 20 Mar 2025
  
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  DOI: 10.1101/2024.05.01.592064
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11092656/
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Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1097276525001479
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Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease

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  DOI: 10.1016/j.celrep.2025.115355
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12124131/
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FEBS Press

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  DOI: 10.1111/febs.70028
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70028
Feb 2025
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RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry

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1. scibot 28 Feb 2025
  
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  DOI: 10.1016/j.cell.2025.01.040
  
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sciencedirect.com/science/article/pii/S0092867425001096
Jan 2025
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Noncanonical inhibition of topoisomerase II alpha by oxidative stress metabolites

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  DOI: 10.1016/j.redox.2025.103504
  
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sciencedirect.com/science/article/pii/S2213231725000175
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Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain

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  DOI: 10.1016/j.celrep.2024.115195
  
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cell.com/cell-reports/fulltext/S2211-1247(24)01546-8
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1-s2.0-S2589004224029377-main-html.html

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52.53.155.43/a4a95d0f48e4f5d6b60e2092f92dc9e622c6d3c5/1-s2.0-S2589004224029377-main-html.html
Dec 2024
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Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength

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  DOI: 10.1016/j.neuron.2018.03.010
  
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pmc.ncbi.nlm.nih.gov/articles/PMC5919779/
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Learning-Related Plasticity in Dendrite-Targeting Layer 1 Interneurons

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.neuron.2018.09.001
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6226614/
Nov 2024
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Drosophila p53 tumor suppressor directly activates conserved asymmetric stem cell division regulators

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  DOI: 10.1016/j.isci.2024.111118
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11546965/
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Plausible, robust biological oscillations through allelic buffering

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  DOI: 10.1016/j.cels.2024.10.002
  
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sciencedirect.com/science/article/pii/S2405471224002990
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Acute multi-level response to defective de novo chromatin assembly in S-phase

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Non-cell-autonomous regulation of germline proteostasis by insulin/IGF-1 signaling-induced dietary peptide uptake via PEPT-1

1
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The role of Imp and Syp RNA-binding proteins in precise neuronal elimination by apoptosis through the regulation of transcription factors

1
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Generation of SOX2ZsGreen reporter authentic porcine induced pluripotent stem cells

1
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Developing zebrafish utilize taste-signaling pathways for oxygen chemoreception

1
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Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay

1
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Robust immune responses are observed after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2 experienced individuals

1
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The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

1
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Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling

1
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A quantitative image analysis platform for assessing trophoblast differentiation.

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Genome-scale exon perturbation screens uncover exons critical for cell fitness

1
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The evolutionarily conserved choroid plexus contributes to the homeostasis of brain ventricles in zebrafish

1
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Comparing behaviours induced by natural memory retrieval and optogenetic reactivation of an engram ensemble in mice

1
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Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes

1
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Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila

1
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Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes

1
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Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish

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Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

2
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Protocol for generating three-dimensional induced early ameloblasts using serum-free media and growth factors

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TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

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LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination

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2024.02.09.579580v1.full-html.html

2
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Cilia-mediated cerebrospinal fluid flow modulates neuronal and astroglial activity in the zebrafish larval brain

1
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Mar 2024
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RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors

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SOX17/ETV2 improves the direct reprogramming of adult fibroblasts to endothelial cells

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The β6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection

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Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons

1
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PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

1
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Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO

1
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Nov 2023
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Targeted perturbation of signaling-driven condensates

1
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Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance

1
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The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

2
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Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence

1
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An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates

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Dendritic atoh1a+ cells serve as transient intermediates during zebrafish Merkel cell development and regeneration

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  DOI: 10.1101/2023.09.14.557830
  
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Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats

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Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling

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Aug 2023
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MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy

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Image-based and machine learning-guided multiplexed serology test for SARS-CoV-2

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Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

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Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5

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PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics

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A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage

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Macrophages drive KSHV B cell latency

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Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER

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Jun 2023
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Characterization of Hofbauer cell polarization and VEGF localization in human term placenta from active and inactive pregnant individuals

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May 2023
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EWSR1 maintains centromere identity

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Metamorphic proteins at the basis of human autophagy initiation and lipid transfer

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Molecular mechanisms of stress-induced reactivation in mumps virus condensates

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Maintenance of a short-lived protein required for long-term memory involves cycles of transcription and local translation

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Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures

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STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease

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Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex

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Hic1 identifies a specialized mesenchymal progenitor population in the embryonic limb responsible for bone superstructure formation

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Mar 2023
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Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions

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Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation

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Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest

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Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons

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Feb 2023
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Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia

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Prenatal low-dose methylmercury exposure causes premature neuronal differentiation and autism-like behaviors in a rodent model

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Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling

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Neuronal excitability as a regulator of circuit remodeling

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The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation

1
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Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells

1
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Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells

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Jan 2023
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The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

1
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Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA

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Teriflunomide as a therapeutic means for myelin repair

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  DOI: 10.1186/s12974-022-02686-6
  
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Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats

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Axonal plasticity in response to active forces generated through magnetic nano-pulling

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CRISPR/Cas9-mediated generation of hESC lines with homozygote and heterozygote p.R331W mutation in CTBP1 to model HADDTS syndrome

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Epidermal stratification requires retromer-mediated desmoglein-1 recycling

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Ginsenoside Rb1 improves energy metabolism after spinal... : Neural Regeneration Research

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Generation of human iPSC line from an arrhythmogenic cardiomyopathy patient with a DSP protein-truncating variant

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TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages

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Enhanced DNA repair through droplet formation and p53 oscillations

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P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

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AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure

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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

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Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

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Adenosine A2A receptors control synaptic remodeling in the adult brain

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Increasing cell size remodels the proteome and promotes senescence

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NMDA receptor-targeted enrichment of CaMKIIα improves fear memory

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Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations

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Robust immune responses are observed after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2 experienced individuals

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Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity

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Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals

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Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography

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Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

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Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

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Mucus sialylation determines intestinal host-commensal homeostasis

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Müller glia fused with adult stem cells undergo neural differentiation in human retinal models

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Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication

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Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis

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CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants

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Upregulation of Neural Cell Adhesion Molecule 1 and Excessive Migration of Purkinje Cells in Cerebellar Cortex

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LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants

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Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis

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REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

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Distinct contributions of partial and full EMT to breast cancer malignancy

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Pig embryonic stem cell line with porcine-specific OCT4 upstream region based dual reporter system

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Extracellular ATP and cAMP signaling promote Piezo2-dependent mechanical allodynia after trigeminal nerve compression injury

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Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism

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Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation

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Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome

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Insulin/IGF-1 signaling and heat stress differentially regulate HSF1 activities in germline development

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Dual film-like organelles enable spatial separation of orthogonal eukaryotic translation

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Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis

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Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila

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Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication

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A wash-free multiplexed mix-and-read suspension array fluorescence immunoassay for anthropogenic markers in wastewater

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Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function

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Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons

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High dietary fat consumption impairs axonal mitochondrial function in vivo

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Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion

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Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior

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Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

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Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells

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Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock

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A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization

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ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER

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Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons

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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

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Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance

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Variability of an Early Developmental Cell Population Underlies Stochastic Laterality Defects

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Corneal nonmyelinating Schwann cells illuminated by single‐cell transcriptomics and visualized by protein biomarkers

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Generation of three human iPSC lines from a retinitis pigmentosa family with SLC7A14 mutation

1
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Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles

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Sep 2020
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Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants

1
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The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing

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Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila

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Identification of a Master Regulator of Differentiation in Toxoplasma

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Parvovirus Minute Virus of Mice Interacts with Sites of Cellular DNA Damage to Establish and Amplify its Lytic Infection

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  DOI: 10.7554/eLife.37750
  
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Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

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Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis

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Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity

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  DOI: 10.1523/JNEUROSCI.1076-19.2019
  
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Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration

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Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation

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Undisturbed climbing fiber pruning in the cerebellar cortex of CX3CR1‐deficient mice

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  DOI: 10.1002/glia.23842
  
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Rat Model of Cockayne Syndrome Neurological Disease

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Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

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Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)

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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

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Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system

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  DOI: 10.1002/glia.23724
  
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Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking

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Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway

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  DOI: 10.1016/j.molcel.2019.07.025
  
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N6-Methyladenosine Modification Controls Circular RNA Immunity

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Untitled document

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Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity

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Combining Developmental and Perturbation-Seq Uncovers Transcriptional Modules Orchestrating Neuronal Remodeling

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Developmental Coordination during Olfactory Circuit Remodeling in Drosophila

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