214 Matching Annotations
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    Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1
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  3. Oct 2026
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    VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver disease
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    M2 type tumor-associated macrophage-derived CCL-18 promotes glioma cell proliferation but does not mediates glioma recurrence after radiotherapy
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    sciencedirect.com/science/article/pii/S2589004226030762
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    Targeted O-GlcNAcylation enables functional rewiring of c-Myc
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    cell.com/cell-chemical-biology/abstract/S2451-9456(26)00318-1
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    A Synergistic Sonosensitive Pyroptosis Nanoactivator for Efficient Lung Adenocarcinoma Therapy
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  8. Sep 2026
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    A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia
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    Levofloxacin enhances 5-fluorouracil efficacy in colorectal cancer by activating the DDR-TP53-mitochondrial apoptosis axis
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    Local lactate-driven H3K18 lactylation impairs anti-influenza immunity through NRF2-dependent dendritic cell dysfunction
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  12. Aug 2026
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    SOX12 and DELTA mediate ecdysone-driven adult neural cell proliferation during metamorphosis
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    Targeted inhibition of the BDNF/AKT/mTOR pathway in the inferior colliculus ameliorates salicylate-induced tinnitus in rats
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    Fstl1 determines luminal size of mouse trachea through negative regulation of BMP4 signaling
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  16. Jul 2026
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    RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity
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    GLP-1 regulates osteo-adipogenic fate of BMSCs via HIF-2-AKT signaling and supports trabecular bone in glucocorticoid-induced osteoporosis
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  19. Jun 2026
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    WNK-SPAK-NKCC1/KCC2 pathway disrupts chloride homeostasis and drives hyperactivation of PVN-CRH neurons in essential hypertension
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    Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effects
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    SPINDOC functions as a mitotic molecular counter to coordinate spatiotemporal CENP-A assembly
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    Inhibiting hepatocytes MAGL alleviates osteoporosis caused by high-fat diet-induced liver fibrosis in male mice
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    Development and characterization of functional sheep endometrial luminal epithelial organoids
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  25. May 2026
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    USP52-RAB11FIP5 axis suppresses ferroptosis by repressing transferrin receptor recycling in head and neck squamous cell carcinoma
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    Genome-Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma
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    The m6A Reader IGF2BP2 Regulates Schwann Cell Autophagy and Neurotrophin Expression via EGR1 in Diabetic Peripheral Neuropathy
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    A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression
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  30. Apr 2026
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    Krüppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity
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    USP15 stabilizes c-Myc to drive sunitinib resistance by suppressing cuproptosis in clear cell renal cell carcinoma
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    Optineurin modulates mTORC2/AKT/STAT3 signaling to control MHC class II expression and adaptive immunity against HSV-1
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    Multivalent 28S rRNA expansion segments enable reconstitution of multilayered nucleolar architecture
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    CBX2 phase-separation contributes to homologous recombination repair and drug resistance in ovarian cancer
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    Vesicle trafficking 1 in breast cancer tissue and serum orchestrates metastatic progression and an immunosuppressive microenvironment
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  37. Mar 2026
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    4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1
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    Astrocytic AEBP1-NPAS3-LIPA pathway coordinates cholesterol homeostasis to regulate Alzheimer’s pathology
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    Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1
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    Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36
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    Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages
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    Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model
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  46. Feb 2026
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    Construction of a clickable probe-based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts
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    16-h fasting optimizes cancer immunotherapy in mice and humans
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  50. Jan 2026
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    Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast–Myofibroblast Transition and Renal Fibrosis
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    Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC
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    Remimazolam mitigates cerebral ischemia/reperfusion injury by concurrently alleviating damage to the blood-brain barrier and RIP3/MLKL-driven necroptosis
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    IRF3 attenuates hypoxia signaling by retaining HIF-α in the cytoplasm
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    PDCD5 promotes substrate release from the TRiC complex in cilia and flagella
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    Mitigating tumor heterogeneity in lung Cancer: A dual-targeted NIR-II imaging strategy for accurate tumor localization and intraoperative navigation
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  59. Dec 2025
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  63. Oct 2025
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    Ribosome dysregulation and intervention in age-related infertility
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    Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
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  66. Sep 2025
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    Microcystin-LR hijacks mitochondrial bioenergetics and Wnt crosstalk: Unveiling a novel dual-pathway mechanism for adipogenesis dysregulation in environmental toxicology
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    Succinate preserves CD8+ T cell fitness to augment antitumor immunity
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    Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development
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  75. Jul 2025
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  81. Jun 2025
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    Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence
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    A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE
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    Mechanism of Modified Tongyou Decoction and Its Separated Formulas Inhibiting Vasculogenic Mimicry in Esophageal Cancer TE-1 Cells via NF-κB/HIF-1α Axis
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  87. Apr 2025
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    Mechanism of Modified Tongyou Decoction and Its Separated Formulas Inhibiting Vasculogenic Mimicry in Esophageal Cancer TE-1 Cells via NF-κB/HIF-1α Axis
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    Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription
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    PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms
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  92. Mar 2025
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    Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone
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    Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
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    Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling
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  99. Feb 2025
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    Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation
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    USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5
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    F-box protein FBXB-65 regulates anterograde transport of a Kinesin-3 motor UNC-104 through a PTM near its cargo-binding PH domain
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    Nrg4 Secreted by Brown Adipose Tissue Suppresses Ferroptosis of Sepsis-Induced Liver Injury
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    Succinylation enables IDE to act as a hub of larval tissue destruction and adult tissue reconstruction during insect metamorphosis
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  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  210. Dec 2022
  211. www.sciencedirect.com www.sciencedirect.com
    Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteomic-Based Approach Reveals the Involvement of Apolipoprotein A-I in Related Phenotypes of Autism Spectrum Disorder in the BTBR Mouse Model
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  213. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  215. Nov 2022
  216. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic metaphase I/anaphase I transition in mouse oocytes
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    FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
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  219. Oct 2022
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    Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival
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  223. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  224. Sep 2022
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    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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  226. Aug 2022
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  228. Jul 2022
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    Splicing factor PRP-19 regulates mitochondrial stress response
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  232. Jun 2022
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    MDM2 Aggravates Adipose Tissue Dysfunction through Ubiquitin-mediated STEAP4 Degradation
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  234. May 2022
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    Hypoxia-inducible factor protects against acute kidney injury via the Wnt/β-catenin signaling pathway
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  236. Mar 2022
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    Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
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    Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression
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  240. Nov 2021
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    Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice
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  242. Oct 2021
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    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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  244. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers
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  245. Sep 2021
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    DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
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  247. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone demethylase LSD1 promotes RIG-I poly-ubiquitination and anti-viral gene expression
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    A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2′3′-cGAMP
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  249. Aug 2021
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    Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10
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  251. Jul 2021
  252. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Septin 4 controls CCNB1 stabilization via APC/CCDC20 during meiotic G2/M transition in mouse oocytes
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  253. Jun 2021
  254. www.cell.com www.cell.com
    Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity
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