227 Matching Annotations
  1. Oct 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Type I IFN drives unconventional IL-1β secretion in lupus monocytes
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      DOI: 10.1016/j.immuni.2024.09.004

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    sciencedirect.com/science/article/pii/S1074761324004485
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    Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier
    1
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      DOI: 10.1016/j.xcrm.2024.101754

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    sciencedirect.com/science/article/pii/S2666379124004841
  4. Sep 2024
  5. www.biorxiv.org www.biorxiv.org
    Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents
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    1. scibot 14 Sep 2024
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      DOI: 10.1101/2024.09.04.611120

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    biorxiv.org/content/10.1101/2024.09.04.611120v1
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bacterial pore-forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11357855/
  7. Aug 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Design, synthesis and biological evaluation of N-salicyloyl tryptamine derivatives as multifunctional neuroprotectants for the treatment of ischemic stroke
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    sciencedirect.com/science/article/pii/S0223523424006767
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    ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes
    1
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    sciencedirect.com/science/article/pii/S2211124724009768
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    The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy
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    sciencedirect.com/science/article/pii/S2666379124004117
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    A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
    1
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    sciencedirect.com/science/article/pii/S2211124724009835
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    Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease
    1
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    sciencedirect.com/science/article/pii/S2211124724009185
  13. Jul 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11290356/
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    The mechano-chemical circuit in fibroblasts and dendritic cells drives basal cell proliferation in psoriasis
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    sciencedirect.com/science/article/pii/S2211124724008428
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    Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer
    1
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    sciencedirect.com/science/article/pii/S2211124724008362
  17. Jun 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractility
    1
    1. scibot 07 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11144731/
  19. May 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multikinase inhibitors modulate non-constitutive proteasome expression in colorectal cancer cells
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    1. scibot 23 May 2024
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      DOI: 10.3389/fmolb.2024.1351641

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    ncbi.nlm.nih.gov/pmc/articles/PMC11106389/
  21. 52.53.155.43 52.53.155.43
    Gingival-derived mesenchymal stem cells alleviate allergic asthma inflammation via HGF in animal models
    1
    1. scibot 10 May 2024
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    52.53.155.43/77b0b81fcd376689bbdc4cf0ee4300be323e1a77/PIIS258900422401040X-html.html
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    Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor
    1
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      DOI: 10.1016/j.stem.2024.04.011

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    sciencedirect.com/science/article/pii/S1934590924001383
  23. 52.53.155.43 52.53.155.43
    Disruption in<i>CYLC1</i>leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice
    2
    1. scibot 03 May 2024
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      DOI: 10.1101/2024.01.11.24301040

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    52.53.155.43/db83a72e264c6715c8b712c9f10e49747778439c/2024.01.11.24301040v1.full-html.html
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatokine ITIH3 Protects Against Hepatic Steatosis by Downregulating Mitochondrial Bioenergetics and De Novo Lipogenesis
    1
    1. scibot 03 May 2024
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      DOI: 10.1016/j.isci.2024.109709

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    ncbi.nlm.nih.gov/pmc/articles/PMC11059128/
  25. Apr 2024
  26. www.embopress.org www.embopress.org
    The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor
    1
    1. scibot 25 Apr 2024
      Abcam, ab8226

      DOI: 10.1038/s44321-024-00051-z

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    embopress.org/doi/full/10.1038/s44321-024-00051-z
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury
    1
    1. scibot 23 Apr 2024
      RRID:AB_306371

      DOI: 10.1016/j.isci.2024.109649

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    ncbi.nlm.nih.gov/pmc/articles/PMC11025009/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gut microbiota-derived cholic acid mediates neonatal brain immaturity and white matter injury under chronic hypoxia
    1
    1. scibot 23 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11025012/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
    1
    1. scibot 20 Apr 2024
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      DOI: 10.1016/j.ebiom.2024.105129

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    ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
  30. www.sciencedirect.com www.sciencedirect.com
    The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome
    1
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      DOI: 10.1016/j.celrep.2024.114058

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    sciencedirect.com/science/article/pii/S2211124724003863
  31. 52.53.155.43 52.53.155.43
    Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis
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    52.53.155.43/949c788aea74d336f07d9a1f924b2be8228a3ec3/1-s2.0-S2589004224007806-main-html.html
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000015/
  33. www.sciencedirect.com www.sciencedirect.com
    TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction
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    sciencedirect.com/science/article/pii/S2211124724003425
  34. dx.doi.org dx.doi.org
    Genetic analysis, phenotype spectrum and functional study of rare osteogenesis imperfecta caused by CRTAP Variants
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      DOI: 10.1210/clinem/dgae025

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    dx.doi.org/10.1210/clinem/dgae025
  35. Mar 2024
  36. www.sciencedirect.com www.sciencedirect.com
    An early cell shape transition drives evolutionary expansion of the human forebrain
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      DOI: 10.1016/j.cell.2021.02.050

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    sciencedirect.com/science/article/pii/S0092867421002397
  37. www.sciencedirect.com www.sciencedirect.com
    Generation of two human induced pluripotent stem cell lines with BAX and BAK1 double knock-out using CRISPR/Cas9
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    sciencedirect.com/science/article/pii/S1873506124000758
  38. www.cell.com www.cell.com
    Myoglobin modulates the Hippo pathway to promote cardiomyocyte differentiation.
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    cell.com/iscience/abstract/S2589-0042(24)00367-5
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    Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes
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    sciencedirect.com/science/article/pii/S2211124724001876
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    Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology
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    sciencedirect.com/science/article/pii/S1097276524000959
  41. Feb 2024
  42. www.sciencedirect.com www.sciencedirect.com
    Pathogenic mycobacterium upregulates cholesterol 25-hydroxylase to promote granuloma development via foam cell formation
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    sciencedirect.com/science/article/pii/S2589004224004255
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    Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment
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    sciencedirect.com/science/article/pii/S2211124724001955
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    CYP7B1-mediated 25-hydroxycholesterol degradation maintains quiescence-activation balance and improves therapeutic potential of mesenchymal stem cells
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      DOI: 10.1016/j.chembiol.2024.01.009

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    sciencedirect.com/science/article/pii/S245194562400045X
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke
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      DOI: 10.1111/jnc.16058

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16058
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments
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      DOI: 10.1172/JCI173299

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    ncbi.nlm.nih.gov/pmc/articles/PMC10849765/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    n-3 polyunsaturated fatty acids delay intervertebral disc degeneration by inhibiting nuclear receptor coactivator 4-mediated iron overload
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      DOI: 10.1016/j.isci.2023.108721

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    Rebalancing TGF-β/PGE2 breaks RT-induced immunosuppressive barriers by enhancing tumor-infiltrated dendritic cell homing
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  51. Dec 2023
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    AID-induced CXCL12 upregulation enhances castration-resistant prostate cancer cell metastasis by stabilizing β-catenin expression
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    NSC48160 targets AMPKα to ameliorate nonalcoholic steatohepatitis by inhibiting lipogenesis and mitochondrial oxidative stress
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    Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization
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    Propionic Acid Driven by the Lactobacillus johnsonii Culture Supernatant Alleviates Colitis by Inhibiting M1 Macrophage Polarization by Modulating the MAPK Pathway in Mice
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    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  59. Oct 2023
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    Cervicovaginal microbiota disorder combined with the change of cytosine phosphate guanine motif- toll like receptor 9 axis was associated with cervical cancerization
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    EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway
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  68. Sep 2023
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    Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells
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    Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity
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    STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion
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    CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis
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    Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line
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  147. Oct 2021
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    Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis
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    Transgenerational Bisphenol A causes deficits in social recognition and alters post-synaptic density genes in mice
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    11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice
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  165. Jul 2021
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    11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice
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    SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis
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    Upregulation of the long noncoding RNA UBOX5 antisense RNA 1 (UBOX5-AS1) under hypoxic conditions promotes epithelial-mesenchymal transition in endometriosis
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  189. Mar 2021
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    Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
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    Inhibition of human microsomal PGE2 synthase‐1 reduces seizure‐induced increases of P‐glycoprotein expression and activity at the blood‐brain barrier
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    Long Noncoding RNA GAS5 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating GDF5 and p38/JNK Signaling Pathway
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    Changes in mitochondrial morphology modulate LPS-induced loss of calcium homeostasis in BV-2 microglial cells
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  200. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
    1
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      DOI: 10.1186/s40478-019-0847-7

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  201. www.fasebj.org www.fasebj.org
    Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier
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      RRID:AB_306371

      DOI: 10.1096/fj.201901460RR

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  202. Jan 2021
  203. link.springer.com link.springer.com
    Characterization of Glycosaminoglycan Disaccharide Composition in Astrocyte Primary Cultures and the Cortex of Neonatal Rats
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      DOI: 10.1007/s11064-020-03195-9

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  204. Dec 2020
  205. www.sciencedirect.com www.sciencedirect.com
    IFI16 knockdown in primary HIV-1 target cells
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      DOI: 10.1016/j.xpro.2020.100236

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  206. Nov 2020
  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of Sortilin and Matrix Vesicles in Nε-Carboxymethyl-Lysine-Induced Diabetic Atherosclerotic Calcification
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      DOI: 10.2147/DMSO.S273029

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  208. Oct 2020
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    TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
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      DOI: 10.1038/s41467-020-18761-6

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  210. Sep 2020
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    Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion
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  212. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis
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  213. elifesciences.org elifesciences.org
    The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline
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  216. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of ROCK signaling pathway accelerates enteric neural crest cell‐based therapy after transplantation in a rat hypoganglionic model
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  217. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Necrostatin‐1 prevents the proapoptotic protein Bcl‐2/adenovirus E1B 19‐kDa interacting protein 3 from integration into mitochondria
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    An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication
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  219. link.springer.com link.springer.com
    Hypercapnia Exacerbates the Blood–Brain Barrier Disruption Via Promoting HIF-1a Nuclear Translocation in the Astrocytes of the Hippocampus: Implication in Further Cognitive Impairment in Hypoxemic Adult Rats
    1
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      DOI: 10.1007/s11064-020-03038-7

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  220. www.mdpi.com www.mdpi.com
    Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity
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      DOI: 10.3390/cells9071618

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  221. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
    1
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      β-actin

      DOI: 10.1158/2159-8290.CD-19-1228

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  222. www.sciencedirect.com www.sciencedirect.com
    Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis
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      DOI: 10.1016/j.cmet.2020.04.006

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    DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis
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      DOI: 10.1016/j.molcel.2020.02.022

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    Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke
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      DOI: 10.1016/j.brainres.2020.146879

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    Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1
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      RRID:AB_306371

      DOI: 10.1016/j.celrep.2020.107999

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  226. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
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      RRID:AB_306371

      DOI: 10.7554/eLife.52570

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  227. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Down‐regulation of microRNA‐34c‐5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve
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    1. scibot 04 Sep 2020
      β‐actin

      DOI: 10.1111/jnc.14998

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  228. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres
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      ab8226

      DOI: 10.7554/eLife.49817

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    Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage
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  230. Jan 2020
  231. www.sciencedirect.com www.sciencedirect.com
    Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
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      AB_306371

      DOI: 10.1016/j.celrep.2019.05.095

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  232. www.sciencedirect.com www.sciencedirect.com
    IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation
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      DOI: 10.1016/j.chom.2019.05.002

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  233. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network
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      DOI: 10.1155/2019/9706792

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    IMM-H004 reduced okadaic acid-induced neurotoxicity by inhibiting Tau pathology in vitro and in vivo
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      DOI: 10.1016/j.neuro.2019.09.012

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    Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos
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      DOI: 10.1016/j.celrep.2019.06.058

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  236. academic.oup.com academic.oup.com
    Pain-Relieving Effect of 4.4 MHz of Pulsed Radiofrequency on Acute Knee Arthritis in Rats
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      RRID:AB_306371

      DOI: 10.1093/pm/pnz264

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  237. elifesciences.org elifesciences.org
    Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans
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      DOI: 10.7554/eLife.49158

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    Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7
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      DOI: 10.1016/j.neuron.2019.11.019

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    Dengue NS2A Protein Orchestrates Virus Assembly
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      DOI: 10.1016/j.chom.2019.09.015

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    Untitled document
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      DOI: 10.1016/j.celrep.2019.01.067

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    A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils
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      DOI: 10.1016/j.immuni.2019.03.001

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