381 Matching Annotations
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    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513552
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    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124725012045
  5. Oct 2025
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    Super-adjuvant nanoparticles for platform cancer vaccination
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    sciencedirect.com/science/article/pii/S2666379125004884
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1368764625001153
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    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
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    Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
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  13. Sep 2025
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    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes
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    Phosphatidylserine-positive extracellular vesicles for detecting multiple operable cancers
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    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    sciencedirect.com/science/article/pii/S0141813025081048
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    A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer
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    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
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    HuR-regulated extracellular vesicles promote endothelial cell remodeling in pancreatic cancer
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  24. Aug 2025
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    PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
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    Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
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    The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma
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  43. Jul 2025
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    A novel defined manganese metabolism‑related gene signature for predicting the prognosis of pancreatic ductal adenocarcinoma
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    The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer
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    CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts
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    Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
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    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma
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  55. Jun 2025
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    EMT-associated bias in the Parsortix® system observed with pancreatic cancer cell lines
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    Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour‐Derived Extracellular Vesicles
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    Stromal Hedgehog Signaling Is Associated with Favorable Outcomes in Pancreatic Cancer
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    Cachexia-induced reprogramming of visceral organ metabolism by human pancreatic cancer xenografts
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    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
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  65. May 2025
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    HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
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    Pharmacologic ascorbate resistant pancreatic cancer demonstrates enhanced metastatic potential
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    Reactivity-based metabolomics reveal cysteine has glyoxalase 1-like and glyoxalase 2-like activities
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    link.springer.com/article/10.1038/s41589-025-01909-0
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    ILF3 mediates lipid metabolism to promote pancreatic cancer development by regulating CPT1A-activated PPARa signaling pathway
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    Novel Approaches to 3D Cancer Heterospheroid Culture and Assay Development for Immunotherapy Screening
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  73. Apr 2025
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity
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    Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids
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    Cytosolic cytochrome c represses ferroptosis
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    Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation
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    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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    VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
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  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
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    Unveiling transcriptional mechanisms of B7-H3 in breast cancer stem cells through proteomic approaches
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    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  84. Mar 2025
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    Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
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  86. Feb 2025
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    The IGF2BP1 oncogene is a druggable m6A-dependent enhancer of YAP1-driven gene expression in ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850222/
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    SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer
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    MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK
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    aacrjournals.org/cancerimmunolres/article/12/10/1452/748716/MR1-Gene-and-Protein-Expression-Are-Enhanced-by
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    Targeting Tumor-Associated Sialic Acids using Chimeric Switch Receptors based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells
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    aacrjournals.org/cancerimmunolres/article/12/10/1380/748721/Targeting-Tumor-Associated-Sialic-Acids-Using
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    Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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  173. Feb 2024
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  186. Jan 2024
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  197. Dec 2023
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  201. Nov 2023
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    SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer
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    IK Channel-Independent Effects of Clotrimazole and Senicapoc on Cancer Cells Viability and Migration
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  204. www.biorxiv.org www.biorxiv.org
    LMO3 is a suppressor of the basal-like/squamous PDAC subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
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  207. Oct 2023
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    Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
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  211. Sep 2023
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    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
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    Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
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  220. Aug 2023
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