480 Matching Annotations
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    Targeting HAS2 to enhance anti-tumor immunity in pancreatic cancer via PD-L1 regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13237160/
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    Sequential cryoablation enhances chemotherapeutic efficacy in pancreatic cancer by downregulating TGF-β mediated fibrosis in the sub-lethal zone
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    sciencedirect.com/science/article/pii/S0306456526001361
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    FLIM Playground: An interactive, end-to-end graphical user interface for analyzing single cells with fluorescence lifetime imaging microscopy
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    sciencedirect.com/science/article/pii/S2667237526001840
  5. Jun 2026
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    Optimized Cryoablation and Combinatorial Chemotherapy Overcome Sublethal Survival in Pancreatic Cancer Cells
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    sciencedirect.com/science/article/pii/S0140700726002021
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    Pyrazolo-quinolinone suppresses epithelial–mesenchymal transition by targeting the CXCR4/NF-κB axis in human pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S0344033826002001
  8. May 2026
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Hui-Xiang Decoction Against Pancreatic Cancer by Regulating AKT and Activating the Hippo Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/cbdv.202502356
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    Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells
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    sciencedirect.com/science/article/pii/S1074761326001792
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    The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue
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    sciencedirect.com/science/article/pii/S2451945626001510
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    Tumor-Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520029
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    Explainable multi-omics modeling for risk stratification in pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13184197/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining ferroptosis inducers with gemcitabine to enhance treatment efficacy in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13185238/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial Multiomics Analyses Reveal That Diabetes Promotes Pancreatic Cancer Progression by Stimulating Cholesterol-Induced Neutrophil Extracellular Trap Formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13176823/
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    Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis
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    nature.com/articles/s42003-026-09538-6
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiomics and Genomic Alteration Characterization Identifies VDAC1 as a Mitochondrial‐Associated Biomarker in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13150345/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alprazolam reduces inflammatory cytokine production in pancreatic cancer-associated fibroblasts
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  19. aacrjournals.org aacrjournals.org
    Lipid Nanoparticle-Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T Cell Infiltration
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    aacrjournals.org/cancerres/article/85/19/3706/765871/Lipid-Nanoparticle-Encapsulated-mRNAs-Encoding
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    Lipid Composition Alters Ferroptosis Sensitivity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13138121/
  21. Apr 2026
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy
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    Synergistic Enhancement of Immunogenic Cell Death Through Photothermal/Photodynamic Effects via Complex Nanoenzymes for Pancreatic Cancer Therapy
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    advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202505709
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    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S221112472600392X
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    The Vitamin D3 Analog Calcipotriol Attenuates Pancreatic Cancer Malignancy via Downregulating Thrombospondin 1 in Pancreatic Stellate Cells
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    onlinelibrary.wiley.com/doi/10.1155/mi/2632235
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  27. www.biorxiv.org www.biorxiv.org
    Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.04.13.717530v1
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    Loss of Regulator of G protein signaling 11 promotes pro-tumorigenic features in pancreatic cancer
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    Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma
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  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment
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    RPA hyperphosphorylation hinders the resolution of R-loops and G-quadruplex-associated R-loops during RAS-driven senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC13076219/
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    Vorinostat Potentiates Chemoimmunotherapy in Immune-Enriched Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202521844
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    Label-free digital protein sensing by integral plasmonic imaging
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    Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
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    pmc.ncbi.nlm.nih.gov/articles/PMC13060627/
  36. www.biorxiv.org www.biorxiv.org
    Oncogenic RAS-driven α2 integrin induction under nutrient stress promotes cancer cell motility
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    biorxiv.org/content/10.64898/2026.04.02.716145v1
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    aacrjournals.org/mct/article/25/1/84/771280/Identification-of-Small-Molecule-Inhibitors-that
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    The Combination of a BCL-xL PROTAC and an mTOR Inhibitor Sensitizes Pancreatic Ductal Adenocarcinoma to KRASG12D Inhibitor Treatment
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    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202503162RR
  40. Mar 2026
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    sciencedirect.com/science/article/pii/S2211124726002664
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517184
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    TIPE2 knockdown enhances the anti-tumor efficacy of NKG2D CAR-T cells against pancreatic cancer via activating NF-κb signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13011749/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Radiation-Enhanced CD24 Membrane Trafficking via GPI Anchoring Mediates Anti-Tumor Immune Evasion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012240/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13003987/
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    Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification
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    sciencedirect.com/science/article/pii/S2451945626000711
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    Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000777
  49. www.biorxiv.org www.biorxiv.org
    L-Lactate reprograms tumor-associated macrophages to drive pancreatic cancer progression via BCL3 lactylation
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    biorxiv.org/content/10.64898/2026.03.06.710237v1
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12970238/
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    DPP4 suppresses pancreatic cancer growth by enhancing ferroptosis sensitivity through stabilization of ACSL4
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    sciencedirect.com/science/article/pii/S0898656826000963
  52. Feb 2026
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12937152/
  54. www.science.org www.science.org
    KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors
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    science.org/doi/10.1126/sciadv.aea2511
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12922744/
  56. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202515606
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    A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity
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    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing
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    sciencedirect.com/science/article/pii/S2211124726000343
  60. pubs.acs.org pubs.acs.org
    5′-NucA-SMCC-DM1 and 5′-NucA-SPDMV-DM1 are Potent Aptamer–Drug Conjugates against Pancreatic Cancer
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    pubs.acs.org/doi/full/10.1021/acsomega.5c11364
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyclic di-GMP suppresses cancer metastasis by targeting proteasome 26S subunit non-ATPase 3 independently of STING
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    pmc.ncbi.nlm.nih.gov/articles/PMC12868630/
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    USP20–RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake
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    sciencedirect.com/science/article/pii/S0304383526000625
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859874/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316562/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Estrogen Production in Pancreatic Cancer Shapes a Tumor Suppressive Stromal Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12862343/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859075/
  68. Jan 2026
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CK2-mediated HDAC5 shuttling regulates DNA end resection through Ku70 deacetylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12846757/
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    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circ72309 modulates gemcitabine metabolism and gemcitabine sensitivity in pancreatic cancer: Serum Circ72309 levels as a potential predictor of treatment response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12823056/
  72. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Metabolic Reprogramming of T Cells by Dual UCP2 and IL-17 Blockade Enhances Immunity Against Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513020
  73. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
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    In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment
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    sciencedirect.com/science/article/pii/S2211124725015992
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833852/
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    Local mechanobiological disruption in solid tumor-driven vascular permeability: a competition between mechanical vs chemical stimuli
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    sciencedirect.com/science/article/pii/S1742706126000243
  77. www.nature.com www.nature.com
    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  78. Dec 2025
  79. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12717533/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  82. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Integrated Multiomics Unravels Hedgehog (HH) Signaling Characteristics in Pancreatic Cancer (PC) and DCBLD2 Regulates HH Signaling to Drive PC Progression
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    onlinelibrary.wiley.com/doi/full/10.1155/humu/4806397
  83. 54.241.53.176 54.241.53.176
    ssrn-5775133-html.html
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  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
  85. www.biorxiv.org www.biorxiv.org
    DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer
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    biorxiv.org/content/10.1101/2025.11.26.690756v1
  86. www.nature.com www.nature.com
    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137021/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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