5,418 Matching Annotations
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    MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model
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    1. scibot 02 Oct 2024
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      DOI: 10.1158/2767-9764.CRC-24-0144

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    ncbi.nlm.nih.gov/pmc/articles/PMC11425777/
  3. www.biorxiv.org www.biorxiv.org
    Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy
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      DOI: 10.1101/2024.09.09.612140

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    biorxiv.org/content/10.1101/2024.09.09.612140v1
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    Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations
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      DOI: 10.1101/2024.09.25.614811

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    Diminished Light Sensitivities of ON Alpha Retinal Ganglion Cells Observed in a Mouse Model of Hyperglycemia
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    sciencedirect.com/science/article/pii/S001448352400335X
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    A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration
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      DOI: 10.1016/j.stem.2024.09.001

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    sciencedirect.com/science/article/pii/S1934590924003151
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    Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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    sciencedirect.com/science/article/pii/S0896627324006548
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    Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance
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    sciencedirect.com/science/article/pii/S1934590924003229
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    Jawbone periosteum-derived cells with high osteogenic potential controlled by R-spondin 3
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  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of striatal dopamine release by the L‐type calcium channel inhibitor isradipine co‐varies with risk factors for Parkinson's
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      RRID:IMSR_JAX:000664

      DOI: 10.1111/ejn.16180

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    ncbi.nlm.nih.gov/pmc/articles/PMC11426196/
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    Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis
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      DOI: 10.4103/NRR.NRR-D-23-01446

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  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macrophage-mediated myelin recycling fuels brain cancer malignancy
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    1. scibot 02 Oct 2024
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    Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
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    1. scibot 02 Oct 2024
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      DOI: 10.1158/2326-6066.CIR-20-1043

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    aacrjournals.org/cancerimmunolres/article/9/9/1008/666146/Overproduction-of-Gastrointestinal-5-HT-Promotes
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    Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation
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    1. scibot 02 Oct 2024
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    sciencedirect.com/science/article/pii/S2451945624003933
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    Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease
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    sciencedirect.com/science/article/pii/S1074761324004175
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    The TMEM132B-GABAA receptor complex controls alcohol actions in the brain
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    sciencedirect.com/science/article/pii/S0092867424010249
  17. www.biorxiv.org www.biorxiv.org
    Chromatin folding motifs define the basic grammar of TAD architecture in single alleles
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    Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer’s Disease
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    Impact of O-GlcNAcylation elevation on mitophagy and glia in the dentate gyrus
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    1. scibot 28 Sep 2024
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    Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis
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      DOI: 10.7554/eLife.97662

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    Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis
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    1. scibot 28 Sep 2024
      RRID:IMSR_JAX:000664

      DOI: 10.1101/2024.09.19.613929

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    biorxiv.org/content/10.1101/2024.09.19.613929v1
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    Single Cell Profiling in the Sox10Dom/+ Hirschsprung Mouse Implicates Hoxa6 in Enteric Neuron Lineage Allocation
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    1. scibot 28 Sep 2024
      Jackson Laboratory Stock_664

      DOI: 10.1101/2024.09.18.613729

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    biorxiv.org/content/10.1101/2024.09.18.613729v2
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    Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia
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      RRID:IMSR_JAX:0006664

      DOI: 10.1101/2024.09.19.613918

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    Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes
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    sciencedirect.com/science/article/pii/S0012160624002343
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    Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS
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    sciencedirect.com/science/article/pii/S221112472401129X
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    Misprogramming of glucose metabolism impairs recovery of hippocampal slices from neuronal GLT-1 knockout mice and contributes to excitotoxic injury through mitochondrial superoxide production
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    Functional efficacy of the MAO-B inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: A comparative study with tranylcypromine
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    A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies
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    Targeting the PAC1 receptor mitigates degradation of myelin and synaptic markers and diminishes locomotor deficits in the cuprizone demyelination model
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      DOI: 10.1111/jnc.16199

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    Pharmacological SOS1 inhibitor BI-3406 demonstrates in vivo anti-tumor activity comparable to SOS1 genetic ablation in KRAS mutant tumors
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      DOI: 10.1101/2024.09.18.613686

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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Robust multisensory deviance detection in the mouse parietal associative area
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      DOI: 10.1016/j.cub.2023.08.002

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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interhemispheric CA1 projections support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome
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      DOI: 10.1101/2024.09.05.611389

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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of immortal-like and functional CAR T cells by defined factors
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      DOI: 10.1084/jem.20232368

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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses
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  35. www.sciencedirect.com www.sciencedirect.com
    Astroglia proliferate upon biogenesis of tunneling nanotubes via α-synuclein dependent transient nuclear translocation of focal adhesion kinase
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  36. www.cell.com www.cell.com
    The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response
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      The Jackson LaboratoryStrain #000664

      DOI: 10.1016/j.immuni.2024.07.006

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    cell.com/immunity/fulltext/S1074-7613(24)00355-8
  37. www.pnas.org www.pnas.org
    Disruption of the ZFP574–THAP12 complex suppresses B cell malignancies in mice
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      DOI: 10.1073/pnas.2409232121

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  38. www.sciencedirect.com www.sciencedirect.com
    The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision
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      DOI: 10.1016/j.neuron.2024.08.015

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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Wide Mapping of RNA-Protein Associations via Sequencing
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      DOI: 10.1101/2024.09.04.611288

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    ncbi.nlm.nih.gov/pmc/articles/PMC11398515/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
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      DOI: 10.21203/rs.3.rs-4797540/v1

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    Median raphe glutamatergic neuron-mediated enhancement of GABAergic transmission and suppression of long-term potentiation in the hippocampus
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    The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring
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    Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway
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    Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
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    Kaempferol reduces pyroptosis in acute lung injury by decreasing ADAM10 activity through the NLRP3/GSDMD pathway.
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    A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation
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    FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation
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    Olfactory bulb targeted QD bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice
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  59. elifesciences.org elifesciences.org
    Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease
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    The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli
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    c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3
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    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
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    Mice Reach Higher Visual Sensitivity at Night by Using a More Efficient Behavioral Strategy
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    Acute focal seizures start as local synchronizations of neuronal ensembles
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  65. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Subcellular NAMPT‐mediated NAD+ salvage pathways and their roles in bioenergetics and neuronal protection after ischemic injury
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    Orofacial Movements Involve Parallel Corticobulbar Projections from Motor Cortex to Trigeminal Premotor Nuclei
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    Transcriptome-wide quantification of double-stranded RNAs in live mouse tissues by dsRIP-Seq
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    CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
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    Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy
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    Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ
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    ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer
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    MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer
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    A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein
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    RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages
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    Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain
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    Input-specific localization of NMDA receptor GluN2 subunits in thalamocortical neurons
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    Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells
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    A distributed auditory network mediated by pontine central gray underlies ultra-fast awakening in response to alerting sounds
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    ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes
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    Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in nucleus accumbens core circuitry engaged by binge-like ethanol drinking
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      RRID:MSR_JAX:000664

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  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Disrupted stress-induced analgesia in a neuropathic pain state is rescued by the endocannabinoid degradation inhibitor JZL195
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  90. www.sciencedirect.com www.sciencedirect.com
    Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models
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    A broadly applicable method for quantifying cardiomyocyte cell division identifies proliferative events following myocardial infarction
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    Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow
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    Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity
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    Leishmania infantum exploits the anti-ferroptosis effects of Nrf2 to escape cell death in macrophages
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    Failure in a population: Tauopathy disrupts homeostatic set-points in emergent dynamics despite stability in the constituent neurons
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    E-cigarette exposure disrupts antitumor immunity and promotes metastasis
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      000664

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    Identification of a novel myosin antigen activating CD8+ T cells in C57BL/6 mice
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    RORγt-dependent antigen-presenting cells direct regulatory T cell-mediated tolerance to food antigen
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    Parabrachial CGRP neurons modulates conditioned active defensive behavior under a naturalistic threat
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    The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis
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    Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice
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      C57BL6/J

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    Application of a bespoke monoclonal antibody panel to characterize immune cell populations in cave nectar bats
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    Gamma-protocadherins regulate dendrite self-recognition and dynamics to drive self-avoidance
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer
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    The Lactate Receptor GPR81 is a Mechanism of Leukemia-Associated Macrophage Polarization in the Bone Marrow Microenvironment
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    Interaction between the TBC1D24 TLDc domain and the KIBRA C2 domain is disrupted by two epilepsy-associated TBC1D24 missense variants
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    Susceptibility to Low Vitamin B6 Diet–induced Gestational Diabetes Is Modulated by Strain Differences in Mice
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      C57BL/6J

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    Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals
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    Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity
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    Salmonella re-engineers the intestinal environment to break colonization resistance in the presence of a compositionally intact microbiota
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    Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization
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    Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS
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    The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton
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    Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition
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    Spatial selectivity of ATase inhibition in mouse models of Charcot–Marie–Tooth disease
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    A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding
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    Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice
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  125. www.cell.com www.cell.com
    Motor cortex is responsible for motoric dynamics in striatum and the execution of both skilled and unskilled actions
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  126. www.sciencedirect.com www.sciencedirect.com
    Effective knockdown-replace gene therapy in a novel mouse model of DNM1 developmental and epileptic encephalopathy
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    TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and function
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    Cells and circuits for amygdala neuroplasticity in the transition to chronic pain
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    Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling
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    Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration
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  131. www.nature.com www.nature.com
    LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aryl Hydrocarbon Receptor Activation in Pulmonary Alveolar Epithelial Cells Limits Inflammation and Preserves Lung Epithelial Cell Integrity
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    A single-cell transcriptomic census of mammalian olfactory epithelium aging
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    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells
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    Phosphoglycerate kinase is a central leverage point in Parkinson’s disease–driven neuronal metabolic deficits
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    Obesity intensifies sex-specific interferon signaling to selectively worsen central nervous system autoimmunity in females
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    Modulation of arterial intima stiffness by disturbed blood flow
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    Epithelial organoid supports resident memory CD8 T cell differentiation
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    Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity
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    Negative feedback control of hypothalamic feeding circuits by the taste of food
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    Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection
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    Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis
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  144. www.nature.com www.nature.com
    Intradermal vaccination with a phytoglycogen nanoparticle and STING agonist induces cytotoxic T lymphocyte-mediated antitumor immunity
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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture
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    Protocol for electrophysiological measurements of circadian changes in excitability in dentate granule cells from adult mice
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    Strategic stabilization of arousal boosts sustained attention
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    Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries
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      The Jackson Laboratory_000664

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  150. www.biorxiv.org www.biorxiv.org
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell
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    Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity
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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2, against MASLD Progression
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    Protocol for transplantation of cells derived from human midbrain organoids into a Parkinson’s disease mouse model to restore motor function
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    Protocol to examine murine visceral adipose tissue immune cells using fluorescence-based flow cytometry
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    BDNF-dependent nano-organization of Neogenin and the WAVE Regulatory Complex promotes actin remodelling in dendritic spines
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    Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territories
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    Synaptotagmins 3 and 7 mediate the majority of asynchronous release from synapses in the cerebellum and hippocampus
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    Omega-3 Reverses the Metabolic and Epigenetically Regulated Placental Phenotype acquired from Pre-conceptional and Peri-conceptional Exposure to Air Pollutants
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    Creation of a novel CRISPR-generated allele to express HA epitope-tagged C1QL1 and improved methods for its detection at synapses
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    Granulosa cells alone, without theca cells, can mediate LH-induced oocyte meiotic resumption
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  198. www.frontiersin.org www.frontiersin.org
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    Krüppel-like Factor (KLF) family members control expression of genes required for serous cavity and alveolar macrophage identities
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      Curator: @bandrow

      SciCrunch record: RRID:IMSR_JAX:000664

      What is this?
      RRID:IMSR_JAX:000664
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    biorxiv.org/content/10.1101/2024.02.28.582578v1
  200. www.sciencedirect.com www.sciencedirect.com
    Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanisms
    1
    1. scibot 13 Aug 2024
      Jackson Laboratory Cat_000664

      DOI: 10.1016/j.devcel.2024.07.017

      Resource: (IMSR Cat# JAX_000664,RRID:IMSR_JAX:000664)

      Curator: @vtello

      SciCrunch record: RRID:IMSR_JAX:000664

      What is this?
      RRID:IMSR_JAX:000664 RRIDCUR:Unresolved
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    sciencedirect.com/science/article/pii/S153458072400457X
  201. www.sciencedirect.com www.sciencedirect.com
    Ing4-deficiency promotes a quiescent yet transcriptionally poised state in hematopoietic stem cells
    1
    1. scibot 13 Aug 2024
      Jackson Laboratory Cat_000664

      DOI: 10.1016/j.isci.2024.110521

      Resource: (IMSR Cat# JAX_000664,RRID:IMSR_JAX:000664)

      Curator: @vtello

      SciCrunch record: RRID:IMSR_JAX:000664

      What is this?
      RRID:IMSR_JAX:000664 RRIDCUR:Unresolved
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    sciencedirect.com/science/article/pii/S2589004224017462
  202. www.sciencedirect.com www.sciencedirect.com
    The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function
    1
    1. scibot 13 Aug 2024
      Jackson Laboratory Cat_000664

      DOI: 10.1016/j.immuni.2024.07.003

      Resource: (IMSR Cat# JAX_000664,RRID:IMSR_JAX:000664)

      Curator: @vtello

      SciCrunch record: RRID:IMSR_JAX:000664

      What is this?
      RRID:IMSR_JAX:000664 RRIDCUR:Unresolved
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    sciencedirect.com/science/article/pii/S1074761324003522