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  2. aacrjournals.org aacrjournals.org
    RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP–negative Glioblastoma
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    1. scibot 02 Oct 2024
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      DOI: 10.1158/1078-0432.CCR-20-2141

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    aacrjournals.org/clincancerres/article/27/2/645/83327/RNA-sequencing-and-Immunohistochemistry-Reveal
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    Glioblastoma TCGA Mesenchymal and IGS 23 Tumors are Identifiable by IHC and have an Immune-phenotype Indicating a Potential Benefit from Immunotherapy
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    1. scibot 02 Oct 2024
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    aacrjournals.org/clincancerres/article/26/24/6600/82892/Glioblastoma-TCGA-Mesenchymal-and-IGS-23-Tumors
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    A clinically effective model based on cell-free DNA methylation and low-dose CT for risk stratification of pulmonary nodules
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    1. scibot 02 Oct 2024
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    sciencedirect.com/science/article/pii/S2666379124004804
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    Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration Resistant Prostate Cancer
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    1. scibot 25 Sep 2024
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    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1535610824003179
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    Tumour-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signalling.
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224019266
  8. Sep 2024
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    Aberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma
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    1. scibot 12 Sep 2024
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      DOI: 10.1158/0008-5472.CAN-22-0677

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    aacrjournals.org/cancerres/article/83/2/195/715074/Aberrant-L-Fucose-Accumulation-and-Increased-Core
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    Multiple direct and indirect roles of the Paf1 complex in transcription elongation, splicing, and histone modifications
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    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010817
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    Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
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    1. scibot 05 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
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    Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
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    1. scibot 05 Sep 2024
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    sciencedirect.com/science/article/pii/S1074761324004072
  13. Aug 2024
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    The Lactate Receptor GPR81 is a Mechanism of Leukemia-Associated Macrophage Polarization in the Bone Marrow Microenvironment
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    1. scibot 29 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11343108/
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    Low-pass nanopore sequencing for measurement of global methylation levels in plants
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    1. scibot 23 Aug 2024
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    biorxiv.org/content/10.1101/2024.08.12.607255v1
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    Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis
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      DOI: 10.7554/eLife.96678

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      DOI: 10.7554/eLife.96678

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    ncbi.nlm.nih.gov/pmc/articles/PMC11335348/
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    Transient Differentiation-State Plasticity Occurs During Acute Lymphoblastic Leukemia Initiation
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    1. scibot 22 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11325147/
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    Dysfunctional BTN3A together with deregulated immune checkpoints and type I/II IFN dictate defective interplay between pDCs and γδ T cells in melanoma patients, which impacts clinical outcomes
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    1. scibot 22 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC8577077/
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    BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
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      DOI: 10.1158/2767-9764.CRC-24-0111

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    ncbi.nlm.nih.gov/pmc/articles/PMC11320024/
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    Multi-omic analysis reveals VEGFR2, PI3K, and JNK mediate small molecule induction of human iPSC-derived cardiomyocyte proliferation
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    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S2589004224017103
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    The multi-level effect of chlorpyrifos during clownfish metamorphosis
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    1. scibot 20 Aug 2024
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    biorxiv.org/content/10.1101/2024.08.02.606305v1
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    Anti-EGFR Antibody–Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292198/
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    Transcriptomic characterization of dying hair cells in the avian cochlea
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    1. scibot 13 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124721002163
  24. pubs.acs.org pubs.acs.org
    Symmetrical Bispyridinium Compounds Act as Open Channel Blockers of Cation-Selective Ion Channels
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      DOI: 10.1021/acsptsci.3c00308

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    pubs.acs.org/doi/10.1021/acsptsci.3c00308
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11287894/
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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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    sciencedirect.com/science/article/pii/S1097276524005793
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    Intrinsically disordered sequences can tune fungal growth and the cell cycle for specific temperatures
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    sciencedirect.com/science/article/pii/S0960982224009187
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    The SRC family kinase inhibitor NXP900 demonstrates potent anti-tumor activity in squamous cell carcinomas
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    sciencedirect.com/science/article/pii/S0021925824021161
  29. Jul 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
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    sciencedirect.com/science/article/pii/S0896627324004914
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    Multi-omics profiling to identify early plasma biomarkers in pre-diagnostic pancreatic ductal adenocarcinoma: a nested case-control study
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    sciencedirect.com/science/article/pii/S1936523324001864
  32. www.science.org www.science.org
    The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1
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      DOI: 10.1126/sciadv.adk1296

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    Evolutionary Dynamics of Lineage-Specific Class-A GPCR Subsets Reveal Widespread Chemosensory Roles and Adaptations in Lophotrochozoa
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    biorxiv.org/content/10.1101/2024.07.14.603414v1
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    Cerebrospinal fluid cfDNA sequencing for classification of central nervous system glioma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11247324/
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    ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11290356/
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    Synaptic plasticity in human thalamocortical assembloids
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407288/
  37. www.biorxiv.org www.biorxiv.org
    PathoGFAIR: a collection of FAIR and adaptable (meta)genomics workflows for (foodborne) pathogens detection and tracking
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      DOI: 10.1101/2024.06.26.600753

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    biorxiv.org/content/10.1101/2024.06.26.600753v1
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTP4A2 Promotes Glioblastoma Progression and Macrophage Polarization under Microenvironmental Pressure
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    ncbi.nlm.nih.gov/pmc/articles/PMC11238266/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
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      DOI: 10.1158/1078-0432.CCR-23-3077

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    ncbi.nlm.nih.gov/pmc/articles/PMC11215407/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-Mitochondrion Sequencing Uncovers Distinct Mutational Patterns and Heteroplasmy Landscape in Mouse Astrocytes and Neurons
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      DOI: 10.1101/2024.06.13.598906

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    ncbi.nlm.nih.gov/pmc/articles/PMC11195285/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1
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      DOI: 10.1126/sciadv.adk1296

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    ncbi.nlm.nih.gov/pmc/articles/PMC11204300/
  42. Jun 2024
  43. www.cell.com www.cell.com
    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
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      DOI: 10.1016/j.isci.2024.110132

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    cell.com/iscience/abstract/S2589-0042(24)01357-9
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abnormally Enhanced Midfrontal Theta-Band Activity During Response Monitoring in Youth with Obsessive-Compulsive Disorder
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      DOI: 10.1016/j.biopsych.2022.10.020

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    Measurement of ctDNA Tumor Fraction Identifies Informative Negative Liquid Biopsy Results and Informs Value of Tissue Confirmation
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    Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome.
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    Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms
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    RAS/RAF co-mutation and ERBB2 copy number modulates HER2 heterogeneity and responsiveness to HER2-directed therapy in colorectal cancer
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    Pharmacologic Targeting of Histone H3K27 Acetylation/BRD4-dependent Induction of ALDH1A3 for Early-phase Drug Tolerance of Gastric Cancer
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    Integrative molecular analyses of the MD Anderson prostate cancer patient-derived xenograft (MDA PCa PDX) series
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    A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice
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    RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B
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  62. www.medrxiv.org www.medrxiv.org
    Proliferative History Is a Novel Driver of Clinical Outcome in Splenic Marginal Zone Lymphoma
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    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2
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  65. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
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    Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary
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    Spatial transcriptomics suggests that alterations occur in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers
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    Comparative Genomic Analysis and Clinical Outcomes of BRAF-mutated Advanced Biliary Tract Cancers
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  86. www.biorxiv.org www.biorxiv.org
    Within-subject changes in methylome profile identify individual signatures of early-life adversity, with a potential to predict neuropsychiatric outcome
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    A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer
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    Comparative transcriptomic analysis of bovine mesenchymal stromal cells reveals tissue-source and species-specific differences
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    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
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    Investigating metabolic dysregulation in serum of triple transgenic Alzheimer’s disease male mice: implications for pathogenesis and potential biomarkers
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    Microglia maintain structural integrity during fetal brain morphogenesis
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    Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression
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    MyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization
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    CRISPR/Cas9-mediated deletion of a GA-repeat in human GPM6B leads to disruption of neural cell differentiation from NT2 cells
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    CRISPR/Cas9-mediated deletion of a GA-repeat in human GPM6B leads to disruption of neural cell differentiation from NT2 cells
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    Establishing a 3D culture system for early organogenesis of monkey embryos ex vivo and single-cell transcriptome analysis of cultured embryos
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    PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function
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    TRIB3, as a robust prognostic biomarker for HNSC, is associated with poor immune infiltration and cancer cell immune evasion
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    Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome
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    A new genomic framework to categorize pediatric acute myeloid leukemia
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    Within-subject changes in methylome profile identify individual signatures of early-life adversity, with a potential to predict neuropsychiatric outcome
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    Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy
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    Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells
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    An essential signaling cascade for avian auditory hair cell regeneration
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    Prospective evaluation of NGS-based sequencing in epilepsy patients: results of seven NASGE-associated diagnostic laboratories
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    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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    Intratumor APOL3 delineates a distinctive immunogenic ferroptosis subset with prognosis prediction in colorectal cancer
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    Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly
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    CRISPR-Cas12a-integrated transgenes in genomic safe harbors retain high expression in human hematopoietic iPSC-derived lineages and primary cells
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    Changes in neuropeptide large dense core vesicle trafficking dynamics contribute to adaptive responses to a systemic homeostatic challenge.
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    Popular Large Language Model Chatbots’ Accuracy, Comprehensiveness, and Self-Awareness in Answering Ocular Symptom Queries
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    Active maintenance of CD8+ T cell naivety through regulation of global genome architecture
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    Evaluating blood oxygen saturation measurements by popular fitness trackers in postoperative patients: a prospective clinical trial
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    Evaluation of risdiplam efficacy in 5q spinal muscular atrophy: A systematic comparison of electrophysiologic with clinical outcome measures
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    A prognostic matrix code defines functional glioblastoma phenotypes and niches
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    Comprehensive Analysis of Tumor Microenvironment Reveals Prognostic ceRNA Network Related to Immune Infiltration in Sarcoma
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    Prognostic Markers of DNA Methylation and Next-Generation Sequencing in Progressive Glioblastoma from the EORTC-26101 Trial
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    Transcriptomic and proteomic profiling reveals distinct pathogenic features of peripheral non-classical monocytes in systemic lupus erythematosus
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    Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung Adenocarcinoma
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    Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor induced colitis
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial network adaptations of microglia reveal sex-specific stress response after injury and UCP2 knockout
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    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3’ UTR of FAIM2
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    Transplantation elicits a clonally diverse CD8+ T cell response that is comprised of potent CD43+ effectors
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    Role of miR-301b-3p/5p in breast cancer: A study based on the cancer GenomeAtlas program (TCGA) and bioinformatics analysis
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    Synergism Between IL21 and Anti-PD-1 Combination Therapy is Underpinned by the Coordinated Reprogramming of the Immune Cellular Network in the Tumor Microenvironment
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    Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus
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    Genome-Wide SNP and Indel Discovery in Abaca (Musa textilis Née) and among Other Musa spp. for Abaca Genetic Resources Management
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  162. Jul 2023
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    Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
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    Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation
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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies
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    Immunological modifications following chemotherapy are associated with delayed recurrence of ovarian cancer
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    The diagnostic significance of the ZNF gene family in pancreatic cancer: a bioinformatics and experimental study
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    Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice
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    Fatal neonatal listeriosis following L. monocytogenes horizontal transmission highlights neonatal susceptibility to orally acquired listeriosis
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    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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    An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
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    DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres
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    Disruption of the gut microbiota confers cisplatin resistance in epithelial ovarian cancer
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  179. www.biorxiv.org www.biorxiv.org
    A prognostic matrix code defines functional glioblastoma phenotypes and niches
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  180. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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  183. www.biorxiv.org www.biorxiv.org
    Tyramine promotes colon cancer risk and development by inducing DNA damage and inflammation
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  184. May 2023
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks
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  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
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    Intrinsic tumor resistance to CAR T cells is a dynamic transcriptional state that is exploitable with low-dose radiation
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  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models
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    Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling
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    KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition
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    Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles
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  197. www.nature.com www.nature.com
    Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
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  199. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice
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    Maternal and food microbial sources shape the infant microbiome of a rural Ethiopian population
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    Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
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    Systematic comparison of multi-omics survival models reveals a widespread lack of noise resistance
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  203. www.biorxiv.org www.biorxiv.org
    Brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke
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    Active maintenance of CD8+ T cell naïvety through regulation of global genome architecture
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  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of Eimeria acervulina infection on the luminal and mucosal microbiota of the duodenum and jejunum in broiler chickens
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