249 Matching Annotations
  1. Jan 2021
  2. www.sciencedirect.com www.sciencedirect.com
    The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling
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    1. scibot 20 Jan 2021
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      DOI: 10.1016/j.celrep.2020.108631

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    sciencedirect.com/science/article/pii/S221112472031620X
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    A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
    1
    1. scibot 08 Jan 2021
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      DOI: 10.1016/j.celrep.2020.108586

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    sciencedirect.com/science/article/pii/S2211124720315758
  4. Dec 2020
  5. www.sciencedirect.com www.sciencedirect.com
    Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
    1
    1. scibot 12 Dec 2020
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      DOI: 10.1016/j.celrep.2020.108490

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    sciencedirect.com/science/article/pii/S2211124720314790
  6. Oct 2020
  7. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
    1
    1. scibot 10 Oct 2020
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      DOI: 10.1016/j.cell.2020.09.020

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    pubmed.ncbi.nlm.nih.gov/33031745/
  8. www.sciencedirect.com www.sciencedirect.com
    Evasion of type-I interferon by SARS-CoV-2
    1
    1. scibot 01 Oct 2020
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      DOI: 10.1016/j.celrep.2020.108234

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    sciencedirect.com/science/article/pii/S2211124720312237
  9. Sep 2020
  10. www.sciencedirect.com www.sciencedirect.com
    Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity
    1
    1. scibot 25 Sep 2020
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      DOI: 10.1016/j.molcel.2020.06.020

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    sciencedirect.com/science/article/pii/S1097276520304226
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    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
    1
    1. scibot 23 Sep 2020
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      DOI: 10.1016/j.immuni.2020.02.002

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    sciencedirect.com/science/article/pii/S107476132030073X
  12. rupress.org rupress.org
    Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy
    1
    1. scibot 23 Sep 2020
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      DOI: 10.1083/jcb.201912144

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    rupress.org/jcb/article/219/9/e201912144/151863/Critical-role-of-mitochondrial-ubiquitination-and
  13. www.sciencedirect.com www.sciencedirect.com
    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
    1
    1. scibot 17 Sep 2020
      RRID:AB_10693472

      DOI: 10.1016/j.celrep.2020.01.054

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    sciencedirect.com/science/article/pii/S2211124720300796
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    ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway
    1
    1. scibot 17 Sep 2020
      RRID:AB_10693472

      DOI: 10.1016/j.celrep.2020.107564

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    sciencedirect.com/science/article/pii/S2211124720305131
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    The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
    1
    1. scibot 17 Sep 2020
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      DOI: 10.1016/j.neuron.2020.03.005

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    sciencedirect.com/science/article/pii/S0896627320301914
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    Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
    1
    1. scibot 17 Sep 2020
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      DOI: 10.1016/j.cell.2020.04.026

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    sciencedirect.com/science/article/pii/S009286742030489X
  17. www.sciencedirect.com www.sciencedirect.com
    TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
    1
    1. scibot 17 Sep 2020
      RRID:AB_10693472

      DOI: 10.1016/j.celrep.2020.03.056

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    sciencedirect.com/science/article/pii/S2211124720303703
  18. elifesciences.org elifesciences.org
    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
    1
    1. scibot 16 Sep 2020
      RRID:AB_10693472

      DOI: 10.7554/eLife.60637

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    elifesciences.org/articles/60637
  19. www.sciencedirect.com www.sciencedirect.com
    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
    1
    1. scibot 13 Sep 2020
      RRID:AB_10693472

      DOI: 10.1016/j.immuni.2020.03.016

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    sciencedirect.com/science/article/pii/S1074761320301291
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reactive oxygen species oxidize STING and suppress interferon production
    1
    1. scibot 10 Sep 2020
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      DOI: 10.7554/eLife.57837

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    ncbi.nlm.nih.gov/pmc/articles/PMC7473769/
  21. www.sciencedirect.com www.sciencedirect.com
    Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
    1
    1. scibot 08 Sep 2020
      RRID:AB_10693472

      DOI: 10.1016/j.immuni.2020.01.014

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    sciencedirect.com/science/article/pii/S107476132030042X
  22. www.cell.com www.cell.com
    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
    1
    1. scibot 04 Sep 2020
      RRID: AB_10693472

      DOI: 10.1016/j.celrep.2018.11.097

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    cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
  23. www.sciencedirect.com www.sciencedirect.com
    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
    1
    1. scibot 04 Sep 2020
      RRID:AB_10693472

      DOI: 10.1016/j.immuni.2020.03.004

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    sciencedirect.com/science/article/pii/S1074761320301175
  24. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
    1
    1. scibot 03 Sep 2020
      anti-TBK1 phosphorylated at S172

      DOI: 10.1016/j.celrep.2020.108044

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      Curator comments: Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody Cell Signaling Technology Cat# 5483

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    sciencedirect.com/science/article/pii/S2211124720310299
  25. Jan 2020
  26. www.cell.com www.cell.com
    Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
    1
    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.celrep.2019.09.050

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    cell.com/cell-reports/fulltext/S2211-1247(19)31238-0
  27. www.sciencedirect.com www.sciencedirect.com
    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
    1
    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.cell.2019.05.036

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    sciencedirect.com/science/article/pii/S0092867419305641
  28. www.sciencedirect.com www.sciencedirect.com
    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
    1
    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.ccell.2019.11.003

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    sciencedirect.com/science/article/pii/S1535610819305239
  29. www.sciencedirect.com www.sciencedirect.com
    Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
    1
    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.cell.2019.05.003

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    sciencedirect.com/science/article/pii/S009286741930501X
  30. www.sciencedirect.com www.sciencedirect.com
    Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
    1
    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.celrep.2019.07.081

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    sciencedirect.com/science/article/pii/S2211124719309854
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
    1
    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.celrep.2019.08.085

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    ncbi.nlm.nih.gov/pmc/articles/PMC6880866/
  32. www.sciencedirect.com www.sciencedirect.com
    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
    1
    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.immuni.2019.11.015

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    sciencedirect.com/science/article/pii/S1074761319304960
  33. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.celrep.2018.11.097

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    sciencedirect.com/science/article/pii/S2211124718318886
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    Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
    1
    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.molcel.2019.02.010

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    sciencedirect.com/science/article/pii/S1097276519301005
  35. www.sciencedirect.com www.sciencedirect.com
    Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus
    1
    1. scibot 13 Jan 2020
      RRID:AB_10693472

      DOI: 10.1016/j.celrep.2019.04.071

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    sciencedirect.com/science/article/pii/S2211124719305443
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      DOI: 10.1016/j.cell.2019.03.046

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  37. www.sciencedirect.com www.sciencedirect.com
    Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS
    1
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      RRID:AB_10693472

      DOI: 10.1016/j.cels.2018.10.010

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    sciencedirect.com/science/article/pii/S2405471218304356
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    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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      RRID:AB_10693472

      DOI: 10.1016/j.molcel.2019.05.006

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    sciencedirect.com/science/article/pii/S1097276519303594
  39. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.cell.2019.01.016

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    sciencedirect.com/science/article/pii/S0092867419300492
  40. www.sciencedirect.com www.sciencedirect.com
    Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
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      DOI: 10.1016/j.cell.2019.01.039

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    sciencedirect.com/science/article/pii/S0092867419301023
  41. www.sciencedirect.com www.sciencedirect.com
    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
    1
    1. scibot 12 Jan 2020
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      DOI: 10.1016/j.molcel.2019.02.038

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  42. Nov 2018
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
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    ncbi.nlm.nih.gov/pmc/articles/PMC3838897/
  44. www.sciencedirect.com www.sciencedirect.com
    Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages
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    1. scibot 05 Nov 2018
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  45. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
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    Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
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    TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
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    Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication
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    Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion
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    InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    Dampened STING-Dependent Interferon Activation in Bats
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  55. Nov 2017
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    Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells
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