336 Matching Annotations
  1. Feb 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
    1
    1. scibot 04 Feb 2022
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      DOI: 10.1016/j.ccell.2022.01.002

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    sciencedirect.com/science/article/pii/S1535610822000046
  3. www.jneurosci.org www.jneurosci.org
    Embryonic pericytes promote microglial homeostasis and their effects on neural progenitors in the developing cerebral cortex
    1
    1. scibot 01 Feb 2022
      RRID:AB_1107769

      DOI: 10.1523/JNEUROSCI.1201-21.2021

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    jneurosci.org/content/42/3/362
  4. Jan 2022
  5. www.sciencedirect.com www.sciencedirect.com
    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
    1
    1. scibot 26 Jan 2022
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      DOI: 10.1016/j.cell.2021.12.039

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    sciencedirect.com/science/article/pii/S0092867421015610
  6. www.sciencedirect.com www.sciencedirect.com
    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    1. scibot 26 Jan 2022
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      DOI: 10.1016/j.ccell.2021.12.009

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    sciencedirect.com/science/article/pii/S1535610821006620
  7. www.nature.com www.nature.com
    Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization
    1
    1. scibot 15 Jan 2022
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      DOI: 10.1038/s42003-021-02972-8

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    nature.com/articles/s42003-021-02972-8
  8. www.sciencedirect.com www.sciencedirect.com
    Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion
    1
    1. scibot 12 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110215

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    sciencedirect.com/science/article/pii/S2211124721017198
  9. Dec 2021
  10. www.sciencedirect.com www.sciencedirect.com
    Virulence factors perforate the pathogen-containing vacuole to signal efferocytosis
    1
    1. scibot 24 Dec 2021
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      DOI: 10.1016/j.chom.2021.12.001

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    sciencedirect.com/science/article/pii/S1931312821005667
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    Resolving the immune landscape of human prostate at a single-cell level in health and cancer
    1
    1. scibot 22 Dec 2021
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      DOI: 10.1016/j.celrep.2021.110132

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    sciencedirect.com/science/article/pii/S2211124721016284
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    Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells
    1
    1. scibot 21 Dec 2021
      RRID:AB_1107769

      DOI: 10.1016/j.immuni.2021.11.017

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    sciencedirect.com/science/article/pii/S1074761321005094
  13. www.nature.com www.nature.com
    Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
    1
    1. scibot 11 Dec 2021
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      DOI: 10.1038/s41467-021-27349-7

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    nature.com/articles/s41467-021-27349-7
  14. www.sciencedirect.com www.sciencedirect.com
    The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota
    1
    1. scibot 09 Dec 2021
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      DOI: 10.1016/j.xcrm.2021.100464

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    sciencedirect.com/science/article/pii/S2666379121003360
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    SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects
    1
    1. scibot 08 Dec 2021
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      DOI: 10.1016/j.celrep.2021.110085

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    sciencedirect.com/science/article/pii/S221112472101576X
  16. www.sciencedirect.com www.sciencedirect.com
    Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load
    1
    1. scibot 02 Dec 2021
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      DOI: 10.1016/j.stem.2021.11.003

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    sciencedirect.com/science/article/pii/S1934590921004513
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
    1
    1. scibot 01 Dec 2021
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      DOI: 10.1016/j.isci.2021.103392

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    ncbi.nlm.nih.gov/pmc/articles/PMC8605339/
  18. Nov 2021
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
    1
    1. scibot 24 Nov 2021
      RRID:AB_1107769

      DOI: 10.1016/j.isci.2021.103348

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    ncbi.nlm.nih.gov/pmc/articles/PMC8593563/
  20. Oct 2021
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RSV infection-elicited high MMP-12–producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration
    1
    1. scibot 28 Oct 2021
      RRID:AB_1107769

      DOI: 10.1016/j.isci.2021.103201

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    ncbi.nlm.nih.gov/pmc/articles/PMC8524145/
  22. pubs.acs.org pubs.acs.org
    Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity
    1
    1. scibot 18 Oct 2021
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      DOI: 10.1021/acs.jmedchem.1c00828

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    pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c00828
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
    1
    1. scibot 08 Oct 2021
      RRID:AB_1107769

      DOI: 10.1016/j.cell.2021.09.019

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    ncbi.nlm.nih.gov/pmc/articles/PMC8650838/
  24. www.sciencedirect.com www.sciencedirect.com
    Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza
    1
    1. scibot 06 Oct 2021
      RRID:AB_1107769

      DOI: 10.1016/j.isci.2021.103131

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    sciencedirect.com/science/article/pii/S2589004221010993
  25. Sep 2021
  26. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target
    1
    1. scibot 28 Sep 2021
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      DOI: 10.1016/j.cell.2021.09.006

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    sciencedirect.com/science/article/pii/S0092867421010539
  27. link.springer.com link.springer.com
    The pivotal role of cytotoxic NK cells in mediating the therapeutic effect of anti-CD47 therapy in mycosis fungoides
    1
    1. scibot 21 Sep 2021
      RRID:AB_1107769

      DOI: 10.1007/s00262-021-03051-x

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    link.springer.com/article/10.1007/s00262-021-03051-x
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell
    1
    1. scibot 18 Sep 2021
      RRID:AB_1107769

      DOI: 10.1136/jitc-2021-003100

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    ncbi.nlm.nih.gov/pmc/articles/PMC8407215/
  29. www.sciencedirect.com www.sciencedirect.com
    Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors
    1
    1. scibot 18 Sep 2021
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      DOI: 10.1016/j.cell.2021.08.020

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    sciencedirect.com/science/article/pii/S0092867421009946
  30. www.sciencedirect.com www.sciencedirect.com
    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
    1
    1. scibot 15 Sep 2021
      RRID:AB_1107769

      DOI: 10.1016/j.xcrm.2021.100399

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    sciencedirect.com/science/article/pii/S2666379121002573
  31. www.sciencedirect.com www.sciencedirect.com
    Effects of exercise and anti-PD-1 on the tumour microenvironment
    1
    1. scibot 08 Sep 2021
      RRID:AB_1

      DOI: 10.1016/j.imlet.2021.08.005

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    sciencedirect.com/science/article/abs/pii/S0165247821001401
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer
    1
    1. scibot 04 Sep 2021
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      DOI: 10.2147/OTT.S326178

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    ncbi.nlm.nih.gov/pmc/articles/PMC8403083/
  33. Aug 2021
  34. www.sciencedirect.com www.sciencedirect.com
    Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
    1
    1. scibot 28 Aug 2021
      RRID:AB_1107769

      DOI: 10.1016/j.chom.2021.08.001

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    sciencedirect.com/science/article/pii/S1931312821003772
  35. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy
    1
    1. scibot 25 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109578

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    sciencedirect.com/science/article/pii/S2211124721010123
  36. www.sciencedirect.com www.sciencedirect.com
    NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells
    1
    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109516

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    sciencedirect.com/science/article/pii/S2211124721009463
  37. www.sciencedirect.com www.sciencedirect.com
    The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer
    1
    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.ccell.2021.07.007

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    sciencedirect.com/science/article/pii/S1535610821003846
  38. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 09 Aug 2021
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      DOI: 10.1016/j.celrep.2018.11.047

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    sciencedirect.com/science/article/pii/S2211124718318102
  39. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 09 Aug 2021
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      DOI: 10.1016/j.immuni.2018.10.007

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    sciencedirect.com/science/article/pii/S1074761318304485
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    1. scibot 09 Aug 2021
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      DOI: 10.1016/j.cell.2018.10.014

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    sciencedirect.com/science/article/pii/S0092867418313229
  41. www.sciencedirect.com www.sciencedirect.com
    Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells
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    1. scibot 09 Aug 2021
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      DOI: 10.1016/j.chom.2018.10.003

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    sciencedirect.com/science/article/pii/S1931312818305419
  42. www.sciencedirect.com www.sciencedirect.com
    Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection
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    1. scibot 07 Aug 2021
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      DOI: 10.1016/j.cell.2018.04.006

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    sciencedirect.com/science/article/pii/S0092867418304598
  43. www.sciencedirect.com www.sciencedirect.com
    Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow
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      DOI: 10.1016/j.celrep.2021.109480

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    sciencedirect.com/science/article/pii/S2211124721009074
  44. www.sciencedirect.com www.sciencedirect.com
    Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
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    1. scibot 01 Aug 2021
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      DOI: 10.1016/j.immuni.2018.11.014

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    sciencedirect.com/science/article/pii/S1074761318305223
  45. Jul 2021
  46. www.sciencedirect.com www.sciencedirect.com
    Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury
    1
    1. scibot 31 Jul 2021
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      DOI: 10.1016/j.cell.2018.12.022

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    sciencedirect.com/science/article/pii/S0092867418316362
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 30 Jul 2021
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      DOI: 10.1016/j.immuni.2018.10.007

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    ncbi.nlm.nih.gov/pmc/articles/PMC6303219/
  48. www.sciencedirect.com www.sciencedirect.com
    Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
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    1. scibot 30 Jul 2021
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      DOI: 10.1016/j.cell.2018.10.038

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    Cutaneous Leishmaniasis Induces a Transmissible Dysbiotic Skin Microbiota that Promotes Skin Inflammation
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    Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity
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    Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response
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    GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair
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  61. May 2021
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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy
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    Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation
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    CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability
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    Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer
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  86. Feb 2021
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  91. Dec 2020
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  93. Oct 2020
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    PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction
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    Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury
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    ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
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    Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
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    TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes
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    Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
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    Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy
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    An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses
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    Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps
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    The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection
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    Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection
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    Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors
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    T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation
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    UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma
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    B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer
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    Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ
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    Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer
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    Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis
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    The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
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    Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
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    Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy
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    Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization
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    CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota
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    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
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    Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice
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    Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis
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    Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation
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    CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity
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    Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
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  136. www.sciencedirect.com www.sciencedirect.com
    LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis
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    Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
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  138. www.sciencedirect.com www.sciencedirect.com
    IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy
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  139. www.sciencedirect.com www.sciencedirect.com
    LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
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  140. www.sciencedirect.com www.sciencedirect.com
    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
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    sciencedirect.com/science/article/pii/S1074761317304235
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    Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity
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  142. www.sciencedirect.com www.sciencedirect.com
    RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis
    1
    1. scibot 05 Nov 2018
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1535610818300011
  143. www.sciencedirect.com www.sciencedirect.com
    Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism
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    sciencedirect.com/science/article/pii/S1074761318301912
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    B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
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    sciencedirect.com/science/article/pii/S1074761318300293
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    Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization
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    sciencedirect.com/science/article/pii/S1074761317305332
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    TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer
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    sciencedirect.com/science/article/pii/S1535610817305238
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    Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation
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    sciencedirect.com/science/article/pii/S1931312817304432
  148. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer
    1
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  149. Nov 2017
  150. www.sciencedirect.com www.sciencedirect.com
    Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
    1
    1. scibot 09 Nov 2017
      RRID:AB_1107769

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  151. www.sciencedirect.com www.sciencedirect.com
    Dietary Manganese Promotes Staphylococcal Infection of the Heart
    1
    1. scibot 08 Nov 2017
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  152. www.sciencedirect.com www.sciencedirect.com
    Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever
    1
    1. scibot 08 Nov 2017
      RRID:AB_1107769

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    sciencedirect.com/science/article/pii/S1931312817302913
  153. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
    1. scibot 08 Nov 2017
      BioXCellCat#BE0089

      Curator: @bandrow

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    sciencedirect.com/science/article/pii/S1074761317302339