532 Matching Annotations
  1. Nov 2021
  2. www.sciencedirect.com www.sciencedirect.com
    Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling
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    1. scibot 24 Nov 2021
      RRID:AB_2118291

      DOI: 10.1016/j.celrep.2021.110036

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    sciencedirect.com/science/article/pii/S2211124721015187
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    Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine
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    1. scibot 24 Nov 2021
      RRID:AB_2118291

      DOI: 10.1016/j.celrep.2021.110044

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    sciencedirect.com/science/article/pii/S2211124721015308
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    An epigenetic mechanism underlying chromosome 17p deletion-driven tumorigenesis
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    1. scibot 19 Nov 2021
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      DOI: 10.1158/2159-8290.CD-20-0336

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    ncbi.nlm.nih.gov/pmc/articles/PMC8591992/
  5. www.nature.com www.nature.com
    Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
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    1. scibot 11 Nov 2021
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      DOI: 10.1038/s41467-021-26600-5

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    nature.com/articles/s41467-021-26600-5
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    1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
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    1. scibot 11 Nov 2021
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      DOI: 10.1016/j.devcel.2021.10.018

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    sciencedirect.com/science/article/pii/S1534580721008492
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    Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors
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    1. scibot 03 Nov 2021
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      DOI: 10.1016/j.celrep.2021.109955

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    sciencedirect.com/science/article/pii/S2211124721014327
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    Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage
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    1. scibot 03 Nov 2021
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      DOI: 10.1016/j.celrep.2021.109938

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    sciencedirect.com/science/article/pii/S221112472101411X
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    Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
    1
    1. scibot 03 Nov 2021
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      DOI: 10.1016/j.celrep.2021.109943

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    sciencedirect.com/science/article/pii/S2211124721014169
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    An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity
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    1. scibot 02 Nov 2021
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      DOI: 10.1016/j.neuron.2021.10.014

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    sciencedirect.com/science/article/pii/S0896627321007820
  11. Oct 2021
  12. www.sciencedirect.com www.sciencedirect.com
    Reprogramming CBX8-PRC1 function with a positive allosteric modulator
    1
    1. scibot 29 Oct 2021
      RRID:AB_2118291

      DOI: 10.1016/j.chembiol.2021.10.003

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    sciencedirect.com/science/article/pii/S2451945621004372
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    A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus
    1
    1. scibot 28 Oct 2021
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      DOI: 10.1016/j.devcel.2021.10.004

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    sciencedirect.com/science/article/pii/S1534580721008054
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
    1
    1. scibot 23 Oct 2021
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      DOI: 10.1016/j.molcel.2021.10.005

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    sciencedirect.com/science/article/pii/S1097276521008340
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    The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
    1
    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109864

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    sciencedirect.com/science/article/pii/S2211124721013310
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    NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain
    1
    1. scibot 12 Oct 2021
      RRID:AB_2118291

      DOI: 10.1016/j.molcel.2021.09.020

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    sciencedirect.com/science/article/pii/S1097276521007541
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    Simultaneous profiling of multiple chromatin proteins in the same cells
    1
    1. scibot 12 Oct 2021
      RRID:AB_2118291

      DOI: 10.1016/j.molcel.2021.09.019

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    sciencedirect.com/science/article/pii/S109727652100753X
  18. Sep 2021
  19. www.sciencedirect.com www.sciencedirect.com
    Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
    1
    1. scibot 22 Sep 2021
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      DOI: 10.1016/j.celrep.2021.109725

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    sciencedirect.com/science/article/pii/S2211124721011748
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    ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
    1
    1. scibot 22 Sep 2021
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      DOI: 10.1016/j.celrep.2021.109706

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    sciencedirect.com/science/article/pii/S2211124721011530
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Environment tunes propagation of cell-to-cell variation in the human macrophage gene network
    1
    1. scibot 04 Sep 2021
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      DOI: 10.1016/j.cels.2017.03.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC8392141/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition
    1
    1. scibot 04 Sep 2021
      RRID:AB_2118291

      DOI: 10.3390/ijms22168792

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    ncbi.nlm.nih.gov/pmc/articles/PMC8395720/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer
    1
    1. scibot 04 Sep 2021
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      DOI: 10.1016/j.isci.2021.102953

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    ncbi.nlm.nih.gov/pmc/articles/PMC8384902/
  24. www.sciencedirect.com www.sciencedirect.com
    Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions
    1
    1. scibot 03 Sep 2021
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      DOI: 10.1016/j.neuron.2021.08.005

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    sciencedirect.com/science/article/pii/S0896627321005808
  25. Aug 2021
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative control of noise in mammalian gene expression by dynamic histone regulation
    1
    1. scibot 17 Aug 2021
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      DOI: 10.7554/eLife.65654

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    ncbi.nlm.nih.gov/pmc/articles/PMC8357418/
  27. www.sciencedirect.com www.sciencedirect.com
    Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
    1
    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.molcel.2021.07.024

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    sciencedirect.com/science/article/pii/S1097276521005931
  28. www.nature.com www.nature.com
    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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    1. scibot 15 Aug 2021
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      DOI: 10.1038/s41467-021-24687-4

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    nature.com/articles/s41467-021-24687-4
  29. www.sciencedirect.com www.sciencedirect.com
    Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
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    1. scibot 13 Aug 2021
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      DOI: 10.1016/j.celrep.2019.04.112

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    sciencedirect.com/science/article/pii/S2211124719306023
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    1. scibot 13 Aug 2021
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      DOI: 10.1016/j.cels.2019.03.012

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    sciencedirect.com/science/article/pii/S2405471219301152
  31. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 13 Aug 2021
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      DOI: 10.1016/j.stem.2019.03.012

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    sciencedirect.com/science/article/pii/S1934590919301110
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 13 Aug 2021
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      DOI: 10.1016/j.ajhg.2016.11.016

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    ncbi.nlm.nih.gov/pmc/articles/PMC5223059/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.neuron.2017.04.022

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    ncbi.nlm.nih.gov/pmc/articles/PMC5508517/
  34. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 12 Aug 2021
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      DOI: 10.15252/embj.2018100293

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    onlinelibrary.wiley.com/doi/10.15252/embj.2018100293
  35. academic.oup.com academic.oup.com
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      DOI: 10.1210/en.2016-1854

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    academic.oup.com/endo/article/158/4/842/2877139
  36. www.cell.com www.cell.com
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      DOI: 10.1016/j.ccell.2017.10.008

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    cell.com/cancer-cell/abstract/S1535-6108(17)30461-0
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.celrep.2018.10.051

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    ncbi.nlm.nih.gov/pmc/articles/PMC6296757/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.celrep.2018.12.094

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    ncbi.nlm.nih.gov/pmc/articles/PMC6344342/
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    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
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      DOI: 10.1016/j.stem.2018.11.014

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    sciencedirect.com/science/article/pii/S1934590918305502
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      DOI: 10.1016/j.stem.2018.10.017

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    sciencedirect.com/science/article/pii/S1934590918304983
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      DOI: 10.1016/j.celrep.2018.10.052

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    sciencedirect.com/science/article/pii/S2211124718316413
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      DOI: 10.1016/j.cell.2018.11.045

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    sciencedirect.com/science/article/pii/S0092867418315708
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    ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
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    1. scibot 07 Aug 2021
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      DOI: 10.1016/j.molcel.2021.07.018

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      Curator comments: Histone H3 (acetyl K27) antibody - ChIP Grade Abcam Cat# ab4729

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    sciencedirect.com/science/article/pii/S1097276521005876
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    Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease
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      DOI: 10.1016/j.immuni.2021.07.004

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    sciencedirect.com/science/article/pii/S1074761321002909
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      DOI: 10.1016/j.celrep.2018.10.051

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    sciencedirect.com/science/article/pii/S2211124718316401
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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    The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
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    Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia
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    A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus
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    Thyroid Hormone Receptor β Suppression of RUNX2 is Mediated by Brahma Related Gene 1 Dependent Chromatin Remodeling
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    AML Subtype Is a Major Determinant of the Association between Prognostic Gene Expression Signatures and Their Clinical Significance
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    Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release
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    Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation
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    Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage
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    Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases
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    Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells
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    Genome‐Wide Estrogen Receptor β Chromatin Binding in Human Colon Cancer Cells Reveals its Tumor Suppressor Activity
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    Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates
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    H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization
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    The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
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    STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma
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    Principles of signaling pathway modulation for enhancing human naive pluripotency induction
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    Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease
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    A compendium and comparative epigenomics analysis of cis -regulatory elements in the pig genome
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    Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1
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    IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis
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    MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity
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    Deficiency of histone methyltransferase SETD2 in liver leads to abnormal lipid metabolism and hepatocarcinoma
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  115. Mar 2021
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway
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    A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function
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    The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
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    Definition of a small core transcriptional circuit regulated by AML1-ETO
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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    Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4
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    The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist
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  131. Dec 2020
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    DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders
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  133. Nov 2020
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    Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
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    Characterization of Organoid Cultures to Study the Effects of Pregnancy Hormones on the Epigenome and Transcriptional Output of Mammary Epithelial Cells
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  136. Oct 2020
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    Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
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    Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring
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    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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  141. Sep 2020
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    The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators
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    Large domains of heterochromatin direct the formation of short mitotic chromosome loops
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    Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue
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    The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression
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    H3K4me1 Distribution Predicts Transcription State and Poising at Promoters
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    Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
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    Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling
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    Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells
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    Genome-wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism
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    Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells
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    Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18
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    GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling
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    REST Inhibits Direct Reprogramming of Pancreatic Exocrine to Endocrine Cells by Preventing PDX1-Mediated Activation of Endocrine Genes
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    Gata3-controlled nucleosome eviction drives Myc enhancer activity in T-cell development and leukemia
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    Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells
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    Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
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    Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity
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    Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression
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    The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
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    Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
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    Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming
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    KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
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    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
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    Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers
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    Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution
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    De novo PacBio long-read and phased avian genome assemblies correct and add to reference genes generated with intermediate and short reads
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    Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma
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      Histone H3 (acetyl K27) rabbit pAb (ChIP grade)

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    The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells
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  170. Aug 2020
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    The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway
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  172. Jan 2020
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    Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4
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    CoBATCH for High-Throughput Single-Cell Epigenomic Profiling
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    A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling
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    A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
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      DOI: 10.1016/j.cell.2019.07.011

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    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
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    Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury
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    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
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    Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet
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    Nucleome Dynamics during Retinal Development
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    The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
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    H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses
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    SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring
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    Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells
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    The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
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    Organization of Chromatin by Intrinsic and Regulated Phase Separation
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    Bone marrow stromal cells transcriptionally repress ESR1 but cannot overcome constitutive ESR1 mutant activity
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    Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
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    ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures
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    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle
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    The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer
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    MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition
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    PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression
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    Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity
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      DOI: 10.1016/j.stem.2019.04.021

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    Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases
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    Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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      DOI: 10.1016/j.cell.2019.10.044

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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes
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    Pioneer Factor-Nucleosome Binding Events during Differentiation Are Motif Encoded
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    Improved CUT&RUN chromatin profiling tools
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    Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
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    Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities
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    Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction
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    Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors
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    Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma
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    MeCP2 Represses Enhancers through Chromosome Topology-Associated DNA Methylation
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    Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function
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    Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons
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    Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition
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      DOI: 10.1158/0008-5472.CAN-18-1888

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