292 Matching Annotations
  1. Jul 2021
  2. www.sciencedirect.com www.sciencedirect.com
    Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration
    1
    1. scibot 01 Jul 2021
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      DOI: 10.1016/j.devcel.2021.06.008

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    sciencedirect.com/science/article/pii/S153458072100486X
  3. Jun 2021
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    Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
    1
    1. scibot 19 Jun 2021
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      DOI: 10.1016/j.cmet.2021.05.019

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    sciencedirect.com/science/article/pii/S1550413121002709
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
    1
    1. scibot 18 Jun 2021
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      DOI: 10.1016/j.isci.2021.102643

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    ncbi.nlm.nih.gov/pmc/articles/PMC8187833/
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    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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    1. scibot 18 Jun 2021
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      DOI: 10.1016/j.ccell.2021.05.015

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    sciencedirect.com/science/article/pii/S1535610821002816
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    Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
    1
    1. scibot 08 Jun 2021
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      DOI: 10.1016/j.immuni.2021.05.003

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    sciencedirect.com/science/article/pii/S1074761321002090
  8. May 2021
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    The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation
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    1. scibot 26 May 2021
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      DOI: 10.1016/j.immuni.2021.04.027

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    sciencedirect.com/science/article/pii/S1074761321001898
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
    1
    1. scibot 22 May 2021
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      DOI: 10.1016/j.devcel.2021.04.030

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    sciencedirect.com/science/article/pii/S1534580721003993
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Limited inhibition of multiple nodes in a driver network blocks metastasis
    1
    1. scibot 21 May 2021
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      DOI: 10.7554/eLife.59696

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    ncbi.nlm.nih.gov/pmc/articles/PMC8128439/
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    The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment
    1
    1. scibot 09 May 2021
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      DOI: 10.1016/j.yexcr.2021.112505

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    sciencedirect.com/science/article/pii/S0014482721000367
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    Combined inhibition of histone deacetylases and BET family proteins as epigenetic therapy for nerve injury-induced neuropathic pain
    1
    1. scibot 09 May 2021
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      DOI: 10.1016/j.phrs.2021.105431

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    sciencedirect.com/science/article/pii/S1043661821000141
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury
    1
    1. scibot 01 May 2021
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      DOI: 10.3389/fimmu.2021.645100

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    ncbi.nlm.nih.gov/pmc/articles/PMC8079743/
  15. Apr 2021
  16. www.sciencedirect.com www.sciencedirect.com
    Discovery of Covalent MKK4/7 Dual Inhibitor
    1
    1. scibot 27 Apr 2021
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      DOI: 10.1016/j.chembiol.2020.08.014

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    sciencedirect.com/science/article/pii/S2451945620303366
  17. www.sciencedirect.com www.sciencedirect.com
    Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation
    1
    1. scibot 27 Apr 2021
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      DOI: 10.1016/j.chembiol.2020.08.010

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    sciencedirect.com/science/article/pii/S2451945620303329
  18. www.sciencedirect.com www.sciencedirect.com
    Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies
    1
    1. scibot 17 Apr 2021
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      DOI: 10.1016/j.ccell.2020.05.004

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    sciencedirect.com/science/article/pii/S1535610820302543
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optogenetic activation of spinal microglia triggers chronic pain in mice
    1
    1. scibot 10 Apr 2021
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      DOI: 10.1371/journal.pbio.3001154

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    ncbi.nlm.nih.gov/pmc/articles/PMC8011727/
  20. Mar 2021
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
    1
    1. scibot 13 Mar 2021
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      DOI: 10.3389/fimmu.2021.620238

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    ncbi.nlm.nih.gov/pmc/articles/PMC7947244/
  22. www.cell.com www.cell.com
    The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity
    1
    1. scibot 03 Mar 2021
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      DOI: 10.1016/j.cmet.2021.02.007

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    cell.com/cell-metabolism/fulltext/S1550-4131(21)00063-2
  23. Feb 2021
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
    1
    1. scibot 28 Feb 2021
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      DOI: 10.1016/j.ccell.2017.05.006

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    ncbi.nlm.nih.gov/pmc/articles/PMC7909318/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity
    1
    1. scibot 27 Feb 2021
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      DOI: 10.1016/j.celrep.2020.108258

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    ncbi.nlm.nih.gov/pmc/articles/PMC7688291/
  26. www.sciencedirect.com www.sciencedirect.com
    Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
    1
    1. scibot 24 Feb 2021
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      DOI: 10.1016/j.celrep.2021.108751

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    sciencedirect.com/science/article/pii/S2211124721000644
  27. Jan 2021
  28. link.springer.com link.springer.com
    Inhibition of p38 Mitogen–Activated Protein Kinase Ameliorates HAP40 Depletion–Induced Toxicity and Proteasomal Defect in Huntington’s Disease Model
    1
    1. scibot 28 Jan 2021
      anti-Phospho-p38 MAPK (Thr180/Tyr182)

      DOI: 10.1007/s12035-020-02280-y

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    link.springer.com/article/10.1007/s12035-020-02280-y
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers
    1
    1. scibot 28 Jan 2021
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      DOI: 10.3390/md19010041

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    ncbi.nlm.nih.gov/pmc/articles/PMC7831112/
  30. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 08 Jan 2021
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      DOI: 10.1111/bph.15306

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15306
  31. Dec 2020
  32. www.sciencedirect.com www.sciencedirect.com
    FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells
    1
    1. scibot 24 Dec 2020
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      DOI: 10.1016/j.cub.2020.11.052

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    sciencedirect.com/science/article/pii/S0960982220317656
  33. Oct 2020
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses
    1
    1. scibot 24 Oct 2020
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      DOI: 10.1371/journal.ppat.1008461

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    ncbi.nlm.nih.gov/pmc/articles/PMC7553310/
  35. link.springer.com link.springer.com
    Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway
    1
    1. scibot 21 Oct 2020
      RRID:AB_2139682

      DOI: 10.1007/s10495-020-01639-9

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    link.springer.com/article/10.1007/s10495-020-01639-9
  36. www.sciencedirect.com www.sciencedirect.com
    Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
    1
    1. scibot 10 Oct 2020
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      DOI: 10.1016/j.jss.2020.08.071

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    sciencedirect.com/science/article/pii/S002248042030634X
  37. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The p38 signaling pathway mediates the TGF‐β1‐induced increase in type I collagen deposition in human granulosa cells
    1
    1. scibot 01 Oct 2020
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      DOI: 10.1096/fj.202001377R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001377R
  38. Sep 2020
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TGFβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration
    1
    1. scibot 25 Sep 2020
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      DOI: 10.7554/eLife.51779

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    ncbi.nlm.nih.gov/pmc/articles/PMC7324157/
  40. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Arctigenin protects mice from thioglycollate‐induced acute peritonitis
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    1. scibot 25 Sep 2020
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      DOI: 10.1002/prp2.660

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    pubmed.ncbi.nlm.nih.gov/32960513/
  41. www.jbc.org www.jbc.org
    The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription
    1
    1. scibot 23 Sep 2020
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      DOI: 10.1074/jbc.RA119.010266

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    jbc.org/content/295/25/8613.full
  42. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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    1. scibot 17 Sep 2020
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      DOI: 10.1002/glia.23498

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    onlinelibrary.wiley.com/doi/full/10.1002/glia.23498
  43. www.sciencedirect.com www.sciencedirect.com
    The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis
    1
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      DOI: 10.1016/j.celrep.2020.108158

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    sciencedirect.com/science/article/pii/S2211124720311475
  44. elifesciences.org elifesciences.org
    EDF1 coordinates cellular responses to ribosome collisions
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      DOI: 10.7554/eLife.58828

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    elifesciences.org/articles/58828
  45. www.sciencedirect.com www.sciencedirect.com
    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
    1
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      DOI: 10.1016/j.cmet.2020.03.007

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    sciencedirect.com/science/article/pii/S1550413120301224
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    The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death
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      DOI: 10.1016/j.celrep.2020.107547

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    sciencedirect.com/science/article/pii/S2211124720304575
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    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
    1
    1. scibot 14 Sep 2020
      RRID:AB_2139682

      DOI: 10.1016/j.celrep.2020.01.054

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    sciencedirect.com/science/article/pii/S2211124720300796
  48. academic.oup.com academic.oup.com
    Chaperone-mediated autophagy governs progression of papillary thyroid carcinoma via PPARγ-SDF1/CXCR4 signaling
    1
    1. scibot 13 Sep 2020
      p-p38 MAPK

      DOI: 10.1210/clinem/dgaa366

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      Curator comments: Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP Rabbit mAb antibody Cell Signaling Technology Cat# 4511

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    academic.oup.com/jcem/article/105/10/dgaa366/5859150
  49. www.sciencedirect.com www.sciencedirect.com
    ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
    1
    1. scibot 09 Sep 2020
      RRID:AB_2139682

      DOI: 10.1016/j.molcel.2020.03.021

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    ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet
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    Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis
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  53. Jan 2020
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    Stress-Induced Epigenetic Changes in Hippocampal Mkp-1 Promote Persistent Depressive Behaviors
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      DOI: 10.1007/s12035-019-01689-4

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    Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury
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    Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain
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    CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation
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    Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain
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    Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity
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    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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    Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
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    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8
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    Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3
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  66. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protein kinase B mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells
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    Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging
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      DOI: 10.1016/j.celrep.2019.04.114

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    Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
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      DOI: 10.1016/j.cell.2019.01.039

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    Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis
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  76. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Loganetin protects against rhabdomyolysis‐induced acute kidney injury by modulating the toll‐like receptor 4 signalling pathway
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      DOI: 10.1111/bph.14595

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  77. Nov 2018
  78. www.sciencedirect.com www.sciencedirect.com
    IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages
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    Red nucleus interleukin‐1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways
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    A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
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    Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice
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    Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
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    Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
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    Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue
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  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
    High expression of glutamate‐ammonia ligase is associated with unfavorable prognosis in patients with ovarian cancer
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  87. www.karger.com www.karger.com
    Micro Integral Membrane Protein (MIMP), a Newly Discovered Anti-Inflammatory Protein of Lactobacillus Plantarum, Enhances the Gut Barrier and Modulates Microbiota and Inflammatory Cytokines
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    β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer
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    Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.
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    Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer
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    IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase
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  93. Nov 2017
  94. www.sciencedirect.com www.sciencedirect.com
    A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1535610817303549
  95. elifesciences.org elifesciences.org
    Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit
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  96. www.sciencedirect.com www.sciencedirect.com
    Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action
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    sciencedirect.com/science/article/pii/S1074761317303199
  97. www.sciencedirect.com www.sciencedirect.com
    Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma
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  98. www.sciencedirect.com www.sciencedirect.com
    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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  99. onlinelibrary.wiley.com onlinelibrary.wiley.com
    GLUL Promotes Cell Proliferation in Breast Cancer
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    onlinelibrary.wiley.com/doi/10.1002/jcb.25775/full
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    A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis
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  101. academic.oup.com academic.oup.com
    PKA-RIIB Deficiency Induces Brown Fatlike Adipocytes in Inguinal WAT and Promotes Energy Expenditure in Male FVB/NJ Mice
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  102. www.sciencedirect.com www.sciencedirect.com
    Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms
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    sciencedirect.com/science/article/pii/S2405471217300121
  103. www.sciencedirect.com www.sciencedirect.com
    Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation
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    sciencedirect.com/science/article/pii/S1097276517300485
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biphasic Regulation of p38 MAPK by Serotonin Contributes to the Efficacy of Stimulus Protocols That Induce Long-Term Synaptic Facilitation
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    ncbi.nlm.nih.gov/pmc/articles/PMC5307297/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC4380931/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis
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