523 Matching Annotations
  1. Jun 2024
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    Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periosti
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    sciencedirect.com/science/article/pii/S1550413124001761
  3. May 2024
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    NRAS mutant dictates AHCYL1-governed ER calcium homeostasis for melanoma tumor growth
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    aacrjournals.org/mcr/article/22/4/386/741848/NRAS-Mutant-Dictates-AHCYL1-Governed-ER-Calcium
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    Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094420/
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    Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids
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    sciencedirect.com/science/article/pii/S1934590924001462
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    Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect
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    ncbi.nlm.nih.gov/pmc/articles/PMC11082451/
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    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
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    Electronic cigarette exposure disrupts airway epithelial barrier function and exacerbates viral infection | American Journal of Physiology-Lung Cellular and Molecular Physiology
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068398/
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    Genome-scale chromatin binding dynamics of RNA Polymerase II general transcription machinery components
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    ncbi.nlm.nih.gov/pmc/articles/PMC11066129/
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    The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ
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    sciencedirect.com/science/article/pii/S2352396424001592
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    The role of age-associated alpha-synuclein aggregation in a conditional transgenic mouse model of Parkinson's disease: Implications for Lewy body formation
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16122
  13. Apr 2024
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    Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
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    sciencedirect.com/science/article/pii/S0092867424003131
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    WW domains form a folded type of nuclear localization signal to guide YAP1 nuclear import
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    rupress.org/jcb/article/223/6/e202308013/276631/WW-domains-form-a-folded-type-of-nuclear
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    Small extracellular vesicles from hypoxia-preconditioned bone marrow mesenchymal stem cells attenuate spinal cord injury via miR-146a-5p-mediated regulation of macrophage polarization
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    ncbi.nlm.nih.gov/pmc/articles/PMC11034578/
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    Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice
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    Pan-neuronal expression of human mutant SOD1 in Drosophila impairs survival and motor performance, induces early neuroinflammation and chromosome aberrations
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    Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line
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    ncbi.nlm.nih.gov/pmc/articles/PMC11008688/
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    Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11003743/
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    Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11001299/
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    Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10998861/
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host
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    “Heterogeneous subpopulations of GABAAR-responding neurons coexist across neuronal networks scales and developmental stages in health and disease”
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    ncbi.nlm.nih.gov/pmc/articles/PMC10966311/
  26. Mar 2024
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    RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation
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    sciencedirect.com/science/article/pii/S2211124724003383
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    The circular RNA circATP8B(2) regulates ROS production and antiviral immunity in Drosophila
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    The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10942603/
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    Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells
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    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
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  32. Feb 2024
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    CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin
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    link.springer.com/article/10.1038/s41388-024-02968-8
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    Tonic NMDAR currents of NR2A-containing NMDARs represent altered ambient glutamate concentration in the supraoptic nucleus
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    ncbi.nlm.nih.gov/pmc/articles/PMC10863629/
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    Machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing
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    Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7
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    Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830871/
  38. Jan 2024
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    PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis
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    The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression
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    sciencedirect.com/science/article/pii/S2211124723015991
  41. www.jneurosci.org www.jneurosci.org
    Protein 4.1N plays a cell-type specific role in hippocampal glutamatergic synapse regulation
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    jneurosci.org/content/43/49/8336
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    Tonic Activation of NR2D-Containing NMDARs Exacerbates Dopaminergic Neuronal Loss in MPTP-Injected Parkinsonian Mice
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  43. Dec 2023
  44. www.sciencedirect.com www.sciencedirect.com
    A forebrain-hypothalamic ER stress driven circuit mediates hepatic steatosis during obesity
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    Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
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    Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling
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    Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1
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    link.springer.com/article/10.1186/s12915-023-01773-1
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    Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MiR-138-5p Upregulation during Neuronal Maturation Parallels with an Increase in Neuronal Survival
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    ncbi.nlm.nih.gov/pmc/articles/PMC10671628/
  50. Nov 2023
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    BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17
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    sciencedirect.com/science/article/pii/S2211124723014808
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    Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity
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    nature.com/articles/s41586-023-06749-3
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    SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
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    link.springer.com/article/10.1007/s00018-023-05011-3
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mass isolation of staged Drosophila pupal intestines for analysis of protein ubiquitylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10682243/
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    Integrative genomic analyses identify lncRNA regulatory networks across pediatric leukemias and solid tumors
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    aacrjournals.org/cancerres/article/83/20/3462/729497/Integrative-Genomic-Analyses-Identify-LncRNA
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance
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    ncbi.nlm.nih.gov/pmc/articles/PMC10621302/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance
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    ncbi.nlm.nih.gov/pmc/articles/PMC10625232/
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    Sequencing-based functional assays for classification of BRCA2 variants in mouse ESCs
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    LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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  61. Oct 2023
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    Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells
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    An early glycolysis burst in microglia regulates mitochondrial dysfunction in oligodendrocytes under neuroinflammation
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    Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes
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    Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport
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    MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer
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    SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
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  69. Sep 2023
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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    Nuclear transport receptor KA120 regulates molecular condensation of MAC3 to coordinate plant immune activation
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    Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics
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  74. Aug 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-scale chromatin interaction dynamic measurements for key components of the RNA Pol II general transcription machinery
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    ncbi.nlm.nih.gov/pmc/articles/PMC10402067/
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    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome
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    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
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    Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3
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    sciencedirect.com/science/article/pii/S2451945623002337
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    Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis
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    LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis
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    Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity
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    Rational design of a booster vaccine against COVID-19 based on antigenic distance
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  85. Jul 2023
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of a Well-Characterized Homozygous Chromodomain-Helicase-DNA-Binding Protein 4G1003D Mutant hESC Line Using CRISPR/eCas9 (ULIEGEe001-A-1)
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    ncbi.nlm.nih.gov/pmc/articles/PMC10342000/
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    Reduced histone gene copy number disrupts Drosophila Polycomb function
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    The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2
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    Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis
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    Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER
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    Homotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics
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    embopress.org/doi/full/10.15252/embr.202256538
  92. Jun 2023
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    Circadian clocks are modulated by compartmentalized oscillating translation
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    Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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    Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage
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    Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation
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