1,254 Matching Annotations
  1. Jul 2025
  2. 52.53.155.43 52.53.155.43
    1-s2.0-S258900422501346X-main-html.html
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    Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
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    link.springer.com/article/10.1186/s12906-025-04967-y
  4. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    biorxiv.org/content/10.1101/2025.06.27.662039v1
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NOD1 promotes leukocyte clearance and limits inflammation in female mice during obesity‐associated acute lung injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227658/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
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    Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps
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    sciencedirect.com/science/article/pii/S1535610825002570
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    The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function
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    dx.doi.org/10.1210/endocr/bqae041
  9. Jun 2025
  10. 52.53.155.43 52.53.155.43
    kong-et-al-adipose-tissue-secreted-spz5-promotes-distal-tumor-progression-via-toll-6-mediated-hh-pathway-activation-in-html.html
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    Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila
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    embopress.org/doi/10.1038/s44318-025-00489-y
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    VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2
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    sciencedirect.com/science/article/pii/S2211124725007028
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    A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient
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    cell.com/cell-reports/fulltext/S2211-1247(25)00701-6
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    Distinct cAMP Regulation in Scleroderma Lung and Skin Myofibroblasts Governs Their Dedifferentiation via p38α Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12186599/
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    EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC
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    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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    Deficiency of Fibroblast Growth Factor 2 Promotes Contractile Phenotype of Pericytes in Ascending Thoracic Aortic Aneurysm
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    FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
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    Role of endogenous NT-3 in neuronal activity and neurogenesis in the hippocampal dentate gyrus
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    FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression
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    Tumor-derived ligands trigger tumor growth and host wasting via differential MEK activation
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    The RXR Agonist MSU-42011 Reduces Tumor Burden in a Murine Preclinical NF1-Deficient Model
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    PTEN protein phosphatase activity regulates metastasis by targeting PKCδ
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    Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling
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    MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma
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    Nerve growth factor signaling tunes axon maintenance protein abundance and kinetics of Wallerian degeneration
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    PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma
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    link.springer.com/article/10.1007/s10142-025-01629-7
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    A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling
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    Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy
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  30. May 2025
  31. journals.lww.com journals.lww.com
    Bromodomain-containing protein 4 knockdown promotes... : Neural Regeneration Research
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Surrogate GPR139 Agonists Reverse Short‐Term Startle Habituation Impairment in Larval Zebrafish
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    pmc.ncbi.nlm.nih.gov/articles/PMC12097293/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12093284/
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    Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
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    Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Activity of the Type II RAF Inhibitor Tovorafenib in Tumor Models Harboring Either a BRAF Fusion or an NF1 Loss-of-Function Mutation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12015663/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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    Phenotypic heterogeneity and plasticity in colorectal cancer metastasis
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    The biased OTR ligands -atosiban and carbetocin- differentially inhibit early or late formalin-induced nociception in rats
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    Independent and synergistic roles of MEK-ERK1/2 and PKC pathways in regulating functional changes in vascular tissue following flow cessation
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    A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
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    Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS
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    KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy
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  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes
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    onlinelibrary.wiley.com/doi/10.1002/aro2.70015
  46. Apr 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer
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    CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer
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    Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies
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    sciencedirect.com/science/article/pii/S1534580725001558
  50. 52.53.155.43 52.53.155.43
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  51. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951319/
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    Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses
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    sciencedirect.com/science/article/pii/S037887412500337X
  54. Mar 2025
  55. 52.53.155.43 52.53.155.43
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    Geometric deep learning and multiple-instance learning for 3D cell-shape profiling
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    cell.com/cell-systems/fulltext/S2405-4712(25)00062-6
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    A microglia clonal inflammatory disorder in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908784/
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    Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
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    Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway
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    ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity
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    Large-scale control over collective cell migration using light-activated epidermal growth factor receptors
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  62. Feb 2025
  63. 52.53.155.43 52.53.155.43
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    MIF-ACKR3 causes irreversible fat loss by impairing adipogenesis in cancer cachexia
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    FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
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  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11847698/
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities
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    onlinelibrary.wiley.com/doi/10.1002/pro.70072
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    Akt is a mediator of artery specification during zebrafish development
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    journals.biologists.com/dev/article/151/17/dev202727/361847/Akt-is-a-mediator-of-artery-specification-during
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    The TSH receptor antibody reactome contributes to retro-orbital inflammation
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    dx.doi.org/10.1210/jendso/bvae182
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    Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium
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    dx.doi.org/10.1210/endocr/bqae123
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    Identification of Meibomian gland stem cell populations and mechanisms of aging
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    Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation
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    Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
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    KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31
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  76. aacrjournals.org aacrjournals.org
    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
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    SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases
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  79. 52.53.155.43 52.53.155.43
    The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis
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  82. Jan 2025
  83. www.sciencedirect.com www.sciencedirect.com
    Neoadjuvant immunotherapy with or without chemotherapy in locally advanced oral squamous cell carcinoma: Randomized, two-arm, phase 2 trial
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  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis
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    OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth
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    A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance
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  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
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    A pair of LysM receptors mediates symbiosis and immunity discrimination in Marchantia
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    Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11742192/
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