1,272 Matching Annotations
  1. Aug 2025
  2. www.biorxiv.org www.biorxiv.org
    Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size
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    biorxiv.org/content/10.1101/2025.07.23.666188v1
  3. Jul 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    P75NTR activation limits CD21lo B cell subsets expansion in response to autoimmune-inducing challenges
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    pmc.ncbi.nlm.nih.gov/articles/PMC12303049/
  5. www.cell.com www.cell.com
    FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism
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    cell.com/cell-reports/abstract/S2211-1247(25)00817-4
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIT1 Drives Oncogenic Transformation and is an Actionable Target in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281470/
  7. www.science.org www.science.org
    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    science.org/doi/10.1126/science.adm9805
  8. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225014555-main-html.html
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    Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors
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    sciencedirect.com/science/article/pii/S1535610825002739
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    Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610825002715
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    Targeting Triple-Negative Breast Cancer with Momordicine-I for Therapeutic Gain in Preclinical Models
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    mdpi.com/2072-6694/17/14/2342
  12. 52.53.155.43 52.53.155.43
    Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.
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    52.53.155.43/cfdc650d76172cca24eedeecbd0bb9156540ab9c/woods-et-al-2023-proteolipid-protein-1-is-involved-in-the-regulation-of-intestinal-motility-and-barrier-function-in-the-html.html
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    PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
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    RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations
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    sciencedirect.com/science/article/pii/S2666379125003088
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11858029/
  17. www.embopress.org www.embopress.org
    Inhibition of the minor spliceosome restricts the growth of a broad spectrum of cancers
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    embopress.org/doi/10.1038/s44319-025-00511-8
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    TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy
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    sciencedirect.com/science/article/pii/S2211124725007727
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    TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC
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    cell.com/cell-reports/abstract/S2211-1247(25)00743-0
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    Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies
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    pmc.ncbi.nlm.nih.gov/articles/PMC11246234/
  21. 52.53.155.43 52.53.155.43
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    Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
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    link.springer.com/article/10.1186/s12906-025-04967-y
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    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    biorxiv.org/content/10.1101/2025.06.27.662039v1
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NOD1 promotes leukocyte clearance and limits inflammation in female mice during obesity‐associated acute lung injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227658/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
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    Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps
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    sciencedirect.com/science/article/pii/S1535610825002570
  27. dx.doi.org dx.doi.org
    The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function
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    dx.doi.org/10.1210/endocr/bqae041
  28. Jun 2025
  29. 52.53.155.43 52.53.155.43
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  30. www.embopress.org www.embopress.org
    Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila
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    embopress.org/doi/10.1038/s44318-025-00489-y
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    VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2
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    sciencedirect.com/science/article/pii/S2211124725007028
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    A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient
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    cell.com/cell-reports/fulltext/S2211-1247(25)00701-6
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinct cAMP Regulation in Scleroderma Lung and Skin Myofibroblasts Governs Their Dedifferentiation via p38α Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12186599/
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    EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC
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    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deficiency of Fibroblast Growth Factor 2 Promotes Contractile Phenotype of Pericytes in Ascending Thoracic Aortic Aneurysm
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172006/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12169444/
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    Role of endogenous NT-3 in neuronal activity and neurogenesis in the hippocampal dentate gyrus
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    FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression
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    sciencedirect.com/science/article/pii/S1550413125002670
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor-derived ligands trigger tumor growth and host wasting via differential MEK activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC6368352/
  41. www.mdpi.com www.mdpi.com
    The RXR Agonist MSU-42011 Reduces Tumor Burden in a Murine Preclinical NF1-Deficient Model
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    mdpi.com/2072-6694/17/12/1920
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    PTEN protein phosphatase activity regulates metastasis by targeting PKCδ
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    sciencedirect.com/science/article/pii/S2589004225010028
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    Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling
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    sciencedirect.com/science/article/pii/S2211124725005820
  44. www.sciencedirect.com www.sciencedirect.com
    MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma
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    sciencedirect.com/science/article/pii/S0092867425005690
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nerve growth factor signaling tunes axon maintenance protein abundance and kinetics of Wallerian degeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005098/
  46. link.springer.com link.springer.com
    PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma
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    link.springer.com/article/10.1007/s10142-025-01629-7
  47. www.sciencedirect.com www.sciencedirect.com
    A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling
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    sciencedirect.com/science/article/pii/S2589004225009563
  48. www.sciencedirect.com www.sciencedirect.com
    Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy
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    sciencedirect.com/science/article/pii/S1074761325002274
  49. May 2025
  50. journals.lww.com journals.lww.com
    Bromodomain-containing protein 4 knockdown promotes... : Neural Regeneration Research
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    journals.lww.com/nrronline/fulltext/2026/02000/bromodomain_containing_protein_4_knockdown.41.aspx
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Surrogate GPR139 Agonists Reverse Short‐Term Startle Habituation Impairment in Larval Zebrafish
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    pmc.ncbi.nlm.nih.gov/articles/PMC12097293/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12093284/
  53. www.sciencedirect.com www.sciencedirect.com
    Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
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    sciencedirect.com/science/article/pii/S0092867425005021
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12055001/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Activity of the Type II RAF Inhibitor Tovorafenib in Tumor Models Harboring Either a BRAF Fusion or an NF1 Loss-of-Function Mutation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12015663/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
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    Phenotypic heterogeneity and plasticity in colorectal cancer metastasis
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    sciencedirect.com/science/article/pii/S2666979X25001375
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    The biased OTR ligands -atosiban and carbetocin- differentially inhibit early or late formalin-induced nociception in rats
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    sciencedirect.com/science/article/pii/S0028390825001935
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    Independent and synergistic roles of MEK-ERK1/2 and PKC pathways in regulating functional changes in vascular tissue following flow cessation
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    sciencedirect.com/science/article/pii/S2772976125000194
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    A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
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    sciencedirect.com/science/article/pii/S2211124725004668
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    Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS
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    KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy
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  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes
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    onlinelibrary.wiley.com/doi/10.1002/aro2.70015
  65. Apr 2025
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11992107/
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    CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer
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    Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies
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    sciencedirect.com/science/article/pii/S1534580725001558
  69. 52.53.155.43 52.53.155.43
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    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951319/
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    Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses
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    sciencedirect.com/science/article/pii/S037887412500337X
  73. Mar 2025
  74. 52.53.155.43 52.53.155.43
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    Geometric deep learning and multiple-instance learning for 3D cell-shape profiling
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    cell.com/cell-systems/fulltext/S2405-4712(25)00062-6
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    A microglia clonal inflammatory disorder in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908784/
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    Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
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    Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway
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    sciencedirect.com/science/article/pii/S1567576925003844
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    ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity
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    sciencedirect.com/science/article/pii/S2211124725001688
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    Large-scale control over collective cell migration using light-activated epidermal growth factor receptors
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    sciencedirect.com/science/article/pii/S2405471225000365
  81. Feb 2025
  82. 52.53.155.43 52.53.155.43
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    MIF-ACKR3 causes irreversible fat loss by impairing adipogenesis in cancer cachexia
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    FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
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  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11847698/
  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities
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    onlinelibrary.wiley.com/doi/10.1002/pro.70072
  87. journals.biologists.com journals.biologists.com
    Akt is a mediator of artery specification during zebrafish development
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    journals.biologists.com/dev/article/151/17/dev202727/361847/Akt-is-a-mediator-of-artery-specification-during
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    The TSH receptor antibody reactome contributes to retro-orbital inflammation
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    dx.doi.org/10.1210/jendso/bvae182
  89. dx.doi.org dx.doi.org
    Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium
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    dx.doi.org/10.1210/endocr/bqae123
  90. link.springer.com link.springer.com
    Identification of Meibomian gland stem cell populations and mechanisms of aging
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    link.springer.com/article/10.1038/s41467-025-56907-6
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    Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation
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  204. May 2024
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