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  1. Nov 2023
  2. www.sciencedirect.com www.sciencedirect.com
    Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish
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    1. scibot 04 Nov 2023
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      DOI: 10.1016/j.isci.2023.108207

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    sciencedirect.com/science/article/pii/S2589004223022848
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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      DOI: 10.1158/1078-0432.CCR-23-0103

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    ncbi.nlm.nih.gov/pmc/articles/PMC10618648/
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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    1. scibot 02 Nov 2023
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    sciencedirect.com/science/article/pii/S2589004223022952
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    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
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    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.immuni.2023.09.013

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    sciencedirect.com/science/article/pii/S1074761323004181
  6. Oct 2023
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    1. scibot 31 Oct 2023
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      DOI: 10.3390/cancers15205082

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    ncbi.nlm.nih.gov/pmc/articles/PMC10605716/
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    Brain Registration and Evaluation for Zebrafish (BREEZE)-mapping: A pipeline for whole-brain structural and activity analyses
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    sciencedirect.com/science/article/pii/S2666166723006147
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    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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    sciencedirect.com/science/article/pii/S2666379123004214
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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    sciencedirect.com/science/article/pii/S1934590923003594
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
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  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling
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    1. scibot 18 Oct 2023
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    Piezo1 activates noncanonical EGFR endocytosis and signaling
    1
    1. scibot 17 Oct 2023
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    Comparative localization of colorectal sensory afferent central projections in the mouse spinal cord dorsal horn and caudal medulla dorsal vagal complex
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    1. scibot 17 Oct 2023
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      DOI: 10.1002/cne.25546

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    onlinelibrary.wiley.com/doi/10.1002/cne.25546
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    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection
    1
    1. scibot 12 Oct 2023
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      DOI: 10.26508/lsa.202302148

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  17. aiche.onlinelibrary.wiley.com aiche.onlinelibrary.wiley.com
    Mechanochemical coupling of MGF mediates periodontal regeneration
    1
    1. scibot 09 Oct 2023
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      DOI: 10.1002/btm2.10603

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  18. 52.53.155.43 52.53.155.43
    can-22-3965-html.html
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    1. scibot 07 Oct 2023
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  19. 52.53.155.43 52.53.155.43
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  20. www.cell.com www.cell.com
    Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.isci.2023.107940

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    cell.com/iscience/abstract/S2589-0042(23)02017-5
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    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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  22. www.cell.com www.cell.com
    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
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    1. scibot 06 Oct 2023
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    cell.com/cell-reports/abstract/S2211-1247(23)01014-8
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    sciencedirect.com/science/article/pii/S2211124723012147
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinome reprogramming is a targetable vulnerability in ESR1 fusion-driven breast cancer
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    1. scibot 06 Oct 2023
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      DOI: 10.1158/0008-5472.CAN-22-3484

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    ncbi.nlm.nih.gov/pmc/articles/PMC10543968/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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  26. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tyrosine hydroxylase phosphorylation is under the control of serine 40
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      DOI: 10.1111/jnc.15963

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    ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
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    sciencedirect.com/science/article/pii/S2589004223019454
  28. Sep 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    1. scibot 09 Sep 2023
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    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose
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      DOI: 10.3390/neuroglia4030011

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    ncbi.nlm.nih.gov/pmc/articles/PMC10361449/
  33. Aug 2023
  34. www.biorxiv.org www.biorxiv.org
    Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target
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    biorxiv.org/content/10.1101/2023.08.14.553180v1
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    LysM-mediated signaling in Marchantia polymorpha highlights the conservation of pattern-triggered immunity in land plants
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  36. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice
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      DOI: 10.7554/eLife.83451

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  40. 52.53.155.43 52.53.155.43
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  41. 52.53.155.43 52.53.155.43
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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403574/
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    Clinical features associated with outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases
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    FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
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    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
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    Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate
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    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
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    Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19
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    52.53.155.43/c4d56db1e6e5c8b1ff3e886498341985c378d3ad/1960-html.html
  214. aacrjournals.org aacrjournals.org
    Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
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    1. scibot 27 Aug 2022
      RRID:AB_2315112

      DOI: 10.1158/2159-8290.CD-20-1628

      Resource: (Cell Signaling Technology Cat# 4370, RRID:AB_2315112)

      Curator: @scibot

      SciCrunch record: RRID:AB_2315112

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      RRID:AB_2315112
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    aacrjournals.org/cancerdiscovery/article/12/8/1960/707258/IL27-Signaling-Serves-as-an-Immunologic-Checkpoint