1,833 Matching Annotations
  1. Mar 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells
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    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113941

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    sciencedirect.com/science/article/pii/S2211124724002699
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113965

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    sciencedirect.com/science/article/pii/S2211124724002936
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    A gut-derived hormone regulates cholesterol metabolism
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    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.cell.2024.02.024

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      DOI: 10.1016/j.cell.2024.02.024

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    sciencedirect.com/science/article/pii/S0092867424002265
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor
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    1. scibot 17 Mar 2024
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      DOI: 10.7554/eLife.90993

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942784/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury
    1
    1. scibot 16 Mar 2024
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      DOI: 10.21203/rs.3.rs-3938716/v1

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    pmc.ncbi.nlm.nih.gov/articles/PMC10925443/
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    Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions
    2
    1. scibot 13 Mar 2024
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      DOI: 10.1016/j.immuni.2024.02.014

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      DOI: 10.1016/j.immuni.2024.02.014

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    sciencedirect.com/science/article/pii/S1074761324000906
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    Pla2g12b drives expansion of triglyceride-rich lipoproteins
    1
    1. scibot 12 Mar 2024
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      DOI: 10.1038/s41467-024-46102-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920679/
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    The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5
    1
    1. scibot 09 Mar 2024
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      DOI: 10.1371/journal.pone.0298820

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    ncbi.nlm.nih.gov/pmc/articles/PMC10919853/
  10. 52.53.155.43 52.53.155.43
    JNEUROSCI.2031-23.2024.full-html.html
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    52.53.155.43/ebd743ddf9d034e800962b7cb762a1da76b21764/JNEUROSCI.2031-23.2024.full-html.html
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    Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide
    1
    1. scibot 08 Mar 2024
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      DOI: 10.1016/j.molcel.2023.12.033

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    sciencedirect.com/science/article/pii/S1097276523010791
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.010

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      DOI: 10.1016/j.molcel.2024.02.010

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    sciencedirect.com/science/article/pii/S1097276524001291
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    ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.
    2
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    sciencedirect.com/science/article/pii/S2589004224004528
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    Alternative splicing decouples local from global PRC2 activity
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.011

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    sciencedirect.com/science/article/pii/S1097276524001308
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    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
    1
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      DOI: 10.1016/j.celrep.2024.113927

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    ncbi.nlm.nih.gov/pmc/articles/PMC11101011/
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    Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon
    2
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.devcel.2024.02.005

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    sciencedirect.com/science/article/pii/S1534580724000765
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    Securin acetylation prevents precocious separase activation and premature sister chromatid separation
    2
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      DOI: 10.1016/j.cub.2024.02.038

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      DOI: 10.1016/j.cub.2024.02.038

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    sciencedirect.com/science/article/pii/S0960982224001805
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    Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.chembiol.2024.01.001

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    sciencedirect.com/science/article/pii/S2451945624000370
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    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
    1
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      DOI: 10.1016/j.celrep.2024.113908

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    sciencedirect.com/science/article/pii/S2211124724002365
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    SARS-CoV-2 targets ribosomal RNA biogenesis
    2
    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113891

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      DOI: 10.1016/j.celrep.2024.113891

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    sciencedirect.com/science/article/pii/S2211124724002195
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    Structure-based design of non-hypertrophic apelin receptor modulator
    2
    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.cell.2024.02.004

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    sciencedirect.com/science/article/pii/S0092867424001259
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
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    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113886

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    ncbi.nlm.nih.gov/pmc/articles/PMC11019558/
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
    2
    1. scibot 01 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724001980
  24. Feb 2024
  25. www.sciencedirect.com www.sciencedirect.com
    PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity
    1
    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113831

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    sciencedirect.com/science/article/pii/S2211124724001591
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    NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP
    1
    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113860

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    sciencedirect.com/science/article/pii/S2211124724001888
  27. 52.53.155.43 52.53.155.43
    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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      DOI: 10.1210/endocr/bqae018

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    52.53.155.43/763b9f4f88af8a11d49032bb21ea7f98fd438708/bqae018-html.html
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    UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis
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    sciencedirect.com/science/article/pii/S2211124724001360
  29. 52.53.155.43 52.53.155.43
    241-html.html
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    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
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    sciencedirect.com/science/article/pii/S2211124724001736
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    Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers
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    sciencedirect.com/science/article/pii/S2211124724001311
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis
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      DOI: 10.1016/j.neuron.2024.01.028

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    pmc.ncbi.nlm.nih.gov/articles/PMC11065635/
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    Nuclear Translocation of Cleaved PCDH9 Impairs Gastric Cancer Metastasis by Downregulating CDH2 Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10865395/
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    Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes
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    sciencedirect.com/science/article/pii/S2211124724000895
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    Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5
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    sciencedirect.com/science/article/pii/S1550413124000123
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    Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion
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      DOI: 10.1016/j.celrep.2024.113760

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    SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
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    A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism
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    A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass
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    COP9 signalosome-mediated deneddylation of CULLIN1 is necessary for SCFEBF1 assembly in Arabidopsis thaliana
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  73. Dec 2023
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    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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    A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival
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    The Crucial Role of Single-Stranded DNA Binding in Enhancing Sensitivity to DNA-Damaging Agents for Schlafen 11 and Schlafen 13
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    ER chaperones use a protein folding and quality control glyco-code
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    An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling
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    Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies
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    SON is an essential m6A target for hematopoietic stem cell fate
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    Systematic analysis of alternative exon-dependent interactome remodeling reveals multitasking functions of gene regulatory factors
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    Synonymous codon usage regulates translation initiation
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    ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation
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    Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor
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    BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development
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    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
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    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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    ADAMTS-4 enhances oligodendrocyte differentiation and remyelination by cleaving NG2 proteoglycan and attenuating PDGFRα signaling
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    Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
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    Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation
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    TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation
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    Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo
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    A direct interaction between CPF and RNA Pol II links RNA 3′ end processing to transcription
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    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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    Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana
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    Unbiased interrogation of functional lysine residues in human proteome
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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    Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis
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    hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA
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    Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains
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    CLMP is a tumor suppressor that determines all-trans retinoic acid response in colorectal cancer
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    Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease
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    Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation
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    Structural and signaling mechanisms of TAAR1 enabled preferential agonist design
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    Determining the structure of protein-bound ceramides, essential lipids for skin barrier function
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    The bone transcription factor Osterix controls extracellular matrix- and node of Ranvier-related gene expression in oligodendrocytes
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    Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1
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    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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    Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation
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    V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation
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    Blue light receptor CRY1 regulates HSFA1d nuclear localization to promote plant thermotolerance
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress
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    MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis
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    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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    PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors
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    Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways
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    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
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    PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly
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    The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A
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    Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits
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    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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    Molecular model of a bacterial flagellar motor in situ reveals a “parts-list” of protein adaptations to increase torque
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    An integrative approach unveils a distal encounter site for rPTPε and phospho-Src complex formation
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    Structural and biochemical insights into the interaction mechanism underlying HORMAD1 and its partner proteins
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    Peroxisomal ERK mediates Akh/glucagon action and glycemic control
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    ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation
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    Universal features of Nsp1-mediated translational shutdown by coronaviruses
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    Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development
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    Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency
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    15-keto-PGE2 Alleviates Nonalcoholic Steatohepatitis through its Covalent Modification of NF-κB Factors
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    AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis
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    ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct
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    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
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    Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5
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    Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling
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    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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    Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation
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    RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS
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    Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
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  155. www.nature.com www.nature.com
    Acetylation reprograms MITF target selectivity and residence time
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      DOI: 10.1038/s41467-023-41793-7

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  156. www.sciencedirect.com www.sciencedirect.com
    LAT1 (SLC7A5) catalyzes Copper(histidinate) transport switching from antiport to uniport mechanism.
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    Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration
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    Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly
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    MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy
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    A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants
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  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis
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    Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10
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  163. www.sciencedirect.com www.sciencedirect.com
    A co-opted endogenous retroviral envelope promotes cell survival by controlling CTR1-mediated copper transport and homeostasis
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson’s disease
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  165. www.sciencedirect.com www.sciencedirect.com
    Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion
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  166. www.sciencedirect.com www.sciencedirect.com
    Structural basis of CD97 activation and G-protein coupling
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  167. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Plk2 promotes synaptic destabilization through disruption of N-cadherin adhesion complexes during homeostatic adaptation to hyperexcitation
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  168. Aug 2023
  169. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanical stimulation from the surrounding tissue activates mitochondrial energy metabolism in Drosophila differentiating germ cells
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    Efficient genome editing in erythroid cells unveils novel MYB target genes and regulatory functions
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  171. www.sciencedirect.com www.sciencedirect.com
    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypermethylation of RNF125 promotes autophagy-induced oxidative stress in asthma by increasing HMGB1 stability
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    A split-luciferase lysate-based approach to identify small-molecule modulators of phosphatase subunit interactions
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    Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development
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  176. 52.53.155.43 52.53.155.43
    Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
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  177. 52.53.155.43 52.53.155.43
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  178. 52.53.155.43 52.53.155.43
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    E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
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    A conserved family of immune effectors cleaves cellular ATP upon viral infection
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    LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to assess receptor-ligand binding in C. elegans using adapted thermal shift assays
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