456 Matching Annotations
  1. Apr 2022
  2. www.sciencedirect.com www.sciencedirect.com
    MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
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    1. scibot 06 Apr 2022
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    sciencedirect.com/science/article/pii/S2211124722003503
  3. aacrjournals.org aacrjournals.org
    The roles of RNA helicases in DNA damage repair and tumorigenesis reveal precision therapeutic strategies
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    1. scibot 05 Apr 2022
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      DOI: 10.1158/0008-5472.CAN-21-2187

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    aacrjournals.org/cancerres/article/82/5/872/681771/The-Roles-of-RNA-Helicases-in-DNA-Damage-Repair
  4. Mar 2022
  5. www.embopress.org www.embopress.org
    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
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    1. scibot 31 Mar 2022
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      DOI: 10.15252/embj.2021110145

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    embopress.org/doi/abs/10.15252/embj.2021110145
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    ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression
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    1. scibot 23 Mar 2022
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    sciencedirect.com/science/article/pii/S2211124722002819
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    Force-generating apoptotic cells orchestrate avian neural tube bending
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    sciencedirect.com/science/article/pii/S1534580722001228
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner
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    1. scibot 04 Mar 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8419025/
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    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
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    sciencedirect.com/science/article/pii/S1097276522000855
  10. Feb 2022
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    Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity
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    sciencedirect.com/science/article/pii/S2211124722001462
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells
    1
    1. scibot 16 Feb 2022
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      DOI: 10.3390/ijms23031116

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    ncbi.nlm.nih.gov/pmc/articles/PMC8835362/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis
    1
    1. scibot 12 Feb 2022
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      DOI: 10.7554/eLife.68677

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    ncbi.nlm.nih.gov/pmc/articles/PMC8824475/
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    RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair
    1
    1. scibot 02 Feb 2022
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    sciencedirect.com/science/article/pii/S2211124722000511
  15. Jan 2022
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    WASH interacts with Ku to regulate DNA double-stranded break repair
    1
    1. scibot 12 Jan 2022
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    sciencedirect.com/science/article/pii/S2589004221016461
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    Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity
    1
    1. scibot 12 Jan 2022
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    sciencedirect.com/science/article/pii/S2589004221015911
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
    1
    1. scibot 05 Jan 2022
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      DOI: 10.1016/j.ccell.2019.04.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  19. Dec 2021
  20. www.sciencedirect.com www.sciencedirect.com
    Assessing kinetics and recruitment of DNA repair factors using high content screens
    1
    1. scibot 29 Dec 2021
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    sciencedirect.com/science/article/pii/S2211124721016764
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
    1
    1. scibot 17 Dec 2021
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      DOI: 10.1158/0008-5472.CAN-20-2960

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    ncbi.nlm.nih.gov/pmc/articles/PMC8260463/
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    Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
    1
    1. scibot 15 Dec 2021
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    sciencedirect.com/science/article/pii/S2211124721015540
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
    1
    1. scibot 09 Dec 2021
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    sciencedirect.com/science/article/pii/S2211124721015710
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
    1
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      DOI: 10.1016/j.isci.2021.103423

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    ncbi.nlm.nih.gov/pmc/articles/PMC8608609/
  25. Nov 2021
  26. www.sciencedirect.com www.sciencedirect.com
    Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
    1
    1. scibot 17 Nov 2021
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      DOI: 10.1016/j.celrep.2021.110004

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    sciencedirect.com/science/article/pii/S2211124721014820
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    Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
    1
    1. scibot 12 Nov 2021
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      DOI: 10.1016/j.molcel.2021.10.015

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    sciencedirect.com/science/article/pii/S1097276521009072
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
    1
    1. scibot 05 Nov 2021
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      DOI: 10.1158/1535-7163.MCT-20-0749

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    ncbi.nlm.nih.gov/pmc/articles/PMC8102334/
  29. www.sciencedirect.com www.sciencedirect.com
    Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug
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      DOI: 10.1016/j.celrep.2021.109957

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    sciencedirect.com/science/article/pii/S2211124721014340
  30. Oct 2021
  31. www.sciencedirect.com www.sciencedirect.com
    RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair
    1
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      DOI: 10.1016/j.celrep.2021.109879

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    sciencedirect.com/science/article/pii/S2211124721013498
  32. link.springer.com link.springer.com
    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    1. scibot 19 Oct 2021
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      DOI: 10.1186/s13046-021-02124-0

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    link.springer.com/article/10.1186/s13046-021-02124-0
  33. www.sciencedirect.com www.sciencedirect.com
    Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability
    1
    1. scibot 09 Oct 2021
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      DOI: 10.1016/j.molcel.2021.09.012

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    sciencedirect.com/science/article/pii/S1097276521007462
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    Prediction and identification of synergistic compound combinations against pancreatic cancer cells
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      DOI: 10.1016/j.isci.2021.103080

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    sciencedirect.com/science/article/pii/S2589004221010488
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    The 3′-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching
    1
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      DOI: 10.1016/j.celrep.2021.109756

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    sciencedirect.com/science/article/pii/S2211124721012109
  36. Sep 2021
  37. www.sciencedirect.com www.sciencedirect.com
    Prediction and identification of synergistic compound combinations against pancreatic cancer cells
    1
    1. scibot 30 Sep 2021
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    sciencedirect.com/science/article/pii/S2589004221010488
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development
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      DOI: 10.7554/eLife.67989

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    ncbi.nlm.nih.gov/pmc/articles/PMC8456695/
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    Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
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      DOI: 10.1016/j.cell.2021.08.035

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    sciencedirect.com/science/article/pii/S0092867421010461
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    RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy
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    sciencedirect.com/science/article/pii/S193459092100343X
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    Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons
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    sciencedirect.com/science/article/pii/S2211124721011104
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    UV-induced reduction in Polycomb repression promotes epidermal pigmentation
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    sciencedirect.com/science/article/pii/S1534580721006365
  43. Aug 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA
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    sciencedirect.com/science/article/pii/S2211124721009712
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    The Cancer SENESCopedia: A delineation of cancer cell senescence
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    sciencedirect.com/science/article/pii/S2211124721008585
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    sciencedirect.com/science/article/pii/S2211124719303638
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      DOI: 10.7554/eLife.22900

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    elifesciences.org/articles/22900
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 11 Aug 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC5426901/
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    UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
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      DOI: 10.1016/j.cell.2018.11.024

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    sciencedirect.com/science/article/pii/S0092867418315162
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    Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
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      DOI: 10.1016/j.devcel.2018.10.026

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    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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    Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration
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    Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
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    The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis
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      Mouse Anti-phospho Histone H2A.X (Ser139) conjugated with Alexa Fluor 647

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    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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    DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation
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  97. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    TMPRSS11a is a novel age‐altered, tissue specific regulator of migration and wound healing
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  98. Apr 2021
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    p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
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    Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells
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    A Genetic Map of the Response to DNA Damage in Human Cells
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      Mouse monoclonal anti-γH2AX

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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
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  103. www.sciencedirect.com www.sciencedirect.com
    Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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    Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
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    Influence of the microenvironment on modulation of the host response by typhoid toxin
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    SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
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  107. Mar 2021
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    DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
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    TRPS1 drives heterochromatic origin refiring and cancer genome evolution
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    Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions
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    The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks
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    A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
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    ER-directed TREX1 limits cGAS activation at micronuclei
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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  115. Feb 2021
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    A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair
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    Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51
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  120. Jan 2021
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    A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
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    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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    The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis
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    MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
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    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
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  126. Dec 2020
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    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
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    Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics
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  131. Nov 2020
  132. royalsocietypublishing.org royalsocietypublishing.org
    Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture
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      DOI: 10.1098/rsob.200200

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    PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage
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    The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells
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      Anti-γH2AX

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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
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      DOI: 10.7554/eLife.57117

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  136. Oct 2020
  137. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest
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  138. Sep 2020
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    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
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    Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
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    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
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  142. www.sciencedirect.com www.sciencedirect.com
    Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner
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    Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity
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  145. elifesciences.org elifesciences.org
    Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice
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    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication
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    PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
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    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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    Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
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    Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles
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    CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
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    Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
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    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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    Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability
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    ATR expands embryonic stem cell fate potential in response to replication stress
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    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
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    Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment
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  160. www.cell.com www.cell.com
    Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12
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  161. academic.oup.com academic.oup.com
    MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis
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      mouse anti-phospho-Histone H2A.X

      DOI: 10.1093/nar/gkaa406

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  162. genesdev.cshlp.org genesdev.cshlp.org
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
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      γH2AX

      DOI: 10.1101/gad.332395.119

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    Zygotic Nuclear F-Actin Safeguards Embryonic Development
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  164. www.nature.com www.nature.com
    N 6 -methyladenosine regulates the stability of RNA:DNA hybrids in human cells
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      anti-γH2AX mouse monoclonal

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  165. academic.oup.com academic.oup.com
    Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase
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      γ-H2AX

      DOI: 10.1093/nar/gkaa503

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  166. elifesciences.org elifesciences.org
    Parvovirus Minute Virus of Mice Interacts with Sites of Cellular DNA Damage to Establish and Amplify its Lytic Infection
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      γ−Η2ΑX

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  167. www.cell.com www.cell.com
    Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
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  168. www.sciencedirect.com www.sciencedirect.com
    Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
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  169. Jan 2020
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    CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons
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      DOI: 10.1016/j.neuron.2019.07.014

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  171. www.eneuro.org www.eneuro.org
    Homeoprotein Neuroprotection of Embryonic Neuronal Cells
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    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
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    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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    Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
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    Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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    TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
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    PCNA Unloading Is Negatively Regulated by BET Proteins
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    Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations
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    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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    Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
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    Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21
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    The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis
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    DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII
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    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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    A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
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    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
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    Genomic Integrity Safeguards Self-Renewal in Embryonic Stem Cells
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    Quiescent Cells Actively Replenish CENP-A Nucleosomes to Maintain Centromere Identity and Proliferative Potential
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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    TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency
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    MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
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    Viral vector‐mediated Cre recombinase expression in substantia nigra induces lesions of the nigrostriatal pathway associated with perturbations of dopamine‐related behaviors and hallmarks of programmed cell death
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    High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells
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    Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence
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    Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
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    The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage
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      What is this?

      RRID:AB_309864 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276518307573
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    1. scibot 05 Nov 2018
      RRID:AB_309864

      Curator: @Jmenke

      Resource used:

      (Millipore Cat# 05-636, RRID:AB_309864)

      SciCrunch record: RRID:AB_309864

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_309864 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627318308468