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371 Matching Annotations

May 2021
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DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1

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  RRID:AB_627268
  
  DOI: 10.1016/j.molcel.2020.07.028
  
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sciencedirect.com/science/article/pii/S1097276520305190
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Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation

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  DOI: 10.1016/j.molcel.2020.06.021
  
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sciencedirect.com/science/article/pii/S1097276520304238
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Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance

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  DOI: 10.1016/j.molcel.2020.06.037
  
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sciencedirect.com/science/article/pii/S1097276520304664
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The 3D Topography of Mitotic Chromosomes

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1. scibot 07 May 2021
  
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  DOI: 10.1016/j.molcel.2020.07.002
  
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sciencedirect.com/science/article/pii/S1097276520304688
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Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

1
1. scibot 05 May 2021
  
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  DOI: 10.1016/j.devcel.2020.11.012
  
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sciencedirect.com/science/article/pii/S1534580720308881
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Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth

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  DOI: 10.1016/j.devcel.2020.05.020
  
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sciencedirect.com/science/article/pii/S1534580720304093
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SAS-6 Association with γ-Tubulin Ring Complex Is Required for Centriole Duplication in Human Cells

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1. scibot 01 May 2021
  
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  DOI: 10.1016/j.cub.2020.04.036
  
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sciencedirect.com/science/article/pii/S0960982220305509
Apr 2021
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Tau seeds are subject to aberrant modifications resulting in distinct signatures

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.109037
  
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sciencedirect.com/science/article/pii/S2211124721003533
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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

1
1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.10.003
  
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sciencedirect.com/science/article/pii/S2451945620303822
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Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.07.016
  
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sciencedirect.com/science/article/pii/S0092867420308813
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Functional insights from a surface antigen mRNA-bound proteome

1
1. scibot 24 Apr 2021
  
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  DOI: 10.7554/eLife.68136
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8051951/
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Mutant p53 suppresses innate immune signaling to promote tumorigenesis

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1. scibot 22 Apr 2021
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.ccell.2021.01.003
  
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sciencedirect.com/science/article/pii/S1535610821000416
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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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1. scibot 20 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.07.008
  
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sciencedirect.com/science/article/pii/S153561082030369X
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Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer

1
1. scibot 19 Apr 2021
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.chembiol.2021.02.005
  
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sciencedirect.com/science/article/pii/S245194562100057X
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A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization

1
1. scibot 15 Apr 2021
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.str.2021.03.016
  
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sciencedirect.com/science/article/pii/S0969212621001143
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Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras

1
1. scibot 09 Apr 2021
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.chembiol.2021.03.011
  
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sciencedirect.com/science/article/pii/S2451945621001501
Jan 2021
www.jneurosci.org www.jneurosci.org

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content

1
1. scibot 29 Jan 2021
  
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  RRID:AB_627268
  
  DOI: 10.1523/JNEUROSCI.1284-20.2020
  
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jneurosci.org/content/41/2/215
Dec 2020
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Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5

1
1. scibot 12 Dec 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.celrep.2020.108490
  
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sciencedirect.com/science/article/pii/S2211124720314790
www.cell.com www.cell.com

ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1

1
1. scibot 10 Dec 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.cub.2020.10.071
  
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cell.com/current-biology/abstract/S0960-9822(20)31614-6
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Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA

1
1. scibot 07 Dec 2020
  
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  anti‐Myc
  
  DOI: 10.15252/embj.2019103654
  
  Resource: (Santa Cruz Biotechnology Cat# sc-40, RRID:AB_627268)
  
  Curator: @Naa003
  
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  Curator comments: c-myc, avian myelocytomatosis viral oncogene homolog antibody Santa Cruz Biotechnology Cat# sc-40
  
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  RRID:AB_627268 RRIDCUR:Missing
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embopress.org/doi/abs/10.15252/embj.2019103654
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 07 Dec 2020
  
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  RRID:AB_627268
  
  DOI: 10.1111/bph.15060
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15060
Nov 2020
www.cell.com www.cell.com

The Temporal Association Cortex Plays a Key Role in Auditory-Driven Maternal Plasticity

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1. scibot 26 Nov 2020
  
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  DOI: DOI:10.1016/j.neuron.2020.05.004
  
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cell.com/neuron/abstract/S0896-6273(20)30350-0
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Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade

1
1. scibot 24 Nov 2020
  
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  DOI: 10.1016/j.chembiol.2020.10.008
  
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sciencedirect.com/science/article/pii/S2451945620304244
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PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval

1
1. scibot 05 Nov 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.celrep.2020.108312
  
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sciencedirect.com/science/article/pii/S2211124720313012
Oct 2020
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

1
1. scibot 27 Oct 2020
  
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  DOI: 10.1016/j.chembiol.2020.10.001
  
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sciencedirect.com/science/article/pii/S2451945620303809
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Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

1
1. scibot 21 Oct 2020
  
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  RRID:AB_627268
  
  DOI: 10.1038/s41467-020-18956-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7560607/
Sep 2020
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RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis

1
1. scibot 26 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.cub.2020.03.042
  
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sciencedirect.com/science/article/pii/S0960982220304127
www.cell.com www.cell.com

Gene-Specific Control of tRNA Expression by RNA Polymerase II

1
1. scibot 26 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.molcel.2020.03.023
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30191-X
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Telomerase Repairs Collapsed Replication Forks at Telomeres

1
1. scibot 26 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.celrep.2020.02.065
  
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sciencedirect.com/science/article/pii/S2211124720302333
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Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity

1
1. scibot 25 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.molcel.2020.06.020
  
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sciencedirect.com/science/article/pii/S1097276520304226
elifesciences.org elifesciences.org

Casein Kinase 1 Dynamics Underlie Substrate Selectivity and the PER2 Circadian Phosphoswitch

1
1. scibot 23 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.7554/eLife.52343
  
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elifesciences.org/articles/52343
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Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

1
1. scibot 23 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.celrep.2020.01.024
  
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sciencedirect.com/science/article/pii/S2211124720300334
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Degradation of Non-coding RNAs Promotes Recycling of Termination Factors at Sites of Transcription

1
1. scibot 23 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.1016/j.celrep.2020.107942
  
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sciencedirect.com/science/article/pii/S2211124720309232
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Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons.

1
1. scibot 23 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.1523/JNEUROSCI.2471-19.2020
  
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jneurosci.org/content/40/19/3720
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The role of Rif1 in telomere length regulation is separable from its role in origin firing

1
1. scibot 23 Sep 2020
  
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  RRID:AB_627268
  
  DOI: 10.7554/eLife.58066
  
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BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS

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Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression

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Proteasomal Degradation of Proteins is Important for the Proper Transcriptional Response to Sulfur Deficiency Conditions in Plants

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BPS Publications

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Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing

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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

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Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

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The endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway

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The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

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MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation

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The Rad53 CHK1/CHK2 -Spt21 NPAT and Tel1 ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

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  DOI: 10.1038/s41467-020-17961-4
  
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The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation

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Recycling endosomes in mature epithelia restrain tumorigenic signaling

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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

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Development of CAR-T cell therapy for B-ALL using a point-of-care approach

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  DOI: 10.1080/2162402X.2020.1752592
  
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The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

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  DOI: 10.1016/j.celrep.2018.11.097
  
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cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
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Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial‐mesenchymal transition and colorectal cancer aggressiveness

1
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  c‐MYC
  
  DOI: 10.1002/ijc.32955
  
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Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling

1
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  anti-c-MYC
  
  DOI: 10.3390/ijms21051773
  
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MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome

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  DOI: 10.1016/j.chembiol.2020.02.002
  
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c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3

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Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

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  DOI: 10.7554/eLife.52779
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7112954/
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Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity

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Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling

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C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

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Spinophilin regulates phosphorylation and interactions of the GluN2B subunit of the N‐Methyl‐D‐Aspartate Receptor

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  DOI: 10.1111/jnc.14831
  
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N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor

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LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion

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Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2

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  DOI: 10.15252/embr.201947845
  
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Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein

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A Consensus Binding Motif for the PP4 Protein Phosphatase

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Pericentrin-mediated SAS-6 recruitment promotes centriole assembly

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  DOI: 10.7554/eLife.41418
  
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Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis

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  DOI: 10.7554/eLife.50850
  
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Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance

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  DOI: 10.1016/j.cell.2019.12.004
  
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Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

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  DOI: 10.1016/j.chembiol.2017.11.007
  
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Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

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STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation

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PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux

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Miro1 Marks Parkinson’s Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson’s Models

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Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis

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The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest

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Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5

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The Ubiquitin-Editing Enzyme A20 Regulates Synapse Remodeling and Efficacy

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Nuclear Pre-snRNA Export Is an Essential Quality Assurance Mechanism for Functional Spliceosomes

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Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer

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OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ

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Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP

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Tracing MYC Expression for Small Molecule Discovery

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Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control

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GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing

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A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster

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mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

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Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction

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CaMKIIβ is localized in dendritic spines as both drebrin‐dependent and drebrin‐independent pools

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SHOU4 Proteins Regulate Trafficking of Cellulose Synthase Complexes to the Plasma Membrane

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Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death

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Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships

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SAD-A Promotes Glucose-stimulated Insulin Secretion through Phosphorylation and Inhibition of GDIα in Male Islet β-cells

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DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4

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A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity

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Recognition and ER Quality Control of Misfolded Formylglycine-Generating Enzyme by Protein Disulfide Isomerase

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Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels

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UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F

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Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair

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Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry

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β4GalT1 Mediates PPARγ N-Glycosylation to Attenuate Microglia Inflammatory Activation

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The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression

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The InR/Akt/TORC1 Growth-Promoting Signaling Negatively Regulates JAK/STAT Activity and Migratory Cell Fate during Morphogenesis

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PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions

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Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain

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Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding

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A Split-Luciferase-Based Trimer Formation Assay as a High-throughput Screening Platform for Therapeutics in Alport Syndrome

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Transcriptional Regulation of the Warburg Effect in Cancer by SIX1

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AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity

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JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex

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Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ

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Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength

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The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30

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Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division

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sciencedirect.com/science/article/pii/S0960982217315166
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Structural Insights into Yeast Telomerase Recruitment to Telomeres

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Untitled document

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MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

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An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.

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NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

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sciencedirect.com/science/article/pii/S1097276517307931
Nov 2017
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Mutations in the netrin-1 gene cause congenital mirror movements

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Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

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A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid‐β oligomers

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onlinelibrary.wiley.com/doi/10.1111/jnc.14118/full
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USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

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ncbi.nlm.nih.gov/pmc/articles/PMC5438252/
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Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

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elifesciences.org/articles/25014
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A Tunable Brake for HECT Ubiquitin Ligases

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PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

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The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling

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RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

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A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

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The Highly Dynamic Nature of ERdj5 Is Key to Efficient Elimination of Aberrant Protein Oligomers through ER-Associated Degradation

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Different Doublecortin (DCX) Patient Alleles Show Distinct Phenotypes in Cultured Neurons EVIDENCE FOR DIVERGENT LOSS-OF-FUNCTION AND “OFF-PATHWAY” CELLULAR MECHANISMS

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jbc.org/content/291/52/26613.long
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p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

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elifesciences.org/content/6/e22207
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YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

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Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

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Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain

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Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17

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sciencedirect.com/science/article/pii/S1097276517301247
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KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents

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jneurosci.org/content/37/5/1162
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Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

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Regulation of mTORC1 by lysosomal calcium and calmodulin

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Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread

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Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer|[rsquo]|s disease

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  anti-myc
  
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TGFβ Signaling Regulates the Timing of CNS Myelination by Modulating Oligodendrocyte Progenitor Cell Cycle Exit through SMAD3/4/FoxO1/Sp1

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ncbi.nlm.nih.gov/pmc/articles/PMC4044250
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Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function

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