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367 Matching Annotations

Apr 2024
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Thymidine nucleotide metabolism controls human telomere length

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1. scibot 14 Apr 2024
  
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  52963
  
  DOI: 10.1038/s41588-023-01339-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11000509/
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The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2

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1. scibot 14 Apr 2024
  
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  Addgene_52963
  
  DOI: 10.1101/2024.03.18.585604
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983909/
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BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response

2
1. scibot 09 Apr 2024
  
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  Addgene52963
  
  DOI: 10.1016/j.molcel.2024.03.011
  
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  plasmid_52963
  
  DOI: 10.1016/j.molcel.2024.03.011
  
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sciencedirect.com/science/article/pii/S1097276524002211
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Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse

1
1. scibot 03 Apr 2024
  
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  AddgeneCat# 52963
  
  DOI: 10.1016/j.xcrm.2024.101471
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983104/
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The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity

2
1. scibot 02 Apr 2024
  
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  Plasmid_52963
  
  DOI: 10.1016/j.cell.2024.03.002
  
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  Plasmid_52963
  
  DOI: 10.1016/j.cell.2024.03.002
  
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sciencedirect.com/science/article/pii/S0092867424002502
Mar 2024
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CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects

1
1. scibot 31 Mar 2024
  
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  52,963
  
  DOI: 10.1038/s41598-024-58094-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10978915/
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Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry

1
1. scibot 29 Mar 2024
  
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  Addgene52963
  
  DOI: 10.1016/j.crmeth.2024.100737
  
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sciencedirect.com/science/article/pii/S2667237524000626
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Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells

1
1. scibot 17 Mar 2024
  
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  52963
  
  DOI: 10.1111/cas.16070
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10920982/
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Repeat DNA methylation is modulated by adherens junction signaling

1
1. scibot 17 Mar 2024
  
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  DOI: 10.1038/s42003-024-05990-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10920906/
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In vivo CRISPR screening directly targeting testicular cells

1
1. scibot 06 Mar 2024
  
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  Addgene: #52963
  
  DOI: 10.1016/j.xgen.2024.100510
  
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sciencedirect.com/science/article/pii/S2666979X24000375
Feb 2024
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

1
1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.02.002
  
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sciencedirect.com/science/article/pii/S1097276524000984
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The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium

1
1. scibot 29 Feb 2024
  
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  pLentiGuide-puro
  
  DOI: 10.1038/s42003-024-05817-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10879184/
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Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes

1
1. scibot 29 Feb 2024
  
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  Plasmid_52963
  
  DOI: 10.1038/s41421-023-00624-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10879117/
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3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression

1
1. scibot 21 Feb 2024
  
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  52963
  
  DOI: 10.1101/2024.01.23.576965
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10849656/
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Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models

1
1. scibot 21 Feb 2024
  
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  Addgene_52963
  
  DOI: 10.1128/mbio.02998-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10870824/
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Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

1
1. scibot 15 Feb 2024
  
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  plasmid_52963
  
  DOI: 10.1126/sciadv.adj4767
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
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Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

1
1. scibot 13 Feb 2024
  
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  52963
  
  DOI: 10.1038/s41467-023-44412-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10761718/
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Aneuploid embryonic stem cells drive teratoma metastasis

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1. scibot 13 Feb 2024
  
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  52963
  
  DOI: 10.1038/s41467-024-45265-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10844504/
journals.plos.org journals.plos.org

CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly

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1. scibot 09 Feb 2024
  
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  DOI: 10.1371/journal.pgen.1011138
  
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journals.plos.org/plosgenetics/article
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Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection

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1. scibot 08 Feb 2024
  
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  DOI: 10.1038/s41467-023-44175-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10761986/
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Detection of senescence using machine learning algorithms based on nuclear features

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1. scibot 08 Feb 2024
  
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  52963
  
  DOI: 10.1038/s41467-024-45421-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10838307/
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Alternative polyadenylation determines the functional landscape of inverted Alu repeats

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1. scibot 06 Feb 2024
  
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  AddgeneCat# 52963
  
  DOI: 10.1016/j.molcel.2024.01.008
  
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sciencedirect.com/science/article/pii/S1097276524000091
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9

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1. scibot 06 Feb 2024
  
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  52,963
  
  DOI: 10.1186/s13059-023-03149-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10785552/
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Micronucleus is not a potent inducer of the cGAS/STING pathway

1
1. scibot 05 Feb 2024
  
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  52963
  
  DOI: 10.26508/lsa.202302424
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10837050/
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Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression

1
1. scibot 05 Feb 2024
  
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  plasmid_52963
  
  DOI: 10.1101/2024.01.02.573986
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10802360/
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Two-step evolution of HIV-1 budding system leading to pandemic in the human population

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1. scibot 02 Feb 2024
  
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  Addgene_52963
  
  DOI: 10.1016/j.celrep.2024.113697
  
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sciencedirect.com/science/article/pii/S2211124724000251
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus

1
1. scibot 20 Jan 2024
  
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  RRID:Addgene_52963
  
  DOI: 10.1128/mbio.02444-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10790771/
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Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma

1
1. scibot 11 Jan 2024
  
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  RRID:Addgene_52963
  
  DOI: 10.1016/j.tvr.2023.200276
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11000110/
Dec 2023
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Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers

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1. scibot 17 Dec 2023
  
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  RRID:Addgene_52963
  
  DOI: 10.1016/j.immuni.2023.11.008
  
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sciencedirect.com/science/article/pii/S1074761323004909
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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

1
1. scibot 15 Dec 2023
  
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  RRID:Addgene_52963
  
  DOI: 10.7554/eLife.87098
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
journals.asm.org journals.asm.org

Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus

1
1. scibot 14 Dec 2023
  
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  RRID:Addgene_52963
  
  DOI: 10.1128/mbio.02444-23
  
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journals.asm.org/doi/10.1128/mbio.02444-23
Nov 2023
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Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1

1
1. scibot 22 Nov 2023
  
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  Addgene_52963
  
  DOI: 10.1016/j.xcrm.2023.101282
  
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sciencedirect.com/science/article/pii/S2666379123004767
biosignaling.biomedcentral.com biosignaling.biomedcentral.com

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

1
1. scibot 18 Nov 2023
  
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  RRID:Addgene_52963
  
  DOI: 10.1186/s12964-023-01335-6
  
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biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01335-6
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HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

1
1. scibot 17 Nov 2023
  
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  RRID:Addgene_52963
  
  DOI: 10.1016/j.celrep.2023.113352
  
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sciencedirect.com/science/article/pii/S2211124723013645
Oct 2023
www.biorxiv.org www.biorxiv.org

Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus

1
1. scibot 27 Oct 2023
  
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  RRID:Addgene_52963
  
  DOI: 10.1101/2023.10.20.563362
  
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biorxiv.org/content/10.1101/2023.10.20.563362v1
www.cell.com www.cell.com

PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C

1
1. scibot 06 Oct 2023
  
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  RRID:Addgene_52963
  
  DOI: 10.1016/j.celrep.2023.113041
  
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cell.com/cell-reports/fulltext/S2211-1247(23)01052-5
Sep 2023
www.nature.com www.nature.com

CRISPR prime editing for unconstrained correction of oncogenic KRAS variants

1
1. scibot 20 Sep 2023
  
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  52963
  
  DOI: 10.1038/s42003-023-05052-1
  
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  Curator: @bandrow
  
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Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression

1
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  DOI: 10.1016/j.ajhg.2023.07.003
  
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Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment

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  DOI: 10.1016/j.celrep.2023.113098
  
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Aug 2023
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Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

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The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC reprogramming

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Jul 2023
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Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal

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Jun 2023
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Generation of Myoglobin (MB)-Knockout human embryonic stem cell (hESC) line (KAIMRCe002- A-1S) using CRISPR/Cas9 technology

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An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

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Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis

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An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation

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IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network

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(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

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aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
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RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition

1
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aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
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Stem cells tightly regulate dead cell clearance to maintain tissue fitness

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May 2023
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Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation and proteomic profiles in Burkitt lymphoma

1
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Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia

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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

1
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  DOI: 10.1016/j.celrep.2023.112538
  
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The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

1
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ncbi.nlm.nih.gov/pmc/articles/PMC6942053/
Apr 2023
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Proteomic discovery of chemical probes that perturb protein complexes in human cells

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Mar 2023
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The protective role of conjunctival goblet cell mucin sialylation

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  DOI: 10.1038/s41467-023-37101-y
  
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nature.com/articles/s41467-023-37101-y
Feb 2023
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Immune surveillance of brain metastatic cancer cells is mediated by IFITM1

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  DOI: 10.15252/embj.2022111112
  
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Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs

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ncbi.nlm.nih.gov/pmc/articles/PMC9910744/
Jan 2023
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Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

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  plasmid_52963
  
  DOI: 10.1016/j.cmet.2022.12.005
  
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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

1
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  DOI: 10.1016/j.celrep.2022.111965
  
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The NLRP1 and CARD8 inflammasomes detect reductive stress

1
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Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens

1
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ncbi.nlm.nih.gov/pmc/articles/PMC9829182/
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Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage

1
1. scibot 10 Jan 2023
  
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  DOI: 10.1111/jnc.15751
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15751
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Chimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation

1
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  plasmid_52963
  
  DOI: 10.1016/j.cell.2022.11.029
  
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Dec 2022
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IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia

1
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embopress.org/doi/10.15252/emmm.202115631
Nov 2022
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Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins

1
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Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

1
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sciencedirect.com/science/article/pii/S2211124722014462
Oct 2022
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The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages

1
1. scibot 08 Oct 2022
  
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  DOI: 10.1002/cbf.3752
  
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onlinelibrary.wiley.com/doi/10.1002/cbf.3752
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Enzyme-free targeted DNA demethylation using CRISPR–dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression

1
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  DOI: 10.1038/s41596-022-00741-3
  
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nature.com/articles/s41596-022-00741-3
Sep 2022
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Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer

1
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  DOI: 10.1111/cas.15558
  
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onlinelibrary.wiley.com/doi/10.1111/cas.15558
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Methionine metabolism controls the B cell EBV epigenome and viral latency

1
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  DOI: 10.1016/j.cmet.2022.08.008
  
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sciencedirect.com/science/article/pii/S1550413122003515
Aug 2022
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ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain

1
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  DOI: 10.1016/j.celrep.2022.111268
  
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Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases

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  DOI: 10.1016/j.cell.2022.06.048
  
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Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing

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Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy

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Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability

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RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition

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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

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Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

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ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer

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Functional elements of the cis-regulatory lincRNA-p21

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SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

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Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection

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Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments

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Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors

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Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms

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APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons

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Selective modulation of a pan-essential protein as a therapeutic strategy in cancer

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A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

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Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion

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HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization

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p53 Promotes Cytokine Expression in Melanoma to Regulate Drug Resistance and Migration

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ZEB1-regulated lnc-Nr2f1 promotes the migration and invasion of lung adenocarcinoma cells

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Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells

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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

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Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus

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Chronic calcium signaling in IgE+ B cells limits plasma cell differentiation and survival

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Genetically Edited Hepatic Cells Expressing the NTCP-S267F Variant are Resistant to Hepatitis B Virus Infection

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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

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Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

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Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome

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Aug 2021
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Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

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A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells

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TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

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Untitled document

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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

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Untitled document

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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

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A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR

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sciencedirect.com/science/article/pii/S0002929721002706
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Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States

1
1. scibot 06 Aug 2021
  
  in Public
  
  Addgene_52963
  
  DOI: 10.1016/j.cels.2017.08.002
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S2405471217303356
Jul 2021
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Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

1
1. scibot 31 Jul 2021
  
  in Public
  
  RRID:Addgene_52963
  
  DOI: 10.1016/j.celrep.2021.109460
  
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sciencedirect.com/science/article/pii/S2211124721008834
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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

1
1. scibot 29 Jul 2021
  
  in Public
  
  RRID: Addgene_52963
  
  DOI: 10.1016/j.cell.2019.10.034
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S0092867419312115
mcr.aacrjournals.org mcr.aacrjournals.org

Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins

1
1. scibot 29 Jul 2021
  
  in Public
  
  Addgene, plasmid #52963
  
  DOI: 10.1158/1541-7786.MCR-19-0747
  
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mcr.aacrjournals.org/content/17/11/2208
www.embopress.org www.embopress.org

A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

1
1. scibot 29 Jul 2021
  
  in Public
  
  lentiGuide‐Puro
  
  DOI: 10.15252/embr.201948235
  
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embopress.org/doi/full/10.15252/embr.201948235
elifesciences.org elifesciences.org

CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

1
1. scibot 28 Jul 2021
  
  in Public
  
  RRID:Addgene_ 52963
  
  DOI: 10.7554/eLife.43653
  
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elifesciences.org/articles/43653
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

1
1. scibot 27 Jul 2021
  
  in Public
  
  RRID_Addgene_52963
  
  DOI: 10.1016/j.ccell.2019.12.007
  
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sciencedirect.com/science/article/pii/S153561081930577X
rupress.org rupress.org

TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity

1
1. scibot 24 Jul 2021
  
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  RRID:Addgene_52963
  
  DOI: 10.1083/jcb.202010180
  
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rupress.org/jcb/article/220/7/e202010180/212098/TRIM37-prevents-formation-of-condensate-organized
Jun 2021
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

1
1. scibot 25 Jun 2021
  
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  52963
  
  DOI: 10.1016/j.cell.2021.05.038
  
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sciencedirect.com/science/article/pii/S0092867421006905
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A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression

1
1. scibot 15 Jun 2021
  
  in Public
  
  RRID:Addgene_52963
  
  DOI: 10.1016/j.immuni.2021.05.016
  
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sciencedirect.com/science/article/pii/S1074761321002223
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Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states

1
1. scibot 11 Jun 2021
  
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  Addgene_52963
  
  DOI: 10.1016/j.ccell.2021.05.005
  
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sciencedirect.com/science/article/pii/S1535610821002713
May 2021
www.embopress.org www.embopress.org

A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression

1
1. scibot 20 May 2021
  
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  Addgene_52963
  
  DOI: 10.15252/embj.2020106696
  
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embopress.org/doi/abs/10.15252/embj.2020106696
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Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

1
1. scibot 19 May 2021
  
  in Public
  
  Plasmid_52963
  
  DOI: 10.1016/j.celrep.2021.109144
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S2211124721004836
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A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis

1
1. scibot 08 May 2021
  
  in Public
  
  plasmid_52963
  
  DOI: 10.1016/j.molcel.2021.01.014
  
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sciencedirect.com/science/article/pii/S1097276521000149
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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

1
1. scibot 07 May 2021
  
  in Public
  
  Addgene_52963
  
  DOI: 10.1016/j.molcel.2020.06.023
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S1097276520304251
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SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts

1
1. scibot 07 May 2021
  
  in Public
  
  Addgene_52963
  
  DOI: 10.1016/j.molcel.2020.05.011
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S1097276520303129
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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus

1
1. scibot 07 May 2021
  
  in Public
  
  Plasmid_52963
  
  DOI: 10.1016/j.molcel.2020.05.015
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S1097276520303166
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In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma

1
1. scibot 07 May 2021
  
  in Public
  
  Addgene_52963
  
  DOI: 10.1016/j.immuni.2021.01.001
  
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sciencedirect.com/science/article/pii/S1074761321000017
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A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability

1
1. scibot 05 May 2021
  
  in Public
  
  Plasmid_52963
  
  DOI: 10.1016/j.devcel.2020.07.022
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S1534580720305979
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Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

1
1. scibot 03 May 2021
  
  in Public
  
  Addgene_52963
  
  DOI: 10.1016/j.molcel.2021.02.025
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S1097276521001350
Apr 2021
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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

1
1. scibot 28 Apr 2021
  
  in Public
  
  Cat#52963
  
  DOI: 10.1016/j.celrep.2021.109013
  
  Resource: RRID:Addgene_52963
  
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  RRIDCUR:Missing RRID:Addgene_52963
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sciencedirect.com/science/article/pii/S2211124721003272
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Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens

1
1. scibot 27 Apr 2021
  
  in Public
  
  Addgene_52963
  
  DOI: 10.1016/j.cels.2020.08.010
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S2405471220302945
www.sciencedirect.com www.sciencedirect.com

Functional interrogation of DNA damage response variants with base editing screens

2
1. scibot 24 Apr 2021
  
  in Public
  
  Addgene Cat#52963
  
  DOI: 10.1016/j.cell.2021.01.041
  
  Resource: RRID:Addgene_52963
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52963
  
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  RRID:Addgene_52963 RRIDCUR:Missing
2. scibot 12 Apr 2021
  
  in Public
  
  Addgene_52963
  
  DOI: 10.1016/j.cell.2021.01.041
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S0092867421000842
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Defining the Teratoma as a Model for Multi-lineage Human Development

1
1. scibot 24 Apr 2021
  
  in Public
  
  Addgene_52963
  
  DOI: 10.1016/j.cell.2020.10.018
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S0092867420313817
www.sciencedirect.com www.sciencedirect.com

A Genetic Map of the Response to DNA Damage in Human Cells

1
1. scibot 23 Apr 2021
  
  in Public
  
  Addgene Cat# 52963
  
  DOI: 10.1016/j.cell.2020.05.040
  
  Resource: RRID:Addgene_52963
  
  Curator: @Naa003
  
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  RRIDCUR:Missing RRID:Addgene_52963
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sciencedirect.com/science/article/pii/S0092867420306735
www.sciencedirect.com www.sciencedirect.com

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

1
1. scibot 17 Apr 2021
  
  in Public
  
  plasmid_52963
  
  DOI: 10.1016/j.ccell.2020.04.017
  
  Resource: RRID:Addgene_52963
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52963
  
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  RRID:Addgene_52963 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610820302166
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In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

1
1. scibot 11 Apr 2021
  
  in Public
  
  plasmid_52963
  
  DOI: 10.1016/j.cell.2021.02.021
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S0092867421001719
Feb 2021
www.sciencedirect.com www.sciencedirect.com

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:_Addgene_52963
  
  DOI: 10.1016/j.ccell.2019.12.007
  
  Resource: RRID:Addgene_52963
  
  Curator: @ethanbadger
  
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  RRIDCUR:Unresolved RRIDCUR:SyntaxError RRID:Addgene_52963
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sciencedirect.com/science/article/pii/S153561081930577X
www.cell.com www.cell.com

TMEM41B IS A PAN-FLAVIVIRUS HOST FACTOR

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:Addgene_52963
  
  DOI: 10.1016/j.cell.2020.12.005
  
  Resource: RRID:Addgene_52963
  
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  RRIDCUR:Validated RRID:Addgene_52963
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cell.com/cell/abstract/S0092-8674(20)31627-5
Jan 2021
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Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

1
1. scibot 29 Jan 2021
  
  in Public
  
  RRID:Addgene_52963
  
  DOI: 10.1016/j.chom.2020.12.009
  
  Resource: RRID:Addgene_52963
  
  Curator: @evieth
  
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  RRID:Addgene_52963 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1931312820306715
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

1
1. scibot 26 Jan 2021
  
  in Public
  
  RRID:Addgene_52963
  
  DOI: 10.1016/j.cell.2020.12.024
  
  Resource: RRID:Addgene_52963
  
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  RRIDCUR:Validated RRID:Addgene_52963
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ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
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The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

1
1. scibot 15 Jan 2021
  
  in Public
  
  Plasmid_52963
  
  DOI: 10.1016/j.chom.2020.04.024
  
  Resource: RRID:Addgene_52963
  
  Curator: @ethanbadger
  
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  RRIDCUR:Validated RRID:Addgene_52963
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sciencedirect.com/science/article/pii/S1931312820302511
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest

1
1. scibot 08 Jan 2021
  
  in Public
  
  RRID:Addgene_52963
  
  DOI: 10.7554/eLife.58461
  
  Resource: RRID:Addgene_52963
  
  Curator: @evieth
  
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  RRIDCUR:Validated RRID:Addgene_52963
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ncbi.nlm.nih.gov/pmc/articles/PMC7781600/
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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

1
1. scibot 07 Jan 2021
  
  in Public
  
  RRID: Addgene_52963
  
  DOI: 10.1016/j.celrep.2020.108532
  
  Resource: RRID:Addgene_52963
  
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sciencedirect.com/science/article/pii/S2211124720315217
Dec 2020
www.sciencedirect.com www.sciencedirect.com

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

1
1. scibot 17 Dec 2020
  
  in Public
  
  lentiGuide-Puro (pXPR_BRD003)
  
  DOI: 10.1016/j.celrep.2020.108493
  
  Resource: RRID:Addgene_52963
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52963
  
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  RRID:Addgene_52963 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S2211124720314820
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Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

1
1. scibot 07 Dec 2020
  
  in Public
  
  RRID:Addgene_52963
  
  DOI: 10.1016/j.celrep.2020.108444
  
  Resource: RRID:Addgene_52963
  
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  RRIDCUR:Validated RRID:Addgene_52963
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sciencedirect.com/science/article/pii/S2211124720314339
Nov 2020
www.sciencedirect.com www.sciencedirect.com

G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

1
1. scibot 12 Nov 2020
  
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  Addgene_52963
  
  DOI: 10.1016/j.celrep.2020.108341
  
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sciencedirect.com/science/article/pii/S2211124720313309
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Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

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1. scibot 05 Nov 2020
  
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  Lenti-Guide-Puro
  
  DOI: 10.1016/j.cell.2020.10.028
  
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sciencedirect.com/science/article/pii/S0092867420313921
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

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1. scibot 26 Sep 2020
  
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  plasmid_52963
  
  DOI: 10.1016/j.cell.2020.09.033
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7489987/
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

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1. scibot 17 Sep 2020
  
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  RRID:Addgene_52963
  
  DOI: 10.1016/j.ccell.2019.12.007
  
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sciencedirect.com/science/article/pii/S153561081930577X
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A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest

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1. scibot 17 Sep 2020
  
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  RRID:Addgene_52963
  
  DOI: 10.1016/j.celrep.2020.107995
  
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  RRID:Addgene_52963 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720309803
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MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation

1
1. scibot 15 Sep 2020
  
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  Addgene_52963
  
  DOI: 10.1016/j.celrep.2020.107860
  
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  RRID:Addgene_52963 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S221112472030841X
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Locally acting transcription factors regulate p53-dependent cis-regulatory element activity

1
1. scibot 15 Sep 2020
  
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  RRID:Addgene_52963
  
  DOI: 10.1093/nar/gkaa147
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7192610/
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TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

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1. scibot 15 Sep 2020
  
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  RRID:Addgene_52963
  
  DOI: 10.1038/s41586-020-2710-1
  
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  RRID:Addgene_52963 RRIDCUR:Validated
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nature.com/articles/s41586-020-2710-1
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A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

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1. scibot 12 Sep 2020
  
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  plasmid_52963
  
  DOI: 10.1038/s41467-020-17099-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7329900/
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The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks

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1. scibot 05 Sep 2020
  
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  RRID:Addgene_52963
  
  DOI: 10.1016/j.celrep.2019.12.067
  
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sciencedirect.com/science/article/pii/S2211124719317243
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Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

1
1. scibot 03 Sep 2020
  
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  Addgene#52963
  
  DOI: 10.1016/j.celrep.2020.108080
  
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sciencedirect.com/science/article/pii/S2211124720310652
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_52963
  
  DOI: 10.7554/eLife.44635
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6570481/
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Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_52963
  
  DOI: 10.1016/j.ccell.2019.05.013
  
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sciencedirect.com/science/article/pii/S1535610819302557
currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com

Untitled document

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1. scibot 13 Jan 2020
  
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  Addgene_52963
  
  DOI: 10.1002/cpim.62
  
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currentprotocols.onlinelibrary.wiley.com/doi/full/10.1002/cpim.62
elifesciences.org elifesciences.org

Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection

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1. scibot 13 Jan 2020
  
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  Addgene_52963
  
  DOI: 10.7554/eLife.22509
  
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elifesciences.org/articles/22509

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