654 Matching Annotations
  1. May 2024
  2. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    sciencedirect.com/science/article/pii/S1097276524003939
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    Targeting ferroptosis-elicited inflammation suppresses hepatocellular carcinoma metastasis and enhances sorafenib efficacy
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    aacrjournals.org/cancerres/article/84/6/841/735013/Targeting-Ferroptosis-Elicited-Inflammation
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    DNA of neutrophil extracellular traps binds TMCO6 to impair CD8+ T-cell immunity in hepatocellular carcinoma.
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    aacrjournals.org/cancerres/article/84/10/1613/745317/DNA-of-Neutrophil-Extracellular-Traps-Binds-TMCO6
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    can-23-2889-html.html
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    The landscape of cancer-rewired GPCR signaling axes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11099383/
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    Pathways for macrophage uptake of cell-free circular RNAs
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    sciencedirect.com/science/article/pii/S1097276524003885
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    Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis
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    sciencedirect.com/science/article/pii/S2666379124002568
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    CREB3 mediates the transcriptional regulation of PGC-1α, a master regulator of energy homeostasis and mitochondrial biogenesis
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14897
  10. Apr 2024
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    Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity
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    The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor
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    Angiopoietin-Related Protein 4-Transcript 3 Increases the Proliferation, Invasion, and Migration of Hepatocellular Carcinoma Cells and Inhibits Apoptosis
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    DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11020935/
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    Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring
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    l-Ornithine-l-Aspartate (LOLA) Normalizes Metabolic Parameters in Models of Steatosis, Insulin Resistance and Metabolic Syndrome
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    Restored glyoxylate metabolism after AGXT gene correction and direct reprogramming of primary hyperoxaluria type 1 fibroblasts
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993186/
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    Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal
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    Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation
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    The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation
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    science.org/doi/10.1126/scisignal.ade4335
  21. Mar 2024
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    A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
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    Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway
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    sciencedirect.com/science/article/pii/S2211383524001230
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    High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae
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    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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    A gut-derived hormone regulates cholesterol metabolism
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    TET2 Regulation of Alcoholic Fatty Liver via Srebp1 mRNA in Paraspeckles
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    Identification and characterization of a small molecule Bcl-2 Functional Converter
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    Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10902018/
  30. 52.53.155.43 52.53.155.43
    Identification and characterization of nuclear localization signals in the circumsporozoite protein of Plasmodium falciparum
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  31. Feb 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
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    Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity
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    Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone
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    ncbi.nlm.nih.gov/pmc/articles/PMC10146093/
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
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    S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway
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    Degradation of AZGP1 suppresses apoptosis and facilitates cholangiocarcinoma tumorigenesis via TRIM25
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    Functionalized tetrahedral DNA frameworks for the capture of circulating tumor cells
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    Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites
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  41. Jan 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of salusin-α upregulates AdipoR2 and activates the PPARα/ApoA5/SREBP-1c pathway to inhibit lipid synthesis in HepG2 cells
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    IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids
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    SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape
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    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
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    The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression
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    Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system
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    Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19
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    DNA methylation-mediated epigenetic regulation of oncogenic RPS2 as a novel therapeutic target and biomarker in hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S0006291X23015474
  50. Dec 2023
  51. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma
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    onlinelibrary.wiley.com/doi/10.1111/cas.16038
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis
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    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
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    Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis
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    sciencedirect.com/science/article/pii/S0944711323006293
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    SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
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    link.springer.com/article/10.1007/s13402-023-00880-z
  56. www.nature.com www.nature.com
    Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
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    nature.com/articles/s41467-023-43657-6
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    Direct tumor irradiation potentiates adoptive NK cell targeting against parental and stem-like cancer in human liver cancer models.
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    sciencedirect.com/science/article/pii/S0360301623081518
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10682354/
  59. Nov 2023
  60. www.sciencedirect.com www.sciencedirect.com
    Abundant binary promoter switches in lineage-determining transcription factors indicate a digital component of cell fate determination
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    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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    The Role of KLF2 in Regulating Hepatic Lipogenesis and Blood Cholesterol Homeostasis via the SCAP/SREBP Pathway
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    sciencedirect.com/science/article/pii/S0022227523001451
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 screen for genome‐wide interrogation of essential MYC‐bound E‐boxes in cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10620128/
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    Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway
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    nature.com/articles/s41389-023-00494-y
  65. Oct 2023
  66. www.sciencedirect.com www.sciencedirect.com
    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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    Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives
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    Comparative genomic analysis of Mycoplasma related to cell culture for infB gene-based loop-mediated isothermal amplification
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    link.springer.com/article/10.1007/s11274-023-03794-y
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    52.53.155.43/dbe8c3e3fbcbeef5c4f8f35843262b8cfb5dca0c/Molecular Oncology - 2023 - Liu - USP7 reduces the level of nuclear DICER impairing DNA damage response and promoting-html.html
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    Some Novel Bioactivities of Virgibacillus halodenitrificans Carotenoids, Isolated from Wadi El-Natrun Lakes
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    A bifunctional anti-PCSK9 scFv/Exendin-4 fusion protein exhibits enhanced lipid-lowering effects via targeting multiple signaling pathways in HFD-fed mice
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atlas of primary cell-type-specific sequence models of gene expression and variant effects
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    The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration
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    Regulation of ERK2 activity by dynamic S-acylation
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  76. Sep 2023
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10514905/
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    Molecular Oncology - 2023 - Azbazdar-html.html
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    The FEBS Journal - 2023 - Takeuchi-html.html
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    52.53.155.43/1a52c544b293ec29827fcbda62621cbc0bb29fbf/The FEBS Journal - 2023 - Takeuchi-html.html
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    Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative promoters and splicing create multiple functionally distinct isoforms of oestrogen receptor alpha in breast cancer and healthy tissues
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    British J Pharmacology - 2023 - Kleszcz-html.html
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10477178/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLAMF1 is expressed and secreted by Hepatocytes and the Liver in Non-Alcoholic Fatty Liver Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC9377786/
  85. Aug 2023
  86. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fba.2023-00045
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    F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit
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    ncbi.nlm.nih.gov/pmc/articles/PMC10415968/
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    TIM3 is a context-dependent co-regulator of cytotoxic T cell function
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    biorxiv.org/content/10.1101/2023.08.03.551797v1
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    Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression
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    Vitamin B2 enables regulation of fasting glucose availability
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328530/
  91. Jul 2023
  92. www.sciencedirect.com www.sciencedirect.com
    A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling
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    Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice
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    An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation
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  194. Apr 2022
  195. www.nature.com www.nature.com
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  201. Mar 2022
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    Establish an assessment model to characterized metastasis ability Single-cell multiomics reveals heterogeneous cell states linked to metastatic potential in liver cancer cell lines
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  209. Feb 2022
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    A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4
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    SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage
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    Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA
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  219. Dec 2021
  220. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    High-fat diet-induced increases in glucocorticoids contribute to the development of non-alcoholic fatty liver disease in mice
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