4,894 Matching Annotations
  1. Sep 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization
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    pmc.ncbi.nlm.nih.gov/articles/PMC7618144/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endoplasmic reticulum junctions serve as a platform for endosome-lysosome interactions through their stop-and-go motion switching
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    pmc.ncbi.nlm.nih.gov/articles/PMC12442848/
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    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
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    The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12443480/
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    A novel MAP7D1 mutation causes mitotic defects and RPS14 accumulation in Shwachman−Diamond syndrome patient cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12421802/
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    Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12420363/
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    sciencedirect.com/science/article/pii/S2666379125004367
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    Ultrabright chemical labeling enables rapid neural connectivity profiling in large tissue samples
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    sciencedirect.com/science/article/pii/S0896627325006579
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    RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity
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    sciencedirect.com/science/article/pii/S1097276525007099
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    Genome-wide mapping of RNA-protein associations through sequencing
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    nature.com/articles/s41587-025-02780-z
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    Activity-dependent localization and dynamics of STIM1 and STIM2 at ER-PM contacts in hippocampal neurons
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    sciencedirect.com/science/article/pii/S2211124725010617
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    Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation
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    biorxiv.org/content/10.1101/2025.09.05.673478v1
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    2025.09.04.674332v2.full-html.html
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    Enzalutamide-Resistant STEAP4+ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone-Sensitive Prostate Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202510602
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    PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis
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    sciencedirect.com/science/article/pii/S266637912500429X
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    Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2666379125004069
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    T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function
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    sciencedirect.com/science/article/pii/S2211124725010733
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    Effective Reduction in Nuclear DNA Contamination Allows Sensitive Mitochondrial DNA Methylation Determination by LC-MS/MS
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    mdpi.com/1422-0067/26/18/8864
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    Unbiased and comprehensive identification of virus-derived circular RNAs in a large range of viral species and families
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    Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis
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    Construction of Synthetic Probiotic Bacteria for In Situ Delivery of Anti-SARS-CoV-2 Nanobodies
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    link.springer.com/article/10.1007/s12602-025-10758-1
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    CD123 Targeted Epigenetic Nanotherapy for Fusion Oncoprotein MLL-AF9 Rearranged Acute Myeloid Leukemia in Preclinical and Patient Derived Xenograft Models
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/adhm.202503118
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    PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region
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    Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12427560/
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    Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL-2 proteins
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70255
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    Teneurin-4 switches between self-recognition and canonical Latrophilin binding to direct neuronal migration
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    biorxiv.org/content/10.1101/2025.09.09.671438v1
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    Dual AAV vectors for efficient delivery of large transgenes
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    nature.com/articles/s41596-025-01243-8
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    A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy
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    Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation
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    Glycogen synthase kinase-3 is essential for Treg development and function
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    sciencedirect.com/science/article/pii/S2211124725010277
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    Autophagy and exosomes play different roles in the disposal of unwanted cellular materials
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    febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.70244
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    A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation
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    Phosphatidylserine-positive extracellular vesicles for detecting multiple operable cancers
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    The E3 ubiquitin ligase SIAH1 targets a bacterial pore-forming toxin to facilitate xenophagy
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    sciencedirect.com/science/article/pii/S2211124725010289
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    ESG-1–60 and ESG-1–61: Novel dopamine D3 receptor-preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents
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    pmc.ncbi.nlm.nih.gov/articles/PMC12418718/
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    Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8
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    sciencedirect.com/science/article/pii/S2666979X2500237X
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    α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
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    The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11387132/
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    Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12
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    Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma
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    aacrjournals.org/bloodcancerdiscov/article/6/5/484/764335/Microbiota-Shape-Metabolic-and-Immune-Determinants
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    Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets
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    aacrjournals.org/cancerdiscovery/article/15/9/1858/764365/Generation-of-a-Biliary-Tract-Cancer-Cell-Line
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    Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer
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    Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling
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    biorxiv.org/content/10.1101/2025.08.31.673338v1
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    Divergent on-target off-tumor effects by CAR T and CAR NK cells suggest different efficacy and safety of cell therapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12416173/
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    Targeting FSP1 to induce ferroptosis in chromophobe renal cell carcinoma
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  49. journals.asm.org journals.asm.org
    An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon
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    journals.asm.org/doi/10.1128/jvi.00435-25
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    The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity
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    biorxiv.org/content/10.1101/2025.09.01.673523v1
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    Sensitive and specific affinity purification-mass spectrometry assisted by PafA-mediated proximity labeling
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    The full-length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice
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    Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer
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    A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
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    Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection
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    An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
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    Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy
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    PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway
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    Preclinical evaluation of an anchored immunotherapy strategy with aluminum hydroxide-tethered interleukin-12 in dogs with advanced malignant melanoma
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction
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    biorxiv.org/content/10.1101/2025.08.28.672891v1
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    Cell membrane cholesterol affects serotonin transporter efflux due to altered transporter oligomerization
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    A human H5N1 influenza virus expressing bioluminescence for evaluating viral infection and identifying therapeutic interventions
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    A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer
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    Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12383277/
  68. www.biorxiv.org www.biorxiv.org
    Lineage-Specific Epigenomic Mapping of Proximal and Distal Fallopian Tube Epithelium Reveals Mesenchymal/Wnt-Driven Tumor Phenotype Diversification
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    CRISPR-Cas13d-Mediated Targeting of a Context-Specific Essential Gene Enables Selective Elimination of Uveal Melanoma
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    YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA | The EMBO Journal
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    Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling
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    Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain
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    Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response
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    Molecular basis for shifted receptor recognition by an encephalitic arbovirus
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    Reelin Increases the Sphingomyelin Content of the Plasma Membrane and Affects the Surface Expression of GPI‐Anchored Proteins in Hippocampal Neurons
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    In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID
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    The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration
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    PCDHGB7 inhibits the progression of triple‐negative breast cancer by suppressing XRCC5/MYC‐mediated ribosome biogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405659/
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    A Commander-independent function of COMMD3 in endosomal trafficking
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    elifesciences.org/articles/105264
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    Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis
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    nature.com/articles/s41556-025-01745-3
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    Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression
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    Tumors hijack macrophages for iron supply to promote bone metastasis and anemia
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  83. journals.plos.org journals.plos.org
    The multifaceted role of the viral 2A protease in enterovirus replication and antagonism of host antiviral responses
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    Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress
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