294 Matching Annotations
  1. Feb 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10866656/
  3. content.iospress.com content.iospress.com
    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad221058
  4. www.sciencedirect.com www.sciencedirect.com
    Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective
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    sciencedirect.com/science/article/pii/S0896627323009315
  5. Jan 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Alterations in Alzheimer's disease microglia transcriptome might be involved in bone pathophysiology
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    sciencedirect.com/science/article/pii/S0969996124000032
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    A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S1934590923002515
  8. www.eneuro.org www.eneuro.org
    Chronic Visual Stimulation with LED Light Flickering at 24, 40, or 80 Hz Failed to Reduce Amyloid β Load in the 5XFAD Alzheimer’s Disease Mouse Model
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    eneuro.org/content/10/8/ENEURO.0189-23.2023
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC10689618/
  10. www.nature.com www.nature.com
    A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
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    nature.com/articles/s41593-022-01240-0
  11. www.mdpi.com www.mdpi.com
    Alteration of Neural Network and Hippocampal Slice Activation through Exosomes Derived from 5XFAD Nasal Lavage Fluid
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    mdpi.com/1422-0067/24/18/14064
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia
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    pmc.ncbi.nlm.nih.gov/articles/PMC10493665/
  13. www.sciencedirect.com www.sciencedirect.com
    Amyloid Deposition and Dendritic Complexity of Corticocortical Projection Cells in Five Familial Alzheimer's Disease Mouse
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    sciencedirect.com/science/article/pii/S0306452222006212
  14. preprints.opticaopen.org preprints.opticaopen.org
    Adaptive vessel tracing and segmentation in OCT enables robust detection of wall-to-lumen ratio abnormalities in 5xFAD mice
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    preprints.opticaopen.org/articles/preprint/Adaptive_vessel_tracing_and_segmentation_in_OCT_enables_robust_detection_of_wall-to-lumen_ratio_abnormalities_in_5xFAD_mice/24038502
  15. link.springer.com link.springer.com
    Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer’s Disease
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    link.springer.com/article/10.1007/s12035-023-03822-w
  16. www.sciencedirect.com www.sciencedirect.com
    Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer’s disease-transgenic mice
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    sciencedirect.com/science/article/pii/S2666354623000777
  17. Dec 2023
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abnormal [18F]NIFENE binding in transgenic 5xFAD mouse model of Alzheimer’s disease: In vivo PET/CT imaging studies of α4β2* nicotinic acetylcholinergic receptors and in vitro correlations with Aβ plaques
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    ncbi.nlm.nih.gov/pmc/articles/PMC10148164/
  19. Oct 2023
  20. www.biorxiv.org www.biorxiv.org
    Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice
    1
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    biorxiv.org/content/10.1101/2023.09.27.559761v1
  21. Sep 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Tracking cell-type-specific temporal dynamics in human and mouse brains
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    sciencedirect.com/science/article/pii/S0092867423009765
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10476643/
  24. Jun 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in the molecular signature of the developing mouse hippocampus
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    ncbi.nlm.nih.gov/pmc/articles/PMC5356301/
  26. www.mdpi.com www.mdpi.com
    Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice
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    mdpi.com/2218-273X/12/3/399
  27. content.iospress.com content.iospress.com
    Parvalbumin-Positive Neuron Loss and Amyloid-β Deposits in the Frontal Cortex of Alzheimer’s Disease-Related Mice
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad181190
  28. May 2023
  29. www.mdpi.com www.mdpi.com
    Optical Redox Imaging of Ex Vivo Hippocampal Tissue Reveals Age-Dependent Alterations in the 5XFAD Mouse Model of Alzheimer’s Disease
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    mdpi.com/2218-1989/12/9/786/htm
  30. genomemedicine.biomedcentral.com genomemedicine.biomedcentral.com
    PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
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    genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01022-0
  31. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15478
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease
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    onlinelibrary.wiley.com/doi/full/10.1111/acel.13380
  33. Apr 2023
  34. asbmr.onlinelibrary.wiley.com asbmr.onlinelibrary.wiley.com
    Degradation of Bone Quality in a Transgenic Mouse Model of Alzheimer′s Disease
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    asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.4723
  35. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Longitudinal study of sub-regional cerebral viscoelastic properties of 5XFAD Alzheimer's disease mice using multifrequency MR elastography
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    onlinelibrary.wiley.com/doi/full/10.1002/mrm.28709
  36. www.science.org www.science.org
    Simultaneous Fe2+/Fe3+ imaging shows Fe3+ over Fe2+ enrichment in Alzheimer’s disease mouse brain
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    science.org/doi/10.1126/sciadv.ade7622
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduction of human Alzheimer’s disease risk and reversal of mouse model cognitive deficit with nucleoside analog use
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    ncbi.nlm.nih.gov/pmc/articles/PMC10055589/
  38. Mar 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Extracellular vesicles derived from inflammatory-educated stem cells reverse brain inflammation—implication of miRNAs
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    sciencedirect.com/science/article/pii/S1525001621004020
  40. www.biorxiv.org www.biorxiv.org
    Silencing of ApoE with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer’s Disease
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    biorxiv.org/content/10.1101/2022.06.28.498012v1
  41. www.science.org www.science.org
    Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis
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    science.org/doi/10.1126/sciadv.abe3954
  42. www.biorxiv.org www.biorxiv.org
    Super-resolution ultrasound imaging of cerebrovascular impairment in a mouse model of Alzheimer’s disease
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    biorxiv.org/content/10.1101/2022.10.05.511008v1
  43. www.mdpi.com www.mdpi.com
    Enhanced Anxiety and Olfactory Microglial Activation in Early-Stage Familial Alzheimer’s Disease Mouse Model
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    mdpi.com/2079-7737/11/6/938
  44. link.springer.com link.springer.com
    SIRT3 Regulates Neuronal Excitability of Alzheimer’s Disease Models in an Oxidative Stress-Dependent Manner
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    link.springer.com/article/10.1007/s12017-021-08693-9
  45. www.sciencedirect.com www.sciencedirect.com
    APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
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    sciencedirect.com/science/article/pii/S2211124723002073
  46. Feb 2023
  47. www.sciencedirect.com www.sciencedirect.com
    The application of alcian blue to identify astrocyte-associated amyloid plaques by using fluorescence and confocal microscopy
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    sciencedirect.com/science/article/pii/S016502702300016X
  48. www.biorxiv.org www.biorxiv.org
    Alteration of neural network and hippocampal slice activation through exosomes derived from 5XFAD nasal lavage fluid
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    biorxiv.org/content/10.1101/2023.01.24.525465v1
  49. Jan 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration
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    sciencedirect.com/science/article/pii/S0889159123000223
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC9852991/
  52. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Functional characterization of the dural sinuses as a neuroimmune interface
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    sciencedirect.com:5037/science/article/pii/S0092867420317621
  53. Nov 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0896627322009540
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The D-serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC9730428/
  56. Oct 2022
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased KIF11/Kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction
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    ncbi.nlm.nih.gov/pmc/articles/PMC9593841/
  58. www.sciencedirect.com www.sciencedirect.com
    SYK coordinates neuroprotective microglial responses in neurodegenerative disease
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    sciencedirect.com/science/article/pii/S0092867422012491
  59. Apr 2022
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective Regional Loss of Cortical Synapses Lacking Presynaptic Mitochondria in the 5xFAD Mouse Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC8267061/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8379081/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Practical considerations for choosing a mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC5741956/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC8262982/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC8707499/
  65. Mar 2022
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC8892702/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer’s Disease
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    ncbi.nlm.nih.gov/labs/pmc/articles/PMC8908099/
  68. Jan 2022
  69. www.nature.com www.nature.com
    Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
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    nature.com/articles/s42003-021-02843-2
  70. Nov 2021
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC8605573/
  72. www.science.org www.science.org
    Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis
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    science.org/doi/10.1126/sciadv.abe3954
  73. Oct 2021
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preparing Viable Hippocampal Slices from Adult Mice for the Study of Sharp Wave-ripples
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    ncbi.nlm.nih.gov/pmc/articles/PMC7842787/
  75. Aug 2021
  76. www.spiedigitallibrary.org www.spiedigitallibrary.org
    Concurrent OCT and OCT angiography of retinal neurovascular degeneration in the 5XFAD Alzheimer’s disease mice
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    spiedigitallibrary.org/journals/neurophotonics/volume-8/issue-3/035002/Concurrent-OCT-and-OCT-angiography-of-retinal-neurovascular-degeneration-in/10.1117/1.NPh.8.3.035002.full
  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24551
  78. Jul 2021
  79. www.nature.com www.nature.com
    Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease
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    nature.com/articles/s41467-019-12242-1
  80. www.sciencedirect.com www.sciencedirect.com
    The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice
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    sciencedirect.com/science/article/pii/S2451945618303465
  81. www.sciencedirect.com www.sciencedirect.com
    TET2 Regulates the Neuroinflammatory Response in Microglia
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    sciencedirect.com/science/article/pii/S2211124719311908
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC6396100/
  83. www.nature.com www.nature.com
    Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models
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    nature.com/articles/s41593-018-0329-4
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment
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    ncbi.nlm.nih.gov/pmc/articles/PMC6934379/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6508668/
  86. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.
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    ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6075814/
  87. www.sciencedirect.com www.sciencedirect.com
    An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0165027018301602
  88. www.sciencedirect.com www.sciencedirect.com
    In vivo two-photon microscopy protocol for imaging microglial responses and spine elimination at sites of fibrinogen deposition in mouse brain
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    sciencedirect.com/science/article/pii/S2666166721003452
  89. Jun 2021
  90. www.nature.com www.nature.com
    RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
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    nature.com/articles/s41419-021-03899-y
  91. www.sciencedirect.com www.sciencedirect.com
    C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
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    sciencedirect.com/science/article/pii/S0896627321003731
  92. May 2021
  93. www.sciencedirect.com www.sciencedirect.com
    White matter aging drives microglial diversity
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    sciencedirect.com/science/article/pii/S0896627321000738
  94. Mar 2021
  95. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Extracellular signal‐regulated kinase regulates microglial immune responses in Alzheimer’s disease
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24829
  96. Feb 2021
  97. link.springer.com link.springer.com
    Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease
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    link.springer.com/article/10.1186/s40478-020-01013-5
  98. Dec 2020
  99. www.nature.com www.nature.com
    Negative feedback control of neuronal activity by microglia
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    nature.com/articles/s41586-020-2777-8
  100. www.sciencedirect.com www.sciencedirect.com
    Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms
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    sciencedirect.com/science/article/pii/S095528632030601X
  101. www.sciencedirect.com www.sciencedirect.com
    ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex
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    sciencedirect.com/science/article/pii/S2666166720302197
  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    RAPGEF2 mediates oligomeric Aβ‐induced synaptic loss and cognitive dysfunction in the 3xTg‐AD mouse model of Alzheimer’s disease
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    onlinelibrary.wiley.com/doi/10.1111/nan.12686
  103. Sep 2020
  104. www.nature.com www.nature.com
    Transcriptome Profile of Nicotinic Receptor-Linked Sensitization of Beta Amyloid Neurotoxicity
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    nature.com/articles/s41598-020-62726-0
  105. alzres.biomedcentral.com alzres.biomedcentral.com
    A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
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    alzres.biomedcentral.com/articles/10.1186/s13195-020-00617-2
  106. www.jneurosci.org www.jneurosci.org
    Inhibitory parvalbumin basket cell activity is selectively reduced during hippocampal sharp wave ripples in a mouse model of familial Alzheimer’s disease
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    jneurosci.org/content/40/26/5116
  107. Aug 2020
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blood lactate dynamics in awake and anaesthetized mice after intraperitoneal and subcutaneous injections of lactate—sex matters
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    ncbi.nlm.nih.gov/pmc/articles/PMC6951280/
  109. Jan 2020
  110. www.jneurosci.org www.jneurosci.org
    Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease
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    jneurosci.org/content/39/13/2441
  111. Nov 2018
  112. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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    onlinelibrary.wiley.com/doi/abs/10.1002/cne.24551
  113. molecularneurodegeneration.biomedcentral.com molecularneurodegeneration.biomedcentral.com
    BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
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    molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-018-0239-7
  114. www.sciencedirect.com www.sciencedirect.com
    Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models
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    sciencedirect.com/science/article/pii/S0896627318301016
  115. bmcneurosci.biomedcentral.com bmcneurosci.biomedcentral.com
    Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease
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    bmcneurosci.biomedcentral.com/articles/10.1186/s12868-018-0406-3
  116. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protection Against β‐Amyloid Neurotoxicity by a Non‐Toxic Endogenous N‐terminal β‐Amyloid Fragment and its Active Hexapeptide Core Sequence
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14257/full
  117. Nov 2017
  118. www.sciencedirect.com www.sciencedirect.com
    Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist
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    sciencedirect.com/science/article/pii/S0028390817300102
  119. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid‐β oligomers
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14118/full