Hypothesis

343 Matching Annotations

Dec 2024
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A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors

1
1. scibot 03 Dec 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.1016/s0092-8674(01)00624-9
  
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cell.com/cell/fulltext/S0092-8674(22)01256-9
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Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

1
1. scibot 03 Dec 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.1016/s0092-8674(00)91910-x
  
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sciencedirect.com/science/article/pii/S0092867420300556
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POT1 recruits and regulates CST-Polα/primase at human telomeres

1
1. scibot 03 Dec 2024
  
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  https://emcore.ucsf.edu/cryoem-software
  
  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/cell/fulltext/S0092-8674(24)00493-8
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Mechanism of gating and partial agonist action in the glycine receptor

1
1. scibot 03 Dec 2024
  
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  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/cell/fulltext/S0092-8674(21)00069-6
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Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents

1
1. scibot 03 Dec 2024
  
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  https://emcore.ucsf.edu/ucsf-software
  
  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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sciencedirect.com/science/article/pii/S0092867423001022
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A protein blueprint of the diatom CO2-fixing organelle

1
1. scibot 03 Dec 2024
  
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  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/cell/fulltext/S0092-8674(24)01073-0
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Structure and mechanism of human cystine exporter cystinosin

1
1. scibot 03 Dec 2024
  
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  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/cell/fulltext/S0092-8674(22)01114-X
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Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress

1
1. scibot 03 Dec 2024
  
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  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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sciencedirect.com/science/article/pii/S0092867424011887
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Structural insights into the chloroplast protein import in land plants

1
1. scibot 03 Dec 2024
  
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  https://emcore.ucsf.edu/ucsf-software
  
  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/cell/fulltext/S0092-8674(24)00894-8
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Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake

1
1. scibot 03 Dec 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/cell/fulltext/S0092-8674(24)00895-X
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Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells

1
1. scibot 03 Dec 2024
  
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  DOI: 10.1016/j.xpro.2022.101339
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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sciencedirect.com/science/article/pii/S2666166722002192
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Expression and purification of phage T7 ejection proteins for cryo-EM analysis

1
1. scibot 03 Dec 2024
  
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  DOI: 10.1016/j.xpro.2021.100960
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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sciencedirect.com/science/article/pii/S2666166721006663
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Assembly and Cryo-EM structure determination of yeast mitochondrial RNA polymerase initiation complex intermediates

1
1. scibot 03 Dec 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.1016/j.xpro.2021.100431
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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sciencedirect.com/science/article/pii/S2666166721001386
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Efficient expression, purification, and visualization by cryo-EM of unliganded near full-length HER3

2
1. scibot 03 Dec 2024
  
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  emcore.ucsf.edu
  
  DOI: 10.1016/bs.mie.2022.03.048
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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2. scibot 03 Dec 2024
  
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  emcore.ucsf.edu
  
  DOI: 10.1016/bs.mie.2022.03.048
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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sciencedirect.com/science/article/pii/S0076687922001392
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Phase Separation of Rubisco by the Folded SSUL Domains of CcmM in Beta-Carboxysome Biogenesis

1
1. scibot 03 Dec 2024
  
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  DOI: 10.1007/978-1-0716-2663-4_14
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
  Curator: @dhovakimyan1
  
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link.springer.com/protocol/10.1007/978-1-0716-2663-4_14
www.cell.com www.cell.com

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

1
1. scibot 03 Dec 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.1002/mgr.30984
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
  Curator: @dhovakimyan1
  
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cell.com/cell-reports/fulltext/S2211-1247(20)30984-0
www.nature.com www.nature.com

Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

2
1. scibot 02 Dec 2024
  
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  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
2. scibot 01 Dec 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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URL

nature.com/articles/s41594-022-00863-y
www.cell.com www.cell.com

Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains

2
1. scibot 02 Dec 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
2. scibot 01 Dec 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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URL

cell.com/immunity/fulltext/S1074-7613(21)00393-9
Nov 2024
www.nature.com www.nature.com

Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

10
1. scibot 29 Nov 2024
  
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  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
2. scibot 28 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
3. scibot 27 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
4. scibot 26 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
5. scibot 25 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
6. scibot 24 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
7. scibot 23 Nov 2024
  
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  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
8. scibot 22 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
9. scibot 21 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
10. scibot 21 Nov 2024
  
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  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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nature.com/articles/s41594-022-00863-y
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Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains

2
1. scibot 29 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:SCR_025781
2. scibot 28 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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cell.com/immunity/fulltext/S1074-7613(21)00393-9
www.sciencedirect.com www.sciencedirect.com

Cms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release

1
1. scibot 28 Nov 2024
  
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  https://emcore.ucsf.edu/cryoem-software
  
  DOI: 10.5553/oenf/157012472014022003001
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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sciencedirect.com/science/article/pii/S2211124722015583
www.cell.com www.cell.com

Structural basis for the transport and substrate selection of human urate transporter 1

1
1. scibot 28 Nov 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.14309/01.ajg.0001042584.98405.b8
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00978-1
www.embopress.org www.embopress.org

Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii | The EMBO Journal

1
1. scibot 28 Nov 2024
  
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  DOI: 10.1038/s44318-024-00274-3
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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embopress.org/doi/full/10.1038/s44318-024-00274-3
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Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

1
1. scibot 28 Nov 2024
  
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  DOI: 10.1016/s1097-2765(00)00003-4
  
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cell.com/molecular-cell/fulltext/S1097-2765(22)00797-3
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Rational exploration of fold atlas for human solute carrier proteins

1
1. scibot 28 Nov 2024
  
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  DOI: 10.1016/s0969-2126(00)80035-0
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/structure/fulltext/S0969-2126(22)00189-7
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The In Situ Structure of Parkinson’s Disease-Linked LRRK2

1
1. scibot 28 Nov 2024
  
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  DOI: 10.1016/s0092-8674(00)91910-x
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
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cell.com/cell/fulltext/S0092-8674(20)30995-8
elifesciences.org elifesciences.org

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

1
1. scibot 27 Nov 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.7554/eLife.48907
  
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The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

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  DOI: 10.7554/eLife.51131
  
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TRPML1 gating modulation by allosteric mutations and lipids

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  DOI: 10.7554/eLife.100987.3
  
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A neutralizing epitope on the SD1 domain of SARS-CoV-2 Spike targeted following infection and vaccination.

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  DOI: 10.4414/saez.2002.09020
  
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Cryo-Electron Tomography Remote Data Collection and Subtomogram Averaging

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  DOI: 10.3791/63923
  
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Molecular structure of an amyloid fibril formed by FUS low-complexity domain

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1. scibot 26 Nov 2024
  
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  DOI: 10.14309/01.ajg.0001045324.24382.8f
  
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Cryo-EM structure of human hexameric MCM2-7 complex

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1. scibot 26 Nov 2024
  
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  DOI: 10.14309/01.ajg.0001045324.24382.8f
  
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Morphological remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography

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1. scibot 26 Nov 2024
  
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  58.Zheng, S.Q. ∙ Keszthelyi, B. ∙ Branlund, E. ...UCSF tomography: an integrated software suite for real-time electron microscopic tomographic data collection, alignment, and reconstructionJ. Struct. Biol. 2007; 157:138-147CrossrefScopus (171)PubMedGoogle Scholarhttps://emcore.ucsf.edu/ucsf-software
  
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Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle

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  DOI: 10.14309/01.ajg.0001042584.98405.b8
  
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A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

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  DOI: 10.14309/01.ajg.0001042584.98405.b8
  
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Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

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  DOI: 10.14309/01.ajg.0001042584.98405.b8
  
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Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex

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  DOI: 10.14309/01.ajg.0001042584.98405.b8
  
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Cryo-EM Structure of the African Swine Fever Virus

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1. scibot 26 Nov 2024
  
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  DOI: 10.14309/01.ajg.0001040516.56966.3f
  
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cell.com/cell-host-microbe/fulltext/S1931-3128(19)30586-4
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Conformational changes of a phosphatidylcholine flippase in lipid membranes

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1. scibot 26 Nov 2024
  
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  DOI: 10.1299/mej.22-00254
  
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Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery

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1. scibot 26 Nov 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.14309/01.ajg.0001042584.98405.b8
  
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CDK5RAP2 activates microtubule nucleator γTuRC by facilitating template formation and actin release

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1. scibot 26 Nov 2024
  
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  DOI: 10.1108/s1534-085620150000017002
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00529-X
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Inhibition of Parkinson’s Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures

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1. scibot 26 Nov 2024
  
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  DOI: 10.1101/2023.09.07.556689
  
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biorxiv.org/content/10.1101/2023.09.07.556689v1
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Nucleosome binding by the pioneer transcription factor OCT4

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1. scibot 26 Nov 2024
  
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  https://emcore.ucsf.edu/ucsf-motioncor2
  
  DOI: 10.1038/s41598-020-68850-1
  
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nature.com/articles/s41598-020-68850-1
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A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core

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  DOI: 10.1038/s41598-023-28114-0
  
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Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A

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1. scibot 26 Nov 2024
  
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  DOI: 10.1016/s1097-2765(00)00096-4
  
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cell.com/molecular-cell/fulltext/S1097-2765(23)00607-X
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Polymerization of ZBTB transcription factors regulates chromatin occupancy

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  DOI: 10.1016/s1097-2765(00)00096-4
  
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cell.com/molecular-cell/fulltext/S1097-2765(24)00513-6
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Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome

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  DOI: 10.1016/s1097-2765(00)00096-4
  
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Structure of the miniature type V-F CRISPR-Cas effector enzyme

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  DOI: 10.1016/s1097-2765(00)00096-4
  
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Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC

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  DOI: 10.1016/s1097-2765(00)00096-4
  
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Molecular mechanism for activation of the 26S proteasome by ZFAND5

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  DOI: 10.1016/s1097-2765(00)00096-4
  
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Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

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  DOI: 10.1016/s1097-2765(00)00003-4
  
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Structures of the human dopamine D3 receptor-Gi complexes

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  DOI: 10.1016/s1097-2765(00)00003-4
  
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Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility

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  DOI: 10.1016/s1097-2765(00)00003-4
  
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Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment

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  DOI: 10.1016/s1074-7613(09)00092-2
  
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cell.com/immunity/fulltext/S1074-7613(21)00186-2
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Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment

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  DOI: 10.1016/s0969-4765(20)30095-3
  
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Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis

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Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy

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  DOI: 10.1016/s0969-4765(20)30040-0
  
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MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling

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  DOI: 10.1016/s0969-4765(20)30003-5
  
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Improving particle quality in cryo-EM analysis using a PEGylation method

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  DOI: 10.1016/s0969-2126(04)00130-3
  
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Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology

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Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae

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Atomic Structures of Anthrax Prechannel Bound with Full-Length Lethal and Edema Factors

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Structural insights into thermophilic chaperonin complexes

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Structure of the iminium reaction intermediate in an engineered aldolase explains the carboligation activity toward arylated ketones and aldehydes

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Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium

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Molecular structures of human ACAT2 disclose mechanism for selective inhibition

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Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson’s disease

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Cryo-EM structures reveal the molecular mechanism of HflX-mediated erythromycin resistance in mycobacteria

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Structure of the peripheral arm of a minimalistic respiratory complex I

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Amphipathic Motifs Regulate N-BAR Protein Endophilin B1 Auto-inhibition and Drive Membrane Remodeling

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Cryo-EM structures reveal two allosteric inhibition modes of PI3KαH1047R involving a re-shaping of the activation loop

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Structural basis of λCII-dependent transcription activation

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Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole

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The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T

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Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms

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  DOI: 10.1016/s0262-1762(20)30260-1
  
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Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

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  201774.Zheng, S.Q. ∙ Palovcak, E. ∙ Armache, J.P. ...MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopyNat. Methods. 2017; 14:331-332CrossrefScopus (4285)PubMedGoogle Scholarhttps://emcore.ucsf.edu/ucsf-motioncor2
  
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Structure-based discovery of CFTR potentiators and inhibitors

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The hemolysin A secretion system is a multi-engine pump containing three ABC transporters

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Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates

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Structural Insights into the Diversity and DNA Cleavage Mechanism of Fanzor

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Molecular basis of RADAR anti-phage supramolecular assemblies

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Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling

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A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2

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Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

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  DOI: 10.7554/eLife.58823
  
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Cryogenic superresolution correlative light and electron microscopy of vitreous sections

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Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2

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  DOI: 10.17487/rfc6355
  
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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

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  DOI: 10.7554/eLife.59038
  
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Structural basis for binding diversity of acetyltransferase p300 to the nucleosome

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  DOI: 10.14309/01.ajg.0001045324.24382.8f
  
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Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes

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Structural insights into GIRK2 channel modulation by cholesterol and PIP2

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Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2

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Improved interface packing and design opportunities revealed by CryoEM analysis of a designed protein nanocage

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  DOI: 10.14309/01.ajg.0001043948.20775.c3
  
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Combinatorial selective ER-phagy remodels the ER during neurogenesis

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  DOI: 10.1038/s41556-024-01356-4
  
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Structure of the Inhibited State of the Sec Translocon

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N6-methyladenosine in 5′ UTR does not promote translation initiation

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  45.Zheng, S.Q. ∙ Palovcak, E. ∙ Armache, J.P. ...MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopyNat. Methods. 2017; 14:331-332CrossrefScopus (4513)PubMedGoogle Scholarhttps://emcore.ucsf.edu/ucsf-motioncor2
  
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Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme

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Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase

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Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae

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Evolving cryo-EM structural approaches for GPCR drug discovery

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Atomic insights into ML-SI3 mediated human TRPML1 inhibition

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Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae

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Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales

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  46.Zheng, S.Q. ∙ Palovcak, E. ∙ Armache, J.P. ...MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopyNat. Methods. 2017; 14:331-332CrossrefScopus (4285)PubMedGoogle Scholarhttps://emcore.ucsf.edu/ucsf-motioncor2
  
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Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel

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Structural mechanisms of GABAA receptor autoimmune encephalitis

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Transport mechanism and pharmacology of the human GlyT1

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Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

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Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase

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An optimized protocol for acquiring and processing cryo-EM data of human 26S proteasome with M1-Ub6

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Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels

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Molecular basis of global promoter sensing and nucleosome capture by the SWR1 chromatin remodeler

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A modular platform for automated cryo-FIB workflows - ProQuest

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  DOI: 10.7554/eLife.70506
  
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Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

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Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure

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In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts

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Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2

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Optical control of fast and processive engineered myosins in vitro and in living cells

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Visualizing chaperonin function in situ by cryo-electron tomography

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Chikungunya virus assembly and budding visualized in situ using cryogenic electron tomography

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Structural mechanisms of gating and selectivity of human rod CNGA1 channel

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Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

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TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels

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Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

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Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

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Voltage Sensor Movements during Hyperpolarization in the HCN Channel

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A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM

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  https://emcore.ucsf.edu/content/easiglow-protocol
  
  DOI: 10.1016/j.xpro.2022.101732
  
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sciencedirect.com/science/article/pii/S2666166722006128
www.cell.com www.cell.com

The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET

1
1. scibot 21 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  DOI: 10.1016/s0969-2126(00)80035-0
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:SCR_025781
  
  What is this?
  
  RRID:SCR_025781
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RRID:SCR_025781

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scibot

URL

cell.com/structure/fulltext/S0969-2126(20)30372-5
link.springer.com link.springer.com

Near-Atomic Resolution Cryo-EM Image Reconstruction of RNA

1
1. scibot 21 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  DOI: 10.1007/978-1-0716-2687-0_12
  
  Resource: University of California at San Francisco Advanced Microscopy Core Facility (RRID:SCR_025781)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:SCR_025781
  
  What is this?
  
  RRID:SCR_025781
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RRID:SCR_025781

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scibot

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link.springer.com/protocol/10.1007/978-1-0716-2687-0_12
www-jove-com-443.vpn.cdutcm.edu.cn www-jove-com-443.vpn.cdutcm.edu.cn

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

1
1. scibot 19 Nov 2024
  
  in Public
  
  https://emcore.ucsf.edu/ucsf-software
  
  DOI: 10.3791/63856
  
  Resource: None
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:SCR_025781
  
  What is this?
  
  RRID:SCR_025781
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scibot

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www-jove-com-443.vpn.cdutcm.edu.cn/es/t/63856/advancing-high-resolution-imaging-virus-assemblies-liquid

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