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  1. Nov 2018
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    Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2
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    Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin
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    Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
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    sciencedirect.com/science/article/pii/S0092867418302824
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    JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex
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    sciencedirect.com/science/article/pii/S1097276518301874
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    The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells
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    The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment
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    The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation
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    elifesciences.org/articles/31879
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    Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia
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    The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis
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    Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer
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    Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau
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    Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus
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    Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM+ and Transient IgG+ Memory B Cells
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    Fast-Evolving Human-Specific Neural Enhancers Are Associated with Aging-Related Diseases
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    A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability
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    The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells
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    Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells
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    Mapping the Mouse Cell Atlas by Microwell-Seq
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    Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
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    Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly
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    Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer
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    Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS
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    IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation
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    Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch
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    Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
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    T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation
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    CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis
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    KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses
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    Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter
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    Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome
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    Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity
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    RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes
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    Brv1 Is Required for Drosophila Larvae to Sense Gentle Touch
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    Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release
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    TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
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    Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint
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    Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation
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    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
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    Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
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    Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization
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    LOSS OF RUNX1 IS ASSOCIATED WITH AGGRESSIVE LUNG ADENOCARCINOMAS
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    Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
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    A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing
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    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
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    Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery
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    Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals
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    A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells
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    Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
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    Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation
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    Glucocorticoids Suppress the Browning of Adipose Tissue via miR-19b in Male Mice
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    Shank Proteins Differentially Regulate Synaptic Transmission
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    Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid
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    Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels
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    An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.
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    Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
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    HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage
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    Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKIIα
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    Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans.
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    MELK is not necessary for the proliferation of basal-like breast cancer cells.
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    Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies
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    Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program
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    A potent human neutralizing antibody Fc-dependently reduces established HBV infections.
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    A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
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  77. Nov 2017
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    p75 neurotrophin receptor interacts with BACE1 and promotes its localization in endosomes aggravating amyloidogenesis
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    Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels
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    Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
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    Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion
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    AAV delivery of GRP78/BiP promotes adaptation of human RPE cell to ER stress
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    Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
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    The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin
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    The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism
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    Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate
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    ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
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    Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction
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    Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition
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    Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination
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    The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells
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    SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition
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