852 Matching Annotations
  1. Jun 2022
  2. www.sciencedirect.com www.sciencedirect.com
    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276522005391
  3. 52.53.155.43 52.53.155.43
    cd-21-0646-html.html
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    BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma
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      DOI: 10.1038/s41388-022-02372-0

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    nature.com/articles/s41388-022-02372-0
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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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    sciencedirect.com/science/article/pii/S2211124722007574
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    A rice protein modulates endoplasmic reticulum homeostasis and coordinates with a transcription factor to initiate blast disease resistance
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    sciencedirect.com/science/article/pii/S2211124722007239
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    A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis
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    sciencedirect.com/science/article/pii/S1550413122001917
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    Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
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    sciencedirect.com/science/article/pii/S1550413122001875
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    Active APPL1 sequestration by Plasmodium favors liver-stage development
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    sciencedirect.com/science/article/pii/S2211124722006611
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    Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis
    1
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    sciencedirect.com/science/article/pii/S2211124722006246
  11. May 2022
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus
    1
    1. scibot 28 May 2022
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      DOI: 10.1126/sciadv.abj6894

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    ncbi.nlm.nih.gov/pmc/articles/PMC9094657/
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    All-viral tracing of monosynaptic inputs to single birthdate-defined neurons in the intact brain
    1
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    sciencedirect.com/science/article/pii/S2667237522000844
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    Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry
    1
    1. scibot 21 May 2022
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      DOI: 10.7554/eLife.77696

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    ncbi.nlm.nih.gov/pmc/articles/PMC9113749/
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    Recurrent circadian circuitry regulates central brain activity to maintain sleep
    1
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      DOI: 10.1016/j.neuron.2022.04.010

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    sciencedirect.com/science/article/pii/S089662732200349X
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    Walking strides direct rapid and flexible recruitment of visual circuits for course control in Drosophila
    1
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      DOI: 10.1016/j.neuron.2022.04.008

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    sciencedirect.com/science/article/pii/S0896627322003476
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    Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition
    1
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      DOI: 10.1016/j.neuron.2022.04.017

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    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
    1
    1. scibot 11 May 2022
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      DOI: 10.7554/eLife.76495

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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
    1
    1. scibot 11 May 2022
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      DOI: 10.7554/eLife.74277

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    ncbi.nlm.nih.gov/pmc/articles/PMC9084893/
  20. Apr 2022
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    Characterization and functional interrogation of the SARS-CoV-2 RNA interactome
    1
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      DOI: 10.1016/j.celrep.2022.110744

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    sciencedirect.com/science/article/pii/S2211124722005083
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of a CRF1-Cre transgenic rat and the role of central amygdala CRF1 cells in nociception and anxiety-like behavior
    1
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      DOI: 10.7554/eLife.67822

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    ncbi.nlm.nih.gov/pmc/articles/PMC9033268/
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    Non-apoptotic activation of Drosophila caspase-2/9 modulates JNK signaling, the tumor microenvironment, and growth of wound-like tumors
    1
    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110718

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    sciencedirect.com/science/article/pii/S221112472200479X
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    Rapid and efficient degradation of endogenous proteins in vivo identifies stage-specific roles of RNA Pol II pausing in mammalian development
    1
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    sciencedirect.com/science/article/pii/S1534580722002076
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    Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
    1
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    sciencedirect.com/science/article/pii/S1074761322001327
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    CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
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      DOI: 10.1016/j.cell.2022.03.005

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    The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma
    1
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  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats
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      DOI: 10.1097/j.pain.0000000000002119

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    ncbi.nlm.nih.gov/pmc/articles/PMC7969388/
  29. Mar 2022
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    Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex
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    1. scibot 30 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110421

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    Mucus sialylation determines intestinal host-commensal homeostasis
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    sciencedirect.com/science/article/pii/S0092867422001933
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    Targeting HNRNPM inhibits cancer stemness and enhances antitumor immunity in Wnt-activated hepatocellular carcinoma
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    Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner
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      DOI: 10.1158/1541-7786.MCR-21-0219

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    ncbi.nlm.nih.gov/pmc/articles/PMC8419025/
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    Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy
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      DOI: 10.1016/j.neuron.2022.01.035

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    Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
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    sciencedirect.com/science/article/pii/S1097276522001125
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    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
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    sciencedirect.com/science/article/pii/S1097276522001186
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    Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Affects Neurogenesis in Mouse Brain
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      DOI: 10.1016/j.brainresbull.2022.02.019

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    sciencedirect.com/science/article/pii/S0361923022000582
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    Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis
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    An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase
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      DOI: 10.1016/j.isci.2022.103813

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    sciencedirect.com/science/article/pii/S2589004222000839
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    Recruitment of DNA to tumor-derived microvesicles
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  41. Feb 2022
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting
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      DOI: 10.26508/lsa.202101279

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    ncbi.nlm.nih.gov/pmc/articles/PMC8807871/
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    Transcriptional regulation of neural stem cell expansion in the adult hippocampus
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      DOI: 10.7554/eLife.72195

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    ncbi.nlm.nih.gov/pmc/articles/PMC8820733/
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    FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
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      DOI: 10.7554/eLife.71892

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    elifesciences.org/articles/71892
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    Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
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    DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding
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    Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes
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    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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    scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells
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    Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila
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    Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes
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    Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
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    MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells
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    Toxoplasma gondii SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity
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    Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production
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    Gene-specific quantification of nascent transcription following targeted degradation of endogenous proteins in cultured cells
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    Coordinated repression of pro-differentiation genes via P-bodies and transcription maintains Drosophila intestinal stem cell identity
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    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts
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    Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
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    LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity
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    Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex
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    RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association
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    RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development
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    A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation
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    A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function
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    MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal
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    MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
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    Andrographolide prevents bone loss via targeting ERRalpha-regulated metabolic adaption of osteoclastogenesis
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    The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation
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    Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival
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    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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    Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation
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    A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development
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    Functional architecture of neural circuits for leg proprioception in Drosophila
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    Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits
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    The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility
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    KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis
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      Rabbit monoclonal antibody anti-HA

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    Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion
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    Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication
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  148. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Functional analysis of novel RUNX2 mutations identified in patients with Cleidocranial dysplasia
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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      Cell Signaling 3724

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    Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
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    TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease
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    Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets
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  172. May 2021
  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit
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    The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation
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    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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    Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment
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    A protocol for rapid degradation of endogenous transcription factors in mammalian cells and identification of direct regulatory targets
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    Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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    AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
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    Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
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    Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer
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    Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation
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    Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program
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    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
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    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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    Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
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    Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis
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    CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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    The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
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    NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
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