1,125 Matching Annotations
  1. Sep 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10483053/
  3. www.sciencedirect.com www.sciencedirect.com
    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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    sciencedirect.com/science/article/pii/S2589004223018370
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10479865/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose
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    ncbi.nlm.nih.gov/pmc/articles/PMC10361449/
  6. Aug 2023
  7. www.biorxiv.org www.biorxiv.org
    Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target
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    biorxiv.org/content/10.1101/2023.08.14.553180v1
  8. www.sciencedirect.com www.sciencedirect.com
    LysM-mediated signaling in Marchantia polymorpha highlights the conservation of pattern-triggered immunity in land plants
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    sciencedirect.com/science/article/pii/S0960982223010400
  9. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    52.53.155.43/5c44b570825d260ed49e3beddaa9d47779a57883/PIIS2211124723009488-html.html
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process
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    ncbi.nlm.nih.gov/pmc/articles/PMC10413268/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10411973/
  13. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
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    52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
  14. 52.53.155.43 52.53.155.43
    ccr-22-2976 (1)-html.html
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    52.53.155.43/a9d00605441caddd3b84705fb749be834fef17fa/ccr-22-2976 (1)-html.html
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403574/
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    sciencedirect.com/science/article/pii/S2589004223015547
  17. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clinical features associated with outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC9898142/
  19. Jul 2023
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
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    ncbi.nlm.nih.gov/pmc/articles/PMC10368912/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI)
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    ncbi.nlm.nih.gov/pmc/articles/PMC10354042/
  23. www.sciencedirect.com www.sciencedirect.com
    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    sciencedirect.com/science/article/pii/S2211124723008057
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    sciencedirect.com/science/article/abs/pii/S2405471223001588
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC9938728/
  26. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
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  27. www.sciencedirect.com www.sciencedirect.com
    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    sciencedirect.com/science/article/pii/S2589004223012786
  28. 52.53.155.43 52.53.155.43
    mcr-22-1031-html.html
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  29. Jun 2023
  30. 52.53.155.43 52.53.155.43
    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    52.53.155.43/9a5455060dac46a2102bae7baf607274e71beaee/1-s2.0-S2589004223012622-main-html.html
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
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    ncbi.nlm.nih.gov/pmc/articles/PMC10304905/
  32. www.sciencedirect.com www.sciencedirect.com
    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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    sciencedirect.com/science/article/pii/S1074761323002376
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Validation of miRNAs as diagnostic and prognostic biomarkers, and possible therapeutic targets in medullary thyroid cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285659/
  34. www.sciencedirect.com www.sciencedirect.com
    Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa
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    sciencedirect.com/science/article/pii/S2589004223009732
  35. www.mdpi.com www.mdpi.com
    Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice
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    mdpi.com/2076-3921/12/6/1303
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    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610823001836
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    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    sciencedirect.com/science/article/pii/S1074761323002315
  38. elifesciences.org elifesciences.org
    Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development
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    elifesciences.org/content/5/e18414
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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    sciencedirect.com/science/article/pii/S2211124723006587
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    sciencedirect.com/science/article/pii/S1550413123002097
  41. 52.53.155.43 52.53.155.43
    Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
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    52.53.155.43/26aa5ba62138ec506c6f952066d20d6f92d1221c/acs.jmedchem.3c00150-html.html
  42. 52.53.155.43 52.53.155.43
    BPS Publications
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    52.53.155.43/a7694b32aeeb75586321cd0d6d28b4685219f279/British J Pharmacology - 2023 - Chen - Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via-html.html
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate
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    ncbi.nlm.nih.gov/pmc/articles/PMC10256685/
  44. aacrjournals.org aacrjournals.org
    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
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    aacrjournals.org/mcr/article/21/6/578/726510/USP10-Regulates-ZEB1-Ubiquitination-and-Protein
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    A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
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    sciencedirect.com/science/article/pii/S258900422301074X
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N6-methyl-2′-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10239700/
  47. www.microbiologyresearch.org www.microbiologyresearch.org
    IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia
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    microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001858
  48. dx.doi.org dx.doi.org
    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  49. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    sciencedirect.com/science/article/pii/S2451945623001502
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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    pmc.ncbi.nlm.nih.gov/articles/PMC10244369/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
  52. www.sciencedirect.com www.sciencedirect.com
    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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    sciencedirect.com/science/article/pii/S2211124723005971
  53. academic.oup.com academic.oup.com
    Casein kinase 1α regulates testosterone synthesis and testis development in adult mice
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    academic.oup.com/endo/article/164/5/bqad042/7079750
  54. academic.oup.com academic.oup.com
    Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing
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    academic.oup.com/endo/article/164/6/bqad045/7079002
  55. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  56. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16069
  57. 52.53.155.43 52.53.155.43
    can-22-3484-html.html
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    52.53.155.43/78582fc87eae4b7ad3ee30a95dff40dcb4611547/can-22-3484-html.html
  58. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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    jneurosci.org/content/43/15/2631
  59. May 2023
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inflammatory and alternatively activated macrophages independently induce metaplasia but cooperatively drive pancreatic precancerous lesion growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC10212997/
  61. www.sciencedirect.com www.sciencedirect.com
    ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
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    sciencedirect.com/science/article/pii/S2211124723005739
  62. www.sciencedirect.com www.sciencedirect.com
    IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
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    sciencedirect.com/science/article/pii/S1097276523003350
  63. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    sciencedirect.com/science/article/pii/S2211124723005818
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Injury-induced activation of the endocannabinoid system promotes axon regeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC10205787/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10208528/
  66. www.nature.com www.nature.com
    ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
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    nature.com/articles/s41467-023-38605-3
  67. www.sciencedirect.com www.sciencedirect.com
    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    sciencedirect.com/science/article/pii/S0006295223002034
  68. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16091
  69. www.sciencedirect.com www.sciencedirect.com
    Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
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    sciencedirect.com/science/article/pii/S258900422300826X
  70. journals.aai.org journals.aai.org
    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
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    journals.aai.org/jimmunol/article/210/8/1098/263495/cGAS-Mediates-Inflammation-by-Polarizing
  71. www.sciencedirect.com www.sciencedirect.com
    Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S1550413123001717
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology
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    ncbi.nlm.nih.gov/pmc/articles/PMC10164898/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of mitogen-activated protein kinase... : Neural Regeneration Research
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    ncbi.nlm.nih.gov/pmc/articles/PMC10154501/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
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    ncbi.nlm.nih.gov/pmc/articles/PMC10161466/
  75. www.sciencedirect.com www.sciencedirect.com
    Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19
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    sciencedirect.com/science/article/pii/S2666379122002166
  76. academic.oup.com academic.oup.com
    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
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    academic.oup.com/endo/article/161/12/bqaa190/5929646
  77. www.sciencedirect.com www.sciencedirect.com
    Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells
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    sciencedirect.com/science/article/pii/S2211124723004497
  78. Apr 2023
  79. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    sciencedirect.com/science/article/pii/S2211124723004473
  80. www.sciencedirect.com www.sciencedirect.com
    A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
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    sciencedirect.com/science/article/pii/S1535610823001289
  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model
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    onlinelibrary.wiley.com/doi/10.1111/cns.14229
  82. www.sciencedirect.com www.sciencedirect.com
    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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    sciencedirect.com/science/article/pii/S2589004223007162
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    ZFP36-mediated mRNA decay regulates metabolism
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    sciencedirect.com/science/article/pii/S2211124723004229
  84. www.sciencedirect.com www.sciencedirect.com
    The p-rpS6-zone delineates wounding responses and the healing process
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    sciencedirect.com/science/article/pii/S1534580723001545
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
  86. www.sciencedirect.com www.sciencedirect.com
    Cell-to-cell variability in Myc dynamics drives transcriptional heterogeneity in cancer cells
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    sciencedirect.com/science/article/pii/S2211124723004126
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
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    ncbi.nlm.nih.gov/pmc/articles/PMC10069870/
  88. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gliotransmission and adenosine signaling promote axon regeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC10173126/
  90. 52.53.155.43 52.53.155.43
    An Overview of Alamadine/MrgD Signaling and Its Role in Cardiomyocytes
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    52.53.155.43/7254c22ae6bee22b365f8332768e6a982ffe9386/ajpcell.00399.2021-html.html
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