1,153 Matching Annotations
  1. Nov 2022
  2. link.springer.com link.springer.com
    ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response
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    1. scibot 17 Nov 2022
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      DOI: 10.1186/s13014-022-02139-7

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    link.springer.com/article/10.1186/s13014-022-02139-7
  3. www.sciencedirect.com www.sciencedirect.com
    Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis
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      DOI: 10.1016/j.xcrm.2022.100821

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    sciencedirect.com/science/article/pii/S2666379122003809
  4. www.science.org www.science.org
    Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells
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    1. scibot 15 Nov 2022
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      DOI: 10.1126/sciadv.abn9912

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  5. www.researchsquare.com www.researchsquare.com
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    1. scibot 11 Nov 2022
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      DOI: 10.21203/rs.3.rs-658360/v1

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    Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair
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    sciencedirect.com/science/article/pii/S2211124722014796
  7. www.embopress.org www.embopress.org
    Sex differences and risk factors for bleeding in Alagille syndrome
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    1. scibot 09 Nov 2022
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      DOI: 10.15252/emmm.202215809

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  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC9623505/
  9. f1000research.com f1000research.com
    Anti-ischemic effect of <i>Tamarindus indica </i>L. seed extract against myocardial hypoxic injury
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      DOI: 10.12688/f1000research.126051.1

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    f1000research.com/articles/11-1235
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    Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy
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    sciencedirect.com/science/article/pii/S2211124722014474
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    Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome
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    1. scibot 03 Nov 2022
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    sciencedirect.com/science/article/pii/S2352396422004935
  12. Oct 2022
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    mcr-22-0182-html.html
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    CDON contributes to Hedgehog-dependent patterning and growth of the developing limb
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    1. scibot 20 Oct 2022
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    sciencedirect.com/science/article/pii/S0012160622001828
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    Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis
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    1. scibot 13 Oct 2022
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    sciencedirect.com/science/article/pii/S1534580722006815
  16. www.nature.com www.nature.com
    C9orf72 functions in the nucleus to regulate DNA damage repair
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    1. scibot 12 Oct 2022
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      DOI: 10.1038/s41418-022-01074-0

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    nature.com/articles/s41418-022-01074-0
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    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
    1
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    sciencedirect.com/science/article/pii/S221112472201275X
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    Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival
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    1. scibot 05 Oct 2022
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      DOI: 10.1016/j.celrep.2022.111435

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    sciencedirect.com/science/article/pii/S2211124722012761
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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    sciencedirect.com/science/article/pii/S2666634022004032
  20. Sep 2022
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    Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells
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      DOI: 10.1016/j.neuron.2022.09.002

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    sciencedirect.com/science/article/pii/S0896627322008078
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    ER stress transforms random olfactory receptor choice into axon targeting precision
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    1. scibot 27 Sep 2022
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      DOI: 10.1016/j.cell.2022.08.025

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    sciencedirect.com/science/article/pii/S0092867422011205
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    sciencedirect.com/science/article/pii/S2211124722012335
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    Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs
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      DOI: 10.1016/j.chembiol.2022.08.007

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    sciencedirect.com/science/article/pii/S2451945622003154
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    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    sciencedirect.com/science/article/pii/S2211124722011287
  26. www.nature.com www.nature.com
    A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
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      DOI: 10.1038/s42003-022-03917-5

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  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
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      DOI: 10.1158/2159-8290.CD-22-0043

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  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration
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      DOI: 10.3389/fendo.2022.957833

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  29. www.sciencedirect.com www.sciencedirect.com
    Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis
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    Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster
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  31. aacrjournals.org aacrjournals.org
    Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells
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      DOI: 10.1158/2767-9764.CRC-22-0270

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    aacrjournals.org/cancerrescommun/article/2/8/842/708157/Na-H-exchanger-1-Enhances-Antitumor-Activity-of
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    Gut microbial DL-endopeptidase alleviates Crohn’s disease via the NOD2 pathway
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  33. Aug 2022
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    Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors
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    SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
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  36. 52.53.155.43 52.53.155.43
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  37. 52.53.155.43 52.53.155.43
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro
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      DOI: 10.3390/ijms23168861

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    ncbi.nlm.nih.gov/pmc/articles/PMC9408494/
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    Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation
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    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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    sciencedirect.com/science/article/pii/S2667237522001485
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    Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
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      DOI: 10.1016/j.stem.2022.07.009

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    sciencedirect.com/science/article/pii/S1934590922003046
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    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
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    sciencedirect.com/science/article/pii/S1535610822003257
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    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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    sciencedirect.com/science/article/pii/S1535610822003245
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    Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity
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    S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway
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    Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma
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    Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway
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    HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance
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    Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
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    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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    T cells mediate kidney tubular injury via impaired PDHA1 and Autophagy in type 1 diabetes
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    Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning
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    Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
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    Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1/JNK signaling pathway in primary mouse neurons
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  60. Jun 2022
  61. 52.53.155.43 52.53.155.43
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  62. 52.53.155.43 52.53.155.43
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Efficiently suppress of ferroptosis using deferoxamine nanoparticles as a new method for retinal ganglion cell protection after traumatic optic neuropathy
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    DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism
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    Targeted ablation of Lgr5-expressing intestinal stem cells in diphtheria toxin receptor-based mouse and organoid models
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    Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer
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  83. Apr 2022
  84. www.science.org www.science.org
    p53 directs leader cell behavior, migration, and clearance during epithelial repair
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    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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    Brown adipose tissue involution associated with progressive restriction in progenitor competence
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis
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    Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors
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    Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis
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    CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories
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    Hyperoxygenation During Mid-Neurogenesis Accelerates Cortical Development in the Fetal Mouse Brain
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    Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models
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    Evaluation of the protective effect of Clitoria ternatea L. against propionic acid induced autistic spectrum disorders in rat model
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    Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
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    Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation
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    Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs
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  136. Jan 2022
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    The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression
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    MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1
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  141. Dec 2021
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    Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo
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    Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
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    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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    TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits
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    Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
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    ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells
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    Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis
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    ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
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    The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
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    Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers
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    Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges
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    Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction
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    Treatment resistance analysis reveals GLUT-1-mediated glucose uptake as a major target of synthetic rocaglates in cancer cells
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration
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    Sensitive timing of undifferentiation in oligodendrocyte progenitor cells and their enhanced maturation in primary visual cortex of binocularly enucleated mice
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    Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
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    Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species
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    Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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    The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors
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    Tafazzin Deficiency Reduces Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets from Male Mice
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    Microglial Depletion Causes Region‐Specific Changes to Developmental Neuronal Cell Death in the Mouse Brain
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    RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes
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