1,834 Matching Annotations
  1. Aug 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to assess receptor-ligand binding in C. elegans using adapted thermal shift assays
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    1. scibot 16 Aug 2023
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      DOI: 10.1016/j.xpro.2023.102477

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    ncbi.nlm.nih.gov/pmc/articles/PMC10415787/
  3. www.science.org www.science.org
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
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    1. scibot 12 Aug 2023
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      DOI: 10.1126/sciadv.adf6895

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    science.org/doi/10.1126/sciadv.adf6895
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice
    1
    1. scibot 10 Aug 2023
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      DOI: 10.1016/j.isci.2023.107375

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    ncbi.nlm.nih.gov/pmc/articles/PMC10433013/
  5. www.sciencedirect.com www.sciencedirect.com
    Cooperative assembly confers regulatory specificity and long-term genetic circuit stability
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    1. scibot 10 Aug 2023
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      DOI: 10.1016/j.cell.2023.07.012

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    sciencedirect.com/science/article/pii/S0092867423007456
  6. 52.53.155.43 52.53.155.43
    Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
    1
    1. scibot 10 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112914

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    52.53.155.43/464fcb14db36fa0ad68672734eea21dbff7f105c/PIIS2211124723009257-html.html
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
    1
    1. scibot 10 Aug 2023
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      DOI: 10.1126/sciadv.adf6895

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    ncbi.nlm.nih.gov/pmc/articles/PMC10403219/
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    Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
    1
    1. scibot 05 Aug 2023
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      DOI: 10.1242/jcs.260675

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    ncbi.nlm.nih.gov/pmc/articles/PMC10399987/
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    High-throughput functional characterization of combinations of transcriptional activators and repressors
    1
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      DOI: 10.1016/j.cels.2023.07.001

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    sciencedirect.com/science/article/abs/pii/S2405471223001862
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    Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure
    1
    1. scibot 03 Aug 2023
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    sciencedirect.com/science/article/pii/S2211124723008951
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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    1. scibot 03 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112927

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    sciencedirect.com/science/article/pii/S2211124723009385
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ
    1
    1. scibot 02 Aug 2023
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      DOI: 10.2337/db22-1016

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    ncbi.nlm.nih.gov/pmc/articles/PMC10382653/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heroin Self-Administration and Extinction Increase Prelimbic Cortical Astrocyte–Synapse Proximity and Alter Dendritic Spine Morphometrics That Are Reversed by N-Acetylcysteine
    1
    1. scibot 01 Aug 2023
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      DOI: 10.3390/cells12141812

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    ncbi.nlm.nih.gov/pmc/articles/PMC10378353/
  14. Jul 2023
  15. www.sciencedirect.com www.sciencedirect.com
    Phosphatidylinositol 3-phosphate regulates iron transport via PI3P-binding CgPil1 protein
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112855

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    sciencedirect.com/science/article/pii/S2211124723008665
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1158/2767-9764.CRC-22-0522

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    ncbi.nlm.nih.gov/pmc/articles/PMC10364643/
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    Banana MKK1 modulates fruit ripening via the MKK1-MPK6-3/11-4-bZIP21 module
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112832

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    sciencedirect.com/science/article/pii/S2211124723008434
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    Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.molcel.2023.06.031

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    sciencedirect.com/science/article/pii/S1097276523005075
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness
    2
    1. scibot 21 Jul 2023
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      DOI: 10.1038/s41392-023-01487-4

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      DOI: 10.1038/s41392-023-01487-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10354099/
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    Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions
    1
    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112822

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    sciencedirect.com/science/article/pii/S2211124723008331
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    Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome
    1
    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112817

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    sciencedirect.com/science/article/pii/S2211124723008288
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    Orphan quality control shapes network dynamics and gene expression
    1
    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.cell.2023.06.015

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    sciencedirect.com/science/article/pii/S0092867423006918
  23. 52.53.155.43 52.53.155.43
    Apical polarity and actomyosin dynamics regulate Hippo signaling by controlling Kibra subcellular localization
    1
    1. scibot 19 Jul 2023
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      DOI: 10.1101/2023.06.05.543736

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    52.53.155.43/32faa65cd8cc5e3ea2a2243b08a233a0e281c4f4/2023.06.05.543736v1.full-html.html
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    Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice
    1
    1. scibot 15 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112812

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    sciencedirect.com/science/article/pii/S2211124723008239
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    Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration
    1
    1. scibot 13 Jul 2023
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      DOI: 10.1016/j.neuron.2023.06.005

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    sciencedirect.com/science/article/pii/S0896627323004658
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    The oxidative folding of nascent polypeptides provides electrons for reductive reactions in the ER
    1
    1. scibot 08 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112742

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    sciencedirect.com/science/article/pii/S2211124723007532
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    Sen1 and Rrm3 ensure permissive topological conditions for replication termination
    1
    1. scibot 07 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112747

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    sciencedirect.com/science/article/pii/S2211124723007581
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    Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1
    1
    1. scibot 06 Jul 2023
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      DOI: 10.1016/j.molcel.2023.06.007

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    sciencedirect.com/science/article/pii/S1097276523004306
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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      DOI: 10.1016/j.celrep.2023.112749

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    sciencedirect.com/science/article/pii/S221112472300760X
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    IFITM1 inhibits trophoblast invasion and is induced in placentas associated with IFN-mediated pregnancy diseases
    1
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      DOI: 10.1016/j.isci.2023.107147

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    sciencedirect.com/science/article/pii/S2589004223012245
  31. Jun 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40
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      DOI: 10.1016/j.str.2023.06.002

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    sciencedirect.com/science/article/abs/pii/S0969212623001983
  33. 52.53.155.43 52.53.155.43
    4405.full-html.html
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    Convergence of multiple RNA-silencing pathways on GW182/TNRC6
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    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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      DOI: 10.1016/j.immuni.2023.06.002

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    sciencedirect.com/science/article/pii/S1074761323002376
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
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      DOI: 10.1080/15548627.2023.2169309

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    ncbi.nlm.nih.gov/pmc/articles/PMC10283425/
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    16p11.2 CNV gene Doc2α functions in neurodevelopment and social behaviors through interaction with Secretagogin
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  38. www.biorxiv.org www.biorxiv.org
    KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss
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      DOI: 10.1101/2023.06.12.543777

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    biorxiv.org/content/10.1101/2023.06.12.543777v1
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    SMYD3 induces sorafenib resistance by activating SMAD2/3-mediated epithelial-mesenchymal transition in hepatocellular carcinoma
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      DOI: 10.1016/j.isci.2023.106994

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    sciencedirect.com/science/article/pii/S2589004223010714
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    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
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      DOI: 10.1016/j.cell.2023.05.039

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    sciencedirect.com/science/article/pii/S0092867423005913
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    Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin
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      DOI: 10.1016/j.molcel.2023.05.022

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    sciencedirect.com/science/article/pii/S1097276523003787
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    Phosphatidylinositol 4-kinase IIα is a glycogen synthase kinase 3-regulated interaction hub for activity-dependent bulk endocytosis
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      DOI: 10.1016/j.celrep.2023.112633

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    A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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    The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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    Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut
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    Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication
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    A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    Ecdysone signaling determines lateral polarity and remodels neurites to form Drosophila’s left-right brain asymmetry
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    X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species
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    Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis
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    The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia
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    Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
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    Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation
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    Capture RIC-seq reveals positional rules of PTBP1-associated RNA loops in splicing regulation
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    An optimized protocol to detect protein ubiquitination and activation by ubiquitination assay in vivo and CCK-8 assay
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    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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    A single-copy knockin translating ribosome immunoprecipitation toolkit for tissue-specific profiling of actively translated mRNAs in C. elegans
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    Structural basis for the Rad6 activation by the Bre1 N-terminal domain
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    Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins
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    Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2
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    Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
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    An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for DNA repair activity
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans
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    Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules
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    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
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    SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
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    Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA
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    Protocol to measure centrosome cohesion deficits mediated by pathogenic LRRK2 in cultured cells using confocal microscopy
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    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
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    Human SMARCA5 is continuously required to maintain nucleosome spacing
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    The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma
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    Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
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    Evolutionarily conserved regulators of tau identify targets for new therapies
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    A central role for regulated protein stability in the control of TFE3 and MITF by nutrients
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    Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy
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    Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay
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    The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation
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    POU1F1/Pou1f1 c.143-83A > G variant disrupts the branch site in pre-mRNA and leads dwarfism
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    The ADP-ribose hydrolase NUDT5 is important for DNA repair
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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    Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics
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    Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice
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    The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2
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    Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression
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    Deconvolution of in vivo protein-RNA contacts using fractionated eCLIP-seq
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    Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells
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    Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication
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