1,096 Matching Annotations
  1. May 2022
  2. www.sciencedirect.com www.sciencedirect.com
    XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
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    1. scibot 25 May 2022
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      DOI: 10.1016/j.cell.2022.04.034

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    sciencedirect.com/science/article/pii/S0092867422005323
  3. aacrjournals.org aacrjournals.org
    Increased microtubule growth triggered by microvesicle-mediated paracrine signaling is required for melanoma cancer cell invasion
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    1. scibot 24 May 2022
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      DOI: 10.1158/2767-9764.CRC-22-0010

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    aacrjournals.org/cancerrescommun/article/2/5/366/698979/Increased-Microtubule-Growth-Triggered-by
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors
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    1. scibot 21 May 2022
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      DOI: 10.1016/j.isci.2022.104348

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    ncbi.nlm.nih.gov/pmc/articles/PMC9117555/
  5. www.researchsquare.com www.researchsquare.com
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    1. scibot 20 May 2022
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      DOI: 10.21203/rs.3.rs-658360/v1

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    researchsquare.com/article/rs-156250/v1
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    A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling
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    1. scibot 18 May 2022
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      DOI: 10.1016/j.cell.2022.04.028

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    sciencedirect.com/science/article/pii/S0092867422005268
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    CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells
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      DOI: 10.1016/j.isci.2022.104314

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    sciencedirect.com/science/article/pii/S2589004222005855
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    NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
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    1. scibot 12 May 2022
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      DOI: 10.1016/j.molcel.2022.04.015

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    sciencedirect.com/science/article/pii/S1097276522003264
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders
    1
    1. scibot 11 May 2022
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      DOI: 10.3389/fphar.2022.846172

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    ncbi.nlm.nih.gov/pmc/articles/PMC9062031/
  10. www.nature.com www.nature.com
    Convergent somatic mutations in metabolism genes in chronic liver disease
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    1. scibot 05 May 2022
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      DOI: 10.1038/s41586-021-03974-6

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    nature.com/articles/s41586-021-03974-6
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    Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
    1
    1. scibot 05 May 2022
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      DOI: 10.1016/j.cmet.2022.04.004

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    sciencedirect.com/science/article/pii/S1550413122001310
  12. www.cell.com www.cell.com
    Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
    1
    1. scibot 05 May 2022
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      DOI: 10.1016/j.cell.2022.04.014

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    cell.com/cell/fulltext/S0092-8674(22)00461-5
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia
    1
    1. scibot 03 May 2022
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      DOI: 10.1158/2159-8290.CD-20-1793

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    ncbi.nlm.nih.gov/pmc/articles/PMC8563373/
  14. Apr 2022
  15. www.sciencedirect.com www.sciencedirect.com
    PIIS2589004222005594-html.html
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    1. scibot 30 Apr 2022
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      DOI: 10.1016/j.isci.2022.104289

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    sciencedirect.com/science/article/pii/S2589004222005594
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    Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile mice
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    1. scibot 28 Apr 2022
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      DOI: 10.1016/j.xcrm.2022.100606

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    sciencedirect.com/science/article/pii/S2666379122001239
  17. link.springer.com link.springer.com
    Energetic metabolic reprogramming in Jurkat DFF40-deficient cancer cells
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    1. scibot 26 Apr 2022
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      DOI: 10.1007/s11010-022-04433-0

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    link.springer.com/article/10.1007/s11010-022-04433-0
  18. aacrjournals.org aacrjournals.org
    Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models
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    1. scibot 22 Apr 2022
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      DOI: 10.1158/1535-7163.MCT-21-0370

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    aacrjournals.org/mct/article/20/12/2352/675163/Rational-Combination-of-CRM1-Inhibitor-Selinexor
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    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
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    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.molcel.2022.03.031

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    sciencedirect.com/science/article/pii/S1097276522002696
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    DNA replication is highly resilient and persistent under the challenge of mild replication stress
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    1. scibot 20 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110701

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    sciencedirect.com/science/article/pii/S2211124722004594
  21. www.sciencedirect.com www.sciencedirect.com
    Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain
    1
    1. scibot 20 Apr 2022
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      DOI: 10.1016/j.neuron.2022.03.030

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    sciencedirect.com/science/article/pii/S0896627322002665
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Foxo1-Klf2-S1pr1-Gnai1-Rac1 signaling axis is a critical mediator of Ostm1 regulatory network in T-lymphopoiesis
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    1. scibot 19 Apr 2022
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      DOI: 10.1016/j.isci.2022.104160

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    ncbi.nlm.nih.gov/pmc/articles/PMC9010627/
  23. www.sciencedirect.com www.sciencedirect.com
    Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial
    1
    1. scibot 15 Apr 2022
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      DOI: 10.1016/j.cmet.2022.03.006

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    sciencedirect.com/science/article/pii/S1550413122000948
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
    1
    1. scibot 14 Apr 2022
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      DOI: 10.7554/eLife.74101

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    ncbi.nlm.nih.gov/pmc/articles/PMC9005190/
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    Rapid establishment of human colonic organoid knockout lines
    1
    1. scibot 14 Apr 2022
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      DOI: 10.1016/j.xpro.2022.101308

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    sciencedirect.com/science/article/pii/S2666166722001885
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    Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
    1
    1. scibot 14 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110636

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    sciencedirect.com/science/article/pii/S2211124722003886
  27. www.sciencedirect.com www.sciencedirect.com
    Brown adipose tissue involution associated with progressive restriction in progenitor competence
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      DOI: 10.1016/j.celrep.2022.110575

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    sciencedirect.com/science/article/pii/S2211124722003199
  28. www.sciencedirect.com www.sciencedirect.com
    Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
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    1. scibot 09 Apr 2022
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      DOI: 10.1016/j.immuni.2022.03.009

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    sciencedirect.com/science/article/pii/S1074761322001327
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling
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    1. scibot 08 Apr 2022
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      DOI: 10.1158/1541-7786.MCR-21-0374

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    ncbi.nlm.nih.gov/pmc/articles/PMC8983529/
  30. www.sciencedirect.com www.sciencedirect.com
    Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy
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    1. scibot 07 Apr 2022
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      DOI: 10.1016/j.jbc.2022.101904

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    sciencedirect.com/science/article/pii/S0021925822003441
  31. academic.oup.com academic.oup.com
    Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans
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    1. scibot 05 Apr 2022
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      DOI: 10.1210/endocr/bqac014

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    academic.oup.com/endo/article/163/4/bqac014/6523230
  32. aacrjournals.org aacrjournals.org
    δ-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice
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      DOI: 10.1158/1940-6207.CAPR-21-0508

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    aacrjournals.org/cancerpreventionresearch/article/15/4/233/682296/Tocotrienol-is-the-Most-Potent-Vitamin-E-Form-in
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies
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      DOI: 10.7554/eLife.73006

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    ncbi.nlm.nih.gov/pmc/articles/PMC8975554/
  34. Mar 2022
  35. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 31 Mar 2022
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      DOI: 10.1111/bph.14558

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14558
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Acute inflammation down-regulates alpha-synuclein expression in enteric neurons
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      DOI: 10.1111/jnc.14656

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14656
  37. www.sciencedirect.com www.sciencedirect.com
    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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      DOI: 10.1016/j.celrep.2022.110583

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    sciencedirect.com/science/article/pii/S2211124722003278
  38. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms
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      DOI: 10.1111/jnc.14666

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14666
  39. www.embopress.org www.embopress.org
    Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission
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      DOI: 10.15252/embj.2021109352

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    embopress.org/doi/abs/10.15252/embj.2021109352
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct and diverse chromatin proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions
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      DOI: 10.7554/eLife.73524

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    ncbi.nlm.nih.gov/pmc/articles/PMC8933006/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle
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      DOI: 10.24272/j.issn.2095-8137.2021.360

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    ncbi.nlm.nih.gov/pmc/articles/PMC8920848/
  42. link.springer.com link.springer.com
    Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury
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      DOI: 10.1186/s12974-022-02427-9

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    link.springer.com/article/10.1186/s12974-022-02427-9
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons
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    1. scibot 15 Mar 2022
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      DOI: 10.3390/cells11050782

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    Central dopaminergic control of cell proliferation in the colonic epithelium
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    Reducing host aldose reductase activity promotes neuronal differentiation of transplanted neural stem cells at spinal cord injury sites and facilitates locomotion recovery
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    Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord
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  47. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Alzheimer’s disease and cerebrovascular pathology alter brain endothelial inward rectifier potassium (KIR2.1) channels
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  48. Feb 2022
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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  50. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces
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    Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans
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    Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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    ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12
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    Targeting CCR2+ macrophages with BET inhibitor overcomes adaptive resistance to anti-VEGF therapy in ovarian cancer
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  57. Jan 2022
  58. www.nature.com www.nature.com
    Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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    NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans
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    Sphingosine 1-phosphate receptor 4 promotes nonalcoholic steatohepatitis by activating NLRP3 inflammasome
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    Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity
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    The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
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    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects in Emerin-nucleoskeleton binding disrupt nuclear structure and promote breast cancer cell motility and metastasis
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  67. Dec 2021
  68. www.science.org www.science.org
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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    Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells
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    Integrative proteo-transcriptomic and immunophenotyping signatures of HIV-1 elite control phenotype: A cross-talk between glycolysis and HIF signaling
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    Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis
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    ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
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    YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis
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    lncRNA BORG:TRIM28 Complexes Drive Metastatic Progression by Inducing α6 Integrin/CD49f Expression in Breast Cancer Stem Cells
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    Methods to separate nuclear soluble fractions reflecting localizations in living cells
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  82. Nov 2021
  83. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing
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    Involvement of the miR-363-5p/P2RX4 Axis in Regulating Schwann Cell Phenotype after Nerve Injury
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    Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts
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    Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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    Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
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    Differentiation of human induced pluripotent stem cells into testosterone-producing Leydig-like cells
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    An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity
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    IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation
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    The TLR4–TRIF–type 1 IFN–IFN-γ pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection
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    Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
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    Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
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    Comparison of Histone H3K4me3 between IVF and ICSI Technologies and between Boy and Girl Offspring
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis
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    CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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    The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors
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      DOI: 10.1210/en.2017-00139

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  173. www.sciencedirect.com www.sciencedirect.com
    Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury
    1
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      DOI: 10.1016/j.cell.2018.12.022

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      DOI: 10.1210/en.2018-00887

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  175. www.sciencedirect.com www.sciencedirect.com
    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
    1
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      DOI: 10.1016/j.celrep.2019.11.079

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  176. mcr.aacrjournals.org mcr.aacrjournals.org
    KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
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      β-actin

      DOI: 10.1158/1541-7786.MCR-19-0077

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    Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
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      DOI: 10.1016/j.celrep.2021.109460

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    SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance
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      DOI: 10.1016/j.celrep.2021.109434

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      DOI: 10.1210/en.2016-1576

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    Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network
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      DOI: 10.1016/j.devcel.2018.10.012

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    Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity
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      DOI: 10.1016/j.molcel.2018.08.030

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    Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence
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      DOI: 10.1016/j.devcel.2018.10.001

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      DOI: 10.1002/brb3.1123

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    An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
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  187. onlinelibrary.wiley.com onlinelibrary.wiley.com
    DFCP1 associates with lipid droplets
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      β‐actin

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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Interleukin 35 ameliorates myocardial ischemia‐reperfusion injury by activating the gp130‐STAT3 axis
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      RRID:AB_476744

      DOI: 10.1096/fj.201901718RR

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  192. onlinelibrary.wiley.com onlinelibrary.wiley.com
    NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate
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      AB_476744

      DOI: 10.1002/jnr.24230

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      RRID:AB_476744

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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum
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    Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study
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    Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
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      β‐actin

      DOI: 10.1111/bph.14678

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      DOI: 10.1016/j.cmet.2018.11.004

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      DOI: 10.1111/jnc.14144

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    Widespread Accumulation of Ribosome-Associated Isolated 3′ UTRs in Neuronal Cell Populations of the Aging Brain
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      RRID:AB_476744

      DOI: 10.1016/j.celrep.2018.10.094

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      DOI: 10.1016/j.celrep.2018.09.049

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  204. europepmc.org europepmc.org
    Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor.
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      DOI: 10.1371/journal.pgen.1007049

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    Impact on Experimental Colitis of Vitamin D Receptor Deletion in Intestinal Epithelial or Myeloid Cells
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      AB_476744

      DOI: 10.1210/en.2017-00139

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    Sustained activation of ERK1/2 MAPK in Schwann cells causes corneal neurofibroma
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      AB_476744

      DOI: 10.1002/jnr.24067

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