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  1. Apr 2022
  2. www.sciencedirect.com www.sciencedirect.com
    PIIS2589004222005594-html.html
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    1. scibot 30 Apr 2022
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    sciencedirect.com/science/article/pii/S2589004222005594
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    Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells
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    1. scibot 29 Apr 2022
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      DOI: 10.1093/carcin/bgac032

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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgac032/6556146
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    A superior loading control for the cellular thermal shift assay
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    1. scibot 29 Apr 2022
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      DOI: 10.1038/s41598-022-10653-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC9035151/
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    Insights into Ferroptosis: Targeting Glycolysis to Treat Graves’ Orbitopathy
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    1. scibot 28 Apr 2022
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      DOI: 10.1210/clinem/dgac163

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    academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac163/6550655
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    Hexokinase 1 cellular localization regulates the metabolic fate of glucose
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    1. scibot 26 Apr 2022
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    sciencedirect.com/science/article/pii/S1097276522001666
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    Role of Estrogen and Its Receptors in Adipose Tissue Glucose Metabolism in Pre- and Postmenopausal Women
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    1. scibot 22 Apr 2022
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      DOI: 10.1210/clinem/dgac042

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    ncbi.nlm.nih.gov/pmc/articles/PMC9016422/
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    Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses
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    1. scibot 21 Apr 2022
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    sciencedirect.com/science/article/pii/S2211124722004880
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    Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection
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    1. scibot 20 Apr 2022
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    sciencedirect.com/science/article/pii/S2211124722004569
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    Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
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    1. scibot 20 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110692

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    sciencedirect.com/science/article/pii/S2211124722004508
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    Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury
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    1. scibot 14 Apr 2022
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      DOI: 10.1016/j.neuron.2022.03.021

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    sciencedirect.com/science/article/pii/S0896627322002574
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    Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
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    1. scibot 13 Apr 2022
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    sciencedirect.com/science/article/pii/S1097276522002647
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    1. scibot 13 Apr 2022
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    sciencedirect.com/science/article/pii/S1074761322001303
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    Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
    1
    1. scibot 09 Apr 2022
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      DOI: 10.1016/j.neo.2022.100785

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    sciencedirect.com/science/article/pii/S1476558622000148
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    Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
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    1. scibot 07 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110634

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    sciencedirect.com/science/article/pii/S2211124722003862
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    Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
    1
    1. scibot 07 Apr 2022
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      DOI: 10.1016/j.str.2022.03.006

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    sciencedirect.com/science/article/pii/S0969212622000879
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction Without Gut Toxicity
    1
    1. scibot 02 Apr 2022
      RRID:AB_561053

      DOI: 10.1158/0008-5472.CAN-21-0524

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    ncbi.nlm.nih.gov/pmc/articles/PMC8488008/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apparent Absence of BMAL1-Dependent Skeletal Muscle–Kidney Cross Talk in Mice
    1
    1. scibot 01 Apr 2022
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      DOI: 10.3390/biom12020261

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    ncbi.nlm.nih.gov/pmc/articles/PMC8961518/
  19. Mar 2022
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    Mucus sialylation determines intestinal host-commensal homeostasis
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    1. scibot 26 Mar 2022
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      DOI: 10.1016/j.cell.2022.02.013

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    sciencedirect.com/science/article/pii/S0092867422001933
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    Peritoneal Restoration by Repurposing Vitamin D Inhibits Ovarian Cancer Dissemination via Blockade of the TGF-β1/Thrombospondin-1 Axis
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    1. scibot 25 Mar 2022
      catalog 2118, CST

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    sciencedirect.com/science/article/pii/S0945053X22000397
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome
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    1. scibot 23 Mar 2022
      RRID:AB_561053

      DOI: 10.1016/j.isci.2022.104001

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    ncbi.nlm.nih.gov/pmc/articles/PMC8927998/
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    Generation of heterozygous (MRli003-A-3) and homozygous (MRli003-A-4) TRPM4 knockout human iPSC lines
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    1. scibot 02 Mar 2022
      RRID:AB_561053

      DOI: 10.1016/j.scr.2022.102731

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    sciencedirect.com/science/article/pii/S1873506122000800
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    Generation of a MSX1 knockout human embryonic stem cell line using CRISPR/Cas9 technology
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    1. scibot 02 Mar 2022
      RRID:AB_561053

      DOI: 10.1016/j.scr.2022.102729

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    sciencedirect.com/science/article/pii/S1873506122000782
  25. Feb 2022
  26. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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    1. scibot 16 Feb 2022
      RRID:AB_561053

      DOI: 10.1016/j.celrep.2022.110395

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    pubmed.ncbi.nlm.nih.gov/35172133/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Attenuation of SARS-CoV-2 Infection by Losartan in Human Kidney Organoids
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    1. scibot 12 Feb 2022
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      DOI: 10.1016/j.isci.2022.103818

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    ncbi.nlm.nih.gov/pmc/articles/PMC8795780/
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    The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
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    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.devcel.2022.01.003

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    sciencedirect.com/science/article/pii/S153458072200003X
  29. www.sciencedirect.com www.sciencedirect.com
    PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP dependent lipid uptake and fatty acid synthesis pathways
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      2118

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    Enhanced immunoprecipitation techniques for the identification of RNA binding protein partners: IGF2BP1 interactions in mammary epithelial cells
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    1. scibot 04 Feb 2022
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      DOI: 10.1016/j.jbc.2022.101649

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    sciencedirect.com/science/article/pii/S0021925822000898
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    Co-adaptor driven assembly of a CUL3 E3 ligase complex
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    1. scibot 04 Feb 2022
      RRID:AB_561053

      DOI: 10.1016/j.molcel.2022.01.004

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    sciencedirect.com/science/article/pii/S1097276522000041
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    Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia
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      DOI: 10.1016/j.isci.2022.103772

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    sciencedirect.com/science/article/pii/S2589004222000426
  33. Jan 2022
  34. www.sciencedirect.com www.sciencedirect.com
    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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      DOI: 10.1016/j.neuron.2021.12.035

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    sciencedirect.com/science/article/pii/S0896627321010904
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    sciencedirect.com/science/article/pii/S2211124722000146
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    PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma
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      RRID:AB_561053

      DOI: 10.1016/j.isci.2021.103725

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    sciencedirect.com/science/article/pii/S2589004221016953
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    Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release
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    sciencedirect.com/science/article/pii/S2211124721017678
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis
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      DOI: 10.7554/eLife.71946

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752091/
  39. 52.53.155.43 52.53.155.43
    en.2019-00132-html.html
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      AB_561053

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    52.53.155.43/557660d1c11b27494adc93fd56191c3d11e841d6/en.2019-00132-html.html
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    Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein
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      2118

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    sciencedirect.com/science/article/pii/S0041008X21004634
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detection of N6-methyladenosine in SARS-CoV-2 RNA by methylated RNA immunoprecipitation sequencing (MeRIP-Seq)
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    1. scibot 05 Jan 2022
      RRID:AB_561053

      DOI: 10.1016/j.xpro.2021.101067

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    ncbi.nlm.nih.gov/pmc/articles/PMC8651518/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    1. scibot 05 Jan 2022
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      DOI: 10.1016/j.ccell.2019.04.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  43. Dec 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Substratum stiffness regulates Erk signaling dynamics through receptor-level control
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      DOI: 10.1016/j.celrep.2021.110181

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    sciencedirect.com/science/article/pii/S2211124721016818
  45. www.nature.com www.nature.com
    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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  57. Nov 2021
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    Effect of Three NR3C1 mutations in Pathogenesis of Pituitary ACTH Adenoma
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    Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution | Arteriosclerosis, Thrombosis, and Vascular Biology
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    TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
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    Silenced ZNF154 Is Associated with Longer Survival in Resectable Pancreatic Cancer
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    Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK
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    Treatment of type 2 diabetes with the designer cytokine IC7Fc
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      GAPDH

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  140. elifesciences.org elifesciences.org
    Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
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    N6-methyladenine DNA Modification in Glioblastoma
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    Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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    The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
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  145. elifesciences.org elifesciences.org
    Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport
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      anti-GAPDH

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  146. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
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    Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA
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  149. academic.oup.com academic.oup.com
    Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation
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  150. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Human Breast Cancer Xenograft Model Implicates Peroxisome Proliferator–activated Receptor Signaling as Driver of Cancer-induced Muscle Fatigue
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    Effects of Prolonged Dietary Curcumin Exposure on Skeletal Muscle Biochemical and Functional Responses of Aged Male Rats
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    BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
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    Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors
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    Fibroblast growth factor 2 regulates activity and gene expression of human post‐mitotic excitatory neurons
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    BMP Signaling Mediated by BMPR1A in Osteoclasts Negatively Regulates Osteoblast Mineralization Through Suppression of Cx43
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    Neuronal VCP loss of function recapitulates FTLD-TDP pathology
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    Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission
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      2118

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    The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease
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    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival
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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy
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    SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1
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  168. Jun 2021
  169. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.
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    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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    Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B
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  173. www.sciencedirect.com www.sciencedirect.com
    Subcellular localization of neuronal nuclei (NeuN) antigen in size and calcitonin gene-related peptide (CGRP) populations of dorsal root ganglion (DRG) neurons during acute peripheral inflammation
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    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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    The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation
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    A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
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    OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
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    DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing
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    The f subunit of human ATP synthase is essential for normal mitochondrial morphology and permeability transition
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    METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection
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    Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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    Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation
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    SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts
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    Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells
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    CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism
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    MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice
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