942 Matching Annotations
  1. Aug 2022
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    Host and microbiome features of secondary infections in lethal covid-19
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    sciencedirect.com/science/article/pii/S2589004222011981
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    Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis
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    sciencedirect.com/science/article/pii/S221112472201021X
  4. Jul 2022
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    AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9309721/
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    Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
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    sciencedirect.com/science/article/pii/S2211124722009305
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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    Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5
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    sciencedirect.com/science/article/pii/S2211124722008658
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    A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase
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    Context-dependent regulation of ferroptosis sensitivity
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    sciencedirect.com/science/article/pii/S2451945622002367
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    Neoadjuvant chemotherapy induces genomic and transcriptomic changes in ovarian cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8936832/
  12. Jun 2022
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    Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice
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    sciencedirect.com/science/article/pii/S2352345X22000972
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    Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    Actions of Parathyroid Hormone Ligand Analogs in Humanized PTH1R Knock-In Mice
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    Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors
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    Supramolecular assembly of GSK3α as a cellular response to amino acid starvation
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    Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion
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    Parsing the role of NSP1 in SARS-CoV-2 infection
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    Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice
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    IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
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    LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
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    YAP1 activation is associated with the progression and response to immunotherapy of non-muscle invasive bladder cancer
    1
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  25. May 2022
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    The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes
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    Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells
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      DOI: 10.1093/humrep/deac112

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    academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deac112/6590738
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    Harnessing cortical plasticity via gabapentinoid administration promotes recovery after stroke
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    academic.oup.com/brain/advance-article/doi/10.1093/brain/awac103/6589844
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    Durable immunogenicity, adaptation to emerging variants and low dose efficacy of AAV-based COVID19 platform in macaques
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    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9
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  31. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide
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    Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs
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    Deconvoluting mechanisms of acquired resistance to RAF inhibitors in BRAF V600E mutant human glioma
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      DOI: 10.1158/1078-0432.CCR-21-2660

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    Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
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    An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress
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    Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells
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    Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding
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    Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue
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  39. Apr 2022
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    Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells
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    PIIS2589004222005594-html.html
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    Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells
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      DOI: 10.1093/carcin/bgac032

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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgac032/6556146
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    A superior loading control for the cellular thermal shift assay
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      DOI: 10.1038/s41598-022-10653-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC9035151/
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    Insights into Ferroptosis: Targeting Glycolysis to Treat Graves’ Orbitopathy
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      DOI: 10.1210/clinem/dgac163

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    academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac163/6550655
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    Hexokinase 1 cellular localization regulates the metabolic fate of glucose
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    Role of Estrogen and Its Receptors in Adipose Tissue Glucose Metabolism in Pre- and Postmenopausal Women
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    Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses
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    Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection
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    Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
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    Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury
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    Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
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    Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
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    Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
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  56. aacrjournals.org aacrjournals.org
    Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction Without Gut Toxicity
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apparent Absence of BMAL1-Dependent Skeletal Muscle–Kidney Cross Talk in Mice
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  58. Mar 2022
  59. www.sciencedirect.com www.sciencedirect.com
    Mucus sialylation determines intestinal host-commensal homeostasis
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    Peritoneal Restoration by Repurposing Vitamin D Inhibits Ovarian Cancer Dissemination via Blockade of the TGF-β1/Thrombospondin-1 Axis
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    Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome
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    Generation of heterozygous (MRli003-A-3) and homozygous (MRli003-A-4) TRPM4 knockout human iPSC lines
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    Generation of a MSX1 knockout human embryonic stem cell line using CRISPR/Cas9 technology
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  64. Feb 2022
  65. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Attenuation of SARS-CoV-2 Infection by Losartan in Human Kidney Organoids
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    The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
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    PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP dependent lipid uptake and fatty acid synthesis pathways
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    Enhanced immunoprecipitation techniques for the identification of RNA binding protein partners: IGF2BP1 interactions in mammary epithelial cells
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    Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia
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  72. Jan 2022
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    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma
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    De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis
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  78. 52.53.155.43 52.53.155.43
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    Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detection of N6-methyladenosine in SARS-CoV-2 RNA by methylated RNA immunoprecipitation sequencing (MeRIP-Seq)
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  82. Dec 2021
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    Substratum stiffness regulates Erk signaling dynamics through receptor-level control
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    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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    Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The spike protein of SARS-CoV-2 virus induces heme oxygenase-1: Pathophysiologic implications
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    Inhibition of TGF-β signaling attenuates disuse-induced trabecular bone loss after spinal cord injury in male mice
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    Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
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    Silenced ZNF154 Is Associated with Longer Survival in Resectable Pancreatic Cancer
    1
    1. scibot 30 Jul 2021
      RRID: AB_561053

      DOI: 10.3390/ijms20215437

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    ncbi.nlm.nih.gov/pmc/articles/PMC6862440/
  177. www.nature.com www.nature.com
    Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK
    1
    1. scibot 30 Jul 2021
      GAPDH

      DOI: 10.1038/s41386-019-0537-y

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    nature.com/articles/s41386-019-0537-y
  178. www.nature.com www.nature.com
    Treatment of type 2 diabetes with the designer cytokine IC7Fc
    1
    1. scibot 30 Jul 2021
      GAPDH

      DOI: 10.1038/s41586-019-1601-9

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    nature.com/articles/s41586-019-1601-9
  179. elifesciences.org elifesciences.org
    Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
    1
    1. scibot 30 Jul 2021
      GAPDH-HRP

      DOI: 10.7554/eLife.47084

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    elifesciences.org/articles/47084
  180. www.sciencedirect.com www.sciencedirect.com
    N6-methyladenine DNA Modification in Glioblastoma
    1
    1. scibot 30 Jul 2021
      RRID:AB_561053

      DOI: 10.1016/j.cell.2018.10.006

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    sciencedirect.com/science/article/pii/S009286741831314X
  181. www.sciencedirect.com www.sciencedirect.com
    Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
    1
    1. scibot 30 Jul 2021
      RRID:AB_561053

      DOI: 10.1016/j.ccell.2018.10.003

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    sciencedirect.com/science/article/pii/S1535610818304690
  182. www.sciencedirect.com www.sciencedirect.com
    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
    1
    1. scibot 30 Jul 2021
      RRID:AB_561053

      DOI: 10.1016/j.cell.2018.09.055

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    sciencedirect.com/science/article/pii/S0092867418313060
  183. www.sciencedirect.com www.sciencedirect.com
    The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
    1
    1. scibot 29 Jul 2021
      RRID: AB_561053

      DOI: 10.1016/j.cell.2019.07.031

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  184. elifesciences.org elifesciences.org
    Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport
    1
    1. scibot 29 Jul 2021
      anti-GAPDH

      DOI: 10.7554/eLife.44752

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  185. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
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      RRID:AB_561053

      DOI: 10.1186/s12964-019-0349-z

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  186. academic.oup.com academic.oup.com
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      RRID:AB_561053

      DOI: 10.1210/en.2018-00853

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    academic.oup.com/endo/article/160/5/1333/5427156
  187. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA
    1
    1. scibot 29 Jul 2021
      RRID:AB_561053

      DOI: 10.1111/jnc.15445

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  188. academic.oup.com academic.oup.com
    Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation
    1
    1. scibot 29 Jul 2021
      RRID:AB_561053

      DOI: 10.1210/en.2018-00105

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    academic.oup.com/endo/article/159/6/2459/4980996
  189. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Human Breast Cancer Xenograft Model Implicates Peroxisome Proliferator–activated Receptor Signaling as Driver of Cancer-induced Muscle Fatigue
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    1. scibot 28 Jul 2021
      AB_561053

      DOI: 10.1158/1078-0432.CCR-18-1565

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  190. www.mdpi.com www.mdpi.com
    Effects of Prolonged Dietary Curcumin Exposure on Skeletal Muscle Biochemical and Functional Responses of Aged Male Rats
    1
    1. scibot 28 Jul 2021
      RRID:AB_561053

      DOI: 10.3390/ijms20051178

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  191. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
    1
    1. scibot 28 Jul 2021
      RRID: AB_561053

      DOI: 10.1186/s12915-018-0617-1

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  192. www.ahajournals.org www.ahajournals.org
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      RRID:AB_561053

      DOI: 10.1161/ATVBAHA.118.310908

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  193. www.jneurosci.org www.jneurosci.org
    Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors
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    1. scibot 27 Jul 2021
      AB_561053

      DOI: 10.1523/JNEUROSCI.1519-16.2016

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    jneurosci.org/content/36/45/11521
  194. www.nature.com www.nature.com
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      RRID:AB_561053

      DOI: 10.1038/s41540-018-0075-y

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  195. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      RRID:AB_10698756

      DOI: 10.1002/jnr.23999

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    onlinelibrary.wiley.com/doi/full/10.1002/jnr.23999
  196. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fibroblast growth factor 2 regulates activity and gene expression of human post‐mitotic excitatory neurons
    1
    1. scibot 27 Jul 2021
      RRID:AB_16422005

      DOI: 10.1111/jnc.14255

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  197. onlinelibrary.wiley.com onlinelibrary.wiley.com
    BMP Signaling Mediated by BMPR1A in Osteoclasts Negatively Regulates Osteoblast Mineralization Through Suppression of Cx43
    1
    1. scibot 27 Jul 2021
      AB_1031003

      DOI: 10.1002/jcb.25746

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    onlinelibrary.wiley.com/doi/10.1002/jcb.25746/full
  198. www.sciencedirect.com www.sciencedirect.com
    Neuronal VCP loss of function recapitulates FTLD-TDP pathology
    1
    1. scibot 22 Jul 2021
      2118

      DOI: 10.1016/j.celrep.2021.109399

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    sciencedirect.com/science/article/pii/S221112472100797X
  199. www.sciencedirect.com www.sciencedirect.com
    Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission
    1
    1. scibot 20 Jul 2021
      2118

      DOI: 10.1016/j.neuropharm.2021.108724

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    sciencedirect.com/science/article/pii/S0028390821002793
  200. www.sciencedirect.com www.sciencedirect.com
    The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease
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    1. scibot 16 Jul 2021
      RRID: AB_561053

      DOI: 10.1016/j.cmet.2021.06.014

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    sciencedirect.com/science/article/pii/S1550413121002849
  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    1. scibot 14 Jul 2021
      RRID:AB_561053

      DOI: 10.1016/j.celrep.2021.109363

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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  202. link.springer.com link.springer.com
    Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival
    1
    1. scibot 10 Jul 2021
      2118

      DOI: 10.1007/s00432-021-03713-4

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    link.springer.com/article/10.1007/s00432-021-03713-4
  203. www.sciencedirect.com www.sciencedirect.com
    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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    1. scibot 09 Jul 2021
      RRID:AB_561053

      DOI: 10.1016/j.molcel.2021.06.016

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  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy
    1
    1. scibot 08 Jul 2021
      RRID:AB_561053

      DOI: 10.7554/eLife.66582

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    ncbi.nlm.nih.gov/pmc/articles/PMC8245133/
  205. www.sciencedirect.com www.sciencedirect.com
    SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
    1
    1. scibot 07 Jul 2021
      RRID:AB_561053

      DOI: 10.1016/j.molcel.2021.06.003

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  206. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1
    1
    1. scibot 03 Jul 2021
      RRID:AB_561053

      DOI: 10.7554/eLife.67123

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  207. Jun 2021
  208. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.
    1
    1. scibot 29 Jun 2021
      RRID:AB_561053

      DOI: 10.1158/2159-8290.CD-20-0797

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  209. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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    1. scibot 29 Jun 2021
      RRID:AB_561053

      DOI: 10.1158/1078-0432.CCR-20-3365

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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation
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      RRID:AB_561053

      DOI: 10.1016/j.isci.2021.102660

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    ncbi.nlm.nih.gov/pmc/articles/PMC8209278/
  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B
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      RRID:AB_561053

      DOI: 10.7554/eLife.67452

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  212. www.sciencedirect.com www.sciencedirect.com
    Subcellular localization of neuronal nuclei (NeuN) antigen in size and calcitonin gene-related peptide (CGRP) populations of dorsal root ganglion (DRG) neurons during acute peripheral inflammation
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    1. scibot 23 Jun 2021
      RRID:AB_561053

      DOI: 10.1016/j.neulet.2021.135974

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    sciencedirect.com/science/article/pii/S0304394021003529
  213. www.sciencedirect.com www.sciencedirect.com
    Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
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    1. scibot 23 Jun 2021
      RRID:AB_561053

      DOI: 10.1016/j.celrep.2021.109280

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