1,696 Matching Annotations
  1. Sep 2024
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    Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification
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    sciencedirect.com/science/article/pii/S1534580724004908
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    SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing
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    sciencedirect.com/science/article/pii/S0167488924001848
  4. Aug 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11347596/
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    Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping
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    ncbi.nlm.nih.gov/pmc/articles/PMC11312450/
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    Tumoral Interferon Beta Induces an Immune-Stimulatory Phenotype in Tumor-Associated Macrophages in Melanoma Brain Metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC11337092/
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    Rhythms in lipid droplet content driven by a metabolic oscillator are conserved throughout evolution
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    ncbi.nlm.nih.gov/pmc/articles/PMC11335272/
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    Defective CFTR modulates mechanosensitive channels TRPV4 and PIEZO1 and drives endothelial barrier failure
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    ncbi.nlm.nih.gov/pmc/articles/PMC11382128/
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    Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11323502/
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    A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs
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    Satellite cell-derived TRIM28 is pivotal for mechanical load- and injury-induced myogenesis
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    embopress.org/doi/10.1038/s44319-024-00227-1
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    MMP9 drives ferroptosis by regulating GPX4 and iron signaling
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    Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies
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    TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer
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    Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway
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    A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis
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    Biodegradable silica nanoparticles for efficient linear DNA gene delivery
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    SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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    SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia
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    Subcellular Redox Responses Reveal Different Cu-dependent Antioxidant Defenses between Mitochondria and Cytosol
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    Adeno-Associated Vector-Delivered CRISPR/SaCas9 System Reduces Feline Leukemia Virus Production In Vitro
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    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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    Petrol Note in Riesling – 1,1,6-Trimethyl-1,2-dihydronaphthalene (TDN) Selectively Activates Human Odorant Receptor OR8H1
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    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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  31. Jul 2024
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    Application of bioluminescence resonance energy transfer assays in primary mouse neuronal cultures
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    Glutathione overproduction mediates lymphoma initiating cells survival and has a sex-dependent effect on lymphomagenesis
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    Presymptomatic Targeted Circuit Manipulation for Ameliorating Huntington’s Disease Pathogenesis
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    biorxiv.org/content/10.1101/2024.07.24.604946v1
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    ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome
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    Structural insights into an atypical histone binding mechanism by a PHD finger
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    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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    Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1–SNAI1 axis
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    ‘Radical’ differences between two FLIM microscopes affect interpretation of cell signaling dynamics
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    Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures
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    MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway
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    Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge
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    Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling
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    SART3 reads methylarginine-marked glycine- and arginine-rich motifs
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    Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity
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    Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding
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    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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    Assembly and activation of EBV latent membrane protein 1
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    Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma
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    Evidence for low affinity of GABA at the vesicular monoamine transporter VMAT2 – implications for transmitter co-release from dopamine neurons
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    Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution
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    A mammalian model reveals inorganic polyphosphate channeling into the nucleolus and induction of a hyper-condensate state
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    ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins
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    The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors
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    Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity
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    Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.
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    Original research: IFNγ mediates the resistance of tumor cells to distinct NK cell subsets
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    Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation
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  62. Jun 2024
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    Enhancing structural diversity through chemical engineering of Ambrosia tenuifolia extract for novel anti-glioblastoma compounds
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    Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs
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    Mutant dominant-negative rhodopsin ∆I256 causes protein aggregates degraded via ERAD and prevents normal rhodopsin from proper membrane trafficking
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    The Exocyst Complex is Required for the Trafficking and Delivery of KCa3.1 to the Basolateral Membrane of Polarized Epithelia
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    ANGPTL4 Stabilizes Bone Morphogenetic Protein 7 Through Deubiquitination and Promotes HCC Proliferation via the SMAD/MAPK Pathway
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    Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule
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    Camelid-derived Tcell engagers harnessing human γδ T cells as promising antitumor immunotherapeutic agents
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    Bacillamide D produced by Bacillus cereus from the mouse intestinal bacterial collection (miBC) is a potent cytotoxin in vitro
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  74. May 2024
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    Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells
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    Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor
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    Epithelial-to-mesenchymal transition and NF-kB pathways are promoted by a mutant form of DDB2, unable to bind PCNA, in UV-damaged human cells
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    Normal vision and development in mice with low functional expression of Kir7.1 in heterozygosis for a blindness-producing mutation inactivating the channel
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    Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection
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    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    Autophagy preferentially degrades non-fibrillar polyQ aggregates
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    Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor
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    Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer
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