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4,612 Matching Annotations

May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetic Screen in a Pre-Clinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities

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1. scibot 20 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1158/1078-0432.CCR-24-1238
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11530313/
52.53.155.43 52.53.155.43

PDF-html.html

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  RRID:CVCL_0063
  
  DOI: 10.1158/0008-5472.can-24-3844
  
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52.53.155.43/0976643c3f79ff08c8e38df9c7b0ed5aea42f921/PDF-html.html
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Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration

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1. scibot 20 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1158/0008-5472.CAN-24-2220
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
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Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

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1. scibot 20 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1158/0008-5472.CAN-24-1388
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11534540/
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Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer

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1. scibot 20 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1126/sciadv.adu0847
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12017310/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Proteomics Analysis of the TDP-43 Interactome in Cellular Models of ALS Pathogenesis

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1. scibot 20 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1111/jnc.70079
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70079
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FEBS Press

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  RRID:CVCL_0063
  
  DOI: 10.1111/febs.70119
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70119
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FEBS Press

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  RRID:CVCL_0063
  
  DOI: 10.1111/febs.70117
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70117
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Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans

1
1. scibot 20 May 2025
  
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  CVCL_0063
  
  DOI: 10.1101/2025.04.01.25324926
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11998800/
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FAT1 Enhances the Sensitivity of Non-Small Cell Lung Cancer to VCP Inhibitors by Regulating the Activation of the Endoplasmic Reticulum Stress Pathway

1
1. scibot 19 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1096/fj.202500097RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500097RR
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MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

1
1. scibot 19 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1084/jem.20240959
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11572484/
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CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection

1
1. scibot 19 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1038/s41598-025-98294-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12032137/
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NAC guides a ribosomal multienzyme complex for nascent protein processing

1
1. scibot 19 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1038/s41586-024-07846-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12039536/
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An acetylated lysine residue of its low-glucose inhibitory domain controls activity and protein interactions of ChREBP

1
1. scibot 18 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.jmb.2025.169189
  
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sciencedirect.com/science/article/pii/S0022283625002554
journals.plos.org journals.plos.org

The impact of fatty acid synthase on HSV-1 infection dynamics

1
1. scibot 17 May 2025
  
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  CRL-3216
  
  DOI: 10.1371/journal.ppat.1013068
  
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journals.plos.org/plospathogens/article
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Integrative characterization of MYC RNA-binding function

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1. scibot 17 May 2025
  
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  RRID: CVCL_0063
  
  DOI: 10.1016/j.xgen.2025.100878
  
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sciencedirect.com/science/article/pii/S2666979X2500134X
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CD38 contributes to tumor progression and tumor microenvironment reshaping in epithelial ovarian cancer

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1. scibot 17 May 2025
  
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  RRID: CVCL_0063
  
  DOI: 10.1016/j.tranon.2025.102414
  
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sciencedirect.com/science/article/pii/S1936523325001457
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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

1
1. scibot 17 May 2025
  
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  ATCCCRL-3216
  
  DOI: 10.1016/j.celrep.2025.115728
  
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sciencedirect.com/science/article/pii/S2211124725004991
www.thelancet.com www.thelancet.com

An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primates

1
1. scibot 17 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.ebiom.2025.105748
  
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thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00192-6/abstract
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Generation of T cell responses against broad KRAS hotspot neoantigens for cell therapy or TCR discovery

1
1. scibot 17 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.crmeth.2025.101049
  
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sciencedirect.com/science/article/pii/S2667237525000852
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Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells

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1. scibot 17 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.cels.2025.101269
  
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sciencedirect.com/science/article/pii/S2405471225001024
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A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons

1
1. scibot 17 May 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.celrep.2025.115695
  
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sciencedirect.com/science/article/pii/S2211124725004668
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system

1
1. scibot 16 May 2025
  
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  CRL-3216
  
  DOI: 10.1128/spectrum.01557-24
  
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  Curator: @evieth
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12054171/
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 16 May 2025
  
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  Cat# CRL-3216
  
  DOI: 10.1101/2025.04.25.650690
  
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52.53.155.43/62595e6b23df6e98095e7fa4f69bad3f98465b54/PDF-html.html
www.biorxiv.org www.biorxiv.org

Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNA

1
1. scibot 16 May 2025
  
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  CRL-3216
  
  DOI: 10.1101/2025.04.24.650501
  
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biorxiv.org/content/10.1101/2025.04.24.650501v1
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Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia

1
1. scibot 16 May 2025
  
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  CRL-3216
  
  DOI: 10.1101/2025.04.23.650120
  
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biorxiv.org/content/10.1101/2025.04.23.650120v1
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ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression

1
1. scibot 16 May 2025
  
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  ATCC, CRL-3216
  
  DOI: 10.1038/s41556-025-01651-8
  
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  Curator: @dhovakimyan1
  
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nature.com/articles/s41556-025-01651-8
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A distinctive IGHV3-66 SARS-CoV-2 neutralizing antibody elicited by primary infection with an Omicron variant

1
1. scibot 16 May 2025
  
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  ATCCCat# CRL-3216
  
  DOI: 10.1016/j.str.2025.04.005
  
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sciencedirect.com/science/article/pii/S096921262500139X
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DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation

1
1. scibot 16 May 2025
  
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  ATCCCRL-3216
  
  DOI: 10.1016/j.molcel.2025.04.019
  
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sciencedirect.com/science/article/pii/S1097276525003612
52.53.155.43 52.53.155.43

1-s2.0-S258900422500882X-main-html.html

1
1. scibot 16 May 2025
  
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  ATCC Cat#CRL-3216
  
  DOI: 10.1016/j.isci.2025.112621
  
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52.53.155.43/4676d174b07a3f5022e6b0e38316e8a0b94412f8/1-s2.0-S258900422500882X-main-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

1-s2.0-S258900422500879X-main-html.html

2
1. scibot 16 May 2025
  
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  CRL-3216
  
  DOI: 10.1016/j.isci.2025.112618
  
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  Curator: @sjvitug
  
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2. scibot 16 May 2025
  
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  ATCC Cat# CRL-3216
  
  DOI: 10.1016/j.isci.2025.112618
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12152665/
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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

1
1. scibot 16 May 2025
  
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  ATCCCat# CRL-3216
  
  DOI: 10.1016/j.immuni.2025.04.020
  
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sciencedirect.com/science/article/pii/S1074761325001839
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Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease

1
1. scibot 16 May 2025
  
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  ATCCCRL-3216
  
  DOI: 10.1016/j.immuni.2025.04.018
  
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sciencedirect.com/science/article/pii/S1074761325001815
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Somatic hypermutation unlocks antibody specificities beyond the primary repertoire

1
1. scibot 16 May 2025
  
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  ATCCCat# CRL-3216
  
  DOI: 10.1016/j.immuni.2025.04.014
  
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sciencedirect.com/science/article/pii/S1074761325001773
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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer

1
1. scibot 16 May 2025
  
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  ATCCCat#CRL-3216
  
  DOI: 10.1016/j.immuni.2025.04.010
  
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sciencedirect.com/science/article/pii/S1074761325001736
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Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells

1
1. scibot 16 May 2025
  
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  ATCCCRL-3216
  
  DOI: 10.1016/j.devcel.2025.04.005
  
  Resource: (RRID:CVCL_0063)
  
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sciencedirect.com/science/article/pii/S1534580725002072
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Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

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  ATCCCRL-3216
  
  DOI: 10.1016/j.celrep.2025.115657
  
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The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions

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EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes

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  ATCCCat# CRL-3216
  
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Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses

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ERBB4 selectively amplifies TGF-β pro-metastatic responses

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The structure of human sweetness

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tRNA modifications tune m6A-dependent mRNA decay

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RNA polymerase II partitioning is a shared feature of diverse oncofusion condensates

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The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism

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Antibody evasiveness of SARS-CoV-2 subvariants KP.3.1.1 and XEC

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Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors

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SLC7A11 is an unconventional H+ transporter in lysosomes

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Oncogenic HNF4α inhibits ferroptotic cell death through activating SLC7A11 by recruiting p300/CBP in breast cancer

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Article PDF-html.html

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Human-specific genomic evolution of a regulatory network enables fine-tuning of N-cadherin gene expression

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GREM1 deficiency induced bone marrow adipose niche promotes B-cell acute lymphoblastic leukemia disease progression

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PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia

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FGFR2 residence in primary cilia is necessary for epithelial cell signaling

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Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness

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  DOI: 10.1016/j.neuron.2025.03.023
  
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Aberrant phase separation drives membranous organelle remodeling and tumorigenesis

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  ATCCCat# CRL3216
  
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ZBP1 senses splicing aberration through Z-RNA to promote cell death

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Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction

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Joint analysis of chromatin accessibility and gene expression in the same single cells reveals cancer-specific regulatory programs

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KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway

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Reprogramming liver metastasis-associated macrophages toward an anti-tumoral phenotype through enforced miR-342 expression

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Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

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Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s disease

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The ectodomain sheddase ADAM10 restricts HIV-1 propagation and is counteracted by Nef

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  DOI: 10.1126/sciadv.adt1836
  
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Molecular Mechanisms of Propofol-Induced Cognitive Impairment: Suppression of Critical Hippocampal Pathways

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PDZK1 inhibits MRP2-mediated oxaliplatin chemosensitivity in hepatocellular carcinoma

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Oncolytic virotherapy provides a potent therapy option for squamous bladder cancer

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Targeted demethylation of the EphA7 promoter inhibits tumorigenesis via the SP1/DNMT1 and PI3K/AKT axes and improves the response to multiple therapies in cervical cancer

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ARID3A inhibits colorectal cancer cell stemness and drug-resistance by targeting a multitude of stemness-associated genes

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SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases

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rational-design-and-development-of-selective-brd7-bromodomain-inhibitors-and-their-activity-in-prostate-cancer-html.html

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CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms

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The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

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  ATCCCat# CRL-3216
  
  DOI: 10.1016/j.celrep.2025.115605
  
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sciencedirect.com/science/article/pii/S2211124725003766
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RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity

1
1. scibot 19 Apr 2025
  
  in Public
  
  Riken Cell BankRCB2202
  
  DOI: 10.1016/j.celrep.2025.115599
  
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CD36-mediated endocytosis of proteolysis-targeting chimeras

1
1. scibot 19 Apr 2025
  
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  ATCCCat# CRL-3216
  
  DOI: 10.1016/j.cell.2025.03.036
  
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A Silicon Rhodamine‐fused Glibenclamide to Label and Detect Malaria‐infected Red Blood Cells

1
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  RRID:CVCL 0063
  
  DOI: 10.1002/cbic.202400628
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12002102/
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Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

1
1. scibot 19 Apr 2025
  
  in Public
  
  RRID:CVCL_0063
  
  DOI: 10.7554/eLife.95347
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12002794/
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HER2 antibody-drug conjugates are active against desmoplastic small round cell tumor

1
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  RRID:CVCL_0063
  
  DOI: 10.1158/1078-0432.CCR-24-1835
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11479846/
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Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity

1
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  RRID:CVCL_0063
  
  DOI: 10.1158/0008-5472.CAN-23-4022
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11997551/
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METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation

1
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  RRID:CVCL_0063
  
  DOI: 10.1136/jitc-2024-011108
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12001370/
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
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  RRID:CVCL_0063
  
  DOI: 10.1111/febs.70099
  
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Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

1
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  RRID:CVCL_0063
  
  DOI: 10.1111/febs.17407
  
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CKAP5 deficiency induces premature ovarian insufficiency

1
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  RRID:CVCL_0063
  
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Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production

1
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  RRID:CVCL_0063
  
  DOI: 10.1038/s44319-025-00388-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11977235/
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1-s2.0-S2589004225006480-main-html.html

2
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.isci.2025.112387
  
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A competition network connects Rab5 and Rab11 GTPases at the surface of endocytic structures

1
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.isci.2025.112170
  
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Loss of UCHL1 Leads to Enhanced Mouse Osteoclast Formation

1
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  RRID:CVCL_0063
  
  DOI: 10.1002/jcp.70032
  
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onlinelibrary.wiley.com/doi/10.1002/jcp.70032
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Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer

1
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  RRID:CVCL_0063
  
  DOI: 10.1002/2211-5463.70022
  
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febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.70022
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BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain

1
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  RRID:ACC-635
  
  DOI: 10.3389/fphar.2025.1575733
  
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Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype

1
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  RRID:CVCL_0063
  
  DOI: 10.1186/s13062-025-00623-0
  
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Exploring B7-H4’s Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities

1
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  RRID:CVCL_0063
  
  DOI: 10.1158/1541-7786.MCR-24-0958
  
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aacrjournals.org/mcr/article/23/4/327/754237/Exploring-B7-H4-s-Role-in-Prostate-Cancer-Dormancy
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Breast Cancer Subtype-Specific Organotropism is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery

1
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  RRID:CVCL_0063
  
  DOI: 10.1158/0008-5472.CAN-24-0479
  
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aacrjournals.org/cancerres/article/85/4/644/751430/Breast-Cancer-Subtype-Specific-Organotropism-Is
52.53.155.43 52.53.155.43

1-s2.0-S2589004225006923-main-html.html

1
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.isci.2025.112431
  
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52.53.155.43 52.53.155.43

1-s2.0-S2589004225006649-main-html.html

1
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  CVCL_0063
  
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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells

1
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  RRID:CVCL_0063
  
  DOI: 10.1007/s13402-025-01055-8
  
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SRPK1 Activation Facilitates Gli3S664 Phosphorylation and Promotes Metastasis in Esophageal Squamous Cell Carcinoma

1
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  RRID:CVCL_0063
  
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Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis

1
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  RRID:CVCL:0063
  
  DOI: 10.1038/s41420-025-02475-z
  
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Gonadotropin-releasing hormone regulates transcription of the inhibin B co-receptor, TGFBR3L, via early growth response one

1
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.jbc.2025.108405
  
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Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

1
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.cell.2025.03.017
  
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52.53.155.43 52.53.155.43

PDF-html.html

1
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  RRID:CVCL_0063
  
  DOI: 10.1158/1078-0432.ccr-24-4024
  
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52.53.155.43/bea453311b69bdd211b414284d8c5a68ab7fa2b9/PDF-html.html
52.53.155.43 52.53.155.43

PDF-html.html

1
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  DOI: 10.1158/0008-5472.can-24-3481
  
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52.53.155.43/4e618aba3cd65bbf93907d966435a11f880c620c/PDF-html.html
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TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

1
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  RRID:CVCL_0063
  
  DOI: 10.1101/2025.04.07.647605
  
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1-s2.0-S2589004225006479-main-html.html

2
1. scibot 12 Apr 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.isci.2025.112386
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.isci.2025.112386
  
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52.53.155.43 52.53.155.43

Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma

1
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  ATCC CRL-3216
  
  DOI: 10.1101/2024.10.22.617161
  
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52.53.155.43/5480965c1766ce5dc1f2ceec9f18c523a1b9a8ab/2024.10.22.617161.full-html.html
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Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence

1
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.cels.2025.101260
  
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FEBS Press

1
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  RRID:CVCL_0063
  
  DOI: 10.1002/1873-3468.70041
  
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A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide

1
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  ATCC, #CRL-3216
  
  DOI: 10.1038/s41467-025-58690-w
  
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Engineered nucleocytosolic vehicles for loading of programmable editors

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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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Transcriptional conservation and evolutionary divergence of cell types across mammalian hypothalamus development

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Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage

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Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus

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PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

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ARHGAP12 suppresses F-actin assembly to control epithelial tight junction mechanics and paracellular leak pathway permeability

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THE ADORA1 MUTATION LINKED TO EARLY-ONSET PARKINSON’S DISEASE ALTERS ADENOSINE A1-A2A RECEPTOR HETEROMER FORMATION AND FUNCTION

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LNS8801: An Enantiomerically Pure Agonist of the G Protein–Coupled Estrogen Receptor Suitable for Clinical Development

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Bright and photostable yellow fluorescent proteins for extended imaging

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Harmine promotes axon regeneration through enhancing glucose metabolism

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Entry Efficiency, Protease Dependence, and Antibody-Mediated Neutralization of SARS-CoV-2 Sublineages KP.3.1.1 and XEC

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A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance

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Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

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An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation

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Molecular basis for the increased fusion activity of the Ebola virus glycoprotein epidemic variant A82V: Insights from simulations and experiments

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Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion

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The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation

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RAF1 kinase contributes to autophagic lysosome reformation

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Molecular basis for shifted receptor recognition by an encephalitic arbovirus

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Structural basis for plasticity in receptor engagement by an encephalitic alphavirus

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PRDM1 Is a Key Regulator of the NKT-cell Central Memory Program and Effector Function

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The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis

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Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer

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FEBS Press

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Tuning In Vitro Cytotoxicity in Diruthenium(I) bis-Cyclopentadienyl Complexes

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Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

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Engineering sonogenetic EchoBack-CAR T cells

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Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage

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Mitochondrial fatty acid oxidation as the target for blocking therapy-resistance and inhibiting tumor recurrence: The proof-of-principle model demonstrated for ovarian cancer cells

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The severity of SLC1A2-associated neurodevelopmental disorders correlates with transporter dysfunction

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A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein

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S-ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide-Induced Depression Via Targeting SIRT2

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Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope

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Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

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PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation

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Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP

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SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity

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Global analysis of protein turnover dynamics in single cells

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Diverse priming outcomes under conditions of very rare precursor B cells

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A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions

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The role of TRPV4 in acute sleep deprivation-induced memory impairment: mechanisms of calcium dysregulation and synaptic plasticity disruption

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PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

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The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2

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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection

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SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response

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Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma

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Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus

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Identification of a new micropeptide altKLF4 derived from KLF4 that influences myeloma chemotherapeutic sensitivity

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Involvement of microRNAs-449/FASN axis in response to trastuzumab therapy in HER2-positive breast cancer

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Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

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SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force

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Translation dysregulation in cancer as a source for targetable antigens

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High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase

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Orchestration of pluripotent stem cell genome reactivation during mitotic exit

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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

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In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer

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The non-catalytic ε DNA polymerase subunit is an NPF motif recognition protein

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Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex

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Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria

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FEBS Press

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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity

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  CRL-3216
  
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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

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  RRID:CVCL_0063
  
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Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3-LPL Axis

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Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells

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The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies

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Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to Kif18a Inhibition

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  CVCL_0063
  
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Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo

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Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming

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Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity

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m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice

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