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Mar 2025
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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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1. scibot 24 Mar 2025
  
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  DOI: 10.1101/2025.03.18.644053
  
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  DOI: 10.1158/1055-9965.epi-24-1833
  
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Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

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1. scibot 24 Mar 2025
  
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  DOI: 10.1093/nar/gkaf200
  
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academic.oup.com/nar/article/53/6/gkaf200/8089753
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The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

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pmc.ncbi.nlm.nih.gov/articles/PMC11870510/
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Safety and Efficacy of Copanlisib in Combination with Nivolumab: A Phase Ib Study in Patients with Advanced Solid Tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC11907410/
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m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice

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  DOI: 10.1016/j.stem.2025.02.011
  
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sciencedirect.com/science/article/pii/S1934590925000797
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Sequential transitions of male sexual behaviors driven by dual acetylcholine-dopamine dynamics

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  DOI: 10.1016/j.neuron.2025.01.032
  
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Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling

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  DOI: 10.1016/j.cmet.2025.02.007
  
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sciencedirect.com/science/article/pii/S1550413125000658
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Long-term CSF responses in adult patients with spinal muscular atrophy type 2 or 3 on treatment with nusinersen

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1. scibot 20 Mar 2025
  
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  DOI: 10.1007/s00415-025-12984-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11909034/
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Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial

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1. scibot 19 Mar 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11911804/
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Oscillatory control over representational geometry of sequence working memory in macaque frontal cortex

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1. scibot 14 Mar 2025
  
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  DOI: 10.1016/j.cub.2025.02.031
  
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sciencedirect.com/science/article/pii/S0960982225001940
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Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

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1. scibot 14 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.018
  
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sciencedirect.com/science/article/pii/S1535610825000704
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Identification of early genes in the pathophysiology of fibrotic interstitial lung disease in a new model of pulmonary fibrosis

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1. scibot 14 Mar 2025
  
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  DOI: 10.1007/s00018-025-05620-0
  
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link.springer.com/article/10.1007/s00018-025-05620-0
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Modular Arrangement of Synaptic and Intrinsic Homeostatic Plasticity within Visual Cortical Circuits

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1. scibot 13 Mar 2025
  
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  DOI: 10.1101/2024.06.01.596982
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11160741/
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Age of tobacco smoking initiation among Iranian adults based on National and Subnational data from the 2021 STEPS survey

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1. scibot 13 Mar 2025
  
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  DOI: 10.1038/s41598-025-86675-8
  
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1-s2.0-S2589004225004274-main-html.html

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1. scibot 13 Mar 2025
  
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  DOI: 10.1016/j.isci.2025.112166
  
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LTA4H improves the tumor microenvironment and prevents HCC progression via targeting the HNRNPA1/LTBP1/TGF-β axis

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.102000
  
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Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects

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1. scibot 08 Mar 2025
  
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  DOI: 10.7554/eLife.97649
  
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Beyond self-reports: serum cotinine reveals sex-and age-related differences of smoking on all-cause and disease-specific mortality

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1. scibot 08 Mar 2025
  
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  DOI: 10.3389/fpubh.2025.1512603
  
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Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics

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1. scibot 07 Mar 2025
  
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  DOI: 10.1101/2025.02.28.640749
  
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  DOI: 10.1101/2025.02.28.640749
  
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A modified decontamination and storage method for sputum from patients with tuberculosis

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pmc.ncbi.nlm.nih.gov/articles/PMC11358684/
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Acetalax and Bisacodyl for the Treatment of Triple-Negative Breast Cancer: A Combined Molecular and Preclinical Study

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  DOI: 10.1158/2767-9764.CRC-24-0435
  
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Benchmarking short-read metagenomics tools for removing host contamination

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1. scibot 07 Mar 2025
  
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  DOI: 10.1093/gigascience/giaf004
  
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academic.oup.com/gigascience/article/doi/10.1093/gigascience/giaf004/8045180
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PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain

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  DOI: 10.1016/j.celrep.2025.115405
  
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sciencedirect.com/science/article/pii/S2211124725001767
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Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner

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  DOI: 10.7554/eLife.94924
  
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Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

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elifesciences.org/reviewed-preprints/101035
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Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice

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  DOI: 10.1016/j.isci.2025.112031
  
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snRNA-seq analysis of the moss Physcomitrium patens identifies a conserved cytokinin-ESR module promoting pluripotent stem cell identity

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Evaluating the Radiation Sensitivity Index and 12-Chemokine Gene Expression Signature for Clinical Use in a CLIA Laboratory

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  DOI: 10.1158/2767-9764.CRC-24-0534
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11873780/
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Surgery-induced reduction in inflammation relates to improved neural inhibitory control in obesity

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  DOI: 10.1101/2025.02.21.25322626
  
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medrxiv.org/content/10.1101/2025.02.21.25322626v1
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Nivolumab combined with induction chemotherapy and radiotherapy in nasopharyngeal carcinoma: A multicenter phase 2 PLATINUM trial

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  DOI: 10.1016/j.ccell.2025.01.014
  
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sciencedirect.com/science/article/pii/S1535610825000327
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Geospatial evaluation of San Francisco, California’s homeless encampment sweeps injunction

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1. scibot 27 Feb 2025
  
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  DOI: 10.3389/fpubh.2025.1516105
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11835865/
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PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma

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1. scibot 27 Feb 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0515
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11836641/
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Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia

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1. scibot 27 Feb 2025
  
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  DOI: 10.1101/2025.01.21.25320683
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838931/
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Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation

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1. scibot 27 Feb 2025
  
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Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

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The Complexly Parcellated, Yet Quantitatively Reduced, Orexinergic/Hypocretinergic System of Humans

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Co-evolution of atypical BRAF and KRAS mutations in colorectal tumorigenesis

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Distinctive physiology of molecularly identified medium spiny neurons in the macaque putamen

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Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants

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Systems immunology analysis of human immune organoids identifies host-specific correlates of protection to different influenza vaccines

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The impact of air pollution on sperm DNA methylation

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Dietary availability acutely influences puberty onset via a hypothalamic neural circuit

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KAT6B overexpression in mice causes aggression, anxiety, and epilepsy

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Cardiac structure and function 1.5 years after COVID-19: results from the EPILOC study

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Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

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The effect of fasting on human memory consolidation

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Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions restricts epithelial permeability in Drosophila

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Mathematically mapping the network of cells in the tumor microenvironment

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Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation

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Atypical hippocampal excitatory neurons express and govern object memory

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Risk Factors for Early Onset Sporadic Colorectal Cancer in Male Veterans

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Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis mediated epithelial-mesenchymal transition

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ccr-24-2611-html.html

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YAP1 suppression by ZDHHC7 is associated with ferroptosis resistance and poor prognosis in ovarian clear cell carcinoma

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Predictive and dynamic signature for anti-angiogenics in combination with PD-1 inhibitor in soft-tissue sarcoma: correlative studies linked to the IMMUNOSARC trial

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Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis

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Hepatocellular Carcinoma Immune Microenvironment Analysis: A Comprehensive Assessment with Computational and Classical Pathology

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Intraperitoneal Nivolumab After Debulking Surgery and Hyperthermic Intraperitoneal Chemotherapy in Advanced Ovarian Cancer: A Phase I Study with Expansion Cohort

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The innate immune landscape of dMMR/MSI cancers predicts outcome of nivolumab treatment: results from the Drug Rediscovery Protocol

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The Tumour Immune Microenvironment Drives Survival Outcomes and Therapeutic Response in an Integrated Molecular Analysis of Gastric Adenocarcinoma

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Radiodensities of skeletal muscle and visceral adipose tissues are prognostic factors in clear cell renal cell carcinoma

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Arginine methylation of DDX3 by PRMT1 mediates mitochondrial homeostasis to promote breast cancer metastasis

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The DNA methyltransferase inhibitor 5-aza-4’-thio-2’-deoxycytidine induces C>G transversions and acute lymphoid leukemia development

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Basal T cell activation predicts yellow fever vaccine response independently of cytomegalovirus infection and sex-related immune variations

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Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy

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Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology

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Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage

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Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer

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Single-molecule m6A detection empowered by endogenous labeling unveils complexities across RNA isoforms

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Advancing the Indian cattle pangenome: characterizing non-reference sequences in Bos indicus

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Single-cell sequencing provides clues about the developmental genetic basis of evolutionary adaptations in syngnathid fishes

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Linking citation and retraction data reveals the demographics of scientific retractions among highly cited authors

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Microglial plasticity governed by state-specific enhancer landscapes

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Alcohol induces long-lasting sleep deficits in Drosophila via subsets of cholinergic neurons

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Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation

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Decoding sound content in the early visual cortex of aphantasic participants

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Deterministic genetic barcoding for multiplexed behavioral and single-cell transcriptomic studies

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A developmental atlas of mouse vestibular-like inner ear organoids

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Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids

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A Cost-Effective Two-Step Approach for Multi-Cancer Early Detection in High-Risk Populations

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A chromosome-scale genome assembly of the pioneer plant Stylosanthes angustifolia: insights into genome evolution and drought adaptation

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Prevalence, comorbidities, and disease-related complications of rheumatoid arthritis in Colombia: a national cross-sectional study based on administrative claims data

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Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision

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Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions

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Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation

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Natural killer cell–mediated cytotoxicity shapes the clonal evolution of B cell leukaemia

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Cancer Prevalence across Vertebrates

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Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies

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Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity

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Ancestry-specific gene expression in peripheral monocytes mediates risk of neurodegenerative disease

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The development of social attention in orangutans: Comparing peering behavior in wild and zoo-housed individuals

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Influence of interoception and body movement on the rubber hand illusion

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Activation of ionotropic and group I metabotropic glutamate receptors stimulates kisspeptin neuron activity in mice

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Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes

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KDM6B-dependent epigenetic programming of uterine fibroblasts in early pregnancy regulates parturition timing in mice

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Assessing the Risks of Potential Pathogens and Antibiotic Resistance Genes Among Heterogeneous Habitats in a Temperate Estuary Wetland: a Meta-analysis

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The Lateral Habenula Is Necessary for Maternal Behavior in the Naturally Parturient Primiparous Mouse Dam

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Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury

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The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer

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Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis

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A practical distribution pattern of α-SMA-positive carcinoma associated fibroblasts indicates poor prognosis of patients with pancreatic ductal adenocarcinoma

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Proteomic patterns associated with ketamine response in major depressive disorders

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Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer

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Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses

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Exploring the Role of Ccn3 in Type III Cell of Mice Taste Buds

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The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model

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A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

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Changes in Skin Cancer-Related Behaviors, Distress, and Beliefs in Response to Receipt of Low- to Moderate-Penetrance Genetic Test Results for Skin Cancer Risk

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Cerebellar transcranial AC stimulation produces a frequency-dependent bimodal cerebellar output pattern

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Personalized Medicine in Acromegaly: The ACROFAST Study

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Early‐life IL‐4 administration induces long‐term changes in microglia in the cerebellum and prefrontal cortex

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The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: Implications for deep space missions, female crews, and potential antioxidant countermeasures

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Light‐exercise‐induced dopaminergic and noradrenergic stimulation in the dorsal hippocampus: Using a rat physiological exercise model

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Development of two machine learning models to predict conversion from primary HER2-0 breast cancer to HER2-low metastases: a proof-of-concept study

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The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis

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can-24-2450-html.html

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Hormone-responsive progenitors have a unique identity and exhibit high motility during mammary morphogenesis

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Burden of Antimicrobial Resistance in Adult Hospitalized Patients With Cancer: A Multicenter Analysis

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Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients

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A Circuit for Integration of Head- and Visual-Motion Signals in Layer 6 of Mouse Primary Visual Cortex

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Mitochondrial Alterations in Alzheimer’s Disease: Insight from the 5xFAD Mouse Model

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Sophisticated perspective-takers are distinctive: Neural idiosyncrasy of functional connectivity in the mentalizing network

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Genomic insights into Neolithic founding paternal lineages around the Qinghai-Xizang Plateau using integrated YanHuang resource

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A cross-cohort study identifies potential oral microbial markers for esophageal squamous cell carcinoma

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Pharmacometabolomics via real-time breath analysis captures metabotypes of asthmatic children associated with salbutamol responsiveness

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Language-specific representation of emotion-concept knowledge causally supports emotion inference

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Intrinsically robust and scalable biofilm segmentation under diverse physical growth conditions

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Between-movie variability severely limits generalizability of “naturalistic” neuroimaging

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SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

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Maintenance pembrolizumab therapy in patients with metastatic HER2-negative breast cancer with prior response to chemotherapy

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Association of Tumor Mutational Burden and PD-L1 with the Efficacy of Pembrolizumab with or without Chemotherapy versus Chemotherapy in Advanced Urothelial Carcinoma

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Reporting quality of quantitative polymerase chain reaction (qPCR) methods in scientific publications

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Improvements in Walking During Subacute Stroke Rehabilitation Translate to Physical Activity at the Chronic Stage: A Sub-Analysis From the Phys Stroke Trial

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Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study

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Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines

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Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer

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Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity

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1-s2.0-S0014488624004266-main-html.html

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Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration

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Neuromuscular fatigability is not affected by the contraction pattern of exercises with a similar mean torque

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Age-Related ECM Stiffness Mediates TRAIL Activation in Muscle Stem Cell Differentiation

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Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction

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Using parenclitic networks on phaeochromocytoma and paraganglioma tumours provides novel insights on global DNA methylation

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Impact of intraoperative hypotension during laparoscopic liver resection on postoperative complications including acute kidney injury

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DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states

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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells

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HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections

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Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids

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Using the R Package, nsink, to assess landscape N removal in coastal catchments

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The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort Study

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