10,000 Matching Annotations
  1. Jul 2025
  2. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    biorxiv.org/content/10.1101/2025.06.27.662039v1
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Potent Inhibitor of Caspase-8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12371506/
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    TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice
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    cell.com/cell-stem-cell/fulltext/S1934-5909(25)00228-0
  5. elifesciences.org elifesciences.org
    Multifaceted role of galanin in brain excitability
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    elifesciences.org/articles/98634
  6. elifesciences.org elifesciences.org
    Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice
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    elifesciences.org/articles/91609
  7. elifesciences.org elifesciences.org
    Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula
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    elifesciences.org/articles/88588
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    The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227201/
  9. elifesciences.org elifesciences.org
    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
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    elifesciences.org/articles/101984
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    Correlation between knee pain and quadriceps condition in osteoarthritis rats treated with cog polydioxanone filaments
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221958/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NOD1 promotes leukocyte clearance and limits inflammation in female mice during obesity‐associated acute lung injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227658/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The proteoglycan decorin does not influence adiposity, glucose tolerance, or aerobic exercise capacity in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227656/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exposing the DNA methylation-responsive compartment of the leukaemic genome in T-ALL cell lines support its potential as a novel therapeutic target in T-ALL
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    pmc.ncbi.nlm.nih.gov/articles/PMC12224799/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HPV16-Expressing Tumors Release Multiple IL1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223509/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223508/
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    RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223513/
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    Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in lethal prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11743868/
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    Clinical Validation of Digital PCR-based ctDNA detection for risk stratification in residual triple negative breast cancer: TRICIA trial results
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    medrxiv.org/content/10.1101/2025.07.02.25330747v1
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    Parkinson’s disease microglia induce endogenous α-synuclein pathology in patient-specific midbrain organoids
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    biorxiv.org/content/10.1101/2025.07.01.662685v1
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    1-s2.0-S0016508525057324-main-html.html
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  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC12216712/
  22. link.springer.com link.springer.com
    AKT/mTOR as a targetable hub to overcome multimodal resistance to EGFR inhibitors in oesophageal squamous cell carcinoma
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    link.springer.com/article/10.1038/s41416-025-03093-3
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12320091/
  24. www.sciencedirect.com www.sciencedirect.com
    The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice
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    sciencedirect.com/science/article/pii/S0969996125002335
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    High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA
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    cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
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    Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein
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    sciencedirect.com/science/article/pii/S2211124725007120
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    Prenatal alcohol exposure promotes nerve injury-induced pathological pain following morphine treatment via NLRP3-mediated peripheral and central proinflammatory immune actions
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    sciencedirect.com/science/article/pii/S0889159125002582
  29. www.atsjournals.org www.atsjournals.org
    USP13 Deficiency Impairs Autophagy and Facilitates Age-related Lung Fibrosis
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    atsjournals.org/doi/10.1165/rcmb.2022-0002OC
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214875/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quantitative measures of clock protein dynamics in the mouse suprachiasmatic nucleus extends the circadian time-keeping model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12218236/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of glucocorticoid receptor function under iron overload
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    pmc.ncbi.nlm.nih.gov/articles/PMC12213461/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endovascular coiling versus microsurgical clipping for extremely small intracranial aneurysms: a comparative analysis of treatment strategies, complications, and clinical outcomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12209622/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221405/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220348/
  36. www.ahajournals.org www.ahajournals.org
    Lysozyme 1 Inflamed CCR2+ Macrophages Promote Obesity-Induced Cardiac Dysfunction | Circulation Research
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    ahajournals.org/doi/full/10.1161/CIRCRESAHA.124.324106
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    Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice
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    ahajournals.org/doi/10.1161/ATVBAHA.123.319674
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    Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein
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    ahajournals.org/doi/10.1161/ATVBAHA.122.318158
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    18F-FLT PET, a Noninvasive Pharmacodynamic Biomarker of Tumor Cell Proliferation, Detected Differential Response to Various Cyclin-Dependent Kinase (CDK) Inhibitors
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  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695182/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor integrin-targeted glucose oxidase enzyme promotes ROS-mediated cell death that combines with interferon alpha therapy for tumor control
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695183/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor-specific antigen delivery for T-cell therapy via a pH-sensitive peptide conjugate
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695185/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Effective TIL Therapy for Patients with Checkpoint-Resistant Melanoma without Lymphodepleting Regimens Requires IFNα
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    pmc.ncbi.nlm.nih.gov/articles/PMC12209825/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214879/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695179/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dissecting FAP+ Cell Diversity in Pancreatic Cancer Uncovers an Interferon-Response Subtype of Cancer-Associated Fibroblasts with Tumor-Restraining Properties
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214878/
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    Novel mechanisms of metformin-induced vasorelaxation of mesenteric arterioles via endothelium-dependent hyperpolarization to treat murine colitis
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    sciencedirect.com/science/article/pii/S0014299925006545
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Locus coeruleus integrity correlates with plasma soluble Axl levels in Alzheimer's disease patients
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    pmc.ncbi.nlm.nih.gov/articles/PMC12213453/
  49. www.mdpi.com www.mdpi.com
    Triiodothyronine or Antioxidants Block the Inhibitory Effects of BDE-47 and BDE-49 on Axonal Growth in Rat Hippocampal Neuron-Glia Co-Cultures
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    mdpi.com/2305-6304/10/2/92
  50. diabetesjournals.org diabetesjournals.org
    The KINGS Ins2+/G32S Mouse: A Novel Model of Beta Cell Endoplasmic Reticulum Stress and Human Diabetes
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    diabetesjournals.org/diabetes/article/69/12/2667/16228/The-KINGS-Ins2-G32S-Mouse-A-Novel-Model-of-Cell
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    TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
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    MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction
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    sciencedirect.com/science/article/pii/S1097276525005052
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    Site-resolved assessment of targeted protein degradation
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  54. www.nature.com www.nature.com
    Molecular docking and biological evaluation of a novel IWS1 inhibitor for the treatment of human retroperitoneal liposarcoma
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    nature.com/articles/s41598-025-07215-y
  55. link.springer.com link.springer.com
    Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy
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  56. onlinelibrary.wiley.com onlinelibrary.wiley.com
    GABA-Producing Levilactobacillus brevis LAB6 Mitigates Pentylenetetrazol-Induced Gut-Brain Dysregulation in SD Rats
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70141
  57. academic.oup.com academic.oup.com
    Isolation of mitochondrial mutation-specific T cell receptors
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    academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf139/8178814
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    Dissociable encoding of motivated behavior by parallel thalamo-striatal projections
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  59. biolres.biomedcentral.com biolres.biomedcentral.com
    Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development
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    biolres.biomedcentral.com/articles/10.1186/s40659-024-00526-w
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    Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
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  61. journals.physiology.org journals.physiology.org
    Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation | American Journal of Physiology-Cell Physiology | American Physiological Society
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    journals.physiology.org/doi/full/10.1152/ajpcell.00745.2024
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    EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV
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  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The distinct roles of NEIL1 and XPA in limiting aflatoxin B1-induced mutagenesis in mice
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  64. journals.physiology.org journals.physiology.org
    Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation
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    Excitatory-neuron-derived interleukin-34 supports cortical developmental microglia function
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    sciencedirect.com/science/article/pii/S1074761325002493
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kcnma1 alternative splicing in mouse kidney: regulation during development and by dietary K+ intake
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    pmc.ncbi.nlm.nih.gov/articles/PMC12151499/
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    ENaC contributes to macrophage dysfunction in cystic fibrosis
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    Sensitivity and activation of endoplasmic reticulum stress response and apoptosis in the perinatal sheep heart
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  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice
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  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An interkinetic envelope surrounds chromosomes between meiosis I and II in C. elegans oocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11670776/
  72. elifesciences.org elifesciences.org
    A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis
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    elifesciences.org/reviewed-preprints/101327v2
  73. www.eneuro.org www.eneuro.org
    Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice
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    eneuro.org/content/10/4/ENEURO.0471-22.2023
  74. journals.plos.org journals.plos.org
    Sniffer restricts arboviral brain infections by regulating ROS levels and protecting blood-brain barrier integrity in Drosophila and mosquitoes
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    journals.plos.org/plospathogens/article
  75. journals.plos.org journals.plos.org
    HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis
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  76. www.liebertpub.com www.liebertpub.com
    Total Flavones of Rhododendron Promotes Microglial Polarization to the M2 Subtype via Inhibiting the NOX2/ROS Pathway in Poststroke Mice with Depression-Like Behavior
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    liebertpub.com/doi/full/10.1089/ars.2025.0948
  77. www.jneurosci.org www.jneurosci.org
    Threonine-53 phosphorylation of dopamine transporter dictates kappa opioid receptor mediated locomotor suppression, aversion, and cocaine reward
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    jneurosci.org/content/45/25/e0171252025
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12202856/
  79. www.biorxiv.org www.biorxiv.org
    Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease
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    biorxiv.org/content/10.1101/2025.06.19.660551v1
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
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    A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses
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    The immune response against cancer is modulated by stromal cell fibronectin
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    sciencedirect.com/science/article/pii/S1476558625000764
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    Sociability genetically separable from social hierarchy in amniotes
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    Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity
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