10,821 Matching Annotations
  1. May 2021
  2. www.sciencedirect.com www.sciencedirect.com
    A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver
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    1. scibot 06 May 2021
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      DOI: 10.1016/j.immuni.2020.08.014

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    sciencedirect.com/science/article/pii/S107476132030371X
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    Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche That Maintains and Replenishes Splenic Red Pulp Macrophages
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    1. scibot 06 May 2021
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      DOI: 10.1016/j.immuni.2020.06.008

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    sciencedirect.com/science/article/pii/S1074761320302387
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    Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA
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    1. scibot 06 May 2021
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      DOI: 10.1016/j.immuni.2020.04.015

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    sciencedirect.com/science/article/pii/S1074761320301734
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    Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis
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    1. scibot 06 May 2021
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      DOI: 10.1016/j.immuni.2020.06.003

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    sciencedirect.com/science/article/pii/S1074761320302338
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    Comprehensive analysis of genomic alterations, clinical outcomes, putative functions and potential therapeutic value of MMP11 in human breast cancer
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    1. scibot 06 May 2021
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      DOI: 10.1016/j.genrep.2020.100852

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    sciencedirect.com/science/article/pii/S2452014420302661
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    Angelica sinensis polysaccharide attenuates CCl4-induced liver fibrosis via the IL-22/STAT3 pathway
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    1. scibot 06 May 2021
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      DOI: 10.1016/j.ijbiomac.2020.06.166

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    sciencedirect.com/science/article/pii/S0141813020336072
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    The glucocorticoid receptor specific modulator CORT108297 reduces brain pathology following status epilepticus
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    1. scibot 06 May 2021
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      DOI: 10.1016/j.expneurol.2021.113703

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    sciencedirect.com/science/article/pii/S0014488621001096
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    Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research
    1
    1. scibot 06 May 2021
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      DOI: 10.1016/j.fct.2021.111967

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    sciencedirect.com/science/article/pii/S0278691521000016
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    Discovery of 4-methyl-N-(4-((4-methylpiperazin- 1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant
    1
    1. scibot 06 May 2021
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      DOI: 10.1016/j.ejmech.2020.112755

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    sciencedirect.com/science/article/pii/S0223523420307273
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    Hepatoprotective effects of ZLY16, a dual peroxisome proliferator-activated receptor α/δ agonist, in rodent model of nonalcoholic steatohepatitis
    1
    1. scibot 06 May 2021
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      DOI: 10.1016/j.ejphar.2020.173300

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    sciencedirect.com/science/article/pii/S0014299920303927
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    Distinct effects on cAMP signaling of carbamazepine and its structural derivatives do not correlate with their clinical efficacy in epilepsy
    1
    1. scibot 06 May 2021
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      DOI: 10.1016/j.ejphar.2020.173413

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    sciencedirect.com/science/article/pii/S0014299920305057
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    A single-cell analysis of the Arabidopsis vegetative shoot apex
    1
    1. scibot 06 May 2021
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      DOI: 10.1016/j.devcel.2021.02.021

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    sciencedirect.com/science/article/pii/S1534580721001611
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    An organelle-tethering mechanism couples flagellation to cell division in bacteria
    1
    1. scibot 06 May 2021
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      DOI: 10.1016/j.devcel.2021.01.013

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    sciencedirect.com/science/article/pii/S153458072100071X
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    FEBS Press
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    1. scibot 06 May 2021
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      DOI: 10.1002/1878-0261.12953

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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12953
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    A BIN2-GLK1 Signaling Module Integrates Brassinosteroid and Light Signaling to Repress Chloroplast Development in the Dark
    1
    1. scibot 06 May 2021
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      DOI: 10.1016/j.devcel.2020.12.001

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    sciencedirect.com/science/article/pii/S153458072030976X
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    Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries Shaping the Heart Loop
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.10.008

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    sciencedirect.com/science/article/pii/S153458072030798X
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    DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.09.021

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    sciencedirect.com/science/article/pii/S153458072030753X
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    A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.08.003

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    sciencedirect.com/science/article/pii/S1534580720306274
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    The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.08.005

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    sciencedirect.com/science/article/pii/S1534580720306298
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    Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.08.002

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    sciencedirect.com/science/article/pii/S1534580720306006
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    A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.07.022

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    sciencedirect.com/science/article/pii/S1534580720305979
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.07.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
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    Chromatin Accessibility Dynamics and a Hierarchical Transcriptional Regulatory Network Structure for Plant Somatic Embryogenesis
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      DOI: 10.1016/j.devcel.2020.07.003

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    sciencedirect.com/science/article/pii/S1534580720305517
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    ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization
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    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.05.011

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    sciencedirect.com/science/article/pii/S1534580720304007
  26. www.nature.com www.nature.com
    Efferent feedback controls bilateral auditory spontaneous activity
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      DOI: 10.1038/s41467-021-22796-8

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    nature.com/articles/s41467-021-22796-8
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
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    1. scibot 05 May 2021
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      DOI: 10.1038/s41467-021-22108-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC8046968/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology
    1
    1. scibot 05 May 2021
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      DOI: 10.7554/eLife.66904

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    ncbi.nlm.nih.gov/pmc/articles/PMC8075583/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair
    1
    1. scibot 05 May 2021
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      DOI: 10.4049/jimmunol.1901263

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    ncbi.nlm.nih.gov/pmc/articles/PMC7443363/
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    Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake
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      DOI: 10.1016/j.celrep.2021.109087

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    sciencedirect.com/science/article/pii/S2211124721004204
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    Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
    1
    1. scibot 04 May 2021
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      DOI: 10.1016/j.devcel.2020.04.018

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    sciencedirect.com/science/article/pii/S1534580720303506
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    Lengthening Neurogenic Period during Neocortical Development Causes a Hallmark of Neocortex Expansion
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      DOI: 10.1016/j.cub.2020.08.046

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    sciencedirect.com/science/article/pii/S0960982220312367
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    Prefrontal Cortical Projection Neurons Targeting Dorsomedial Striatum Control Behavioral Inhibition
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      DOI: 10.1016/j.cub.2020.08.031

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    sciencedirect.com/science/article/pii/S0960982220311854
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    Retinal Inputs to the Thalamus Are Selectively Gated by Arousal
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      DOI: 10.1016/j.cub.2020.07.065

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    sciencedirect.com/science/article/pii/S0960982220310903
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    A randomized trial of adjuvant chemotherapy versus observation in patients with nasopharyngeal carcinoma with detectable post-radiotherapy pEBV DNA
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      DOI: 10.1158/1078-0432.CCR-20-3519

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    clincancerres.aacrjournals.org/content/clincanres/early/2021/03/09/1078-0432.CCR-20-3519.full.pdf
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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      DOI: 10.1016/j.stem.2021.02.008

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    sciencedirect.com/science/article/pii/S1934590921000588
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model
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      DOI: 10.3389/fnmol.2021.576038

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    ncbi.nlm.nih.gov/pmc/articles/PMC8075567/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of functionally distinct macrophage subpopulations in Drosophila
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      DOI: 10.7554/eLife.58686

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    ncbi.nlm.nih.gov/pmc/articles/PMC8062135/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus
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      DOI: 10.7554/eLife.61437

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    ncbi.nlm.nih.gov/pmc/articles/PMC8064751/
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    PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice
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      DOI: 10.7554/eLife.65311

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    ncbi.nlm.nih.gov/pmc/articles/PMC8064759/
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    GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys
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      DOI: 10.1016/j.xcrm.2021.100263

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    sciencedirect.com/science/article/pii/S2666379121000793
  42. Apr 2021
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    An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila
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      DOI: 10.1016/j.cmet.2020.12.017

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    Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport
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    Phytopathogen Effectors Use Multiple Mechanisms to Manipulate Plant Autophagy
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    K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap
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    HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins
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    Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon
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    4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors
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    Lateral Habenula Mediates Defensive Responses Only When Threat and Safety Memories Are in Conflict
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    Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor
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    Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
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    Modulation of stimulated dopamine release in rat nucleus accumbens shell by GABA in vitro: Effect of sub‐chronic phencyclidine pretreatment
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    Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis
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    mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus
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    Phasic Off responses of auditory cortex underlie perception of sound duration
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    Improved HIV-positive infant survival is correlated with high levels of HIV-specific ADCC activity in multiple cohorts
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    Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer
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    Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope
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    Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning
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    Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C
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    Repetitive Blast Exposure Produces White Matter Axon Damage without Subsequent Myelin Remodeling: <italic toggle="yes">In Vivo</italic> Analysis of Brain Injury Using Fluorescent Reporter Mice
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    Low expression of the PPARγ-regulated gene thioredoxin-interacting protein accompanies human melanoma progression and promotes experimental lung metastases
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    Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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    Astragaloside IV prevents Aβ1-42 oligomers-induced memory impairment and hippocampal cell apoptosis by promoting PPARγ/BDNF signaling pathway
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    Ionizing radiation induces BH4 deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis
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    Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: behavioural and neurochemical analyses
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    Properties of multivesicular release from mouse rod photoreceptors support transmission of single-photon responses
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    Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype
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    Complement C5a promotes antigen cross-presentation by Peyer’s patch monocyte-derived dendritic cells and drives a protective CD8+ T cell response
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    Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes
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    A nexus of intrinsic dynamics underlies translocase priming
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    The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
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    Rapid eye movement sleep deprivation impairs neuronal plasticity and reduces hippocampal neuronal arborization in male albino rats: Noradrenaline is involved in the process
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    Investigating oligodendrocyte connexins: Heteromeric interactions between Cx32 and mutant or wild‐type forms of Cx47 do not contribute to or modulate gap junction function
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    Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance
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    Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging
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    Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation
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    Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity
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    Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments
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    Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex
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    Three-dimensional reconstruction of a whole insect reveals its phloem sap-sucking mechanism at nano-resolution
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    Protocol for live enhanced resolution confocal imaging of dendritic spinule dynamics in primary mouse cortical neuron culture
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    A polarity pathway for exocyst-dependent intracellular tube extension
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    Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling
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    Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex
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    Capturing human trophoblast development with naive pluripotent stem cells in vitro
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    Nucleus accumbens neurons expressing dopamine D1 receptors modulate states of consciousness in sevoflurane anesthesia
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    Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5
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    Parallel synaptic acetylcholine signals facilitate large monopolar cell repolarization and modulate visual behavior in Drosophila
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    SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms
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    Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation
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    Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain
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    Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron
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    NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation
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    Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors
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    Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways
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    PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
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    The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr
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    Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor
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    The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
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    A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation
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    Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model
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    Elucidating the role of hypoxia/reoxygenation in hippocampus-dependent memory impairment: do SK channels play role?
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase
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  168. elifesciences.org elifesciences.org
    Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    All-trans retinoic acid induces synaptic plasticity in human cortical neurons
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate
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  171. www.sciencedirect.com www.sciencedirect.com
    Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation
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    Molecular pathways behind acquired obesity: adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
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    Integrated regulatory network in Pseudomonas syringae reveals dynamics of virulence
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  174. www.nature.com www.nature.com
    Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice
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    Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals
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    Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes
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  177. Mar 2021
  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein and Signaling Pathway Responses to rhIL-6 Intervention Before Lobaplatin Treatment in Osteosarcoma Cells
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  179. journals.sagepub.com journals.sagepub.com
    Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain - Ariel Diaz, Paola Merino, Patrick McCann, Manuel A Yepes, Laura G Quiceno, Enrique Torre, Amelia Tomkins, Xiaodong Zhang, Chadwick M Hales, Frank C Tong, Manuel Yepes, 2021
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  180. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enriching neural stem cell and anti‐inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats
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    Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling
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  182. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Interleukin-10 does not contribute to the anti-contractile nature of PVAT in health
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atoh7-independent specification of retinal ganglion cell identity
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      DOI: 10.1126/sciadv.abe4983

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  186. elifesciences.org elifesciences.org
    Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells
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      DOI: 10.7554/eLife.62250

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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans
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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells
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      DOI: 10.7554/eLife.64207

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  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment
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  190. elifesciences.org elifesciences.org
    Multiple time-scales of decision-making in the hippocampus and prefrontal cortex
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      DOI: 10.7554/eLife.66227

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  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells
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      DOI: 10.1158/2643-3230.BCD-20-0161

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  192. academic.oup.com academic.oup.com
    Brain Volumes in Mice are Smaller at Birth After Term or Preterm Cesarean Section Delivery
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      DOI: 10.1093/cercor/bhab033

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    academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhab033/6179454
  193. www.frontiersin.org www.frontiersin.org
    C21orf91 Regulates Oligodendroglial Precursor Cell Fate—A Switch in the Glial Lineage?
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      DOI: 10.3389/fncel.2021.653075

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    Cyclopiazonic Acid-Induced Ca2+ Store Depletion Initiates Endothelium-Dependent Hyperpolarization-Mediated Vasorelaxation of Mesenteric Arteries in Healthy and Colitis Mice
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  195. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice
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    Extracellular signal‐regulated kinase regulates microglial immune responses in Alzheimer’s disease
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  197. www.frontiersin.org www.frontiersin.org
    Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury in Mice
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      DOI: 10.3389/fcell.2021.661462

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    Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection
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      DOI: 10.7554/eLife.65958

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    Oral efficacy of Δ(9)-tetrahydrocannabinol and cannabidiol in a mouse neuropathic pain model
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    H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
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  201. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ground state depletion microscopy as a tool for studying microglia–synapse interactions
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      DOI: 10.1002/jnr.24819

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  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
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