879 Matching Annotations
  1. May 2021
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    Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis
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    1. scibot 14 May 2021
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      DOI: 10.1016/j.chom.2021.04.006

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    sciencedirect.com/science/article/pii/S1931312821001827
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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    1. scibot 11 May 2021
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      DOI: 10.1016/j.molcel.2021.04.019

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    sciencedirect.com/science/article/pii/S1097276521003245
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    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    1. scibot 10 May 2021
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      DOI: 10.1016/j.chembiol.2021.04.013

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    sciencedirect.com/science/article/pii/S2451945621002063
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    AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
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    1. scibot 09 May 2021
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      DOI: 10.1016/j.molcel.2021.04.010

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    sciencedirect.com/science/article/pii/S1097276521003154
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    Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
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    1. scibot 09 May 2021
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      DOI: 10.1016/j.stem.2020.09.019

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    sciencedirect.com/science/article/pii/S193459092030494X
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    Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer
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    1. scibot 09 May 2021
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      DOI: 10.1016/j.stem.2020.07.003

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    sciencedirect.com/science/article/pii/S1934590920303416
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2021.03.008

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    sciencedirect.com/science/article/pii/S0896627321001562
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    Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2020.10.035

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    sciencedirect.com/science/article/pii/S089662732030859X
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Neural Network for Wind-Guided Compass Navigation
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2020.06.022

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    ncbi.nlm.nih.gov/pmc/articles/PMC7507644/
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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.molcel.2021.03.001

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    sciencedirect.com/science/article/pii/S1097276521001696
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    Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation
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    1. scibot 08 May 2021
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      DOI: 10.1016/j.molcel.2020.10.026

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    sciencedirect.com/science/article/pii/S1097276520307334
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    Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program
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    1. scibot 08 May 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC7654708/
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    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.10.008

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    sciencedirect.com/science/article/pii/S1097276520306912
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    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.10.018

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    sciencedirect.com/science/article/pii/S1097276520307255
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    Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.06.021

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    sciencedirect.com/science/article/pii/S1097276520304238
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    Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
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    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.06.019

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    sciencedirect.com/science/article/pii/S1097276520304214
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    Generation of Plasmodium yoelii malaria parasite for conditional degradation of proteins
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molbiopara.2020.111346

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    sciencedirect.com/science/article/pii/S0166685120301109
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    Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion
    1
    1. scibot 06 May 2021
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      DOI: 10.1016/j.devcel.2021.01.016

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    sciencedirect.com/science/article/pii/S1534580721000745
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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      DOI: 10.1016/j.devcel.2020.11.016

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    sciencedirect.com/science/article/pii/S1534580720309254
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    Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.10.014

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    sciencedirect.com/science/article/pii/S1534580720308340
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.08.006

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    sciencedirect.com/science/article/pii/S1534580720306304
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    A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.cmet.2021.04.006

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    sciencedirect.com/science/article/pii/S1550413121001728
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    CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance
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    1. scibot 04 May 2021
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      DOI: 10.1016/j.stem.2021.04.011

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    sciencedirect.com/science/article/pii/S1934590921001685
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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    1. scibot 03 May 2021
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      DOI: 10.1016/j.stem.2021.02.008

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    sciencedirect.com/science/article/pii/S1934590921000588
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    Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity
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      DOI: 10.1016/j.devcel.2021.04.012

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    ncbi.nlm.nih.gov/pmc/articles/PMC8570296/
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    The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
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      DOI: 10.1016/j.molcel.2021.04.009

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    sciencedirect.com/science/article/pii/S1097276521003142
  28. Apr 2021
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    NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
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    1. scibot 30 Apr 2021
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      DOI: 10.1016/j.cmet.2020.10.021

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    sciencedirect.com/science/article/pii/S1550413120305544
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    TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation
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      DOI: 10.1016/j.cmet.2020.10.010

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    sciencedirect.com/science/article/pii/S155041312030543X
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    PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle
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    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.cmet.2020.06.017

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    sciencedirect.com/science/article/pii/S1550413120303181
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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      DOI: 10.1016/j.stem.2021.03.005

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    sciencedirect.com/science/article/pii/S1934590921001119
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    A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms
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      DOI: 10.1016/j.cell.2020.09.051

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    sciencedirect.com/science/article/pii/S0092867420312484
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    A Cellular Mechanism to Detect and Alleviate Reductive Stress
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      DOI: 10.1016/j.cell.2020.08.034

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    sciencedirect.com/science/article/pii/S009286742031076X
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    Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells
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    sciencedirect.com/science/article/pii/S0092867420308084
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    A visual pathway for skylight polarization processing in Drosophila
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      DOI: 10.7554/eLife.63225

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    elifesciences.org/articles/63225
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    CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
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    sciencedirect.com/science/article/pii/S0092867420307534
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    Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
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    sciencedirect.com/science/article/pii/S0092867420306838
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    MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
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    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
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      DOI: 10.1016/j.ccell.2020.10.009

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    ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
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    Posttranscriptional regulation of de novo lipogenesis by glucose-induced O-GlcNAcylation
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      DOI: 10.1016/j.molcel.2021.02.009

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    sciencedirect.com/science/article/pii/S1097276521000952
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    Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis
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    sciencedirect.com/science/article/pii/S1097276521000988
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    SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
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    PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression
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    Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes
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    Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis
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    Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
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    Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss
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    The Cation Channel TMEM63B Is an Osmosensor Required for Hearing
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    MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation
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  132. academic.oup.com academic.oup.com
    Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles
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      DOI: 10.1210/endocr/bqaa074

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  133. www.sciencedirect.com www.sciencedirect.com
    Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
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    Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival
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    Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription
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  136. elifesciences.org elifesciences.org
    A genetic, genomic, and computational resource for exploring neural circuit function
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  137. www.sciencedirect.com www.sciencedirect.com
    c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
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    A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin
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    Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner
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    Functional Assessment In Vivo of the Mouse Homologue of the Human Ala-9-Ser NHE6 Variant
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    Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
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    Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36
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    Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair
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  145. genesdev.cshlp.org genesdev.cshlp.org
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
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  146. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes
    1
    1. scibot 04 Sep 2020
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  147. www.mdpi.com www.mdpi.com
    Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling
    1
    1. scibot 04 Sep 2020
      HA-tag

      DOI: 10.3390/ijms21051773

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  148. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis
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      DOI: 10.1016/j.cmet.2020.03.010

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  149. www.mdpi.com www.mdpi.com
    HUNK Phosphorylates Rubicon to Support Autophagy
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      anti-HA

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    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
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      anti-HA

      DOI: 10.1016/j.celrep.2020.108044

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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular mechanisms that regulate export of the planar cell-polarity protein Frizzled-6 out of the endoplasmic reticulum
    1
    1. scibot 03 Sep 2020
      anti-HA

      DOI: 10.1074/jbc.RA120.012835

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  152. www.mdpi.com www.mdpi.com
    Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells
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      DOI: 10.3390/cancers12061643

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  153. www.sciencedirect.com www.sciencedirect.com
    Non-canonical Receptive Field Properties and Neuromodulation of Feature-Detecting Neurons in Flies
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      DOI: 10.1016/j.cub.2020.04.069

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  154. Aug 2020
  155. www.sciencedirect.com www.sciencedirect.com
    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
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    1. scibot 26 Aug 2020
      RRID:AB_1549

      DOI: 10.1016/j.celrep.2020.107974

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  156. Jan 2020
  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network
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      DOI: 10.1074/jbc.RA118.001906

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  158. academic.oup.com academic.oup.com
    Protein arginine methyltransferase 1 interacts with PGC1α and modulates thermogenic fat activation
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      DOI: 10.1210/en.2019-00504

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  159. www.jneurosci.org www.jneurosci.org
    Anterior Cingulate Cortex to Ventral Hippocampus Circuit Mediates Contextual Fear Generalization
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      DOI: 10.1523/JNEUROSCI.2739-18.2019

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  160. www.sciencedirect.com www.sciencedirect.com
    HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70
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      RRID:AB_1549585

      DOI: 10.1016/j.celrep.2019.09.023

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    Sleep Regulation by Neurotensinergic Neurons in a Thalamo-Amygdala Circuit
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      DOI: 10.1016/j.neuron.2019.05.015

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    Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements
    1
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      DOI: 10.1016/j.cell.2019.08.013

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  163. www.sciencedirect.com www.sciencedirect.com
    IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation
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      DOI: 10.1016/j.chom.2019.05.002

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    Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis
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      DOI: 10.1016/j.celrep.2019.07.045

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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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      DOI: 10.1016/j.cell.2019.05.036

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    SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
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  167. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition
    1
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      RRID:AB_1549585

      DOI: 10.1016/j.molcel.2019.07.018

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    Visualization of Protein Sorting at the Trans-Golgi Network and Endosomes Through Super-Resolution Imaging
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    Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila
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    Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
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    DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters
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    Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation
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    Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding
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    Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
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    Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder
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    KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels
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    Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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    Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases
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    Chemogenetic Inhibition of the Amygdala Modulates Emotional Behavior Expression in Infant Rhesus Monkeys
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    Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
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    Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss
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    Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch
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    Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination
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    α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    The Translational Landscape of the Human Heart
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    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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    53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
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    Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy
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    ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97
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    Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM
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    CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4
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    sciencedirect.com/science/article/pii/S1097276519300577
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_1549585

      DOI: 10.7554/eLife.41913

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      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC6336405/
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      DOI: 10.1016/j.celrep.2018.12.050

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    sciencedirect.com/science/article/pii/S2211124718319806
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    Encoding of Odor Fear Memories in the Mouse Olfactory Cortex
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      DOI: 10.1016/j.cub.2018.12.003

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    sciencedirect.com/science/article/pii/S096098221831604X