869 Matching Annotations
  1. May 2021
  2. www.sciencedirect.com www.sciencedirect.com
    Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation
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    1. scibot 08 May 2021
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      DOI: 10.1016/j.molcel.2020.10.026

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    sciencedirect.com/science/article/pii/S1097276520307334
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    Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program
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    1. scibot 08 May 2021
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      DOI: 10.1016/j.molcel.2020.10.022

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    ncbi.nlm.nih.gov/pmc/articles/PMC7654708/
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    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
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    1. scibot 07 May 2021
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    sciencedirect.com/science/article/pii/S1097276520306912
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    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.10.018

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    sciencedirect.com/science/article/pii/S1097276520307255
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    Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
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    1. scibot 07 May 2021
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    sciencedirect.com/science/article/pii/S1097276520304238
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    Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
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    1. scibot 07 May 2021
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    sciencedirect.com/science/article/pii/S1097276520304214
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    Generation of Plasmodium yoelii malaria parasite for conditional degradation of proteins
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      DOI: 10.1016/j.molbiopara.2020.111346

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    sciencedirect.com/science/article/pii/S0166685120301109
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    Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion
    1
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    sciencedirect.com/science/article/pii/S1534580721000745
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    sciencedirect.com/science/article/pii/S1534580720309254
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    Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.10.014

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    sciencedirect.com/science/article/pii/S1534580720308340
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
    1
    1. scibot 05 May 2021
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    sciencedirect.com/science/article/pii/S1534580720306304
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    A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.cmet.2021.04.006

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    sciencedirect.com/science/article/pii/S1550413121001728
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    CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance
    1
    1. scibot 04 May 2021
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      DOI: 10.1016/j.stem.2021.04.011

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    sciencedirect.com/science/article/pii/S1934590921001685
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
    1
    1. scibot 03 May 2021
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      DOI: 10.1016/j.stem.2021.02.008

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    sciencedirect.com/science/article/pii/S1934590921000588
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity
    1
    1. scibot 01 May 2021
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      DOI: 10.1016/j.devcel.2021.04.012

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    ncbi.nlm.nih.gov/pmc/articles/PMC8570296/
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    The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
    1
    1. scibot 01 May 2021
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      DOI: 10.1016/j.molcel.2021.04.009

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    sciencedirect.com/science/article/pii/S1097276521003142
  18. Apr 2021
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    NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
    1
    1. scibot 30 Apr 2021
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      DOI: 10.1016/j.cmet.2020.10.021

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    sciencedirect.com/science/article/pii/S1550413120305544
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    TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.cmet.2020.10.010

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    sciencedirect.com/science/article/pii/S155041312030543X
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    PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.cmet.2020.06.017

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    sciencedirect.com/science/article/pii/S1550413120303181
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.stem.2021.03.005

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    sciencedirect.com/science/article/pii/S1934590921001119
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    A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms
    1
    1. scibot 24 Apr 2021
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      DOI: 10.1016/j.cell.2020.09.051

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    sciencedirect.com/science/article/pii/S0092867420312484
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    A Cellular Mechanism to Detect and Alleviate Reductive Stress
    1
    1. scibot 24 Apr 2021
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      DOI: 10.1016/j.cell.2020.08.034

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    sciencedirect.com/science/article/pii/S009286742031076X
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    Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells
    1
    1. scibot 24 Apr 2021
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      DOI: 10.1016/j.cell.2020.06.031

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    sciencedirect.com/science/article/pii/S0092867420308084
  26. elifesciences.org elifesciences.org
    A visual pathway for skylight polarization processing in Drosophila
    1
    1. scibot 24 Apr 2021
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      DOI: 10.7554/eLife.63225

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    elifesciences.org/articles/63225
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    CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
    1
    1. scibot 24 Apr 2021
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      DOI: 10.1016/j.cell.2020.06.021

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    sciencedirect.com/science/article/pii/S0092867420307534
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    Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
    1
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      DOI: 10.1016/j.cell.2020.05.050

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    sciencedirect.com/science/article/pii/S0092867420306838
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    MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
    1
    1. scibot 22 Apr 2021
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      DOI: 10.1016/j.ccell.2021.02.006

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    sciencedirect.com/science/article/pii/S1535610821001082
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
    1
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      DOI: 10.1016/j.ccell.2020.10.009

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    ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
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    Posttranscriptional regulation of de novo lipogenesis by glucose-induced O-GlcNAcylation
    1
    1. scibot 19 Apr 2021
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      DOI: 10.1016/j.molcel.2021.02.009

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    sciencedirect.com/science/article/pii/S1097276521000952
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    Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis
    1
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      DOI: 10.1016/j.molcel.2021.02.012

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    SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
    1
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      DOI: 10.1016/j.ccell.2020.05.022

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    sciencedirect.com/science/article/pii/S1535610820302725
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    Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer
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    PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression
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    sciencedirect.com/science/article/pii/S1535610820302683
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    DNAJC5 promotes hepatocellular carcinoma cells proliferation though regulating SKP2 mediated p27 degradation
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      DOI: 10.1016/j.bbamcr.2021.118994

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    sciencedirect.com/science/article/pii/S0167488921000483
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    DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network
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    sciencedirect.com/science/article/pii/S1097276521002628
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    A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease
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      DOI: 10.1016/j.cmet.2021.03.024

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    sciencedirect.com/science/article/pii/S1550413121001315
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    The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
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      DOI: 10.1016/j.immuni.2021.03.008

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    sciencedirect.com/science/article/pii/S1074761321001205
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    Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
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      DOI: 10.1016/j.cell.2021.03.031

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    sciencedirect.com/science/article/pii/S0092867421003627
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    Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras
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      DOI: 10.1016/j.chembiol.2021.03.011

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    sciencedirect.com/science/article/pii/S2451945621001501
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation
    1
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      DOI: 10.7554/eLife.63886

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  43. Mar 2021
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  88. Oct 2020
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    SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
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    Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B
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    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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  93. Sep 2020
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    The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells
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    Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
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    Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
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    Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
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    The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis
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    A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity
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    Inhibitory Interactions and Columnar Inputs to an Object Motion Detector in Drosophila
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    A Multi-regional Network Encoding Heading and Steering Maneuvers in Drosophila
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    Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease
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    A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation
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    THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells
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    Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss
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    The Cation Channel TMEM63B Is an Osmosensor Required for Hearing
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    MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation
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    Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles
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    Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
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    Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival
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    Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription
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    c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3
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    Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
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  129. www.sciencedirect.com www.sciencedirect.com
    A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin
    1
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  130. www.sciencedirect.com www.sciencedirect.com
    Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner
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    Functional Assessment In Vivo of the Mouse Homologue of the Human Ala-9-Ser NHE6 Variant
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      DOI: 10.1523/ENEURO.0046-19.2019

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  132. www.sciencedirect.com www.sciencedirect.com
    Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
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  133. www.sciencedirect.com www.sciencedirect.com
    Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36
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  134. www.sciencedirect.com www.sciencedirect.com
    Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair
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  135. genesdev.cshlp.org genesdev.cshlp.org
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
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  136. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes
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  137. www.mdpi.com www.mdpi.com
    Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling
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  138. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis
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  139. www.mdpi.com www.mdpi.com
    HUNK Phosphorylates Rubicon to Support Autophagy
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  140. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular mechanisms that regulate export of the planar cell-polarity protein Frizzled-6 out of the endoplasmic reticulum
    1
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      DOI: 10.1074/jbc.RA120.012835

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  142. www.mdpi.com www.mdpi.com
    Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells
    1
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  143. www.sciencedirect.com www.sciencedirect.com
    Non-canonical Receptive Field Properties and Neuromodulation of Feature-Detecting Neurons in Flies
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      DOI: 10.1016/j.cub.2020.04.069

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  144. Aug 2020
  145. www.sciencedirect.com www.sciencedirect.com
    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
    1
    1. scibot 26 Aug 2020
      RRID:AB_1549

      DOI: 10.1016/j.celrep.2020.107974

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  146. Jan 2020
  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network
    1
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      RRID:AB_1549585

      DOI: 10.1074/jbc.RA118.001906

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  148. academic.oup.com academic.oup.com
    Protein arginine methyltransferase 1 interacts with PGC1α and modulates thermogenic fat activation
    1
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      DOI: 10.1210/en.2019-00504

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  149. www.jneurosci.org www.jneurosci.org
    Anterior Cingulate Cortex to Ventral Hippocampus Circuit Mediates Contextual Fear Generalization
    1
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      DOI: 10.1523/JNEUROSCI.2739-18.2019

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  150. www.sciencedirect.com www.sciencedirect.com
    HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70
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      DOI: 10.1016/j.celrep.2019.09.023

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    Sleep Regulation by Neurotensinergic Neurons in a Thalamo-Amygdala Circuit
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      DOI: 10.1016/j.neuron.2019.05.015

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    Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements
    1
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      DOI: 10.1016/j.cell.2019.08.013

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    IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation
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      DOI: 10.1016/j.chom.2019.05.002

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    Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis
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      DOI: 10.1016/j.celrep.2019.07.045

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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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      DOI: 10.1016/j.cell.2019.05.036

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    SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
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    Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition
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      RRID:AB_1549585

      DOI: 10.1016/j.molcel.2019.07.018

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  158. www.frontiersin.org www.frontiersin.org
    Visualization of Protein Sorting at the Trans-Golgi Network and Endosomes Through Super-Resolution Imaging
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      DOI: 10.3389/fcell.2019.00181

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  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila
    1
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      DOI: 10.1016/j.celrep.2019.06.070

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  160. www.sciencedirect.com www.sciencedirect.com
    Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
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      DOI: 10.1016/j.celrep.2019.11.007

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    DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters
    1
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      DOI: 10.1016/j.celrep.2019.11.045

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  162. www.sciencedirect.com www.sciencedirect.com
    Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation
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      DOI: 10.1016/j.devcel.2019.11.019

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    Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding
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      DOI: 10.1016/j.cub.2019.11.029

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    Optical Pooled Screens in Human Cells
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      DOI: 10.1016/j.cell.2019.09.016

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    Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
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      DOI: 10.7554/eLife.49187

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    Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder
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      DOI: 10.1016/j.ebiom.2019.11.014

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    KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels
    1
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      DOI: 10.1016/j.celrep.2019.06.001

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    ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97
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    Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM
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    CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4
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    Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity
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      DOI: 10.1016/j.cub.2018.12.019

      Resource: (Cell Signaling Technology Cat# 3724, RRID:AB_1549585)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_1549585

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      RRID:AB_1549585 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0960982218316518
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    FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis
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    1. scibot 12 Jan 2020
      RRID:AB_1549585

      DOI: 10.1016/j.devcel.2018.12.021

      Resource: (Cell Signaling Technology Cat# 3724, RRID:AB_1549585)

      Curator: @Naa003

      SciCrunch record: RRID:AB_1549585

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      RRID:AB_1549585 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1534580718311171
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    Untitled document
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    1. scibot 12 Jan 2020
      RRID:AB_1549585

      DOI: 10.1016/j.celrep.2019.01.049

      Resource: (Cell Signaling Technology Cat# 3724, RRID:AB_1549585)

      Curator: @evieth

      SciCrunch record: RRID:AB_1549585

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      RRID:AB_1549585 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719300671