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  1. Jul 2021
  2. www.cell.com www.cell.com
    Gut-microbiota-targeted diets modulate human immune status
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    1. scibot 13 Jul 2021
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      DOI: 10.1016/j.cell.2021.06.019

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    cell.com/cell/fulltext/S0092-8674(21)00754-6
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    The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression
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    1. scibot 09 Jul 2021
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    sciencedirect.com/science/article/pii/S0960982221008253
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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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    1. scibot 03 Jul 2021
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00493-7
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    Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits
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    sciencedirect.com/science/article/pii/S2405844021015590
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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    1. scibot 01 Jul 2021
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    sciencedirect.com/science/article/pii/S1357272521001060
  7. Jun 2021
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    1. scibot 30 Jun 2021
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    sciencedirect.com/science/article/pii/S2211124721006628
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration
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    1. scibot 26 Jun 2021
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      DOI: 10.7554/eLife.68830

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    ncbi.nlm.nih.gov/pmc/articles/PMC8219383/
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    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
    1
    1. scibot 23 Jun 2021
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    sciencedirect.com/science/article/pii/S2211124721006392
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    Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
    1
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    sciencedirect.com/science/article/pii/S2211124721006471
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
    1
    1. scibot 23 Jun 2021
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    sciencedirect.com/science/article/pii/S2211124721006483
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    1. scibot 22 Jun 2021
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    sciencedirect.com/science/article/pii/S1097276521004445
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    Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage
    1
    1. scibot 19 Jun 2021
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    sciencedirect.com/science/article/pii/S0944711321001732
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    Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
    1
    1. scibot 19 Jun 2021
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    sciencedirect.com/science/article/pii/S1550413121002709
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
    1
    1. scibot 18 Jun 2021
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      DOI: 10.1016/j.isci.2021.102643

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    ncbi.nlm.nih.gov/pmc/articles/PMC8187833/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence
    1
    1. scibot 18 Jun 2021
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      DOI: 10.7554/eLife.64204

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    ncbi.nlm.nih.gov/pmc/articles/PMC8203294/
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    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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    1. scibot 18 Jun 2021
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      DOI: 10.1016/j.ccell.2021.05.015

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    sciencedirect.com/science/article/pii/S1535610821002816
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    Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening
    1
    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109233

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    sciencedirect.com/science/article/pii/S2211124721005921
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    NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma
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    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109238

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    sciencedirect.com/science/article/pii/S2211124721005970
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    Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality
    1
    1. scibot 09 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109223

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    sciencedirect.com/science/article/pii/S221112472100574X
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    The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia
    1
    1. scibot 04 Jun 2021
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      DOI: 10.1016/j.cub.2021.04.078

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    sciencedirect.com/science/article/pii/S0960982221006254
  23. May 2021
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression
    1
    1. scibot 28 May 2021
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      DOI: 10.7554/eLife.67409

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    ncbi.nlm.nih.gov/pmc/articles/PMC8143796/
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    Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome
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    1. scibot 26 May 2021
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      DOI: 10.1016/j.celrep.2021.109161

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    sciencedirect.com/science/article/pii/S2211124721005039
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    The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation
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    1. scibot 26 May 2021
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      DOI: 10.1016/j.immuni.2021.04.027

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    sciencedirect.com/science/article/pii/S1074761321001898
  27. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia
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    1. scibot 20 May 2021
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      DOI: 10.1111/jnc.15291

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15291
  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK
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      DOI: 10.1111/jnc.15303

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15303
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    VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway
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      DOI: 10.1016/j.devcel.2021.04.027

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    sciencedirect.com/science/article/pii/S1534580721003968
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
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      DOI: 10.7554/eLife.68348

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    ncbi.nlm.nih.gov/pmc/articles/PMC8118655/
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    SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
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    1. scibot 15 May 2021
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      DOI: 10.1016/j.molcel.2021.04.002

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    sciencedirect.com/science/article/pii/S1097276521002690
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    LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through MEK/ERK signaling pathway
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      DOI: 10.1016/j.molmet.2021.101230

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    sciencedirect.com/science/article/pii/S2212877821000752
  33. academic.oup.com academic.oup.com
    PDZ domain protein SYNJ2BP regulates GRK-dependent Sst2A phosphorylation and downstream MAPK signaling
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      DOI: 10.1210/endocr/bqaa229

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    academic.oup.com/endo/article/162/2/bqaa229/6031468
  34. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    Cell of Origin Influences Pancreatic Cancer Subtype
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    cancerdiscovery.aacrjournals.org/content/11/3/660
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    Synergistic interaction of nerve growth factor and glial cell‐line derived neurotrophic factor in muscular mechanical hyperalgesia in rats
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      DOI: 10.1113/JP280683

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP280683
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    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    sciencedirect.com/science/article/pii/S2451945621002063
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    Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
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    sciencedirect.com/science/article/pii/S0092867421004955
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    The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment
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      DOI: 10.1016/j.yexcr.2021.112505

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    sciencedirect.com/science/article/pii/S0014482721000367
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    Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium
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      DOI: 10.1016/j.stem.2020.06.021

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    sciencedirect.com/science/article/pii/S1934590920302885
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    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    sciencedirect.com/science/article/pii/S0944711320301562
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    Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice – Possible hippocampal MAPKs specificity
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      DOI: 10.1016/j.neuropharm.2020.108302

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    sciencedirect.com/science/article/pii/S0028390820303701
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    Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation
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      DOI: 10.1016/j.molcel.2020.10.026

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    sciencedirect.com/science/article/pii/S1097276520307334
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    Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy
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      DOI: 10.1016/j.immuni.2020.09.006

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    sciencedirect.com/science/article/pii/S1074761320304003
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    eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition
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      Anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb

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    Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury
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    Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
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    Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
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      Rabbit anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) Monoclonal antibody

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    Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma
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    TNFα-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation
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    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
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    CDKN2A Deletion in Melanoma Excludes T Cell Infiltration by Repressing Chemokine Expression in a Cell Cycle-Dependent Manner
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    An inhibitory circuit from brainstem to GnRH neurons in male mice: a new role for the RFRP receptor
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    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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    Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
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  88. Jan 2021
  89. www.frontiersin.org www.frontiersin.org
    DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion
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  90. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function
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      DOI: 10.1096/fj.202002203R

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    Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer
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    Lactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle
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  93. Dec 2020
  94. www.cell.com www.cell.com
    Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells
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  95. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma
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    Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death
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      Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

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  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ascorbate deficiency decreases dopamine release in gulo–/– and APP/PSEN1 mice
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      P‐p44/42 MAPK

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  98. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling
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  100. Nov 2020
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    Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait
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  102. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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  105. www.frontiersin.org www.frontiersin.org
    Polyunsaturated Fatty Acids Influence LPS-Induced Inflammation of Fish Macrophages Through Differential Modulation of Pathogen Recognition and p38 MAPK/NF-κB Signaling
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  106. Oct 2020
  107. www.sciencedirect.com www.sciencedirect.com
    Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts
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    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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    Activation of Neuronal Ras‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice
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  112. www.cell.com www.cell.com
    Hypothalamic Dopamine Neurons Control Sensorimotor Behavior by Modulating Brainstem Premotor Nuclei in Zebrafish
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    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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    TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
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    Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
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  118. Sep 2020
  119. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Roles of Pyk2 in signal transduction after gonadotropin‐releasing hormone receptor stimulation
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  120. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling
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      phospho ERK1/2

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    SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
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    Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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  125. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Angiotensin‐(1‐7) Mitigated Angiotensin II‐induced Abdominal Aortic Aneurysms in Apolipoprotein E Knockout Mice
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila
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  128. www.sciencedirect.com www.sciencedirect.com
    ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
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    Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress
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    Nutrient-Driven O-GlcNAcylation Controls DNA Damage Repair Signaling and Stem/Progenitor Cell Homeostasis
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    Correcting abnormalities in miR‐124/PTPN1 signaling rescues tau pathology in Alzheimer’s disease
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    Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
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    The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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    Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling
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    The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
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    An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of Protein Kinase A and EPAC to chronic inflammatory pain
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    Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging
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    Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease
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    Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis
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    Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis
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    A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies
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    Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus
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    Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation
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    A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐ angiogenesis effects via targeting VEGFR‐2 signaling
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    The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
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    Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury
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    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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    Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands
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    CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies
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    The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation
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    Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway
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      RRID:AB_2315112 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14849
  208. www.sciencedirect.com www.sciencedirect.com
    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
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      RRID:AB_2315112

      DOI: 10.1016/j.celrep.2019.07.086

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      RRID:AB_2315112 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719310022
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    EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
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    1. scibot 13 Jan 2020
      RRID:AB_2315112

      DOI: 10.1016/j.celrep.2019.06.020

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      RRID:AB_2315112 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719307867
  210. www.sciencedirect.com www.sciencedirect.com
    Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis
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      DOI: 10.1016/j.molcel.2019.07.028

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      RRID:AB_2315112 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276519305830
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    DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters
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      RRID:AB_2315112

      DOI: 10.1016/j.celrep.2019.11.045

      Resource: (Cell Signaling Technology Cat# 4370, RRID:AB_2315112)

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      RRID:AB_2315112 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S221112471931527X
  212. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.14774

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      RRID:AB_2315112 RRIDCUR:Validated
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14774