1,833 Matching Annotations
  1. Nov 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Purification of exosome-enriched proteins produced in a Drosophila cell line by size exclusion chromatography
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    1. scibot 11 Nov 2022
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      DOI: 10.1016/j.xpro.2022.101834

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    sciencedirect.com/science/article/pii/S2666166722007146
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    CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors
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      DOI: 10.1016/j.neuron.2022.10.018

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    sciencedirect.com/science/article/pii/S0896627322009473
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    LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly
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    1. scibot 04 Nov 2022
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      DOI: 10.1016/j.molcel.2022.09.022

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    sciencedirect.com/science/article/pii/S109727652200911X
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell intrinsic TIM-3 induces glioblastoma progression
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    1. scibot 04 Nov 2022
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      DOI: 10.1016/j.isci.2022.105329

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    ncbi.nlm.nih.gov/pmc/articles/PMC9618784/
  6. rupress.org rupress.org
    V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
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    1. scibot 03 Nov 2022
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      DOI: 10.1083/jcb.202205045

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    rupress.org/jcb/article/222/1/e202205045/213623/V-ATPase-TORC1-mediated-ATFS-1-translation-directs
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    Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
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    1. scibot 03 Nov 2022
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      DOI: 10.1016/j.chembiol.2022.10.005

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    sciencedirect.com/science/article/pii/S2451945622003592
  8. academic.oup.com academic.oup.com
    An enChIP system for the analysis of genome functions in budding yeast
    1
    1. scibot 01 Nov 2022
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      DOI: 10.1093/biomethods/bpac025

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    academic.oup.com/biomethods/article/7/1/bpac025/6762078
  9. Oct 2022
  10. www.sciencedirect.com www.sciencedirect.com
    Structure and functionality of a multimeric human COQ7:COQ9 complex
    1
    1. scibot 28 Oct 2022
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    sciencedirect.com/science/article/pii/S1097276522009601
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity
    1
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      DOI: 10.1016/j.isci.2022.105293

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    ncbi.nlm.nih.gov/pmc/articles/PMC9589213/
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    METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma
    1
    1. scibot 26 Oct 2022
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      DOI: 10.1016/j.celrep.2022.111530

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    sciencedirect.com/science/article/pii/S2211124722013869
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    A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation
    1
    1. scibot 26 Oct 2022
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    sciencedirect.com/science/article/pii/S2211124722013985
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection
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    1. scibot 26 Oct 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9533670/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9587000/
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    ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins
    1
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      DOI: 10.1016/j.molcel.2022.09.035

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    sciencedirect.com/science/article/pii/S109727652200956X
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    Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer
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    1. scibot 23 Oct 2022
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    sciencedirect.com/science/article/pii/S1097276522009558
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    Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas
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    1. scibot 22 Oct 2022
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    sciencedirect.com/science/article/pii/S1097276522009340
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    RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
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    1. scibot 20 Oct 2022
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    sciencedirect.com/science/article/pii/S1097276522009352
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    Allelic variation in the Arabidopsis TNL CHS3/CSA1 immune receptor pair reveals two functional cell-death regulatory modes
    1
    1. scibot 20 Oct 2022
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      DOI: 10.1016/j.chom.2022.09.013

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    sciencedirect.com/science/article/pii/S1931312822004693
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    CasPlay provides a gRNA-barcoded CRISPR-based display platform for antibody repertoire profiling
    1
    1. scibot 20 Oct 2022
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      DOI: 10.1016/j.crmeth.2022.100318

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    sciencedirect.com/science/article/pii/S2667237522002089
  22. academic.oup.com academic.oup.com
    Brain-wide connectivity map of mouse thermosensory cortices
    1
    1. scibot 19 Oct 2022
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      DOI: 10.1093/cercor/bhac386

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    academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhac386/6762895
  23. elifesciences.org elifesciences.org
    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
    1
    1. scibot 19 Oct 2022
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      DOI: 10.7554/eLife.79771

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    elifesciences.org/articles/79771
  24. www.sciencedirect.com www.sciencedirect.com
    GPC3-Unc5 receptor complex structure and role in cell migration
    1
    1. scibot 18 Oct 2022
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      DOI: 10.1016/j.cell.2022.09.025

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    sciencedirect.com/science/article/pii/S0092867422011977
  25. www.cell.com www.cell.com
    Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity
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    1. scibot 18 Oct 2022
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      DOI: 10.1016/j.neuron.2022.09.021

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    cell.com/neuron/fulltext/S0896-6273(22)00860-1
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    Spatial epitope barcoding reveals clonal tumor patch behaviors
    1
    1. scibot 16 Oct 2022
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      DOI: 10.1016/j.ccell.2022.09.014

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    sciencedirect.com/science/article/pii/S1535610822004433
  27. www.sciencedirect.com www.sciencedirect.com
    The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
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    1. scibot 08 Oct 2022
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      DOI: 10.1016/j.isci.2022.105066

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    sciencedirect.com/science/article/pii/S2589004222013384
  28. www.nature.com www.nature.com
    Enzyme-free targeted DNA demethylation using CRISPR–dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression
    1
    1. scibot 08 Oct 2022
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      DOI: 10.1038/s41596-022-00741-3

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    nature.com/articles/s41596-022-00741-3
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia
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    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.isci.2022.105139

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    ncbi.nlm.nih.gov/pmc/articles/PMC9526175/
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    Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex
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    sciencedirect.com/science/article/pii/S1097276522008954
  31. Sep 2022
  32. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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    1. scibot 29 Sep 2022
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      DOI: 10.15252/embr.202154136

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    embopress.org/doi/10.15252/embr.202154136
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    Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis
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    sciencedirect.com/science/article/pii/S2211124722012402
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape
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      DOI: 10.7554/eLife.80111

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    ncbi.nlm.nih.gov/pmc/articles/PMC9507126/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
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      DOI: 10.1126/sciadv.abo6333

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    ncbi.nlm.nih.gov/pmc/articles/PMC9462691/
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    Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors
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    sciencedirect.com/science/article/pii/S030146812200072X
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    Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL
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    sciencedirect.com/science/article/pii/S2666166722005901
  38. www.authorea.com www.authorea.com
    ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
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      DOI: 10.22541/au.166126327.70529620/v1

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    authorea.com/users/503180/articles/582965-isx9-a-small-molecule-targeting-axin-activates-wnt-β-catenin-signaling-and-promotes-hair-regrowth
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC9474293/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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      DOI: 10.1042/BCJ20220161

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    ncbi.nlm.nih.gov/pmc/articles/PMC9472821/
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    ATP hydrolysis tunes specificity of a AAA+ protease
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    sciencedirect.com/science/article/pii/S2211124722012426
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic refactor of essential genes decodes functionally constrained sequences in yeast genome
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    ncbi.nlm.nih.gov/pmc/articles/PMC9460170/
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    Structure and mechanism of human cystine exporter cystinosin
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      DOI: 10.1016/j.cell.2022.08.020

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    Integrative RNA-omics discovers GNAS alternative splicing as a phenotypic driver of splicing factor-mutant neoplasms
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    Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
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    Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis
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    Acetylation of p62 regulates base excision repair through interaction with APE1
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    Sen1 is a key regulator of transcription-driven conflicts
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    Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5
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    CaMKII binds both substrates and activators at the active site
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    Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA
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    Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism
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    The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex
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    Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion
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    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
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    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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    Tandem immuno-purification of affinity-tagged proteins from mouse testis extracts for MS analysis
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    UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth
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    TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
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    Time-resolved Phosphoproteome and Proteome Analysis Reveals Kinase Signalling on Master Transcription Factors During Myogenesis
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    Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome
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    An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates
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    γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor
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    DDX41 is required for cGAS-STING activation against DNA virus infection
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9
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    Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15
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    Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells
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    Chromatin remodeling is restricted by transient GATA6 binding during iPSC differentiation to definitive endoderm
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    Quantitative analysis of protein-RNA interactions in fission yeast
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    Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
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    Adipose mitochondrial metabolism controls body growth by modulating systemic cytokine and insulin signaling
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    Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors
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    KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4
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    BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43
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    Gene regulatory networks shape developmental plasticity of root cell types under water extremes in rice
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    ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer
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    Generation of RYBP FLAG-HA knock-in human embryonic stem cell line through CRISPR/Cas9-mediated homologous recombination
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    The Mettl3 epitranscriptomic writer amplifies p53 stress responses
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    Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells
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    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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    Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis
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    CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming
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    Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
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    GFI1 cooperates with IKZF1/IKAROS to activate gene expression in T-cell acute lymphoblastic leukemia
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    The roles of RNA helicases in DNA damage repair and tumorigenesis reveal precision therapeutic strategies
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    Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies
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    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
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    Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly
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    Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies
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    A local insulin reservoir in Drosophila alpha cell homologs ensures developmental progression under nutrient shortage
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    RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development
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    Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML
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    Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis
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  170. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains
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  172. www.sciencedirect.com www.sciencedirect.com
    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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    Generation of a GFI1-flag knock-in human embryonic stem cell line using CRISPR-Cas9 technology
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    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
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    Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis
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    Cryo-EM structure of the human TACAN in a closed state
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  177. Feb 2022
  178. www.sciencedirect.com www.sciencedirect.com
    Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
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    Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
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  180. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes
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  183. www.sciencedirect.com www.sciencedirect.com
    Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants
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    Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity
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  185. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex
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    Co-adaptor driven assembly of a CUL3 E3 ligase complex
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
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    Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2
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    Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.
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    An oncogenic enhancer encodes selective selenium dependency in AML
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  195. www.nature.com www.nature.com
    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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  196. Jan 2022
  197. www.molbiolcell.org www.molbiolcell.org
    Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport
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    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
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    Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems
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    Compartmentalization of telomeres through DNA-scaffolded phase separation
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    Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis
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    Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216
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  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation
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      DOI: 10.7554/eLife.72867

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