1,815 Matching Annotations
  1. Oct 2022
  2. www.sciencedirect.com www.sciencedirect.com
    CasPlay provides a gRNA-barcoded CRISPR-based display platform for antibody repertoire profiling
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    1. scibot 20 Oct 2022
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      DOI: 10.1016/j.crmeth.2022.100318

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    sciencedirect.com/science/article/pii/S2667237522002089
  3. academic.oup.com academic.oup.com
    Brain-wide connectivity map of mouse thermosensory cortices
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    1. scibot 19 Oct 2022
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      DOI: 10.1093/cercor/bhac386

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    academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhac386/6762895
  4. elifesciences.org elifesciences.org
    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
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    1. scibot 19 Oct 2022
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      DOI: 10.7554/eLife.79771

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    elifesciences.org/articles/79771
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    GPC3-Unc5 receptor complex structure and role in cell migration
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    1. scibot 18 Oct 2022
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      DOI: 10.1016/j.cell.2022.09.025

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    sciencedirect.com/science/article/pii/S0092867422011977
  6. www.cell.com www.cell.com
    Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity
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      DOI: 10.1016/j.neuron.2022.09.021

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    cell.com/neuron/fulltext/S0896-6273(22)00860-1
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    Spatial epitope barcoding reveals clonal tumor patch behaviors
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    sciencedirect.com/science/article/pii/S1535610822004433
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    The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
    1
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      DOI: 10.1016/j.isci.2022.105066

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    sciencedirect.com/science/article/pii/S2589004222013384
  9. www.nature.com www.nature.com
    Enzyme-free targeted DNA demethylation using CRISPR–dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression
    1
    1. scibot 08 Oct 2022
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      DOI: 10.1038/s41596-022-00741-3

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    nature.com/articles/s41596-022-00741-3
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia
    1
    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.isci.2022.105139

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    ncbi.nlm.nih.gov/pmc/articles/PMC9526175/
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    Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex
    1
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    sciencedirect.com/science/article/pii/S1097276522008954
  12. Sep 2022
  13. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
    1
    1. scibot 29 Sep 2022
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      DOI: 10.15252/embr.202154136

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    embopress.org/doi/10.15252/embr.202154136
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    Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis
    1
    1. scibot 29 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111403

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    sciencedirect.com/science/article/pii/S2211124722012402
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape
    1
    1. scibot 27 Sep 2022
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      DOI: 10.7554/eLife.80111

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    ncbi.nlm.nih.gov/pmc/articles/PMC9507126/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
    1
    1. scibot 27 Sep 2022
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      DOI: 10.1126/sciadv.abo6333

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    ncbi.nlm.nih.gov/pmc/articles/PMC9462691/
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    Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors
    1
    1. scibot 27 Sep 2022
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      DOI: 10.1016/j.diff.2022.09.002

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    sciencedirect.com/science/article/pii/S030146812200072X
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    Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL
    1
    1. scibot 22 Sep 2022
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      DOI: 10.1016/j.xpro.2022.101710

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    sciencedirect.com/science/article/pii/S2666166722005901
  19. www.authorea.com www.authorea.com
    ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
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    1. scibot 22 Sep 2022
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      DOI: 10.22541/au.166126327.70529620/v1

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    authorea.com/users/503180/articles/582965-isx9-a-small-molecule-targeting-axin-activates-wnt-β-catenin-signaling-and-promotes-hair-regrowth
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions
    1
    1. scibot 22 Sep 2022
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      DOI: 10.1016/j.isci.2022.105011

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    ncbi.nlm.nih.gov/pmc/articles/PMC9474293/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
    1
    1. scibot 22 Sep 2022
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      DOI: 10.1042/BCJ20220161

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    ncbi.nlm.nih.gov/pmc/articles/PMC9472821/
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    ATP hydrolysis tunes specificity of a AAA+ protease
    1
    1. scibot 21 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111405

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    sciencedirect.com/science/article/pii/S2211124722012426
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic refactor of essential genes decodes functionally constrained sequences in yeast genome
    1
    1. scibot 21 Sep 2022
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      DOI: 10.1016/j.isci.2022.104982

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    ncbi.nlm.nih.gov/pmc/articles/PMC9460170/
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    Structure and mechanism of human cystine exporter cystinosin
    1
    1. scibot 17 Sep 2022
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      DOI: 10.1016/j.cell.2022.08.020

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    sciencedirect.com/science/article/pii/S009286742201114X
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    Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover
    1
    1. scibot 16 Sep 2022
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      DOI: 10.1016/j.molcel.2022.08.018

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    sciencedirect.com/science/article/pii/S1097276522008073
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    Control of ribosomal RNA synthesis by hematopoietic transcription factors
    1
    1. scibot 16 Sep 2022
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      DOI: 10.1016/j.molcel.2022.08.027

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    sciencedirect.com/science/article/pii/S1097276522008474
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    Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation
    1
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      DOI: 10.1016/j.celrep.2022.111345

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    sciencedirect.com/science/article/pii/S2211124722011731
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    Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development
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      DOI: 10.1016/j.celrep.2022.111350

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    sciencedirect.com/science/article/pii/S2211124722011780
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    Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity
    1
    1. scibot 10 Sep 2022
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      DOI: 10.1016/j.neuron.2022.08.016

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    sciencedirect.com/science/article/pii/S0896627322007486
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    Shear stress activates nociceptors to drive Drosophila mechanical nociception
    1
    1. scibot 10 Sep 2022
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      DOI: 10.1016/j.neuron.2022.08.015

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    sciencedirect.com/science/article/pii/S0896627322007474
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    Target protein localization and its impact on PROTAC-mediated degradation
    1
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      DOI: 10.1016/j.chembiol.2022.08.004

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    sciencedirect.com/science/article/pii/S2451945622003129
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    Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages
    1
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      DOI: 10.1016/j.celrep.2022.111315

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    sciencedirect.com/science/article/pii/S2211124722011391
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    A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing
    1
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    sciencedirect.com/science/article/pii/S221112472201083X
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative RNA-omics discovers GNAS alternative splicing as a phenotypic driver of splicing factor-mutant neoplasms
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      DOI: 10.1158/2159-8290.CD-21-0508

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904276/
  35. Aug 2022
  36. www.sciencedirect.com www.sciencedirect.com
    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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    sciencedirect.com/science/article/pii/S2211124722011135
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    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    sciencedirect.com/science/article/pii/S2211124722010865
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    Ubiquitination of phosphatidylethanolamine in organellar membranes
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    sciencedirect.com/science/article/pii/S1097276522007614
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    Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction
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    sciencedirect.com/science/article/pii/S2589004222012135
  40. 52.53.155.43 52.53.155.43
    ccr-21-3603-html.html
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain
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      DOI: 10.1126/sciadv.abo5633

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    ncbi.nlm.nih.gov/pmc/articles/PMC9348805/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans
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      DOI: 10.7554/eLife.76436

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    ncbi.nlm.nih.gov/pmc/articles/PMC9388098/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk
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      DOI: 10.3389/fnagi.2022.896522

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    The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations
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    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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    N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
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    Protocol for viral vector-mediated measurement of transcription factor activity of mouse brain
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    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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    Neuronal paxillin and drebrin mediate BDNF-induced force transduction and growth cone turning in a soft-tissue-like environment
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    Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases
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    Multi-facet roles of RNA editing in promoting loss-of-function of PODXL in cancer
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    TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
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    BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL
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    Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation
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    Broad-spectrum chemicals block ROS detoxification to prevent plant fungal invasion
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    Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis
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    Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation
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    The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors
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    A dRASSF-STRIPAK-Imd-JAK/STAT axis controls antiviral immune response in Drosophila
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    PABP/purine-rich motif as an initiation module for cap-independent translation in pattern-triggered immunity
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    Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
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    Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
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    Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
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    Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis
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    Acetylation of p62 regulates base excision repair through interaction with APE1
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    Sen1 is a key regulator of transcription-driven conflicts
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    CaMKII binds both substrates and activators at the active site
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    Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA
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    Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism
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    The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex
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    Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
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    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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    Tandem immuno-purification of affinity-tagged proteins from mouse testis extracts for MS analysis
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    UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth
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    Time-resolved Phosphoproteome and Proteome Analysis Reveals Kinase Signalling on Master Transcription Factors During Myogenesis
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    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
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    Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
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    Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly
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    Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies
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    A local insulin reservoir in Drosophila alpha cell homologs ensures developmental progression under nutrient shortage
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    RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
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    Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair
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    Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain
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    Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport
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    Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development
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    Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML
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    Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis
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    Robust regulatory architecture of pan-neuronal gene expression
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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    Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains
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    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
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    Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
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    Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
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    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4
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    The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes
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    Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity
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    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex
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    Co-adaptor driven assembly of a CUL3 E3 ligase complex
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
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    Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2
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    Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.
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    An oncogenic enhancer encodes selective selenium dependency in AML
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    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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  177. Jan 2022
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    Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport
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    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
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    Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems
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    Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis
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    Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216
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    Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation
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    A fluorescence recovery after photobleaching protocol to measure surface diffusion of DAGLα in primary cultured cortical mouse neurons
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    Global RNA interactome of Salmonella discovers a 5′ UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity
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    Metastasis enhancer PGRMC1 boosts store-operated Ca2+ entry by uncoiling Ca2+ sensor STIM1 for focal adhesion turnover and actomyosin formation
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    Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons
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    Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death
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    Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity
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    GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors
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    The sex determination gene doublesex regulates expression and secretion of the basement membrane protein Collagen IV
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    Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
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    Identification and functional characterization of transcriptional activators in human cells
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    Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality
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    An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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  200. Dec 2021
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    NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis
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    Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
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    RNA circles with minimized immunogenicity as potent PKR inhibitors
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