669 Matching Annotations
  1. Jan 2020
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    sciencedirect.com/science/article/pii/S2211124719300051
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    Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
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    sciencedirect.com/science/article/pii/S2352396418306273
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    MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
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    sciencedirect.com/science/article/pii/S1097276519301029
  5. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Viral vector‐mediated Cre recombinase expression in substantia nigra induces lesions of the nigrostriatal pathway associated with perturbations of dopamine‐related behaviors and hallmarks of programmed cell death
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14684
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    sciencedirect.com/science/article/pii/S0960982219301460
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    High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells
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    sciencedirect.com/science/article/pii/S1550413119300695
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    Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence
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    sciencedirect.com/science/article/pii/S1097276518308438
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    ncbi.nlm.nih.gov/pmc/articles/PMC6392498/
  11. Nov 2018
  12. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S1534580718308256
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    Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
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    sciencedirect.com/science/article/pii/S2211124718315419
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    The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage
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    sciencedirect.com/science/article/pii/S1097276518307573
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    Impeding DNA Break Repair Enables Oocyte Quality Control
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    Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair
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    Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11
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    Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
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    Germ Cell–Specific Retinoic Acid Receptor α Functions in Germ Cell Organization, Meiotic Integrity, and Spermatogonia
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    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
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    Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors
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    Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer
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    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
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    SLFN11 Blocks Stressed Replication Forks Independently of ATR
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    Detection of DNA Double Strand Breaks by γH2AX Does Not Result in 53bp1 Recruitment in Mouse Retinal Tissues
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    Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations
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    An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential
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    The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression
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    Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
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    PRDM9 Methyltransferase Activity Is Essential for Meiotic DNA Double-Strand Break Formation at Its Binding Sites
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    The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair
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    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
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    The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations
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    A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.
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    Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle
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    Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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    SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage
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    Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice
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    academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/iox150/4638519
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    Early Histone H4 Acetylation during Chromatin Remodeling in Equine Spermatogenesis
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    Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
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    The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.
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    europepmc.org/articles/PMC5703642/
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    Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration
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  53. wellcomeopenresearch.org wellcomeopenresearch.org
    Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer
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    wellcomeopenresearch.org/articles/2-110
  54. academic.oup.com academic.oup.com
    Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response
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    academic.oup.com/endo/article/158/11/4000/4093568
  55. Nov 2017
  56. www.sciencedirect.com www.sciencedirect.com
    SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs
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    TERRA RNA Antagonizes ATRX and Protects Telomeres
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    Genome Organization Drives Chromosome Fragility
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    Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport
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    Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects
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    Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining
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    ncbi.nlm.nih.gov/pmc/articles/PMC5468090/
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    A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
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    RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice
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    Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9
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    CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes
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    p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo
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    BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice
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    Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1
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    The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence
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    Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
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    NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
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    TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair
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