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1,369 Matching Annotations

Dec 2022
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Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model

1
1. scibot 31 Dec 2022
  
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  DOI: 10.3389/fnbeh.2022.1087075
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9772010/
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Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality

1
1. scibot 30 Dec 2022
  
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  DOI: 10.1016/j.isci.2022.105766
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9793319/
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Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

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1. scibot 22 Dec 2022
  
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  DOI: 10.3390/cells11244116
  
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mdpi.com/2073-4409/11/24/4116
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Increased replication origin firing links replication stress to whole chromosomal instability in human cancer

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  DOI: 10.1016/j.celrep.2022.111836
  
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sciencedirect.com/science/article/pii/S2211124722017284
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The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

1
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  DOI: 10.1016/j.celrep.2022.111819
  
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VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARβ/δ activation

1
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Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

1
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  DOI: 10.7554/eLife.78609
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9754625/
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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

1
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Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage

1
1. scibot 13 Dec 2022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9727431/
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PERIOD 2 Regulates Low Dose Radioprotection via PER2/pGSK3β/β-Catenin/Per2 Loop

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ncbi.nlm.nih.gov/pmc/articles/PMC9708791/
Nov 2022
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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.molcel.2022.11.002
  
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sciencedirect.com/science/article/abs/pii/S1097276522010644
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Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2

1
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  DOI: 10.1016/j.celrep.2022.111709
  
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Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells

1
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ncbi.nlm.nih.gov/pmc/articles/PMC9672935/
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B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer

1
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  DOI: 10.1016/j.isci.2022.105419
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9646953/
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CRABP2 is associated with thyroid cancer recurrence and promotes invasion via the integrin/FAK/AKT pathway

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  DOI: 10.1210/endocr/bqac171
  
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academic.oup.com/endo/article-abstract/163/12/bqac171/6761323
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The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

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  DOI: 10.1091/mbc.E22-03-0096
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9635304/
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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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  DOI: 10.1016/j.molcel.2022.10.026
  
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CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation

1
1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111639
  
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sciencedirect.com/science/article/pii/S2211124722015108
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The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool

1
1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111645
  
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FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism

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  DOI: 10.1016/j.celrep.2022.111668
  
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sciencedirect.com/science/article/pii/S221112472201542X
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  DOI: 10.21203/rs.3.rs-658360/v1
  
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researchsquare.com/article/rs-7216019/'https://www.researchsquare.com/article/rs-7216019/v1
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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

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Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma

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  DOI: 10.1016/j.celrep.2022.111601
  
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Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway

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  DOI: 10.1016/j.chembiol.2022.10.003
  
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Metabolic regulation by p53 prevents R-loop-associated genomic instability

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  DOI: 10.1016/j.celrep.2022.111568
  
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Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice

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  DOI: 10.1002/glia.24292
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24292
Oct 2022
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Brain Endothelial Cells in Contrary to the Aortic Do Not Transport but Degrade Low-Density Lipoproteins via Both LDLR and ALK1

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  DOI: 10.3390/cells11193044
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9564369/
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The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

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  DOI: 10.1016/j.isci.2022.105233
  
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Long noncoding RNA Pvt1 promotes the proliferation and... : Neural Regeneration Research

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  DOI: 10.4103/1673-5374.353497
  
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journals.lww.com/nrronline/Fulltext/2023/05000/Long_noncoding_RNA_Pvt1_promotes_the_proliferation.35.aspx
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GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

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  DOI: 10.7554/eLife.81083
  
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The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice

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  DOI: 10.1016/j.cmet.2022.09.019
  
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Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

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  DOI: 10.1038/s41467-022-33749-0
  
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nature.com/articles/s41467-022-33749-0
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Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex

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  DOI: 10.1016/j.celrep.2022.111483
  
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Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

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  DOI: 10.1016/j.devcel.2022.09.002
  
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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

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A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency

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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

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S1-END-seq reveals DNA secondary structures in human cells

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m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation

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Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome

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Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton

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Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock

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Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism

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BPS Publications

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Expression pattern of NLRC5 in the postnatal mouse brain

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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages

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Cancer genes disfavoring T cell immunity identified via integrated systems approach

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Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1

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A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication

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Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

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LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease

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IGSF1 deficiency leads to reduced TSH production independent of alterations in thyroid hormone action in male mice

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Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity

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A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase

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Upregulation of FOXO1 contributes to lipopolysaccharide-induced pulmonary endothelial injury by induction of autophagy

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BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1

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Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth

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Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response

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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

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Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia

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Mechanoreceptor Piezo1 Is Downregulated in Multiple Sclerosis Brain and Is Involved in the Maturation and Migration of Oligodendrocytes in vitro

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Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance

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Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation

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Monocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity

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A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

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Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity

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Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity

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Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury

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UPF1 promotes rapid degradation of m6A-containing RNAs

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DDX41 is required for cGAS-STING activation against DNA virus infection

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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

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Increased microtubule growth triggered by microvesicle-mediated paracrine signaling is required for melanoma cancer cell invasion

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Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors

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A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling

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CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells

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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition

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Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders

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Convergent somatic mutations in metabolism genes in chronic liver disease

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Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML

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Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia

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PIIS2589004222005594-html.html

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Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile mice

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Energetic metabolic reprogramming in Jurkat DFF40-deficient cancer cells

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Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models

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CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair

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DNA replication is highly resilient and persistent under the challenge of mild replication stress

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Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain

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A Foxo1-Klf2-S1pr1-Gnai1-Rac1 signaling axis is a critical mediator of Ostm1 regulatory network in T-lymphopoiesis

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Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

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Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

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Rapid establishment of human colonic organoid knockout lines

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Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes

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Brown adipose tissue involution associated with progressive restriction in progenitor competence

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Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C

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MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling

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Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy

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Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans

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δ-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice

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Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

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Mar 2022
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BPS Publications

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Acute inflammation down-regulates alpha-synuclein expression in enteric neurons

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Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells

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Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms

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Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

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Distinct and diverse chromatin proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions

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Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle

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Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury

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Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons

1
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  DOI: 10.3390/cells11050782
  
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Central dopaminergic control of cell proliferation in the colonic epithelium

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Reducing host aldose reductase activity promotes neuronal differentiation of transplanted neural stem cells at spinal cord injury sites and facilitates locomotion recovery

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Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord

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Alzheimer’s disease and cerebrovascular pathology alter brain endothelial inward rectifier potassium (KIR2.1) channels

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MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

1
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LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function

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Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces

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Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans

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Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults

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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12

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Targeting CCR2+ macrophages with BET inhibitor overcomes adaptive resistance to anti-VEGF therapy in ovarian cancer

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Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes

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  DOI: 10.1038/s41596-021-00638-7
  
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Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

1
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NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans

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Sphingosine 1-phosphate receptor 4 promotes nonalcoholic steatohepatitis by activating NLRP3 inflammasome

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Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity

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The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

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TGFBR3L is an inhibin B co-receptor that regulates female fertility

1
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  DOI: 10.1126/sciadv.abl4391
  
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Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

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Defects in Emerin-nucleoskeleton binding disrupt nuclear structure and promote breast cancer cell motility and metastasis

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Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

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TGFBR3L is an inhibin B co-receptor that regulates female fertility

1
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Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells

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Integrative proteo-transcriptomic and immunophenotyping signatures of HIV-1 elite control phenotype: A cross-talk between glycolysis and HIF signaling

1
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Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis

1
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ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway

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  DOI: 10.1096/fj.202002031RR
  
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Dynamic stem cell selection safeguards the genomic integrity of the epidermis

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Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease

1
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  DOI: 10.7554/eLife.73753
  
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YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis

1
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lncRNA BORG:TRIM28 Complexes Drive Metastatic Progression by Inducing α6 Integrin/CD49f Expression in Breast Cancer Stem Cells

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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

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  DOI: 10.7554/eLife.73430
  
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Methods to separate nuclear soluble fractions reflecting localizations in living cells

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Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice

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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

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Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

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Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing

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Involvement of the miR-363-5p/P2RX4 Axis in Regulating Schwann Cell Phenotype after Nerve Injury

1
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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

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Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts

1
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Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency

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FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma

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Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

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Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex

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Oct 2021
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Differentiation of human induced pluripotent stem cells into testosterone-producing Leydig-like cells

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  DOI: 10.1210/endocr/bqab202
  
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An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity

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Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival

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IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

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Effect of retinol dehydrogenase gene transfer in a novel rat model of Stargardt disease

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  DOI: 10.1096/fj.202002525RRR
  
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The TLR4–TRIF–type 1 IFN–IFN-γ pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection

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Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein

1
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  DOI: 10.1038/s42003-021-02633-w
  
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Immortalized striatal precursor neurons from Huntington’s disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics

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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK

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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

1
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Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging

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A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

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Thiamine deficiency and recovery: impact of recurrent episodes and beneficial effect of treatment with Trolox and dimethyl sulfoxide

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  DOI: 10.1007/s00210-021-02148-5
  
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Comparison of Histone H3K4me3 between IVF and ICSI Technologies and between Boy and Girl Offspring

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  DOI: 10.3390/ijms22168574
  
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Aug 2021
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Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

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Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis

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CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance

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  DOI: 10.1016/j.celrep.2021.109549
  
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CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

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Sex and brain region specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice

1
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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

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3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice

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Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis

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NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

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GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

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Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

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Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis

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The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors

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TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer

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Genetic interactions of G-quadruplexes in humans

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Crosstalk control and limits of physiological c-Jun N-terminal kinase activity for cell viability and neurite stability in differentiated PC12 cells - ScienceDirect

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