942 Matching Annotations
  1. Jun 2021
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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    1. scibot 16 Jun 2021
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      DOI: 10.3390/cancers13112840

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    ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
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    Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion
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    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.cell.2021.05.015

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    sciencedirect.com/science/article/pii/S0092867421006322
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    The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation
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    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109252

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    sciencedirect.com/science/article/pii/S2211124721006173
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    Identification and validation of selective deubiquitinase inhibitors
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    1. scibot 16 Jun 2021
      RRID:AB_1031003

      DOI: 10.1016/j.chembiol.2021.05.012

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    sciencedirect.com/science/article/pii/S2451945621002579
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    A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
    1
    1. scibot 09 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109217

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    sciencedirect.com/science/article/pii/S2211124721005684
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    Muscle regeneration controlled by a designated DNA dioxygenase
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    nature.com/articles/s41419-021-03817-2
  8. May 2021
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    Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors
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    1. scibot 29 May 2021
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      DOI: 10.1016/j.cels.2021.05.002

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    sciencedirect.com/science/article/pii/S2405471221001575
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    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
    1
    1. scibot 28 May 2021
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    sciencedirect.com/science/article/pii/S0092867421005729
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
    1
    1. scibot 21 May 2021
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      DOI: 10.7554/eLife.66519

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    ncbi.nlm.nih.gov/pmc/articles/PMC8128440/
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    BPS Publications
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    1. scibot 20 May 2021
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      DOI: 10.1111/bph.15340

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15340
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    DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation
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    1. scibot 19 May 2021
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      DOI: 10.7554/eLife.61769

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    ncbi.nlm.nih.gov/pmc/articles/PMC8116049/
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    1. scibot 18 May 2021
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      DOI: 10.1016/j.cell.2021.04.022

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    Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing
    1
    1. scibot 13 May 2021
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      DOI: 10.1016/j.stem.2021.04.003

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    sciencedirect.com/science/article/pii/S1934590921001600
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    The f subunit of human ATP synthase is essential for normal mitochondrial morphology and permeability transition
    1
    1. scibot 12 May 2021
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      DOI: 10.1016/j.celrep.2021.109111

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    sciencedirect.com/science/article/pii/S2211124721004459
  17. journals.physiology.org journals.physiology.org
    Altered calcium handling in cardiomyocytes from arginine:glycine amidinotransferase knockout mice is rescued by creatine
    1
    1. scibot 11 May 2021
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      DOI: 10.1152/ajpheart.00300.2020

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    journals.physiology.org/doi/abs/10.1152/ajpheart.00300.2020
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    METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection
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    1. scibot 11 May 2021
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      DOI: 10.1016/j.celrep.2021.109091

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    sciencedirect.com/science/article/pii/S2211124721004253
  19. academic.oup.com academic.oup.com
    Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder
    1
    1. scibot 10 May 2021
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      DOI: 10.1210/endocr/bqaa211

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    academic.oup.com/endo/article/162/1/bqaa211/5988952
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    Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis
    1
    1. scibot 09 May 2021
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      DOI: 10.1016/j.ymthe.2021.01.032

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    sciencedirect.com/science/article/pii/S1525001621000666
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    Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells
    1
    1. scibot 09 May 2021
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      DOI: 10.1016/j.stem.2021.04.006

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    sciencedirect.com/science/article/pii/S1934590921001636
  22. www.sciencedirect.com www.sciencedirect.com
    Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2021.02.023

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    sciencedirect.com/science/article/pii/S0896627321001239
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    Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2020.10.012

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    sciencedirect.com/science/article/pii/S0896627320308084
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2020.07.023

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    sciencedirect.com/science/article/pii/S0896627320305675
  25. www.jneurosci.org www.jneurosci.org
    The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling
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      DOI: 10.1523/JNEUROSCI.2386-20.2021

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    jneurosci.org/content/41/8/1650
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.07.010

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    sciencedirect.com/science/article/pii/S1097276520304767
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    Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation
    1
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      DOI: 10.1016/j.molcel.2020.04.033

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    sciencedirect.com/science/article/pii/S1097276520302756
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    SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts
    1
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      DOI: 10.1016/j.molcel.2020.05.011

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    sciencedirect.com/science/article/pii/S1097276520303129
  29. www.sciencedirect.com www.sciencedirect.com
    Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells
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    1. scibot 06 May 2021
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      DOI: 10.1016/j.devcel.2021.02.020

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    sciencedirect.com/science/article/pii/S153458072100160X
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    Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells
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      DOI: 10.1016/j.devcel.2021.01.012

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    sciencedirect.com/science/article/pii/S1534580721000708
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.08.006

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    sciencedirect.com/science/article/pii/S1534580720306304
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    An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells
    1
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      DOI: 10.1016/j.devcel.2020.08.001

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    sciencedirect.com/science/article/pii/S1534580720305992
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology
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    1. scibot 05 May 2021
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      DOI: 10.7554/eLife.66904

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    ncbi.nlm.nih.gov/pmc/articles/PMC8075583/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis
    1
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      DOI: 10.1152/ajplung.00069.2019

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    ncbi.nlm.nih.gov/pmc/articles/PMC7272732/
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    CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism
    1
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      GAPDH

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    sciencedirect.com/science/article/pii/S002222752100064X
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    C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly
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      DOI: 10.1016/j.cmet.2021.01.005

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    sciencedirect.com/science/article/pii/S155041312100005X
  37. Apr 2021
  38. www.sciencedirect.com www.sciencedirect.com
    MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice
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      DOI: 10.1016/j.cmet.2020.12.019

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    sciencedirect.com/science/article/pii/S1550413120307178
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    The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
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    sciencedirect.com/science/article/pii/S1550413120306069
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    Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells
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      DOI: 10.1016/j.cmet.2020.10.017

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    sciencedirect.com/science/article/pii/S1550413120305507
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    Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
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      DOI: 10.1016/j.cmet.2020.08.004

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    sciencedirect.com/science/article/pii/S1550413120304174
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    The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development
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      DOI: 10.1016/j.cmet.2020.05.008

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    sciencedirect.com/science/article/pii/S1550413120302473
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    A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex
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      DOI: 10.1016/j.chembiol.2021.02.007

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    sciencedirect.com/science/article/pii/S2451945621000921
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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      Rabbit anti-GADPH

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    Low expression of the PPARγ-regulated gene thioredoxin-interacting protein accompanies human melanoma progression and promotes experimental lung metastases
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    Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
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    The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
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    Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras
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    Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and Its Target APOBEC3G and Thereby Pancreatic Cancer Progression
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    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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    Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency
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    Apurinic/apyrimidinic endonuclease 1/reduction-oxidation effector factor-1 (APE1) regulates the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome through modulating transcription factor NF-κB and promoting the secretion of inflammatory mediators in macrophages
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    The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24
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    Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice
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    Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
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    ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy
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      GAPDH

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    Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
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    ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through Autophagy
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    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
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  84. Dec 2020
  85. academic.oup.com academic.oup.com
    A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
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      anti-GAPDH

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    CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
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    Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
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    Weak acids induce PGE 2 production in human oesophageal cells: novel mechanisms underlying GERD symptoms
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    A Hemidesmosome-to-Cytoplasm Translocation of Small Heat Shock Proteins Provides Immediate Protection against Heat Stress
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    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation
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  91. Nov 2020
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    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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    De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment
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      rabbit polyclonal anti-GAPDH

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    Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway
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    A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration
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    Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
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    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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    Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry
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    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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    Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
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    Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes
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      glyceraldehyde‐3‐phosphate dehydrogenase

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    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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    Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
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    Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner
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    A novel HER2-targeting antibody 5G9 identified by large-scale trastuzumab-based screening exhibits potent synergistic antitumor activity
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    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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    Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
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    Sex‐dependent pronociceptive role of spinal α5‐GABAA receptor and its epigenetic regulation in neuropathic rodents
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  123. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication
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    Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53
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    Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress
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    ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin
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    Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge
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    Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC‐5 fibroblasts via regulating lipid accumulation and mitochondrial function
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    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
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    Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis | American Journal of Physiology-Lung Cellular and Molecular Physiology
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    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
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    Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis
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    Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains
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    Structural Basis for Target-Directed MicroRNA Degradation
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress
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    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
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    Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
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    Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma
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    TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine‐induced chemokine production and neutrophil migration
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    PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD
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    CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity
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    Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1
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    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)
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    Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway
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      RRID:AB_561053 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14849
  208. www.sciencedirect.com www.sciencedirect.com
    The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation
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    1. scibot 13 Jan 2020
      RRID:AB_561053

      DOI: 10.1016/j.chembiol.2019.04.011

      Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

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      RRID:AB_561053 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2451945619301424
  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic HKDC1 Expression Contributes to Liver Metabolism
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    1. scibot 13 Jan 2020
      RRID:AB_561053

      DOI: 10.1210/en.2018-00887

      Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

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    ncbi.nlm.nih.gov/pmc/articles/PMC6334269/
  210. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Hippocampal BDNF regulates a shift from flexible, goal‐directed to habit memory system function following cocaine abstinence
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    1. scibot 13 Jan 2020
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      DOI: 10.1002/hipo.23127

      Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

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      RRID:AB_561053 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/full/10.1002/hipo.23127
  211. www.sciencedirect.com www.sciencedirect.com
    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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    1. scibot 13 Jan 2020
      AB_561053

      DOI: 10.1016/j.immuni.2019.07.007

      Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

      Curator: @ethanbadger

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      RRID:AB_561053 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761319303231