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Jun 2026
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Th17-Mediated Antitumor Immunity in Patient-Derived Organoid and Autologous Immune Cell Co-Cultures Predicts Response to Immunotherapy in Head and Neck Cancer

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An INF2-dependent actin-mediated step in inositol 1,4,5-trisphosphate receptor cluster formation and activity

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A TME-powered implantable battery for visual monitoring and electrochemical immunotherapy of postoperative tumor recurrence

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Dysregulated NF-κB dynamics impair proteostasis and drive premature differentiation in aging B cell development

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Hormetic fasting extends Caenorhabditis elegans lifespan via H3K27 acetylation of lipid catabolism and antioxidant genes

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The hepatitis E virus capsid protein forms amyloid-like fibrils that sequester TANK-binding kinase 1 to dampen antiviral responses

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Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling

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Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice

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Exosome-like biogenesis from the Golgi releases extracellular vesicles lacking conventional tetraspanins that mediate immune evasion in cancer

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EGFR- and HER3-targeted bispecific antibody-drug conjugate demonstrates antitumor activity in metastatic castration-resistant prostate cancer

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  DOI: 10.1172/JCI201090
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13221231/
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DGAT1 Drives Racially Divergent Fibroblast Activation via ERK1/2-Dependent Tumorigenic Signaling in Prostate Cancer

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  DOI: 10.1158/2767-9764.CRC-25-0701
  
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PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition

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  DOI: 10.1158/0008-5472.CAN-25-3625
  
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ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis

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  DOI: 10.1158/0008-5472.CAN-25-3006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13195636/
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IMIREG: a lineage-resolved regulon signature unveiling immune engagement archetypes and predicting immunotherapy response across diverse cancers

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  DOI: 10.1038/s41698-026-01453-7
  
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Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs acute myeloid leukemia chemoresistance

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  DOI: 10.1038/s41375-026-02904-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13233328/
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The modulation of AUF1 regulates the R-loop resolution activating the immune response in DDR

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  DOI: 10.1016/j.isci.2026.115900
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13196424/
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Unbiased CRISPR synthetic lethal screening for genetic vulnerabilities in a succinate dehydrogenase-loss model of paraganglioma

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  DOI: 10.1016/j.isci.2026.115885
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13194163/
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AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth

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  DOI: 10.1016/j.devcel.2025.05.008
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12258181/
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Replaying germinal center evolution on a quantified affinity landscape

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  DOI: 10.1016/j.cell.2026.05.013
  
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Conditional deletion of Cc2d1a increases irritability-like behavior by decreasing oxytocin expression via the prelimbic-hypothalamic pathway

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Ionizing radiation enhances prognostically significant cellular immunity programs in the brain metastasis microenvironment

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Using targeted therapy to promote a pro-inflammatory tumour microenvironment and anti-tumour immune response in high grade serous ovarian cancer

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  DOI: 10.1038/s41416-026-03416-y
  
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PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition

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A specialized population of hair afferents dedicated to transmitting mechanical itch

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  DOI: 10.1016/j.neuron.2026.05.017
  
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A hypothalamic circuit for anticipating future changes in energy balance

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  DOI: 10.1016/j.neuron.2026.05.010
  
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Prolonged Inflammation Associates With Greater Infarct Size and Poor Outcome After ST-Segment Elevation Myocardial Infarction

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Precision tumor-on-chip for personalized assessment of drug efficacy and immune cell delivery

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  DOI: 10.1016/j.crmeth.2026.101475
  
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Intracellular acidification by microbiota-derived valeric acid facilitates trans-kingdom ecology limiting Candida parapsilosis colonization

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sciencedirect.com/science/article/pii/S1931312826002015
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Targeting the Conserved RNA-Dependent RNA Polymerase with Antisense Oligonucleotides Suppresses SARS-CoV-2 Variants

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  DOI: 10.1016/j.bbrc.2026.153866
  
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sciencedirect.com/science/article/pii/S0006291X26006303
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Targeting CD73-A2aR-Mediated Adenosine Signaling at the Tumor-Immune Interface Overcomes Radioresistance

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  DOI: 10.64898/2026.05.26.727904
  
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biorxiv.org/content/10.64898/2026.05.26.727904v1
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2026.05.25.727656.full-html.html

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54.241.53.176/32c5a2f4753f61ee28ea249cdeb257eadb13655d/2026.05.25.727656.full-html.html
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A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

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  DOI: 10.1085/jgp.202513945
  
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Type I interferon signaling in hematopoietic cells impairs neutrophil antibacterial function in the middle ear during viral co-infection

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  DOI: 10.1016/j.xcrm.2026.102846
  
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Comprehensive mapping of human CD4+ T cell epitopes for Nipah and measles as prototype Paramyxoviruses

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  DOI: 10.1016/j.xcrm.2026.102838
  
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Spinal NLRP3 blockade reverses morphine-prolonged neuropathic pain and proinflammatory immune actions in prenatal alcohol-exposed male mice

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  DOI: 10.1016/j.neuropharm.2026.111052
  
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Reductive death is averted by a conserved de novo lipogenic switch

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  DOI: 10.1016/j.molcel.2026.05.011
  
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VTA dopamine inputs activate accumbal D1 receptors to promote alcohol seeking

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Targeting arginine metabolism overcomes chemotherapy resistance in aggressive-variant prostate cancers

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Pan-cancer analysis reveals Rho kinase addiction as a vulnerability of de-differentiated cancer cells

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DCAF8 binds DDB1 via an N-terminal helix-loop-helix motif to assemble CRL4 and promote cell cycle progression

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Faf1 accelerates p97-mediated protein unfolding by promoting ubiquitin engagement

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Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: a randomized controlled trial

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Mural cells protect the adult brain from hemorrhage but do not control the blood–brain barrier in developing zebrafish

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miR-3648 regulates cell functions and acts as a potential biomarker to predict prognosis in breast cancer and its bioinformatics analysis

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Engineering high-quality cultured beef through curcumin-driven metabolic reprogramming in a high-protein scaffold

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Identification of an immediate-early gene-activated fibroblast state in frozen shoulder capsular fibrosis

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Sexual identity of Akh neurons shapes Nucb1-dependent metabolic and reproductive plasticity

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Rapid neuronal labeling and functional imaging in the developing mouse brain with AAV-PHP.eB

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Development of far-red fluorescent proteins for temporal domain multiplexing and super-resolution imaging

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Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens

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Characterization of a transmembrane-activating STING agonist using genetically humanized mice

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Reversible loss of hematopoietic stem cells transplant potency by chronic Salmonella infection

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Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair

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Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor

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Chaperone-mediated autophagy is a tumor-suppressive mechanism in hepatocellular carcinoma

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NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis

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Hsa-miR-25-3p Inhibition Sensitizes Patient-Derived Glioblastoma Cells to Temozolomide via β-catenin Downregulation

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Association of Lp(a) with Stroke and Cerebral Injury on MRI: Insights from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and Investigation of Neurocognitive Aging-MRI (SOL-INCA MRI)

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Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

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Clonal origin and early lineage divergence in adenosquamous carcinoma

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The Role of TRPV4 in Repeated Variate Stress-Induced Increases in Voiding Frequency and Somatic Sensitivity in Male and Female Mice

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Super-Enhancer-Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

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Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging

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Fascicle lengthening during a large torque reduction subsequently decreases dorsiflexion torque steadiness

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Hyperactivated glycolysis drives spatially patterned Kupffer cell depletion in MASLD

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The Neuroanatomy of the Hawaiian Bobtail Squid Juvenile Bacterial Light Organ

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A Conserved Enhancer Locus in Extrachromosomal DNA and Homogeneously Staining Regions Activates MYC Transcription in Group 3 Medulloblastoma

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OTUB2 induces M2 tumor-associated macrophage polarization and increases CD274 expression in gastric cancer cells to aggravate the progression of gastric cancer

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Protocol for validating drug efficacy and safety in scalable 96-well platforms of human cortical organoids and melanoma brain metastases

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Patient-derived organoids from metastatic colorectal cancer mirror tumor heterogeneity and predict patient survival and drug sensitivity

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ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A

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Maternal-fetal type I interferon signaling drives TREM2 dysregulation and synaptic dysfunction in neurodevelopmental disorders

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Multitarget inhibition of biofilm, virulence, and quorum sensing of Pseudomonas aeruginosa by FDA-approved natural bioactives

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Optimized multiplex immunofluorescent protocols for simultaneous in situ identification of α-motoneuron subtypes

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Reciprocal compensation of caspase-2 and p53 regulates the DNA damage response in HCT116 colon cancer cells

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Antibodies blocking PlGF or VEGF interactions with the NRP1 receptor mediate antiproliferative effects

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Topical rewetting restores the autoimmune-damaged corneal stroma

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Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit

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Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells

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Uncovering spatially resolved functional genomics with CRISPR screen sequencing

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A causal link between autoantibodies and neurological symptoms in long COVID

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2026.05.18.725972.full-html.html

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2026.05.15.725565.full-html.html

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Membrane-bound TRAIL-armoring augments CAR-T cells in mesothelin-positive solid malignancies

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Ketogenic Diet Modulates Depressive-Like Behavior via Gut Bacterial Metabolism of Tyrosine

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Insulin Producing Cells Specific dilp2 Knockdown Induced T1D Model Reveals Circadian and Oxidative Stress Associated DEPs

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CSNK2B gene replacement rescues autism-related phenotypes and establishes translational EEG biomarkers

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Human retinal organoids functionally bridge a transected optic nerve in a rat model

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Elevated zygotic let-7f-5p alters developmental trajectories and sex-specific somatic growth

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Single-dose intrapalatal injection of erythromycin-loaded microparticles mitigates periodontitis-induced alveolar bone loss and enhances bone regeneration

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A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth

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Electrospun nanocomposite dressing integrating cerium dioxide and collagen accelerates pressure injury healing

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Hypomorphic biliverdin reductase a mutations define bilirubin anti-malarial threshold

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RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition

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TLR7 induces autophagy in non-small cell lung cancer tumor cells and influences anti-tumors responses in patients

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Hippocampal transcriptome profiling in a 22q11.2 deletion syndrome mouse model: comparison with human schizophrenia

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ILK-Dependent Modulation of DPP4 Prevents Progression of Calcific Aortic Valve Disease

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Mitochondrial Imaging Detects Early Cardiac Changes Following Cancer Immunotherapy

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Dual Inhibition of TRIP13 and Aurora A Induces Mitotic DNA Damage and Concurrent Pyroptotic-apoptotic Cell Death in Rb-deficient Cancer Cells

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Core Clock Protein Subcellular Dynamics Coordinate Local and Global Circadian Control in Syncytia

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Growth hormone-releasing hormone attenuates amyloid deposition and neuroinflammation in Alzheimer’s disease models

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The proteomics and phosphoproteomics landscape of melanoma under T cell attack

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  DOI: 10.1016/j.xcrm.2026.102829
  
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NFATC1 dysfunction-triggered MSC senescence induces tooth aging amenable to senolytic therapy

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  DOI: 10.1016/j.stemcr.2026.102925
  
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cGAS/STING sensing in dendritic cells discriminates between daptomycin sensitive and resistant Staphylococcus aureus clinical isolates

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Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

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Single-domain antibody inhibitors target the coiled coil arms of the Bacillus subtilis SMC complex

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Applications of adeno-associated virus for 3D single-cell morphometric analysis in iPSC-derived midbrain organoids

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Alterations in glucocorticoid homeostasis following sleeve gastrectomy

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Glucocorticoids induce a phagocytic C1Q+ macrophage phenotype primed for IFNγ-dependent CXCL9 secretion

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Slow-wave sleep engages brainstem circuitry to prevent stress-induced anxiety

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Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization

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Gut microbiota-derived succinate links proteostasis collapse to α-synuclein pathology and aging

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Proteomic Signatures of Regeneration: Uncovering Extracellular Matrix-Associated Cues in Goldfish Spinal Cord Repair

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Characterisation of cold-selective lamina I spinal projection neurons in the mouse

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Endogenous corazonin signaling modulates the post-mating switch in behavior and physiology in females of the brown planthopper and Drosophila

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FAS-controlled T cells drive lymphoproliferation through glycolysis without effector differentiation

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A Three-Gene Interferon Signature Predicts Sustained Complete Remission in Pediatric AML Patients

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LSC-like Phenotypes Aid in the Prognosis of Adult and Elderly Acute Myeloid Leukemia Patients at a Resource-Limited Health Center

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Hepatic stellate cell-specific METTL3 deficiency promotes hepatocellular carcinoma progression via BMP10-SMAD1/5/8 signaling

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Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and CD155/TIGIT Pathway

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Human LFA-1 governs T cell immune surveillance of the skin

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Neutrophil serine proteases degrade endothelial cortactin and promote extravasation

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Decoding the human CD4+ T cell epitope repertoire for Lassa fever virus reveals T cell-based pan-mammarenavirus vaccine candidates

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Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling

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Placental lipid droplets and histone marks reveal a metabolic-epigenetic phenotype in the BTBR mouse model of autism.

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Hyperexcitable VTA-mPFC dopaminergic circuit disrupts sleep spindle and mediates sleep fragmentation after chronic social defeat stress

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Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins

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Dietary soy shapes the microbiome to induce commensal-specific T follicular helper cells and IgA production

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Targeting ATP13A4-polyamine homeostasis axis to improve radiosensitivity of lung adenocarcinoma

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Glycogen and lactate metabolism in mouse fetal Sertoli cells sustain the germ line

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USP22 Inhibition Potentiates GPC3 Chimeric Antigen Receptor Macrophages Efficacy in Hepatocellular Carcinoma by Downregulating Tumor CD24 Expression

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Progressive Hypoxia Exacerbates Breast Cancer Metastasis by Paracrine Modulation of the Blood-brain Barrier Endothelium

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Selective reduction of KCNA4 in vulnerable glutamatergic–serotonin neurons of the dorsal raphe nucleus in Alzheimer's disease

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Peripheral cholecystokinin promotes thermogenesis via vagal afferent signalling, hypothalamic oxytocin and sympathetic outflow to brown adipose tissue

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Tumors mimic the niche to inhibit neighboring stem cell differentiation

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Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

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The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells

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Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism

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Bendless-mediated K63 ubiquitination modulates cellular signalling to regulate Drosophila hematopoiesis

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LOX Inhibition Disrupts a Collagen-Integrin–MYC Axis to Suppress Progression of Invasive Lobular Carcinoma

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NSD1-Mediated PPARγ Methylation Enhances PTEN Activity to Suppress Glycolysis and Tumor Progression in Endometrial Cancer

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Spatial Multiomics Analyses Reveal That Diabetes Promotes Pancreatic Cancer Progression by Stimulating Cholesterol-Induced Neutrophil Extracellular Trap Formation

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GAL3ST1-Mediated Histone Tyrosine Sulfation Induced by Cancer-Associated Fibroblasts Promotes Gastric Cancer Metastasis

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Systematic Characterisation of GLP-1R in Human Enteric Nervous System: Implications for GLP-1 as a Key Regulator of Colonic Activity

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BPS Publications

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Macrophage-Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro

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Empagliflozin Restores the Colonic Mucous Barrier by an AMPK/SOX4-Dependent Pathway in Glycogen Storage Disease Type Ib

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Impaired vitamin D signaling reveals neutrophils as key drivers of prostate cancer dissemination

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BMAL2 is a druggable target for ovarian clear cell carcinoma (OCCC)

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The anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients

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Protocol for a multi-modal performance-profiling workflow of CAR T cell products

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Cancer-associated fibroblast-derived protein S100-A11 influences the response to anti-HER2 therapies in HER2-positive breast cancer

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A regulatory circuitry driving a noradrenergic to mesenchymal transition highlights YAP/TAZ as critical players in neuroblastoma plasticity

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Resolvin E1 and Maresin 1 Attenuate NLRP3-Associated Inflammation and Invasion in Oral Squamous Cell Carcinoma

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Location and mapping of the human rostromedial tegmental nucleus and associated midbrain inhibitory nuclei regulating dopamine neurons

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The Host Cell Factor Phosphatase-2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type-1

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Expansion of NKG2A+CD8+ T cells with regulatory signatures distinguish individuals living with HIV-2 from those with HIV-1

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ISG15 negatively regulates RIPK3-mediated cell death and viral pathogenesis

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Accelerated basement membrane remodeling and serum matrix fragments as biomarkers of fibrosis in Alport syndrome

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Human Sperm-Induced Cell-Cell Fusion Requiring JUNO (hSPICER): A paradigm shift to test sperm fertilizing potential

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Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma

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Spirohydantoin derivatives exert dopamine D2-like receptor-independent cytotoxicity in glioblastoma cells with possible involvement of calpain inhibition

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Non-competing Trop2 nanobody-based radiotheranostics for precision imaging and therapy of pancreatic cancer

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Remote ischemic per-conditioning did not modulate kidney Klotho expression in acute kidney injury induced by renal ischemia/reperfusion injury

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Preclinical efficacy of tasquinimod-based combinations in advanced myeloproliferative neoplasms (MPN) in blastic phase

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PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA

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Evaluating T-Cell Clonality In Skin Using a Quantitative TRBC1-Clonality Score

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An optimized method to visualize lipid droplets in mouse brain tissue

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Autophagy-lysosomal dependency defines a vulnerable physiological state in drug-tolerant persister cells of triple-negative breast cancer

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Discovery of Bistratamides as Efficacious Reversers of P-Glycoprotein-Mediated Multidrug Resistance

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IL-15 and IL-21 synergy improves anti-tumor efficacy of iPSC-derived cytotoxic T cells in solid tumors

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Trial-ready external controls for gene therapy: The MATCH cohort in maple syrup urine disease

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Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies

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S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

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  DOI: 10.1016/j.molcel.2026.04.016
  
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Cancer-linked ANKRD26-RET uses an unusual combination of pathomechanisms leading to strongly increased cell proliferation

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  DOI: 10.1016/j.biopha.2026.119479
  
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A Bidirectional Survivin Promoter Enhances IL-2, GM-CSF, and Apoptin Co-expression for Breast Cancer Gene Therapy

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  DOI: 10.1111/aji.70226
  
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Protocol for gaze estimation using facial orientation in marmosets during a social preference test

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HyPIC-3D enables characterization of migratory cancer cell subpopulations in 3D hypoxic microenvironments

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FEBS Press

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  DOI: 10.1002/1878-0261.70266
  
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Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

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Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge

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ChREBPα: a central metabolic sensor driving lipid droplet renewal in preimplantation mouse embryos

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Caffeine ingestion improves morning neuromuscular performance to evening levels in healthy females

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CD70 regulates the NF1/Ras/ERK axis to promote metastatic potential in clear cell renal cell carcinoma

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Dietary Fat Content Influences PanIN Progression and Pancreatic Cancer Development in Mice

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Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

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Proteostasis failure and mitochondrial dysfunction contribute to chromosomal instability-induced microcephaly

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5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling

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Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly

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  DOI: 10.1016/j.cub.2026.04.037
  
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Ferroptosis inhibition enhances liver and lung graft function

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A2A Receptor Activation Restores Lipid and Mitochondrial Homeostasis, Limiting Mycobacterium leprae Persistence in Human Monocytes

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  DOI: 10.3390/metabo16050304
  
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Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer

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Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

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pmc.ncbi.nlm.nih.gov/articles/PMC13148824/

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