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May 2021
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Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development

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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

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Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon

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Time- and area-dependent macrophage/microglial responses after focal infarction of the macaque internal capsule

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ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

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Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy

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Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression

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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

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Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

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The Lon Protease Links Nucleotide Metabolism with Proteotoxic Stress

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SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts

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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus

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Novel association of genetic variants in non-coding regulatory regions with HIV-1 infection

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Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons

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Longitudinal proteomics analysis in the immediate microenvironment of islet allografts during progression of rejection

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Phospholipase Cβ3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze

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Evaluation of the ameliorative effects of oral administration of metformin on epileptogenesis in the temporal lobe epilepsy model in rats

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Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

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Casein phosphopeptide–amorphous calcium phosphate fluoride treatment enriches the symbiotic dental plaque microbiome in children

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Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats

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Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

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Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues

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Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

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Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium

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A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization

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Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation

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A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver

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Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche That Maintains and Replenishes Splenic Red Pulp Macrophages

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Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA

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Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

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Comprehensive analysis of genomic alterations, clinical outcomes, putative functions and potential therapeutic value of MMP11 in human breast cancer

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Angelica sinensis polysaccharide attenuates CCl4-induced liver fibrosis via the IL-22/STAT3 pathway

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  DOI: 10.1016/j.ijbiomac.2020.06.166
  
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The glucocorticoid receptor specific modulator CORT108297 reduces brain pathology following status epilepticus

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Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

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  DOI: 10.1016/j.fct.2021.111967
  
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Discovery of 4-methyl-N-(4-((4-methylpiperazin- 1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant

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Hepatoprotective effects of ZLY16, a dual peroxisome proliferator-activated receptor α/δ agonist, in rodent model of nonalcoholic steatohepatitis

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  DOI: 10.1016/j.ejphar.2020.173300
  
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Distinct effects on cAMP signaling of carbamazepine and its structural derivatives do not correlate with their clinical efficacy in epilepsy

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A single-cell analysis of the Arabidopsis vegetative shoot apex

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An organelle-tethering mechanism couples flagellation to cell division in bacteria

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FEBS Press

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A BIN2-GLK1 Signaling Module Integrates Brassinosteroid and Light Signaling to Repress Chloroplast Development in the Dark

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Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries Shaping the Heart Loop

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DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation

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A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation

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The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana

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Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway

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A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability

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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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Chromatin Accessibility Dynamics and a Hierarchical Transcriptional Regulatory Network Structure for Plant Somatic Embryogenesis

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ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

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Efferent feedback controls bilateral auditory spontaneous activity

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In situ architecture of neuronal α-Synuclein inclusions

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Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

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Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair

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Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake

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Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation

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Lengthening Neurogenic Period during Neocortical Development Causes a Hallmark of Neocortex Expansion

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Prefrontal Cortical Projection Neurons Targeting Dorsomedial Striatum Control Behavioral Inhibition

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Retinal Inputs to the Thalamus Are Selectively Gated by Arousal

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A randomized trial of adjuvant chemotherapy versus observation in patients with nasopharyngeal carcinoma with detectable post-radiotherapy pEBV DNA

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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

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The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model

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Identification of functionally distinct macrophage subpopulations in Drosophila

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Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

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PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

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GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys

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An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila

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Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

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Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming

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Central Alteration in Peripheral Neuropathy of Trembler-J Mice: Hippocampal pmp22 Expression and Behavioral Profile in Anxiety Tests

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Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans

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Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis

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Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons

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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

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Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation

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Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

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SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

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Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport

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Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice

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Disulfiram Treatment Normalizes Body Weight in Obese Mice

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Signatures of antagonistic pleiotropy in a bacterial flagellin epitope

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Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

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Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms

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Targeted Depletion of Bacteria from Mixed Populations by Programmable Adhesion with Antagonistic Competitor Cells

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Phytopathogen Effectors Use Multiple Mechanisms to Manipulate Plant Autophagy

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K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap

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HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins

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Regulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors

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Mechanisms of differential desensitization of metabotropic glutamate receptors

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Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon

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4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors

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Discovery of Covalent MKK4/7 Dual Inhibitor

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Defining and Manipulating B Cell Immunodominance Hierarchies to Elicit Broadly Neutralizing Antibody Responses against Influenza Virus

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Lateral Habenula Mediates Defensive Responses Only When Threat and Safety Memories Are in Conflict

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Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice

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LncRNA CALB2 sponges miR-30b-3p to promote odontoblast differentiation of human dental pulp stem cells via up-regulating RUNX2

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Follicular regulatory T cells produce neuritin to regulate B cells

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Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23

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Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells

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Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

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Co-option of Neutrophil Fates by Tissue Environments

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A Cellular Mechanism to Detect and Alleviate Reductive Stress

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High discrepancy in thrombotic events in non-small cell lung cancer patients with different genomic alterations

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A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

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Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2

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Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics

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Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

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Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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  DOI: 10.1016/j.cell.2021.03.048
  
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Modulation of stimulated dopamine release in rat nucleus accumbens shell by GABA in vitro: Effect of sub‐chronic phencyclidine pretreatment

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Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

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mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus

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  DOI: 10.1186/s11689-021-09357-2
  
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Cascade diversification directs generation of neuronal diversity in the hypothalamus

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Phasic Off responses of auditory cortex underlie perception of sound duration

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Improved HIV-positive infant survival is correlated with high levels of HIV-specific ADCC activity in multiple cohorts

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Hypoxia-induced depression of synaptic transmission becomes irreversible by intracellular accumulation of non-excitatory amino acids

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Cytoplasmic polyadenylation by TENT5A is required for proper bone formation

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In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury

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Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

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Dysregulated CRMP Mediates Circadian Deficits in a Drosophila Model of Fragile X Syndrome

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  DOI: 10.1007/s12264-021-00682-z
  
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Cell Lineage-Based Stratification for Glioblastoma

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Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope

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  DOI: 10.1074/jbc.RA120.012713
  
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Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma

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  DOI: 10.1074/jbc.RA119.012260
  
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Dual blockade of EGFR and CDK4/6 delays head and neck squamous cell carcinoma progression by inducing metabolic rewiring

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  DOI: 10.1016/j.canlet.2021.04.004
  
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Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning

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  DOI: 10.1016/j.xpro.2021.100454
  
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Cell intercalation driven by SMAD3 underlies secondary neural tube formation

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  DOI: 10.1016/j.devcel.2021.03.023
  
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Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

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  DOI: 10.1016/j.devcel.2021.03.032
  
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BPS Publications

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  DOI: 10.1111/bph.15428
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15428
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Repetitive Blast Exposure Produces White Matter Axon Damage without Subsequent Myelin Remodeling: <italic toggle="yes">In Vivo</italic> Analysis of Brain Injury Using Fluorescent Reporter Mice

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  DOI: 10.1089/neur.2020.0058
  
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liebertpub.com/doi/abs/10.1089/neur.2020.0058
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Low expression of the PPARγ-regulated gene thioredoxin-interacting protein accompanies human melanoma progression and promotes experimental lung metastases

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  DOI: 10.1038/s41598-021-86329-5
  
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Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis

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  DOI: 10.3389/fncel.2021.632354
  
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Dichotomic Hippocampal Transcriptome After Glutamatergic vs. GABAergic Deletion of the Cannabinoid CB1 Receptor

1
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  DOI: 10.3389/fnsyn.2021.660718
  
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Targeting obesity-induced macrophages during preneoplastic growth promotes mammary epithelial stem/progenitor activity, DNA damage and tumor formation

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SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses

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Infection with a newly designed dual fluorescent reporter HIV-1 effectively identifies latently infected CD4+ T cells

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  DOI: 10.7554/eLife.63810
  
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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

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Astragaloside IV prevents Aβ1-42 oligomers-induced memory impairment and hippocampal cell apoptosis by promoting PPARγ/BDNF signaling pathway

1
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  DOI: 10.1016/j.brainres.2020.147041
  
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Zika virus NS1 affects the junctional integrity of human brain microvascular endothelial cells

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  DOI: 10.1016/j.biochi.2020.06.011
  
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Ionizing radiation induces BH4 deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis

1
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Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: behavioural and neurochemical analyses

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Antibody evasion by the P.1 strain of SARS-CoV-2

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  DOI: 10.1016/j.cell.2021.03.055
  
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A membrane arm of mitochondrial complex I sufficient to promote respirasome formation

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  DOI: 10.1016/j.celrep.2021.108963
  
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Properties of multivesicular release from mouse rod photoreceptors support transmission of single-photon responses

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Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

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Complement C5a promotes antigen cross-presentation by Peyer’s patch monocyte-derived dendritic cells and drives a protective CD8+ T cell response

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Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

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A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus

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A nexus of intrinsic dynamics underlies translocase priming

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The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design

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Rapid eye movement sleep deprivation impairs neuronal plasticity and reduces hippocampal neuronal arborization in male albino rats: Noradrenaline is involved in the process

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Investigating oligodendrocyte connexins: Heteromeric interactions between Cx32 and mutant or wild‐type forms of Cx47 do not contribute to or modulate gap junction function

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Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance

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Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging

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The orbitofrontal cortex is necessary for learning to ignore

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Early stem cell aging in the mature brain

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Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation

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Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity

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Functional interrogation of DNA damage response variants with base editing screens

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Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments

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Optogenetic activation of spinal microglia triggers chronic pain in mice

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Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex

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Three-dimensional reconstruction of a whole insect reveals its phloem sap-sucking mechanism at nano-resolution

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Protocol for live enhanced resolution confocal imaging of dendritic spinule dynamics in primary mouse cortical neuron culture

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A polarity pathway for exocyst-dependent intracellular tube extension

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Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum–mitochondria associations

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Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

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Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex

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Capturing human trophoblast development with naive pluripotent stem cells in vitro

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Nucleus accumbens neurons expressing dopamine D1 receptors modulate states of consciousness in sevoflurane anesthesia

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Estrogen receptor 2b is the major determinant of sex-typical mating behavior and sexual preference in medaka

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The Upd3 cytokine couples inflammation to maturation defects in Drosophila

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Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5

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Parallel synaptic acetylcholine signals facilitate large monopolar cell repolarization and modulate visual behavior in Drosophila

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SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms

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Pathogenic GRM7 mutations associated with neurodevelopmental disorders impair axon outgrowth and presynaptic terminal development

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Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation

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CHPG enhances BDNF and myelination in cuprizone‐treated mice through astrocytic metabotropic glutamate receptor 5

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Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain

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Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

1
1. scibot 07 Apr 2021
  
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  RRID:SCR_002798
  
  DOI: 10.1016/j.celrep.2021.108951
  
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NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation

1
1. scibot 07 Apr 2021
  
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  RRID:SCR_002798
  
  DOI: 10.1016/j.celrep.2021.108949
  
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Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors

1
1. scibot 07 Apr 2021
  
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  RRID:SCR_002798
  
  DOI: 10.1016/j.celrep.2021.108964
  
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sciencedirect.com/science/article/pii/S2211124721002783
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Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways

1
1. scibot 07 Apr 2021
  
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  RRID:SCR_002798
  
  DOI: 10.1016/j.celrep.2021.108956
  
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PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding

1
1. scibot 07 Apr 2021
  
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  RRID:SCR_002798
  
  DOI: 10.1016/j.jbc.2021.100636
  
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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

1
1. scibot 06 Apr 2021
  
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  RRID: SCR_002798
  
  DOI: 10.1016/j.chom.2021.03.001
  
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Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

1
1. scibot 06 Apr 2021
  
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  DOI: 10.7554/eLife.66097
  
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The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

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1. scibot 06 Apr 2021
  
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  DOI: 10.7554/eLife.61313
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7997661/
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A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation

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  DOI: 10.7554/eLife.63886
  
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Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model

1
1. scibot 03 Apr 2021
  
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  DOI: 10.1016/j.neuint.2021.105036
  
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Elucidating the role of hypoxia/reoxygenation in hippocampus-dependent memory impairment: do SK channels play role?

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1. scibot 03 Apr 2021
  
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  DOI: 10.1007/s00221-021-06095-8
  
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Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase

2
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  DOI: 10.1111/bph.14937
  
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Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

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  DOI: 10.7554/eLife.62483
  
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All-trans retinoic acid induces synaptic plasticity in human cortical neurons

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1. scibot 02 Apr 2021
  
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  DOI: 10.7554/eLife.63026
  
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Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

1
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  DOI: 10.7554/eLife.66488
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8009679/
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Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation

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  DOI: 10.1016/j.celrep.2021.108913
  
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Molecular pathways behind acquired obesity: adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

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  DOI: 10.1016/j.xcrm.2021.100226
  
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sciencedirect.com/science/article/pii/S2666379121000422
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Integrated regulatory network in Pseudomonas syringae reveals dynamics of virulence

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  DOI: 10.1016/j.celrep.2021.108920
  
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sciencedirect.com/science/article/pii/S2211124721002345
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Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice

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1. scibot 01 Apr 2021
  
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  DOI: 10.1038/s41401-021-00628-1
  
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nature.com/articles/s41401-021-00628-1
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Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals

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  DOI: 10.1038/s12276-021-00585-z
  
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nature.com/articles/s12276-021-00585-z

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