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ARHGAP12 suppresses F-actin assembly to control epithelial tight junction mechanics and paracellular leak pathway permeability

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THE ADORA1 MUTATION LINKED TO EARLY-ONSET PARKINSON’S DISEASE ALTERS ADENOSINE A1-A2A RECEPTOR HETEROMER FORMATION AND FUNCTION

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LNS8801: An Enantiomerically Pure Agonist of the G Protein–Coupled Estrogen Receptor Suitable for Clinical Development

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Bright and photostable yellow fluorescent proteins for extended imaging

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Harmine promotes axon regeneration through enhancing glucose metabolism

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Entry Efficiency, Protease Dependence, and Antibody-Mediated Neutralization of SARS-CoV-2 Sublineages KP.3.1.1 and XEC

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A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance

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Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

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An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation

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Molecular basis for the increased fusion activity of the Ebola virus glycoprotein epidemic variant A82V: Insights from simulations and experiments

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Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion

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The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation

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RAF1 kinase contributes to autophagic lysosome reformation

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Molecular basis for shifted receptor recognition by an encephalitic arbovirus

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Structural basis for plasticity in receptor engagement by an encephalitic alphavirus

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PRDM1 Is a Key Regulator of the NKT-cell Central Memory Program and Effector Function

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The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis

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Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer

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FEBS Press

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Tuning In Vitro Cytotoxicity in Diruthenium(I) bis-Cyclopentadienyl Complexes

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Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

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Engineering sonogenetic EchoBack-CAR T cells

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Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage

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Mitochondrial fatty acid oxidation as the target for blocking therapy-resistance and inhibiting tumor recurrence: The proof-of-principle model demonstrated for ovarian cancer cells

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The severity of SLC1A2-associated neurodevelopmental disorders correlates with transporter dysfunction

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A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein

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S-ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide-Induced Depression Via Targeting SIRT2

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Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope

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Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

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PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation

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Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP

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SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity

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Global analysis of protein turnover dynamics in single cells

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Diverse priming outcomes under conditions of very rare precursor B cells

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A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions

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The role of TRPV4 in acute sleep deprivation-induced memory impairment: mechanisms of calcium dysregulation and synaptic plasticity disruption

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PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

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The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2

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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection

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SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response

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Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma

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Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus

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Identification of a new micropeptide altKLF4 derived from KLF4 that influences myeloma chemotherapeutic sensitivity

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Involvement of microRNAs-449/FASN axis in response to trastuzumab therapy in HER2-positive breast cancer

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Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

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SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force

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Translation dysregulation in cancer as a source for targetable antigens

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High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase

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Orchestration of pluripotent stem cell genome reactivation during mitotic exit

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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

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In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer

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The non-catalytic ε DNA polymerase subunit is an NPF motif recognition protein

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Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex

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Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria

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FEBS Press

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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity

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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

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Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3-LPL Axis

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Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells

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The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies

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Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to Kif18a Inhibition

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Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo

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Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming

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Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity

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m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice

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  ATCCCat#CRL-1573
  
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Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay

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A microglia clonal inflammatory disorder in Alzheimer’s disease

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A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy

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Comprehensive discovery and functional characterization of the noncanonical proteome

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Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations

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DAP12-associated synthetic antigen receptors enable multi-targeting of T cells with independent chimeric receptors in a small genetic payload

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PIF/harbinger transposon-derived protein promotes 7SL expression to enhance pathogen resistance

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Protocol for the simultaneous activation and lentiviral transduction of primary human T cells with artificial T cell receptors

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  American Type Culture Collection (ATCC)Cat# CRL-3216
  
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Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death

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Compact transcription factor cassettes generate functional, engraftable motor neurons by direct conversion

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Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology

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Mitochondrial dysfunction drives a neuronal exhaustion phenotype in methylmalonic aciduria

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Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis

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1-s2.0-S2589004225004316-main (1)-html.html

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Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag

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TTC7A-ALK, a novel ALK fusion variant identified in a patient with metastatic lung adenocarcinoma, exhibits excellent response to crizotinib

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Primary ciliary protein kinase A activity in the prefrontal cortex modulates stress in mice

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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

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Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease

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Engineering mtDNA deletions by reconstituting end joining in human mitochondria

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Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

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A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode

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Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma

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Metabolic engineering to facilitate anti-tumor immunity

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Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy

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A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans

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Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

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VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

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Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts

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TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness

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RNF10 and RIOK3 facilitate 40S ribosomal subunit degradation upon 60S biogenesis disruption or amino acid starvation

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FEBS Press

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Large Donor CRISPR for Whole-Coding Sequence Replacement of Cell Adhesion Molecule LRRTM2

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  CRL-3216
  
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Antigenic drift expands influenza viral escape pathways from recalled humoral immunity

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Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons

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FEBS Press

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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

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Preferential allosteric modulation of Otop1 channels by small molecule compounds

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Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death

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Anti-tumor efficacy and safety of AEV01 in preclinical glioblastoma and hepatocellular carcinoma models

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The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses

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1-s2.0-S2589004225003785-main-html.html

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  ATCC, USA Cat#CRL-3216
  
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The endogenous antigen-specific CD8+ T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments

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ALS-linked VapB P56S mutation alters neuronal mitochondrial turnover at the synapse

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PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma

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OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

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OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity

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Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

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AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity

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Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D

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Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia

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1-s2.0-S2589004225003657-main-html.html

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Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

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Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics

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Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss

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TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms

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NAT10-mediated mRNA N4-acetylation is essential for the translational regulation during oocyte meiotic maturation in mice

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An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding

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SFP6 fluorescent probes for imaging SAM dynamics in living cells

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NAT10-mediated mRNA N4-acetylation is essential for the translational regulation during oocyte meiotic maturation in mice

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Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation

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Pharmacological characterisation of a clinical candidate, TG-0054, a small molecule inverse agonist targeting CXCR4

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EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models

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Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance

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Clathrin functions in intracellular sorting during receptor-mediated endocytosis

1
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  RRID:CVCL_0063
  
  DOI: 10.1002/1873-3468.70016
  
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RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus

1
1. scibot 21 Feb 2025
  
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  ATCC CRL-3216
  
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CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer

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  Cat#CRL-3216
  
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Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

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  CVCL_0063
  
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Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses

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  RRID:CVCL_0063
  
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CV1-secreting sCAR-T cells potentiate the abscopal effect of microwave ablation in heterogeneous tumors

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  ATCCCRL-3216
  
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Structural basis for channel gating and blockade in tri-heteromeric GluN1-2B-2D NMDA receptor

1
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  ATCCCRL-3216
  
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Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2

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  ATCCCat# CRL-3216
  
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Pre-clinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms (MPN) transformed to AML

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  RRID:CVCL_0063
  
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Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry

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  RRID:CVCL_0063
  
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BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

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  RRID:CVCL_0063
  
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cir-24-0484-html.html

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The IAP antagonist tolinapant enhances the anti-tumor activity of cell therapies

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Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer

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T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome

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Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes

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PDF-html.html

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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis mediated epithelial-mesenchymal transition

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Vasorin exocytosed from glioma cells facilitates angiogenesis via VEGFR2/AKT signaling pathway

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Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism

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The EMCV protein 2B* is required for efficient cell lysis via both caspase-3-dependent and -independent pathways during infection

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  HEK293T (human embryonic kidney, CRL-3216, ATCC)
  
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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MEK inhibitors lead to PDGFR pathway upregulation and sensitize tumors to RAF dimer inhibitors in NF1-deficient malignant peripheral nerve sheath tumor (MPNST)

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Mutant IDH modulates suppressive myeloid populations in malignant glioma

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Targeting GPC2 on intraocular and CNS metastatic retinoblastomas with local and systemic delivery of CAR T-cells

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can-24-0479-html.html

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Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer

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Arginine methylation of DDX3 by PRMT1 mediates mitochondrial homeostasis to promote breast cancer metastasis

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SPARC stabilizes ApoE to induce cholesterol-dependent invasion and sorafenib resistance in hepatocellular carcinoma

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A Genetically Encoded Magnetic Resonance Imaging Reporter Enables Sensitive Detection and Tracking of Spontaneous Metastases in Deep Tissues

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Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy

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1-s2.0-S2950329925000189-main-html.html

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RIOK3 mediates the degradation of 40S ribosomes

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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

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  RRID:CVCL_0063
  
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Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

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  ATCCCRL-3216
  
  DOI: 10.1016/j.cell.2024.12.031
  
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Complex regulation of Cav2.2 N-type Ca2+ channels by Ca2+ and G-proteins

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1. scibot 11 Feb 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1371/journal.pone.0314839
  
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DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming

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1. scibot 11 Feb 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1158/2159-8290.CD-24-0634
  
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Glioblastoma Cortical Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer

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1. scibot 11 Feb 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1158/2159-8290.CD-23-1336
  
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Development of a highly sensitive method to detect translational infidelity

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1. scibot 11 Feb 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1093/biomethods/bpaf008
  
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Single-molecule m6A detection empowered by endogenous labeling unveils complexities across RNA isoforms

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.014
  
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Imaging lipid rafts reveals the principle of ApoE4-induced Aβ upregulation in human neurons

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.isci.2025.111893
  
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Equine adult, fetal and ESC-tenocytes have differential migratory, proliferative and gene expression responses to factors upregulated in the injured tendon

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.cdev.2025.204003
  
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1-s2.0-S2589004225002226-main-html.html

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1. scibot 07 Feb 2025
  
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  ATCC Cat#CRL-3216
  
  DOI: 10.1016/j.isci.2025.111962
  
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Heterozygous pathogenic STT3A variation leads to dominant congenital glycosylation disorders and functional validation in zebrafish

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1. scibot 07 Feb 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1186/s13023-025-03557-y
  
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EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer

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1. scibot 07 Feb 2025
  
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  DOI: 10.1186/s12935-025-03637-w
  
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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

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1. scibot 07 Feb 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1101/2024.11.25.625235
  
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Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo

1
1. scibot 07 Feb 2025
  
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  CVCL_0063
  
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Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss

1
1. scibot 07 Feb 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.devcel.2025.01.004
  
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Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development

1
1. scibot 07 Feb 2025
  
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  DOI: 10.1016/j.chom.2025.01.004
  
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TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment

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1. scibot 07 Feb 2025
  
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  DOI: 10.1016/j.celrep.2024.114960
  
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Dab1 expression level controls Reelin-induced PI3K-Akt activation in early GABAergic neurons

1
1. scibot 07 Feb 2025
  
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  RRID:CVCL_0063
  
  DOI: 10.1016/j.bbrc.2025.151444
  
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