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1,098 Matching Annotations

Jan 2020
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The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex

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  DOI: 10.1016/j.celrep.2019.11.064
  
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sciencedirect.com/science/article/pii/S2211124719315554
rupress.org rupress.org

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival

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  DOI: 10.1083/jcb.201904051
  
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rupress.org/jcb/article/218/11/3827/120917/Chemotherapy-induced-senescent-cancer-cells-engulf
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The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity

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  DOI: 10.1016/j.celrep.2019.08.028
  
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sciencedirect.com/science/article/pii/S2211124719310629
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Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

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  DOI: 10.7554/eLife.45572
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6584702/
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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  DOI: 10.1111/bph.14777
  
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bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14777
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ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery

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  DOI: 10.1038/s41467-019-13582-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6915695/
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Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

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  DOI: 10.1016/j.cmet.2019.09.009
  
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sciencedirect.com/science/article/pii/S1550413119305121
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RIPLET and not TRIM25 is required for endogenous RIG‐I‐dependent anti‐viral responses

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  DOI: 10.1111/imcb.12284
  
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onlinelibrary.wiley.com/doi/full/10.1111/imcb.12284
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Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

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sciencedirect.com/science/article/pii/S1550413119306199
advances.sciencemag.org advances.sciencemag.org

Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress

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  DOI: 10.1126/sciadv.aax1978
  
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advances.sciencemag.org/content/5/9/eaax1978
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CD16‐158‐Valine Chimeric Receptor T Cells Overcome the Resistance of Kras‐Mutated Colorectal Carcinoma Cells to Cetuximab

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  DOI: 10.1002/ijc.32618
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.32618
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GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway

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  DOI: 10.1016/j.yexcr.2019.111806
  
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sciencedirect.com/science/article/pii/S0014482719306949
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Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells

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sciencedirect.com/science/article/pii/S0014299919308313
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γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

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  DOI: 10.1016/j.molcel.2019.09.007
  
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sciencedirect.com/science/article/pii/S1097276519306926
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VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells

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  DOI: 10.1016/j.cels.2019.05.009
  
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sciencedirect.com/science/article/pii/S2405471219301905
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Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

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  DOI: 10.1016/j.cell.2019.06.003
  
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sciencedirect.com/science/article/pii/S0092867419306312
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Monitoring Poly(ADP-ribosyl)glycohydrolase Activity with a Continuous Fluorescent Substrate

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  DOI: 10.1016/j.chembiol.2018.09.008
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6309520/
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Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment

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  DOI: 10.1002/ijc.32670
  
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onlinelibrary.wiley.com/doi/full/10.1002/ijc.32670
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Radioresistance of KRAS/TP53‐Mutated Lung Cancer can be overcome by Radiation Dose Escalation or EGFR Tyrosine Kinase Inhibition In Vivo

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  DOI: 10.1002/ijc.32598
  
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onlinelibrary.wiley.com/doi/full/10.1002/ijc.32598
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BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

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  DOI: 10.1016/j.cell.2019.06.005
  
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sciencedirect.com/science/article/pii/S0092867419306336
cancerres.aacrjournals.org cancerres.aacrjournals.org

Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non–Small Cell Lung Cancer Cells

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  DOI: 10.1158/0008-5472.CAN-18-2156
  
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cancerres.aacrjournals.org/content/79/10/2511
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GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers

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sciencedirect.com/science/article/pii/S2211124719306916
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Prognostic Impact of Melatonin Receptors MT1 and MT2 in Non-Small Cell Lung Cancer (NSCLC)

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  DOI: 10.3390/cancers11071001
  
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mdpi.com/2072-6694/11/7/1001
insight.jci.org insight.jci.org

ROR1-CAR T-cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models

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  DOI: 10.1172/jci.insight.126345
  
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insight.jci.org/articles/view/126345
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RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

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sciencedirect.com/science/article/pii/S2451945619304015
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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

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  DOI: 10.1016/j.molcel.2019.10.016
  
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sciencedirect.com/science/article/pii/S1097276519307944
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Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity

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  DOI: 10.1016/j.chom.2019.09.012
  
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sciencedirect.com/science/article/pii/S1931312819304792
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Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

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  DOI: 10.1016/j.cub.2019.01.029
  
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sciencedirect.com/science/article/pii/S0960982219300314
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Untitled document

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  DOI: 10.1016/j.celrep.2019.02.052
  
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sciencedirect.com/science/article/pii/S2211124719302311
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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  DOI: 10.7554/eLife.44161
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6436895/
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non‐small cell lung cancer cells via Nrf2 inhibition

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  DOI: 10.1111/bph.14652
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14652
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Impaired Wound Healing of Alveolar Lung Epithelial Cells in a Breathing Lung-On-A-Chip

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  DOI: 10.3389/fbioe.2019.00003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6360510/
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MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network

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  DOI: 10.1016/j.molcel.2019.02.012
  
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Untitled document

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  DOI: 10.7554/eLife.45079
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6491042/
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Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies

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  DOI: 10.1016/j.celrep.2019.02.041
  
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  DOI: 10.1016/j.celrep.2019.01.043
  
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.02.038
  
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Transcriptional Regulation of the Warburg Effect in Cancer by SIX1

1
1. scibot 05 Nov 2018
  
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The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment

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Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target

1
1. scibot 05 Nov 2018
  
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  A549
  
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Collective Infection of Cells by Viral Aggregates Promotes Early Viral Proliferation and Reveals a Cellular-Level Allee Effect

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A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

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A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival

1
1. scibot 05 Nov 2018
  
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Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

1
1. scibot 05 Nov 2018
  
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Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation

1
1. scibot 05 Nov 2018
  
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The Proto-oncogene c-Kit Inhibits Tumor Growth by Behaving as a Dependence Receptor

1
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Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

1
1. scibot 05 Nov 2018
  
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Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

1
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Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal

1
1. scibot 05 Nov 2018
  
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  CCL-185
  
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Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity

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Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

1
1. scibot 05 Nov 2018
  
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  CCL-185
  
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Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

1
1. scibot 05 Nov 2018
  
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  CCL-185
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5972227/
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Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids

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Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

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1. scibot 05 Nov 2018
  
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

1
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Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

1
1. scibot 05 Nov 2018
  
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  CCL-185
  
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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

1
1. scibot 05 Nov 2018
  
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  CCL-185
  
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An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3

1
1. scibot 05 Nov 2018
  
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  CCL-185
  
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Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread

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GPR68 Senses Flow and Is Essential for Vascular Physiology

1
1. scibot 05 Nov 2018
  
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  CRM-CCL-185
  
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Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

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The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells

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Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription

1
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CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

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  CRM-CCL-185
  
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A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations

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sciencedirect.com/science/article/pii/S2405471218301091
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Untitled document

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onlinelibrary.wiley.com/doi/10.1002/cpmc.50/full
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The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling

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LOSS OF RUNX1 IS ASSOCIATED WITH AGGRESSIVE LUNG ADENOCARCINOMAS

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onlinelibrary.wiley.com/doi/10.1002/jcp.26201/full
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As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

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sciencedirect.com/science/article/pii/S1550413117307167
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Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1931312817304389
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Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

1
1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S0092867417312448
europepmc.org europepmc.org

Untitled document

1
1. scibot 05 Nov 2018
  
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europepmc.org/articles/PMC5659819/
Nov 2017
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Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

1
1. scibot 08 Nov 2017
  
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  CRM-CCL-185
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1097276517306536
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Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

1
1. scibot 08 Nov 2017
  
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  CCL-185
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S0092867417310474
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Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication

1
1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S1931312817303360
elifesciences.org elifesciences.org

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

1
1. scibot 08 Nov 2017
  
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  RRID:CVCL_0023
  
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elifesciences.org/articles/27713
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Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages

1
1. scibot 08 Nov 2017
  
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  RRID:CVCL_0023
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1931312817303037
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

1
1. scibot 08 Nov 2017
  
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  Human: A549ATCCCCL-185
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1097276517303945
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A Splice Variant of Centrosomin Converts Mitochondria to Microtubule-Organizing Centers

1
1. scibot 08 Nov 2017
  
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  Human: A549 cellsATCCCat#CCL-185
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S096098221730698X
elifesciences.org elifesciences.org

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
  Curator: @chewbeccax
  
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elifesciences.org/articles/25555
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Systematic Quantification of Population Cell Death Kinetics in Mammalian Cells

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
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sciencedirect.com/science/article/pii/S2405471217301813
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5345931/
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RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
  Curator: @Zeljana_Babic
  
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sciencedirect.com/science/article/pii/S0960982217304268
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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

1
1. scibot 08 Nov 2017
  
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  A549
  
  Curator: @kaitlinsung
  
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sciencedirect.com/science/article/pii/S0092867417304725
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A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis

1
1. scibot 08 Nov 2017
  
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  CCL-185
  
  Curator: @gabimpine
  
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sciencedirect.com/science/article/pii/S1097276517302046
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Human Adaptation of Ebola Virus during the West African Outbreak

2
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
  Curator: @chewbeccax
  
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2. scibot 08 Nov 2017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5101188/
elifesciences.org elifesciences.org

p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
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elifesciences.org/content/6/e22207
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MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5342109/
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O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

1
1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S1535610817300624
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

2
1. scibot 08 Nov 2017
  
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  RRID: CVCL_0023
  
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2. scibot 08 Nov 2017
  
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pmc.ncbi.nlm.nih.gov/articles/PMC5092050/
elifesciences.org elifesciences.org

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
  Curator: @chewbeccax
  
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elifesciences.org/content/6/e20444
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Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome

1
1. scibot 08 Nov 2017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5206578/
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Regulation of mTORC1 by lysosomal calcium and calmodulin

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
  Curator: @gabimpine
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5106211/
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Human Adaptation of Ebola Virus during the West African Outbreak

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
  Curator: @chewbeccax
  
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Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

1
1. scibot 08 Nov 2017
  
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  CVCL_0023
  
  Curator: @gabimpine
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4959878/