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May 2021
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Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

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1. scibot 01 May 2021
  
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  DOI: 10.1016/j.cmet.2021.03.004
  
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Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

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  DOI: 10.1016/j.cmet.2021.03.003
  
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C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly

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  DOI: 10.1016/j.cmet.2021.01.005
  
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Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse

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  DOI: 10.1016/j.molcel.2021.04.006
  
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Apr 2021
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Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells

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A High-Density Human Mitochondrial Proximity Interaction Network

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  DOI: 10.1016/j.cmet.2020.07.017
  
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Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity

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Coordinate regulation of the senescent state by selective autophagy

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1. scibot 29 Apr 2021
  
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  DOI: 10.1016/j.devcel.2021.04.008
  
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sciencedirect.com/science/article/pii/S1534580721003178
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Plant roots employ cell-layer-specific programs to respond to pathogenic and beneficial microbes

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.chom.2020.11.014
  
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sciencedirect.com/science/article/pii/S1931312820306363
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Acetylation of Cytidine Residues Boosts HIV-1 Gene Expression by Increasing Viral RNA Stability

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.chom.2020.05.011
  
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sciencedirect.com/science/article/pii/S1931312820302936
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In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2021.02.009
  
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sciencedirect.com/science/article/pii/S2451945621000945
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Opening of cohesin’s SMC ring is essential for timely DNA replication and DNA loop formation

1
1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.108999
  
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sciencedirect.com/science/article/pii/S2211124721003132
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Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing

1
1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.molcel.2021.03.004
  
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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

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1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.10.003
  
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sciencedirect.com/science/article/pii/S2451945620303822
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Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors

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1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.08.012
  
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sciencedirect.com/science/article/pii/S2451945620303342
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Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11

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1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.08.008
  
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sciencedirect.com/science/article/pii/S2451945620303056
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Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production

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1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.08.006
  
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sciencedirect.com/science/article/pii/S2451945620303032
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Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190

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1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.08.007
  
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A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome

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1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.05.010
  
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GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

1
1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.molcel.2021.03.025
  
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sciencedirect.com/science/article/pii/S1097276521002203
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p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.12.025
  
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sciencedirect.com/science/article/pii/S0092867420317475
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High-Throughput Discovery and Characterization of Human Transcriptional Effectors

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.11.024
  
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sciencedirect.com/science/article/pii/S0092867420315415
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A Cellular Mechanism to Detect and Alleviate Reductive Stress

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.08.034
  
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sciencedirect.com/science/article/pii/S009286742031076X
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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.08.009
  
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A tri-functional amino acid enables mapping of binding sites for posttranslational-modification-mediated protein-protein interactions

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.molcel.2021.04.001
  
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Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors

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1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.10.009
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
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YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis

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1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.10.004
  
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sciencedirect.com/science/article/pii/S1535610820304980
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The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase

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1. scibot 20 Apr 2021
  
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  DOI: 10.1126/science.abc5809
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8053355/
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Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer

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1. scibot 20 Apr 2021
  
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  DOI: 10.1016/j.molcel.2021.03.043
  
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sciencedirect.com/science/article/pii/S1097276521002641
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Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery

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1. scibot 19 Apr 2021
  
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  DOI: 10.7150/thno.53316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7914370/
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Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

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1. scibot 19 Apr 2021
  
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sciencedirect.com/science/article/pii/S1097276521000988
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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

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1. scibot 17 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.04.014
  
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sciencedirect.com/science/article/pii/S1535610820302130
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Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly

1
1. scibot 16 Apr 2021
  
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  mouse monoclonal anti-FLAG M2
  
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sciencedirect.com/science/article/pii/S0006295220305165
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A membrane arm of mitochondrial complex I sufficient to promote respirasome formation

1
1. scibot 15 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.108963
  
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sciencedirect.com/science/article/pii/S2211124721002771
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The dystonia gene THAP1 controls DNA double-strand break repair choice

1
1. scibot 15 Apr 2021
  
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  DOI: 10.1016/j.molcel.2021.03.034
  
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sciencedirect.com/science/article/pii/S109727652100229X
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Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS

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1. scibot 14 Apr 2021
  
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  DOI: 10.1016/j.molcel.2021.02.033
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00143-X
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Investigating oligodendrocyte connexins: Heteromeric interactions between Cx32 and mutant or wild‐type forms of Cx47 do not contribute to or modulate gap junction function

1
1. scibot 13 Apr 2021
  
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  RRID:AB_262044
  
  DOI: 10.1002/glia.23999
  
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onlinelibrary.wiley.com/doi/full/10.1002/glia.23999
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Functional interrogation of DNA damage response variants with base editing screens

1
1. scibot 12 Apr 2021
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.cell.2021.01.041
  
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β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

1
1. scibot 08 Apr 2021
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.cub.2021.01.081
  
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cell.com/current-biology/abstract/S0960-9822(21)00146-9
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Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5

1
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  RRID:AB_262044
  
  DOI: 10.1523/JNEUROSCI.0422-20.2021
  
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jneurosci.org/content/41/11/2523
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Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation

1
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  DOI: 10.1016/j.cmet.2021.03.006
  
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GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

1
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  RRID:AB_262044
  
  DOI: 10.1126/sciadv.abe2470
  
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Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons

1
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  ANTI-FLAG® M2 antibody (produced in mouse)
  
  DOI: 10.1016/j.celrep.2021.108914
  
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UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

1
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  DOI: 10.1016/j.celrep.2021.108925
  
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A nuclear-based quality control pathway for non-imported mitochondrial proteins

1
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  DOI: 10.7554/eLife.61230
  
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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

1
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  DOI: 10.1016/j.celrep.2021.108862
  
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H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model

1
1. scibot 22 Mar 2021
  
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  DOI: 10.1016/j.ccell.2021.01.005
  
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Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins

1
1. scibot 22 Mar 2021
  
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  DOI: 10.1016/j.chembiol.2021.01.007
  
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Basis of specificity for a conserved and promiscuous chromatin remodeling protein

1
1. scibot 20 Mar 2021
  
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  RRID:AB_262044
  
  DOI: 10.7554/eLife.64061
  
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elifesciences.org elifesciences.org

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

1
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  DOI: 10.7554/eLife.62873
  
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Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback

1
1. scibot 19 Mar 2021
  
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  DOI: 10.1016/j.cels.2021.02.004
  
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Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy

1
1. scibot 17 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108857
  
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A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection

1
1. scibot 17 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108859
  
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DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1

1
1. scibot 17 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108840
  
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Functional proteomics protocol for the identification of interaction partners in Tetrahymena thermophila

1
1. scibot 10 Mar 2021
  
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  Mouse ANTI-FLAG
  
  DOI: 10.1016/j.xpro.2021.100362
  
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CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory pathway

1
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  RRID:AB_262044
  
  DOI: 10.15252/embr.202051349
  
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embopress.org/doi/abs/10.15252/embr.202051349
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The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity

1
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  DOI: 10.1016/j.cmet.2021.02.007
  
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cell.com/cell-metabolism/fulltext/S1550-4131(21)00063-2
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Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line

1
1. scibot 02 Mar 2021
  
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  Anti-FLAG
  
  DOI: 10.1016/j.jbc.2021.100475
  
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Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription

1
1. scibot 02 Mar 2021
  
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  RRID:AB_262044
  
  DOI: 10.7554/eLife.62326
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7895526/
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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

1
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  DOI: 10.1016/j.cell.2020.12.031
  
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Feb 2021
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Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis

1
1. scibot 28 Feb 2021
  
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  RRID:AB_262044
  
  DOI: 10.17912/micropub.biology.000347
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7786221/
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Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency

1
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  DOI: 10.1016/j.molcel.2020.11.045
  
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The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals

1
1. scibot 28 Feb 2021
  
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  DOI: 10.7554/eLife.63088
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7819710/
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Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

1
1. scibot 28 Feb 2021
  
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  DOI: 10.1016/j.cmet.2020.12.011
  
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The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6

1
1. scibot 27 Feb 2021
  
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  FLAG
  
  DOI: 10.1073/pnas.2015887118
  
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pnas.org/content/118/1/e2015887118
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Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast

1
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  DOI: 10.7554/eLife.58155
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7647399/
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Neuroprotective activity of ursodeoxycholic acid in CHMP2BIntron5 models of frontotemporal dementia

1
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  DOI: 10.1016/j.nbd.2020.105047
  
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Ribosome Collision Is Critical for Quality Control during No-Go Decay

1
1. scibot 26 Feb 2021
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.molcel.2017.08.019
  
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cell.com/molecular-cell/abstract/S1097-2765(17)30616-0
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α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

1
1. scibot 26 Feb 2021
  
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  RRID:AB_262044
  
  DOI: 10.7554/eLife.56825
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7406352/
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Serotonin signaling by maternal neurons upon stress ensures progeny survival

1
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  DOI: 10.7554/eLife.55246
  
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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

1
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Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

1
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CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

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ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

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CARM1 regulates replication fork speed and stress response by stimulating PARP1

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Vezatin is required for the maturation of the neuromuscular synapse

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  DOI: 10.1091/mbc.E19-06-0313
  
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Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

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Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells

1
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SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans

1
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  DOI: 10.7554/eLife.60681
  
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Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

1
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Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

1
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  DOI: 10.1016/j.cub.2021.01.007
  
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Diverse viral proteases activate the NLRP1 inflammasome

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  DOI: 10.7554/eLife.60609
  
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Semi-automated single-molecule microscopy screening of fast-dissociating specific antibodies directly from hybridoma cultures

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The nascent polypeptide in the 60S subunit determines the Rqc2-dependency of ribosomal quality control

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  DOI: 10.1093/nar/gkab005
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab005/6123380
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ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

1
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Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis

1
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Ecd promotes U5 snRNP maturation and Prp8 stability

1
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  DOI: 10.1093/nar/gkaa1274
  
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Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis

1
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  DOI: 10.17912/micropub.biology.000347
  
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Therapeutic genetic variation revealed in diverse Hsp104 homologs

1
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Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling

1
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A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction

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  DOI: 10.15252/embj.2020104712
  
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embopress.org/doi/abs/10.15252/embj.2020104712
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Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival

1
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  DOI: 10.1016/j.celrep.2020.108599
  
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Piwil1 Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression

1
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  DOI: 10.1016/j.celrep.2020.108522
  
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DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

1
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  DOI: 10.1016/j.celrep.2020.108569
  
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Bistable, Biphasic Regulation of PP2A-B55 Accounts for the Dynamics of Mitotic Substrate Phosphorylation

1
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TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A

1
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An RNA Repair Operon Regulated by Damaged tRNAs

1
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  DOI: 10.1016/j.celrep.2020.108527
  
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AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9

1
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  DOI: 10.7554/eLife.61669
  
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Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5

1
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Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε

1
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  RRID: AB_262044
  
  DOI: 10.1016/j.molcel.2020.10.016
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30723-1
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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  RRID:AB_262044
  
  DOI: 10.1111/bph.15060
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15060
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Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA

1
1. scibot 07 Dec 2020
  
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  anti‐Flag
  
  DOI: 10.15252/embj.2019103654
  
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embopress.org/doi/abs/10.15252/embj.2019103654
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TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease

1
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  DOI: 10.1016/j.celrep.2020.108418
  
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sciencedirect.com/science/article/pii/S2211124720314078
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ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

1
1. scibot 28 Nov 2020
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.molcel.2020.10.031
  
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Essentiality of CENP-A Depends on Its Binding Mode to HJURP

1
1. scibot 26 Nov 2020
  
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  Mouse monoclonal anti-FLAG M2
  
  DOI: 10.1016/j.celrep.2020.108388
  
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BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment

1
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  AB_262044
  
  DOI: 10.1016/j.celrep.2020.108397
  
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An Aphid-Secreted Salivary Protease Activates Plant Defense in Phloem

1
1. scibot 21 Nov 2020
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.cub.2020.09.020
  
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cell.com/current-biology/abstract/S0960-9822(20)31351-8
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Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin

1
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  RRID:AB_262044
  
  DOI: 10.1016/j.cub.2020.09.078
  
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cell.com/current-biology/abstract/S0960-9822(20)31448-2
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A Systematic Protein Turnover Map for Decoding Protein Degradation

1
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  RRID:AB_262044
  
  DOI: 10.1016/j.celrep.2020.108378
  
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The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19CCAN Complex in Meiotic Kinetochore Assembly

1
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  RRID:AB_262044
  
  DOI: 10.1016/j.cub.2020.10.025
  
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Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast

1
1. scibot 12 Nov 2020
  
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  RRID:AB_262044
  
  DOI: 10.7554/eLife.61245
  
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Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism

1
1. scibot 11 Nov 2020
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.cub.2020.10.011
  
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GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

1
1. scibot 07 Nov 2020
  
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  anti-FLAG
  
  DOI: 10.1016/j.celrep.2020.108332
  
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Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex

1
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  RRID:AB_SLCC6485
  
  DOI: 10.1016/j.celrep.2020.108342
  
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sciencedirect.com/science/article/pii/S2211124720313310
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Defining Essential Enhancers for Pluripotent Stem Cells Using a Features-Oriented CRISPR-Cas9 Screen

1
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  RRID:AB_262044
  
  DOI: 10.1016/j.celrep.2020.108309
  
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Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy under Nutrient Stress via Drosophila Upd2 Repression

1
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  DOI: 10.1016/j.celrep.2020.108321
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9036415/
Oct 2020
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The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

1
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  RRID:AB_262044
  
  DOI: 10.1016/j.celrep.2020.108295
  
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Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

1
1. scibot 27 Oct 2020
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.devcel.2020.09.025
  
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sciencedirect.com/science/article/pii/S1534580720307577
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Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks

1
1. scibot 24 Oct 2020
  
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  RRID:AB_262044
  
  DOI: 10.7554/eLife.56450
  
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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

1
1. scibot 24 Oct 2020
  
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  RRID:AB_262044
  
  DOI: 10.1038/s41467-020-18761-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7532188/
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 22 Oct 2020
  
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  RRID:AB_262044
  
  DOI: 10.1002/1873-3468.13931
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.13931
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MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression

1
1. scibot 20 Oct 2020
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.celrep.2020.108267
  
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sciencedirect.com/science/article/pii/S2211124720312560
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Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target

1
1. scibot 17 Oct 2020
  
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  RRID:AB_262044
  
  DOI: 10.1016/j.celrep.2020.108252
  
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sciencedirect.com/science/article/pii/S2211124720312419
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TRPV4 activity regulates nuclear Ca2+ and transcriptional functions of β‐catenin in a renal epithelial cell model

1
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  RRID:AB_262044
  
  DOI: 10.1002/jcp.30096
  
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onlinelibrary.wiley.com/doi/10.1002/jcp.30096
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Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments

1
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  RRID:AB_262044
  
  DOI: 10.7554/eLife.57297
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7541089/
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MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression

1
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  DOI: 10.1016/j.celrep.2020.108228
  
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sciencedirect.com/science/article/pii/S2211124720312171
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Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation

1
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  RRID:AB_262044
  
  DOI: 10.1016/j.celrep.2020.108235
  
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pubmed.ncbi.nlm.nih.gov/33027661/
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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

1
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  DOI: 10.1016/j.cell.2020.09.002
  
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cell.com/cell/fulltext/S0092-8674(20)31143-0
Sep 2020
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C-Terminal Motifs of the MTW1 Complex Cooperatively Stabilize Outer Kinetochore Assembly in Budding Yeast

1
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  RRID:AB_262044
  
  DOI: 10.1016/j.celrep.2020.108190
  
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sciencedirect.com/science/article/pii/S2211124720311797
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Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating

1
1. scibot 30 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108201
  
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sciencedirect.com/science/article/pii/S2211124720311906
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Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence

1
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  RRID:AB_262044
  
  DOI: 10.1016/j.chom.2020.04.005
  
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sciencedirect.com/science/article/pii/S1931312820302328
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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

1
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  DOI: 10.7554/eLife.37993
  
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elifesciences.org/articles/37993
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High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

1
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  DOI: 10.1038/s41467-020-17209-1
  
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nature.com/articles/s41467-020-17209-1
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FRET kinase sensor development reveals SnRK2/OST1 activation by ABA but not by MeJA and high CO2 during stomatal closure

1
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  DOI: 10.7554/eLife.56351
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7289597/
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Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia

1
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  DOI: 10.1016/j.celrep.2020.108170
  
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Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

1
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  DOI: 10.7554/eLife.52779
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7112954/
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TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance

1
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  DOI: 10.1016/j.celrep.2020.107685
  
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Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

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Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication

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Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

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The COMET toolkit for composing customizable genetic programs in mammalian cells

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The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis

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A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling

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An Optimized Immunoprecipitation Protocol for Assessing Protein-RNA Interactions In Vitro

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Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes

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Conserved Tao kinase activity regulates dendritic arborization, cytoskeletal dynamics and sensory function in Drosophila

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The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

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A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel

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Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

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A Genetic Toggle for Chemical Control of Individual Plk1 Substrates

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CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching

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Molecular mechanisms underlying altered neurobehavioural development of female offspring of mothers with polycystic ovary syndrome: FOS-mediated regulation of neurotrophins in placenta

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BRAG2a mediates mGluR-dependent AMPA receptor internalization at excitatory postsynapses through the interaction with PSD-95 and endophilin 3

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Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase

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The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia

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Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations

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APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

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The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation

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Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

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The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

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Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation

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Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells

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Organismal benefits of transcription speed control at gene boundaries

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ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains

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An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

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Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2

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Differential Cellular Response to Translocated Toxic Effectors and Physical Penetration by the Type VI Secretion System

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Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1

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Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

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Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

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Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation

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L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis

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Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition

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Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth

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Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss

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Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

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Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome

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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

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The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death

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Ordered patterning of the sensory system is susceptible to stochastic features of gene expression

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FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

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KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

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TMEM163 Regulates ATP-Gated P2X Receptor and Behavior

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Insights Into the Mechanism of MCT8 Oligomerization

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Ago2-Dependent Processing Allows miR-451 to Evade the Global MicroRNA Turnover Elicited during Erythropoiesis

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NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

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A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

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Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity

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Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis

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Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function

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  DOI: 10.1186/s12915-020-00787-3
  
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An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

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Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor

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Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart

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Hierarchy in Hfq Chaperon Occupancy of Small RNA Targets Plays a Major Role in Their Regulation

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CenH3-Independent Kinetochore Assembly in Lepidoptera Requires CCAN, Including CENP-T

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