301 Matching Annotations
  1. Last 7 days
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    One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade
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    1. scibot 17 May 2024
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    sciencedirect.com/science/article/pii/S2451945624001697
  3. May 2024
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    Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy
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    sciencedirect.com/science/article/pii/S0092867424004100
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    Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030325/
  6. Apr 2024
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    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    1. scibot 30 Apr 2024
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    sciencedirect.com/science/article/pii/S2666379124001976
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    LKB1 prevents ILC2 exhaustion to enhance antitumor immunity
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    1. scibot 26 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124723015917
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    Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy
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    sciencedirect.com/science/article/pii/S2211124724004698
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    QDPR deficiency drives immune suppression in pancreatic cancer
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    1. scibot 23 Apr 2024
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    sciencedirect.com/science/article/pii/S1550413124001190
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    TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation
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    1. scibot 18 Apr 2024
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      DOI: 10.1084/jem.20231236

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    ncbi.nlm.nih.gov/pmc/articles/PMC11010340/
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    Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity
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      DOI: 10.1016/j.immuni.2024.03.017

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    sciencedirect.com/science/article/pii/S1074761324001389
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    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
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    1. scibot 12 Apr 2024
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    sciencedirect.com/science/article/pii/S2666379124001253
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    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
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    sciencedirect.com/science/article/pii/S1535610824000916
  15. Mar 2024
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    Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity
    1
    1. scibot 27 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724003310
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    Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection
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    1. scibot 22 Mar 2024
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    sciencedirect.com/science/article/pii/S0092867424002496
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    Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration
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    1. scibot 19 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724002596
  19. www-cell-com.proxy.uchicago.edu www-cell-com.proxy.uchicago.edu
    Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer
    1
    1. scibot 15 Mar 2024
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    www-cell-com.proxy.uchicago.edu/cell/fulltext/S0092-8674(24)00224-1
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    Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers
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    Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis
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    sciencedirect.com/science/article/pii/S2211124724002626
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function
    1
    1. scibot 12 Mar 2024
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      DOI: 10.1186/s13046-024-02985-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10921725/
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    Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity
    1
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    sciencedirect.com/science/article/pii/S2211124724002602
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    Maternal inflammation regulates fetal emergency myelopoiesis
    2
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    sciencedirect.com/science/article/pii/S0092867424001235
  25. Feb 2024
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    UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
    1
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    sciencedirect.com/science/article/pii/S1097276524000911
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    The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis
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    sciencedirect.com/science/article/pii/S2211124724001529
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    Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48
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    sciencedirect.com/science/article/pii/S2211124724001281
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    Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma
    3
    1. scibot 21 Feb 2024
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    sciencedirect.com/science/article/pii/S2666379124000387
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas
    1
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      DOI: 10.1158/2767-9764.CRC-23-0399

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  31. www.biorxiv.org www.biorxiv.org
    Loss of TIM4-Dependent Efferocytosis in Kupffer Cells Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
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      DOI: 10.1101/2024.01.30.578023

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    biorxiv.org/content/10.1101/2024.01.30.578023v1
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    Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in human NSCLC
    2
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    sciencedirect.com/science/article/pii/S2211124724000950
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    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    An axon-T cell feedback loop enhances inflammation and axon degeneration
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    sciencedirect.com/science/article/pii/S2211124724000494
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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  36. Jan 2024
  37. www.sciencedirect.com www.sciencedirect.com
    Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
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    sciencedirect.com/science/article/pii/S1535610823004464
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities
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    ncbi.nlm.nih.gov/pmc/articles/PMC10518355/
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    Renal macrophages monitor and remove particles from urine to prevent tubule obstruction
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    Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation
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      DOI: 10.1016/j.chom.2023.12.006

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    sciencedirect.com/science/article/pii/S1931312823005012
  41. dx.doi.org dx.doi.org
    Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade
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      DOI: 10.1158/2159-8290.CD-22-1301

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    dx.doi.org/10.1158/2159-8290.CD-22-1301
  42. 52.53.155.43 52.53.155.43
    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors
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    1. scibot 10 Jan 2024
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      DOI: 10.1126/sciimmunol.abq2424

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    Interferon-stimulated neutrophils as a predictor of immunotherapy response
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    Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
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  45. Dec 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preventive Treatment with PD-1 Antibody Increases Tissue-Resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis
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    Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis
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  51. 52.53.155.43 52.53.155.43
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  52. Nov 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals
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    E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC
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    CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis
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  56. Oct 2023
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    Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation
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    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling
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    Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    Supplementation with a high-glucose drink stimulates anti-tumor immune responses to glioblastoma via gut microbiota modulation
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    The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy
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    Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer
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    Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
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  66. Sep 2023
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    Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration
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    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
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    Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma
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  70. Aug 2023
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    Sepsis induces non-classic innate immune memory in granulocytes
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    Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
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    CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity
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  74. 52.53.155.43 52.53.155.43
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    CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells
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    A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells
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    METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy
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    TIM3 is a context-dependent co-regulator of cytotoxic T cell function
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  79. 52.53.155.43 52.53.155.43
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OncoLoop: A network-based precision cancer medicine framework
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  81. Jul 2023
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    SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck
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    Lung injury induces a polarized immune response by self-antigen-specific CD4+ Foxp3+ regulatory T cells
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    Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
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    TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation
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  86. Jun 2023
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    Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses
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    PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
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    Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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    Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer
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  92. May 2023
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    IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
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    CCL19+ dendritic cells potentiate clinical benefit of anti-PD-(L)1 immunotherapy in triple-negative breast cancer
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    Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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    LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration
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    Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer
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  98. Apr 2023
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    Targeting ULK1 decreases interferon-γ-mediated resistance to immune checkpoint inhibitors
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    Lenvatinib or anti-VEGF in combination with anti-PD-1 differentially augments anti-tumor activity in melanoma
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    Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy
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    Identification of fibrocyte cluster in tumors reveals the role in antitumor immunity by PD-L1 blockade
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    NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection
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    Variant enterovirus A71 found in immune-suppressed patient binds to heparan sulfate and exhibits neurotropism in B-cell-depleted mice
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    Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens
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    Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma
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    An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses
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    Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody
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    Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
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    Lacticaseibacillus rhamnosus Probio-M9 enhanced the antitumor response to anti-PD-1 therapy by modulating intestinal metabolites
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    Thymus Antibody-Secreting Cells Possess an Interferon Gene Signature and are Preferentially Expanded in Young Female Mice
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  113. Feb 2023
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    Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer
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  115. Jan 2023
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    S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas
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    MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
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    Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1
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    Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes
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    Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung
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    IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
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    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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    Mouse placenta fetal macrophages arise from endothelial cells outside the placenta
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  127. Nov 2022
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    STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation
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    Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
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    Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis
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    Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy
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  132. Oct 2022
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    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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    Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation
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    PARP-inhibition reprograms macrophages toward an anti-tumor phenotype
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  136. Sep 2022
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    Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1
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    Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis
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  140. Aug 2022
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    B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema
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  142. www.sciencedirect.com www.sciencedirect.com
    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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    Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment
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    Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway
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    Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment
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  146. Jul 2022
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    Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection
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    Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells
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  149. Jun 2022
  150. 52.53.155.43 52.53.155.43
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  151. 52.53.155.43 52.53.155.43
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    Androgens drive sexual dimorphism in liver metastasis by promoting hepatic accumulation of neutrophils
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance
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    Unravelling the sex-specific diversity and functions of adrenal gland macrophages
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    Poroptosis: a form of cell death depending on plasma membrane nanopores formation
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    Nt5e deficiency does not affect post-stroke inflammation and lesion size in a murine ischemia/reperfusion stroke model
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    Flow cytometry analysis of endothelial cells and subsets of exhausted CD8+ T cells in murine tumor models
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    PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
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  159. May 2022
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    Newly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection
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    The C5a-C5aR1 complement axis is essential for neutrophil recruitment to draining lymph nodes via high endothelial venules in cutaneous leishmaniasis
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    Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
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    Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche
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  164. Apr 2022
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    Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation
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  168. aacrjournals.org aacrjournals.org
    mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment
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      DOI: 10.1158/1541-7786.MCR-20-0799

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    aacrjournals.org/mcr/article/19/4/717/672854/mDKN-01-a-Novel-Anti-DKK1-mAb-Enhances-Innate
  169. Mar 2022
  170. www.sciencedirect.com www.sciencedirect.com
    Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites
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    The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells
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  173. elifesciences.org elifesciences.org
    A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx
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    CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
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  175. Feb 2022
  176. www.sciencedirect.com www.sciencedirect.com
    An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
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    Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
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  178. www.jneurosci.org www.jneurosci.org
    Embryonic pericytes promote microglial homeostasis and their effects on neural progenitors in the developing cerebral cortex
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  179. Jan 2022
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    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
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    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization
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  183. www.sciencedirect.com www.sciencedirect.com
    Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion
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  184. Dec 2021
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    Virulence factors perforate the pathogen-containing vacuole to signal efferocytosis
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    Resolving the immune landscape of human prostate at a single-cell level in health and cancer
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    Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells
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    Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
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    The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota
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    SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects
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    Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
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  193. Nov 2021
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    CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
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  195. Oct 2021
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    RSV infection-elicited high MMP-12–producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration
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  197. pubs.acs.org pubs.acs.org
    Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity
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    Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
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    Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza
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  200. Sep 2021
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    In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target
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    The pivotal role of cytotoxic NK cells in mediating the therapeutic effect of anti-CD47 therapy in mycosis fungoides
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    Original research: CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell
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    Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors
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    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
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    Effects of exercise and anti-PD-1 on the tumour microenvironment
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    A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer
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  208. Aug 2021
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    Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
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    Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy
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    NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells
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    The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer
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      DOI: 10.1016/j.celrep.2018.11.047

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    Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells
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    Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection
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      DOI: 10.1016/j.cell.2018.04.006

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